LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

Download all related citations
Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Taichman RS et al. Human osteosarcomas inhibit hematopoietic colony formation: partial reversal by antibody to transforming growth factor-beta 1. 1997 Bone pmid:9315339
Mullol J et al. [Eosinophil activation by epithelial cells of the respiratory mucosa. Comparative study of normal mucosa and inflammatory mucosa]. 1997 Med Clin (Barc) pmid:9303983
Jakobsson PJ et al. Characterization of microsomal GST-II by western blot and identification of a novel LTC4 isomer. 1997 J Lipid Mediat Cell Signal pmid:9302651
Hamasaki Y et al. Post-transcriptional regulation of LTC4 synthase activity by retinoic acid in rat basophilic leukemia cells. 1997 Biochim. Biophys. Acta pmid:9295165
Stride BD et al. Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. 1997 Mol. Pharmacol. pmid:9281595
Cunningham FM et al. Pharmacology of the 5-lipoxygenase inhibitors BAY Y 1015 and BAY X 1005 in the horse. 1997 J. Vet. Pharmacol. Ther. pmid:9280370
Sainte-Laudy J et al. [Bioclinical interest in the assay of leukotrienes in four cases of sensitization to trophallergens]. 1997 Allerg Immunol (Paris) pmid:9254120
Sabbah A et al. [Allergy to mosquitoes and use of new immunobiological parameters]. 1997 Allerg Immunol (Paris) pmid:9254117
Ibe BO et al. Leukotriene synthesis by isolated perinatal ovine intrapulmonary vessels correlates with age-related changes in 5-lipoxygenase protein. 1997 Biochem. Mol. Med. pmid:9232199
Bacha EA et al. Gastric antigen challenge releases gastrin and eicosanoids and protects against ethanol. 1997 J. Surg. Res. pmid:9228931
Sabbah A et al. [Anaphylactic or anaphylactoid reactions to paracetamol. Report of 3 cases]. 1997 Allerg Immunol (Paris) pmid:9221011
Patella V et al. Heterogeneous effects of protamine on human mast cells and basophils. 1997 Br J Anaesth pmid:9215027
Chavis C et al. Leukotriene E4 plasma levels in adult asthmatic patients with variable disease severity. 1997 Allergy pmid:9201374
Forssmann U et al. Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. 1997 J. Exp. Med. pmid:9182688
Leynadier F [Drug allergies: value of the leucotriene C4 release test?]. 1997 Presse Med pmid:9180883
Genovese A et al. Loratadine and desethoxylcarbonyl-loratadine inhibit the immunological release of mediators from human Fc epsilon RI+ cells. 1997 Clin. Exp. Allergy pmid:9179431
Akagi M et al. Anti-allergic effect of tea-leaf saponin (TLS) from tea leaves (Camellia sinensis var. sinensis). 1997 Biol. Pharm. Bull. pmid:9178940
Hamasaki Y et al. The Chinese herbal medicine, shinpi-to, inhibits IgE-mediated leukotriene synthesis in rat basophilic leukemia-2H3 cells. 1997 J Ethnopharmacol pmid:9174973
Planquois JM et al. Differential inhibition by selective phosphodiesterase inhibitors of antigen, LTC4 and histamine-induced contraction of guinea-pig isolated trachea. 1996 Pulm Pharmacol pmid:9160414
Abe T et al. [Multidrug resistance protein (MRP)]. 1997 Nippon Rinsho pmid:9155156
Pedersen KE et al. Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism. 1997 J. Pharmacol. Exp. Ther. pmid:9152370
Takano T et al. Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. 1997 J. Exp. Med. pmid:9151906
Frieling T et al. Leukotriene-evoked cyclic chloride secretion is mediated by enteric neuronal modulation in guinea-pig colon. 1997 Naunyn Schmiedebergs Arch. Pharmacol. pmid:9151302
KuÅŸtimur S et al. Effect of nordihydroguaretic acid and fluconazole on the LTC4/PGE2 ratio in the kidney of mice damaged by Candida albicans. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9150373
Bozkurt S et al. The cytoprotective effect of iloprost against carbon tetrachloride induced necrosis in rat liver. 1997 Res. Commun. Mol. Pathol. Pharmacol. pmid:9144840
