LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Edema D004487 152 associated lipids
Arthritis D001168 41 associated lipids
Hypotension D007022 41 associated lipids
Gastritis D005756 27 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Osteosarcoma D012516 50 associated lipids
Carcinoma, Small Cell D018288 21 associated lipids
Asthma D001249 52 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Weber M and Dahinden CA Basophil and eosinophil activation by CC chemokines. 1995 May-Jun Int. Arch. Allergy Immunol. pmid:7542061
Miadonna A et al. Antiallergic activity of loratadine: inhibition of leukotriene C4 release from human leucocytes. 1995 Clin. Exp. Allergy pmid:7541309
Rachmilewitz D et al. Sulfhydryl blocker-induced rat colonic inflammation is ameliorated by inhibition of nitric oxide synthase. 1995 Gastroenterology pmid:7541005
Smit NP et al. Stimulation of cultured melanocytes in medium containing a serum substitute: Ultroser-G. 1995 Pigment Cell Res. pmid:7540755
Murakami M et al. The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. 1995 J. Exp. Med. pmid:7540649
Thomas JW et al. Potent interleukin 3 receptor agonist with selectively enhanced hematopoietic activity relative to recombinant human interleukin 3. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7537376
Patella V et al. Human heart mast cells: a definitive case of mast cell heterogeneity. 1995 Int. Arch. Allergy Immunol. pmid:7536502
Büyükgebiz O et al. Captopril increases endothelin serum concentrations and preserves intestinal mucosa after mesenteric ischemia-reperfusion injury. 1994 Res Exp Med (Berl) pmid:7536337
Weber M et al. Monocyte chemotactic protein MCP-2 activates human basophil and eosinophil leukocytes similar to MCP-3. 1995 J. Immunol. pmid:7535823
Patella V et al. Human heart mast cells. Isolation, purification, ultrastructure, and immunologic characterization. 1995 J. Immunol. pmid:7533185
Patella V et al. The antineoplastic bryostatins affect human basophils and mast cells differently. 1995 Blood pmid:7532037
Egger D et al. IL-4 renders mast cells functionally responsive to endothelin-1. 1995 J. Immunol. pmid:7530742
Teshigawara H and Moriya Y The role of leukotriene C4 in biphasic release of histamine from mouse mastocytoma cell line (P-815). 1994 Gen. Pharmacol. pmid:7530673
Horikawa T et al. Melanocyte mitogens induce both melanocyte chemokinesis and chemotaxis. 1995 J. Invest. Dermatol. pmid:7530272
Miyamasu M et al. Chemotactic agonists induce cytokine generation in eosinophils. 1995 J. Immunol. pmid:7529800
Mita H et al. [Release of chemical mediators in the conjunctival lavage fluids after eye provocation with allergen or compound 48/80]. 1994 Arerugi pmid:7526828
Ramachers U et al. Direct effects of second-generation H1-receptor antagonists on the activation of human basophils. 1994 Agents Actions pmid:7526656
Tedeschi A et al. Nasal eosinophilia induced by PAF-acether is accompanied by the release of eosinophil cationic protein. 1994 Eur. Respir. J. pmid:7525344
Zuany-Amorim C et al. Strain-dependency of leukotriene C4 generation from isolated lungs of immunized mice. 1994 Br. J. Pharmacol. pmid:7524994
Tsopanoglou NE et al. Leukotrienes C4 and D4 promote angiogenesis via a receptor-mediated interaction. 1994 Eur. J. Pharmacol. pmid:7523148
Yamamura H et al. Endothelin-1 induces release of histamine and leukotriene C4 from mouse bone marrow-derived mast cells. 1994 Eur. J. Pharmacol. pmid:7522171
Miadonna A et al. Modulation of allergen-induced nasal symptoms and mediator release by treatment with N-acetyl-aspartyl-glutamate (ZY15106). 1994 Eur. J. Clin. Pharmacol. pmid:7518775
Sainte-Laudy J et al. [Demonstration of sulfite-group-specific IgE in patients with intolerance to preservatives]. 1994 Allerg Immunol (Paris) pmid:7518236
