Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Allen S et al. | Differential leukotriene constrictor responses in human atherosclerotic coronary arteries. | 1998 | Circulation | pmid:9641692 |
Koshino T et al. | Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein mRNAs in the peripheral blood leukocytes of asthmatics. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9642160 |
Peters-Golden M | Cell biology of the 5-lipoxygenase pathway. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9647604 |
Priebe W et al. | Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9647783 |
Nagata M et al. | Granulocyte macrophage colony-stimulating factor augments ICAM-1 and VCAM-1 activation of eosinophil function. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9651192 |
Hamasaki Y et al. | Inhibition of leukotriene synthesis by terfenadine in vitro. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654399 |
Schuligoi R et al. | Effects of the cyclooxygenase-2 inhibitor NS-398 on thromboxane and leukotriene synthesis in rat peritoneal cells. | 1998 | Inflamm. Res. | pmid:9657255 |
Pfau JC et al. | A comparison of the effects of lipopolysaccharide and ceramide on arachidonic acid metabolism in THP-1 monocytic cells. | 1998 | Cell. Immunol. | pmid:9665757 |
Mitsunobu F et al. | Different roles of histamine and leukotriene C4 in the airways between patients with atopic and nonatopic asthma. | 1998 | J Asthma | pmid:9669831 |
Lukaszyk A et al. | The role of epidermal growth factor in platelet-endothelium interactions. | 1998 | J. Physiol. Pharmacol. | pmid:9670106 |