Nguyen T and Gupta S Leukotriene C4 secretion from normal murine mast cells by a probenecid-sensitive and multidrug resistance-associated protein-independent mechanism. 1997 J. Immunol. pmid:9144509
Carter BZ et al. Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice. 1997 J. Biol. Chem. pmid:9139674
Bureau MF et al. 5-Lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs. 1997 Eur. J. Pharmacol. pmid:9137918
el-Ahmady O et al. Elevated concentrations of interleukins and leukotriene in response to Mycobacterium tuberculosis infection. 1997 Ann. Clin. Biochem. pmid:9133249
Ishizuka Y et al. Effect of 1,6-dihydro-2[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidineca rboxyli c acid on ethanol-induced microvascular injury in rats. 1996 Arzneimittelforschung pmid:9125278
Hsieh KH Evaluation of efficacy of traditional Chinese medicines in the treatment of childhood bronchial asthma: clinical trial, immunological tests and animal study. Taiwan Asthma Study Group. 1996 Pediatr Allergy Immunol pmid:9116877
Sala A et al. Pharmacological modulation of human platelet leukotriene C4-synthase. 1997 Biochem. Pharmacol. pmid:9113110
Zeltsman D et al. Pathophysiologic plasma levels of leukotriene C4 in relation to the hemodynamic dysfunction and mediator release of graded bacteremia. 1997 Shock pmid:9110414
Madon J et al. Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein. 1997 FEBS Lett. pmid:9109389
Gagari E et al. Differential release of mast cell interleukin-6 via c-kit. 1997 Blood pmid:9108382
Wang D et al. An approach to the understanding of the nasal early-phase reaction induced by nasal allergen challenge. 1997 Allergy pmid:9105520
Puder M and Soberman RJ Glutathione conjugates recognize the Rossmann fold of glyceraldehyde-3-phosphate dehydrogenase. 1997 J. Biol. Chem. pmid:9099752
Scoggan KA et al. Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes. 1997 J. Biol. Chem. pmid:9092565
de Paulis A et al. Human synovial mast cells. II. Heterogeneity of the pharmacologic effects of antiinflammatory and immunosuppressive drugs. 1997 Arthritis Rheum. pmid:9082935
Sumizawa T et al. Reversal of multidrug resistance-associated protein-mediated drug resistance by the pyridine analog PAK-104P. 1997 Mol. Pharmacol. pmid:9058594
Damtew B and Spagnuolo PJ Leukotriene C4 from vascular endothelium enhances neutrophil adhesiveness. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9051719
Schuligoi R et al. Release of calcitonin gene-related peptide in cardiac anaphylaxis. 1997 Naunyn Schmiedebergs Arch. Pharmacol. pmid:9050016
Gissurarson SR et al. Effect of lobaric acid on cysteinyl-leukotriene formation and contractile activity of guinea pig taenia coli. 1997 J. Pharmacol. Exp. Ther. pmid:9023290
Sare M et al. The effects of indomethacin, NDGA, allopurinol and superoxide dismutase on prostaglandin E2 and leukotriene C4 levels after mesenteric ischemia-reperfusion injury. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:9014215
Dhillon HS et al. Regional generation of leukotriene C4 after experimental brain injury in anesthetized rats. 1996 J. Neurotrauma pmid:9002063
Garcia C et al. Effects of synthetic peptido-leukotrienes on bone resorption in vitro. 1996 J. Bone Miner. Res. pmid:8992883
Kobayashi S et al. [Inhibitory effect of ONO-1078, a novel leukotriene receptor antagonist, on human peripheral blood eosinophils]. 1996 Arerugi pmid:8990528
Akasaka R et al. Effects of three different Ca(2+)-ATPase inhibitors on Ca2+ response and leukotriene release in RBL-2H3 cells. 1996 Inflamm. Res. pmid:8988402
Campbell A et al. Overview of allergic mechanisms. Ebastine has more than an antihistamine effect. 1996 Drugs pmid:8983912
Bäck M et al. The cysteinyl-leukotriene receptor antagonist BAY u9773 is a competitive antagonist of leukotriene C4 in the guinea-pig ileum. 1996 Eur. J. Pharmacol. pmid:8982726