Bürgi B et al. The degradation product of the C5a anaphylatoxin C5adesarg retains basophil-activating properties. 1994 Eur. J. Immunol. pmid:7517876
Wettstein M and Häussinger D [Effect of hypoxia on nitric oxide formation and leukotriene metabolism in the perfused rat liver]. 1994 Zentralbl Chir pmid:7517604
YeÄŸen C et al. Effect of verapamil and iloprost (ZK 36374) on endothelin release after mesenteric ischemia-reperfusion injury. 1994 Eur Surg Res pmid:7516292
Aktan AO et al. Does PGE2 act as a mediator for endothelin release? 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7511821
Marone G et al. Anti-inflammatory effects of glucocorticoids and cyclosporin A on human basophils. 1993 Eur. J. Clin. Pharmacol. pmid:7508864
Mifune T et al. Chemical mediator and cellular reaction in the bronchoalveolar lavage fluid of patients with steroid-dependent intractable asthma (SDIA). 1993 Acta Med. Okayama pmid:7505996
Casolaro V et al. Nimesulide, a sulfonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from human basophils and mast cells. 1993 J. Pharmacol. Exp. Ther. pmid:7505332
Mita H et al. Purification of human blood basophils and leukotriene C4 generation following calcium ionophore stimulation. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:7505057
Culo F et al. Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice. 1995 Eur J Gastroenterol Hepatol pmid:7496865
Ochensberger B et al. IgE-independent interleukin-4 expression and induction of a late phase of leukotriene C4 formation in human blood basophils. 1995 Blood pmid:7492759
Sampson AP et al. Persistent increase in plasma and urinary leukotrienes after acute asthma. 1995 Arch. Dis. Child. pmid:7492159
Grønbech JE and Lacy ER Role of gastric blood flow in impaired defense and repair of aged rat stomachs. 1995 Am. J. Physiol. pmid:7491966
Kurokawa H et al. Gamma-glutamylcysteine synthetase gene overexpression results in increased activity of the ATP-dependent glutathione S-conjugate export pump and cisplatin resistance. 1995 Biochem. Biophys. Res. Commun. pmid:7488097
Müller D et al. Stimulation of bile flow and inhibition of biliary secretion of taurocholate and leukotriene C4 in thioacetamide-induced liver fibrosis. 1993 Z Gastroenterol pmid:7483705
Buyukgebiz O et al. Allopurinol inhibits endothelin release after mesenteric ischemia-reperfusion injury. 1995 Transplant. Proc. pmid:7482880
Herman CA et al. Leukotriene C4-stimulated contractions in bullfrog lung are affected by cold acclimation and calcium antagonists. 1995 Prostaglandins pmid:7480797
Yakubu MA et al. Hematoma-induced enhanced cerebral vasoconstrictions to leukotriene C4 and endothelin-1 in piglets: role of prostanoids. 1995 Pediatr. Res. pmid:7478789
Malaviya R and Abraham SN Interaction of bacteria with mast cells. 1995 Meth. Enzymol. pmid:7476393
Mannervik B et al. Transformation of leukotriene A4 methyl ester to leukotriene C4 monomethyl ester by cytosolic rat glutathione transferases. 1984 FEBS Lett. pmid:6548194
Pönicke K and Förster W Influence of leukotriene C4 on aggregation and on malondialdehyde formation of human blood platelets. 1984 Biomed. Biochim. Acta pmid:6440558
Romero R et al. Increased amniotic fluid leukotriene C4 concentration in term human parturition. 1988 Am. J. Obstet. Gynecol. pmid:3421265
Paoletti P et al. CSF leukotriene C4 following subarachnoid hemorrhage. 1988 J. Neurosurg. pmid:3418380
Angi MR et al. [Quantitative evaluation of conjunctival irritation by simultaneous determination of histamine, serotonin and leukotriene C4 in tears]. 1987 Oct-Dec Ophtalmologie pmid:3153930
Maury G et al. Racemic LTA4 methyl ester bioconversion into LTC4 methyl ester by various glutathione S-transferases. 1987 Biochem. Int. pmid:3125835
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