Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Fukuishi N et al. | Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor. | 2001 | Phytomedicine | pmid:11824521 |
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Jedlitschky G and Keppler D | Transport of leukotriene C4 and structurally related conjugates. | 2002 | Vitam. Horm. | pmid:11898391 |
Guo A et al. | Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). | 2002 | Drug Metab. Dispos. | pmid:11901101 |
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de las Heras B et al. | Effects of six diterpenes on macrophage eicosanoid biosynthesis. | 2001 | Life Sci. | pmid:12005260 |
Christmas P et al. | Membrane localization and topology of leukotriene C4 synthase. | 2002 | J. Biol. Chem. | pmid:12023288 |
Mao Q et al. | GSH-dependent photolabeling of multidrug resistance protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain. | 2002 | J. Biol. Chem. | pmid:12034727 |
Conrad S et al. | A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance. | 2002 | Pharmacogenetics | pmid:12042670 |
Oliveira SH et al. | Increased responsiveness of murine eosinophils to MIP-1beta (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8. | 2002 | J. Leukoc. Biol. | pmid:12050188 |
Fernández SB et al. | Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells. | 2002 | J. Biol. Chem. | pmid:12060660 |
Bandeira-Melo C et al. | Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. | 2002 | J. Allergy Clin. Immunol. | pmid:12063527 |
Thomas LL et al. | Immobilized lactoferrin is a stimulus for eosinophil activation. | 2002 | J. Immunol. | pmid:12097406 |
Gibbs BF et al. | Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization. | 2002 | J. Leukoc. Biol. | pmid:12149431 |
Hashizume K and Black KL | Increased endothelial vesicular transport correlates with increased blood-tumor barrier permeability induced by bradykinin and leukotriene C4. | 2002 | J. Neuropathol. Exp. Neurol. | pmid:12152787 |
Ohashi M et al. | Effects of phalloidin on the biliary excretion of cholephilic compounds in rats. | 2002 | Pharmacology | pmid:12169763 |
Arango P and Kountakis SE | Presence of cysteinyl leukotrienes in asthmatic patients with chronic sinusitis. | 2002 | Laryngoscope | pmid:12169896 |
Haimeur A et al. | Charged amino acids in the sixth transmembrane helix of multidrug resistance protein 1 (MRP1/ABCC1) are critical determinants of transport activity. | 2002 | J. Biol. Chem. | pmid:12186871 |
Gebhardt T et al. | Cultured human intestinal mast cells express functional IL-3 receptors and respond to IL-3 by enhancing growth and IgE receptor-dependent mediator release. | 2002 | Eur. J. Immunol. | pmid:12209644 |
Hagmann W et al. | Reconstitution of transport-active multidrug resistance protein 2 (MRP2; ABCC2) in proteoliposomes. | 2002 | Biol. Chem. | pmid:12222674 |
Yang Y et al. | Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistance-associated protein 1. | 2002 | J. Biol. Chem. | pmid:12235150 |
Bandeira-Melo C et al. | Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion. | 2002 | J. Exp. Med. | pmid:12235216 |
Suzuki Y et al. | Silver activates calcium signals in rat basophilic leukemia-2H3 mast cells by a mechanism that differs from the Fc epsilon RI-activated response. | 2002 | J. Immunol. | pmid:12244196 |
Nobata K et al. | Alpha(1L)-, but not alpha(1H)-, adrenoceptor antagonist prevents allergic bronchoconstriction in guinea pigs in vivo. | 2002 | Eur. J. Pharmacol. | pmid:12323390 |
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Tsuruoka S et al. | Functional analysis of ABCA8, a new drug transporter. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12379217 |
Liu S et al. | Neuroimmune interactions in guinea pig stomach and small intestine. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12388180 |
Oleschuk CJ et al. | Substitution of Trp1242 of TM17 alters substrate specificity of human multidrug resistance protein 3. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12388190 |
Keitel V et al. | A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2). | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12388192 |
Vargaftig BB and Singer M | Leukotrienes, IL-13, and chemokines cooperate to induce BHR and mucus in allergic mouse lungs. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12388339 |
Koike K et al. | Multiple membrane-associated tryptophan residues contribute to the transport activity and substrate specificity of the human multidrug resistance protein, MRP1. | 2002 | J. Biol. Chem. | pmid:12388549 |
Hashimoto K et al. | Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome. | 2002 | Hepatology | pmid:12395335 |
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