LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Carotid Artery Injuries D020212 8 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Myocardial Ischemia D017202 11 associated lipids
Hyperbilirubinemia D006932 11 associated lipids
Acute-Phase Reaction D000210 12 associated lipids
Airway Obstruction D000402 13 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Uveitis D014605 14 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Authors Title Published Journal PubMed Link
Horak F et al. Effect of continuous allergen challenge on clinical symptoms and mediator release in dust-mite-allergic patients. 1998 Allergy pmid:9491231
Chavis C et al. Leukotriene E4 plasma levels in adult asthmatic patients with variable disease severity. 1997 Allergy pmid:9201374
Crampette L et al. Inhibition of mediator and cytokine release from dispersed nasal polyp cells by terfenadine. 1996 Allergy pmid:8836342
Zuberbier T et al. Histamine releasability of basophils and skin mast cells in chronic urticaria. 1996 Allergy pmid:8721524
Kupczyk M et al. Lipoxin A4 generation is decreased in aspirin-sensitive patients in lysine-aspirin nasal challenge in vivo model. 2009 Allergy pmid:19385948
Gulliksson M et al. Release of prostaglandin D2 and leukotriene C4 in response to hyperosmolar stimulation of mast cells. 2006 Allergy pmid:17073880
Kowalski ML et al. Inhibition of nasal polyp mast cell and eosinophil activation by desloratadine. 2005 Allergy pmid:15575935
Schauer U et al. Blood eosinophils, eosinophil-derived proteins, and leukotriene C4 generation in relation to bronchial hyperreactivity in children with atopic dermatitis. 1995 Allergy pmid:7604934
Kalayci O et al. ALOX5 promoter genotype, asthma severity and LTC production by eosinophils. 2006 Allergy pmid:16364163
Taskila K et al. Histamine and LTC4 in stinging nettle-induced urticaria. 2000 Allergy pmid:10921474