| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cough | D003371 | 19 associated lipids |
| Drug Eruptions | D003875 | 30 associated lipids |
| Dermatitis, Atopic | D003876 | 19 associated lipids |
| Drug Hypersensitivity | D004342 | 20 associated lipids |
| Ear Diseases | D004427 | 7 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Eosinophilia | D004802 | 4 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Moneret-Vautrin DA et al. | Human basophil activation measured by CD63 expression and LTC4 release in IgE-mediated food allergy. | 1999 | Ann. Allergy Asthma Immunol. | pmid:9988204 |
| Urasaki T et al. | Cytosolic phospholipase A2, increased and activated in the eosinophils of patients with hypereosinophilic syndrome in vivo, is involved in the augmented release of leukotriene C4. | 1999 | Inflamm. Res. | pmid:9987681 |
| Brock TG et al. | Decreased leukotriene C4 synthesis accompanies adherence-dependent nuclear import of 5-lipoxygenase in human blood eosinophils. | 1999 | J. Immunol. | pmid:9973428 |
| Mayatepek E et al. | LTB4 and LTC4 are absent in the cerebrospinal fluid of human immunodeficiency virus type 1-seropositive persons with toxoplasmic encephalitis: evidence for inhibition of 5-lipoxygenase by Toxoplasma gondii. | 1999 | J. Infect. Dis. | pmid:9952384 |
| Lärfars G et al. | Activation of nitric oxide release and oxidative metabolism by leukotrienes B4, C4, and D4 in human polymorphonuclear leukocytes. | 1999 | Blood | pmid:9949184 |
| Ochensberger B et al. | Regulation of cytokine expression and leukotriene formation in human basophils by growth factors, chemokines and chemotactic agonists. | 1999 | Eur. J. Immunol. | pmid:9933081 |
| Akpek EA et al. | A study of adenosine treatment in experimental acute spinal cord injury. Effect on arachidonic acid metabolites. | 1999 | Spine | pmid:9926381 |
| Bannenberg G et al. | Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers. | 1999 | J. Biol. Chem. | pmid:9890956 |
| Tsuruta R et al. | Soluble vascular cell adhesion molecule (VCAM)-Fc fusion protein induces leukotriene C4 secretion in platelet-activating factor-stimulated eosinophils. | 1999 | J. Leukoc. Biol. | pmid:9886248 |
| Suzuki H and Sugiyama Y | Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2. | 1998 | Semin. Liver Dis. | pmid:9875554 |
| Wu RY and Wei EQ | [Inhibitory effects of tachykinin receptor antagonists on leukotriene C4-induced cardiovascular responses in guinea pigs]. | 1996 | Yao Xue Xue Bao | pmid:9863223 |
| Anadol AZ et al. | Role of endogenous endothelin peptides in intestinal ischemia-reperfusion injury in rats. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9849655 |
| Haberl C et al. | Release of prostaglandin D2 by murine mast cells: importance of metabolite formation for antiproliferative activity. | 1998 | Mediators Inflamm. | pmid:9836493 |
| Ohashi H et al. | Sulochrin inhibits eosinophil activation and chemotaxis. | 1998 | Inflamm. Res. | pmid:9831326 |
| Horizoe T et al. | ER-34122, a novel dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity in an arachidonic acid-induced ear inflammation model. | 1998 | Inflamm. Res. | pmid:9831321 |
| Chu XY et al. | Biliary excretion mechanism of CPT-11 and its metabolites in humans: involvement of primary active transporters. | 1998 | Cancer Res. | pmid:9823324 |
| Bakos E et al. | Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain. | 1998 | J. Biol. Chem. | pmid:9822694 |
| Takafuji S et al. | Release of granule proteins from human eosinophils stimulated with mast-cell mediators. | 1998 | Allergy | pmid:9821474 |
| Mayatepek E and Flock B | Leukotriene C4-synthesis deficiency: a new inborn error of metabolism linked to a fatal developmental syndrome. | 1998 | Lancet | pmid:9820300 |
| Kjellström S et al. | On-line coupling of microdialysis sampling with liquid chromatography for the determination of peptide and non-peptide leukotrienes. | 1998 | J Chromatogr A | pmid:9818423 |
| Yamane Y et al. | Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress. | 1998 | J. Biol. Chem. | pmid:9813007 |
| Wei EQ et al. | Effect of ONO-1078, a leukotriene antagonist, on capsaicin- and substance P-induced bronchoconstriction and airway microvascular leakage in guinea pigs. | 1996 | Zhongguo Yao Li Xue Bao | pmid:9812736 |
| Yatabe T et al. | Studies on 5-lipoxygenase inhibitors. II. Discovery, optical resolution and enantioselective synthesis of FR110302, a highly potent non-redox type 5-lipoxygenase inhibitor. | 1998 | Chem. Pharm. Bull. | pmid:9810693 |
