Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Genovese A et al. | Human cardiac mast cells in anaphylaxis. | 2010 | Chem Immunol Allergy | pmid:20519884 |
Sachs-Olsen C et al. | Eoxins: a new inflammatory pathway in childhood asthma. | 2010 | J. Allergy Clin. Immunol. | pmid:20920774 |
Akin C et al. | Mast cell activation syndrome: Proposed diagnostic criteria. | 2010 | J. Allergy Clin. Immunol. | pmid:21035176 |
Mueller CF et al. | Angiotensin II triggers release of leukotriene C4 in vascular smooth muscle cells via the multidrug resistance-related protein 1. | 2010 | Mol. Cell. Biochem. | pmid:19685171 |
Borrelli I et al. | Benzene metabolites inhibit the release of proinflammatory mediators and cytokines from human basophils. | 2010 Jul-Sep | Int J Immunopathol Pharmacol | pmid:20943043 |
Bridges CC et al. | MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21134393 |
Becher UM et al. | Inhibition of leukotriene C4 action reduces oxidative stress and apoptosis in cardiomyocytes and impedes remodeling after myocardial injury. | 2011 | J. Mol. Cell. Cardiol. | pmid:21112334 |
Zhu Y and Bertics PJ | Chemoattractant-induced signaling via the Ras-ERK and PI3K-Akt networks, along with leukotriene C4 release, is dependent on the tyrosine kinase Lyn in IL-5- and IL-3-primed human blood eosinophils. | 2011 | J. Immunol. | pmid:21106848 |
Szabó Z et al. | ABCC6 does not transport adenosine - relevance to pathomechanism of pseudoxanthoma elasticum. | 2011 | Mol. Genet. Metab. | pmid:21813308 |
Megaraj V et al. | Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2). | 2011 | Pharmacogenet. Genomics | pmid:21691255 |
Hirata H et al. | Over-expression of the LTC4 synthase gene in mice reproduces human aspirin-induced asthma. | 2011 | Clin. Exp. Allergy | pmid:21429049 |
Wickham S et al. | Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. | 2011 | Anal. Biochem. | pmid:21447318 |
Nagy E et al. | Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblasts. | 2011 | Circulation | pmid:21403093 |
Zhang Y et al. | [Effects of polydatin on bleomycin-induced pulmonary fibrosis in rats]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22368872 |
Kim SJ et al. | Manassantin A isolated from Saururus chinensis inhibits 5-lipoxygenase-dependent leukotriene C4 generation by blocking mitogen-activated protein kinase activation in mast cells. | 2011 | Biol. Pharm. Bull. | pmid:22040894 |
Carnini C et al. | Synthesis of cysteinyl leukotrienes in human endothelial cells: subcellular localization and autocrine signaling through the CysLT2 receptor. | 2011 | FASEB J. | pmid:21753081 |
Wang JL et al. | [The mechanism of airway inflammation in eosinophilic bronchitis and cough variant asthma]. | 2011 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:21781515 |
Furukawa M et al. | Terpenoids and phenethyl glucosides from Hyssopus cuspidatus (Labiatae). | 2011 | Phytochemistry | pmid:21893325 |
Alvarez C et al. | Leukotriene C(4) prevents the complete maturation of murine dendritic cells and modifies interleukin-12/interleukin-23 balance. | 2011 | Immunology | pmid:21896013 |
Jin M et al. | Luteolin-7-O-glucoside suppresses leukotriene C(4) production and degranulation by inhibiting the phosphorylation of mitogen activated protein kinases and phospholipase Cγ1 in activated mouse bone marrow-derived mast cells. | 2011 | Biol. Pharm. Bull. | pmid:21720009 |