LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Pneumococcal Infections D011008 7 associated lipids
Eosinophilia D004802 4 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cough D003371 19 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Status Asthmaticus D013224 4 associated lipids
Pseudoxanthoma Elasticum D011561 2 associated lipids
Rhinitis, Allergic, Perennial D012221 6 associated lipids
Acute-Phase Reaction D000210 12 associated lipids
Uveitis D014605 14 associated lipids
Periapical Periodontitis D010485 6 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Angina Pectoris D000787 27 associated lipids
Hyperbilirubinemia, Hereditary D006933 3 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Drug Eruptions D003875 30 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Mesenteric Vascular Occlusion D008641 4 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

Download all related citations
Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Genovese A et al. Human cardiac mast cells in anaphylaxis. 2010 Chem Immunol Allergy pmid:20519884
Sachs-Olsen C et al. Eoxins: a new inflammatory pathway in childhood asthma. 2010 J. Allergy Clin. Immunol. pmid:20920774
Akin C et al. Mast cell activation syndrome: Proposed diagnostic criteria. 2010 J. Allergy Clin. Immunol. pmid:21035176
Mueller CF et al. Angiotensin II triggers release of leukotriene C4 in vascular smooth muscle cells via the multidrug resistance-related protein 1. 2010 Mol. Cell. Biochem. pmid:19685171
Borrelli I et al. Benzene metabolites inhibit the release of proinflammatory mediators and cytokines from human basophils. 2010 Jul-Sep Int J Immunopathol Pharmacol pmid:20943043
Bridges CC et al. MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury. 2011 Toxicol. Appl. Pharmacol. pmid:21134393
Becher UM et al. Inhibition of leukotriene C4 action reduces oxidative stress and apoptosis in cardiomyocytes and impedes remodeling after myocardial injury. 2011 J. Mol. Cell. Cardiol. pmid:21112334
Zhu Y and Bertics PJ Chemoattractant-induced signaling via the Ras-ERK and PI3K-Akt networks, along with leukotriene C4 release, is dependent on the tyrosine kinase Lyn in IL-5- and IL-3-primed human blood eosinophils. 2011 J. Immunol. pmid:21106848
Szabó Z et al. ABCC6 does not transport adenosine - relevance to pathomechanism of pseudoxanthoma elasticum. 2011 Mol. Genet. Metab. pmid:21813308
Megaraj V et al. Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2). 2011 Pharmacogenet. Genomics pmid:21691255
Hirata H et al. Over-expression of the LTC4 synthase gene in mice reproduces human aspirin-induced asthma. 2011 Clin. Exp. Allergy pmid:21429049
Wickham S et al. Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. 2011 Anal. Biochem. pmid:21447318
Nagy E et al. Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblasts. 2011 Circulation pmid:21403093
Zhang Y et al. [Effects of polydatin on bleomycin-induced pulmonary fibrosis in rats]. 2011 Zhongguo Zhong Yao Za Zhi pmid:22368872
Kim SJ et al. Manassantin A isolated from Saururus chinensis inhibits 5-lipoxygenase-dependent leukotriene C4 generation by blocking mitogen-activated protein kinase activation in mast cells. 2011 Biol. Pharm. Bull. pmid:22040894
Carnini C et al. Synthesis of cysteinyl leukotrienes in human endothelial cells: subcellular localization and autocrine signaling through the CysLT2 receptor. 2011 FASEB J. pmid:21753081
Wang JL et al. [The mechanism of airway inflammation in eosinophilic bronchitis and cough variant asthma]. 2011 Zhonghua Jie He He Hu Xi Za Zhi pmid:21781515
Furukawa M et al. Terpenoids and phenethyl glucosides from Hyssopus cuspidatus (Labiatae). 2011 Phytochemistry pmid:21893325
Alvarez C et al. Leukotriene C(4) prevents the complete maturation of murine dendritic cells and modifies interleukin-12/interleukin-23 balance. 2011 Immunology pmid:21896013
Jin M et al. Luteolin-7-O-glucoside suppresses leukotriene C(4) production and degranulation by inhibiting the phosphorylation of mitogen activated protein kinases and phospholipase Cγ1 in activated mouse bone marrow-derived mast cells. 2011 Biol. Pharm. Bull. pmid:21720009