| Sciuto AM et al. | Post-exposure treatment with isoproterenol attenuates pulmonary edema in phosgene-exposed rabbits. | 1998 Sep-Oct | J Appl Toxicol | pmid:9804432 |
| Matsushita N et al. | Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects. | 1998 | Jpn. J. Pharmacol. | pmid:9804057 |
| Ohtsuka Y et al. | Chronic oral antigen exposure induces lymphocyte migration in anaphylactic mouse intestine. | 1998 | Pediatr. Res. | pmid:9803464 |
| Templeton AG et al. | Effects of S-salbutamol on human isolated bronchus. | 1998 | Pulm Pharmacol Ther | pmid:9802957 |
| Bartosz G et al. | Human mast cells secreting leukotriene C4 express the MRP1 gene-encoded conjugate export pump. | 1998 Aug-Sep | Biol. Chem. | pmid:9792445 |
| Nakano R et al. | A leukotriene receptor antagonist, ONO-1078, modulates drug sensitivity and leukotriene C4 efflux in lung cancer cells expressing multidrug resistance protein. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9790952 |
| Carter BZ et al. | gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene family member, is expressed primarily in spleen. | 1998 | J. Biol. Chem. | pmid:9774450 |
| Miura K et al. | Phosphorylation of cytosolic phospholipase A2 by IL-3 is associated with increased free arachidonic acid generation and leukotriene C4 release in human basophils. | 1998 | J. Allergy Clin. Immunol. | pmid:9768595 |
| Bermejo Benito P et al. | In vivo and in vitro antiinflammatory activity of saikosaponins. | 1998 | Life Sci. | pmid:9763210 |
| Wen FQ et al. | Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758210 |
| Amat M et al. | Leukotriene A4 hydrolase and leukotriene C4 synthase activities in human chondrocytes: transcellular biosynthesis of Leukotrienes during granulocyte-chondrocyte interaction. | 1998 | Arthritis Rheum. | pmid:9751098 |
| Nishida M et al. | Lack of active lung anaphylaxis in congenitally mast cell-deficient Ws/Ws rats sensitized with the nematode Nippostrongylus brasiliensis. | 1998 | APMIS | pmid:9740510 |
| Geirsson A et al. | Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells. | 1998 | J. Cell. Physiol. | pmid:9731750 |
| Miller DS et al. | Excretory transport of xenobiotics by dogfish shark rectal gland tubules. | 1998 | Am. J. Physiol. | pmid:9728065 |
| Ishihara K et al. | Inhibition of icosanoid production in MC/9 mouse mast cells by n-3 polyunsaturated fatty acids isolated from edible marine algae. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9720225 |
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| Lebel B et al. | Inhibition of mediator release from dispersed nasal polyp cells by cyclosporin A. | 1998 | Int. Arch. Allergy Immunol. | pmid:9693278 |
| Iikura M et al. | Secretory IgA induces degranulation of IL-3-primed basophils. | 1998 | J. Immunol. | pmid:9686618 |
| Akman A et al. | Effects of lodoxamide, disodium cromoglycate and fluorometholone on tear leukotriene levels in vernal keratoconjunctivitis. | 1998 | Eye (Lond) | pmid:9683957 |
| Stenke L et al. | Novel enzymatic abnormalities in AML and CML in blast crisis: elevated leucocyte leukotriene C4 synthase activity paralleled by deficient leukotriene biosynthesis from endogenous substrate. | 1998 | Br. J. Haematol. | pmid:9674747 |
| Lukaszyk A et al. | The role of epidermal growth factor in platelet-endothelium interactions. | 1998 | J. Physiol. Pharmacol. | pmid:9670106 |
| Mitsunobu F et al. | Different roles of histamine and leukotriene C4 in the airways between patients with atopic and nonatopic asthma. | 1998 | J Asthma | pmid:9669831 |
| Pfau JC et al. | A comparison of the effects of lipopolysaccharide and ceramide on arachidonic acid metabolism in THP-1 monocytic cells. | 1998 | Cell. Immunol. | pmid:9665757 |
| Schuligoi R et al. | Effects of the cyclooxygenase-2 inhibitor NS-398 on thromboxane and leukotriene synthesis in rat peritoneal cells. | 1998 | Inflamm. Res. | pmid:9657255 |
| Hamasaki Y et al. | Inhibition of leukotriene synthesis by terfenadine in vitro. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654399 |
| Nagata M et al. | Granulocyte macrophage colony-stimulating factor augments ICAM-1 and VCAM-1 activation of eosinophil function. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9651192 |
| Priebe W et al. | Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9647783 |