Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Lin TY and London CA | Characterization and modulation of canine mast cell derived eicosanoids. | 2010 | Vet. Immunol. Immunopathol. | pmid:20036014 |
Korzekwa A et al. | Leukotrienes are auto-/paracrine factors in the bovine corpus luteum: an in vitro study. | 2010 | Reprod. Domest. Anim. | pmid:19645858 |
Silva RC et al. | Leukotrienes produced in allergic lung inflammation activate alveolar macrophages. | 2010 | Cell. Physiol. Biochem. | pmid:20798516 |
Quan Z et al. | Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation. | 2010 | J Ethnopharmacol | pmid:20699114 |
Alvarenga PH et al. | The function and three-dimensional structure of a thromboxane A2/cysteinyl leukotriene-binding protein from the saliva of a mosquito vector of the malaria parasite. | 2010 | PLoS Biol. | pmid:21152418 |
Lee SJ et al. | 4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK. | 2010 | Toxicol. Appl. Pharmacol. | pmid:19837106 |
Chebolu S et al. | Pranlukast prevents cysteinyl leukotriene-induced emesis in the least shrew (Cryptotis parva). | 2010 | Eur. J. Pharmacol. | pmid:19941848 |
Zhang T et al. | Pharmacology and immunological actions of a herbal medicine ASHMI on allergic asthma. | 2010 | Phytother Res | pmid:19998324 |
Kawamura F et al. | Effects of menadione, a reactive oxygen generator, on leukotriene secretion from RBL-2H3 cells. | 2010 | Biol. Pharm. Bull. | pmid:20460770 |
Houssen ME et al. | Natural anti-inflammatory products and leukotriene inhibitors as complementary therapy for bronchial asthma. | 2010 | Clin. Biochem. | pmid:20430018 |
Kitahata Y et al. | Prolonged culture of mast cells with high-glucose medium enhances the Fc epsilon RI-mediated degranulation response and leukotriene C4 production. | 2010 | Int. Arch. Allergy Immunol. | pmid:20523060 |
Tancowny BP et al. | Substance P primes lipoteichoic acid- and Pam3CysSerLys4-mediated activation of human mast cells by up-regulating Toll-like receptor 2. | 2010 | Immunology | pmid:20497485 |
Inoue T et al. | Epigallocatechin-3-gallate inhibits mast cell degranulation, leukotriene C4 secretion, and calcium influx via mitochondrial calcium dysfunction. | 2010 | Free Radic. Biol. Med. | pmid:20510351 |
Kawakami Y et al. | Functional expression of single-chain antibody to leukotriene C(4). | 2010 | Biochem. Biophys. Res. Commun. | pmid:20079714 |
Di Sotto A et al. | Pharmacological and phytochemical study on a Sisymbrium officinale Scop. extract. | 2010 | J Ethnopharmacol | pmid:19969059 |
Wunder F et al. | Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor. | 2010 | Br. J. Pharmacol. | pmid:20423349 |
Oh YC et al. | Anti-allergic activity of a platycodon root ethanol extract. | 2010 | Int J Mol Sci | pmid:20717534 |
Okubo M et al. | Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors. | 2010 | Mol Pain | pmid:20846451 |
Korzekwa AJ et al. | Leukotrienes modulate secretion of progesterone and prostaglandins during the estrous cycle and early pregnancy in cattle: an in vivo study. | 2010 | Reproduction | pmid:20813877 |
Black AT et al. | Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. | 2010 | Toxicol. Appl. Pharmacol. | pmid:20840853 |