LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Pneumococcal Infections D011008 7 associated lipids
Eosinophilia D004802 4 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cough D003371 19 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Status Asthmaticus D013224 4 associated lipids
Pseudoxanthoma Elasticum D011561 2 associated lipids
Rhinitis, Allergic, Perennial D012221 6 associated lipids
Acute-Phase Reaction D000210 12 associated lipids
Uveitis D014605 14 associated lipids
Periapical Periodontitis D010485 6 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Angina Pectoris D000787 27 associated lipids
Hyperbilirubinemia, Hereditary D006933 3 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Drug Eruptions D003875 30 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Mesenteric Vascular Occlusion D008641 4 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

Download all related citations
Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Genovese A et al. Human cardiac mast cells in anaphylaxis. 2010 Chem Immunol Allergy pmid:20519884
Sachs-Olsen C et al. Eoxins: a new inflammatory pathway in childhood asthma. 2010 J. Allergy Clin. Immunol. pmid:20920774
Akin C et al. Mast cell activation syndrome: Proposed diagnostic criteria. 2010 J. Allergy Clin. Immunol. pmid:21035176
Lin TY and London CA Characterization and modulation of canine mast cell derived eicosanoids. 2010 Vet. Immunol. Immunopathol. pmid:20036014
Korzekwa A et al. Leukotrienes are auto-/paracrine factors in the bovine corpus luteum: an in vitro study. 2010 Reprod. Domest. Anim. pmid:19645858
Mueller CF et al. Angiotensin II triggers release of leukotriene C4 in vascular smooth muscle cells via the multidrug resistance-related protein 1. 2010 Mol. Cell. Biochem. pmid:19685171
Inoue T et al. Epigallocatechin-3-gallate inhibits mast cell degranulation, leukotriene C4 secretion, and calcium influx via mitochondrial calcium dysfunction. 2010 Free Radic. Biol. Med. pmid:20510351
Kawakami Y et al. Functional expression of single-chain antibody to leukotriene C(4). 2010 Biochem. Biophys. Res. Commun. pmid:20079714
Di Sotto A et al. Pharmacological and phytochemical study on a Sisymbrium officinale Scop. extract. 2010 J Ethnopharmacol pmid:19969059
Wunder F et al. Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor. 2010 Br. J. Pharmacol. pmid:20423349
Oh YC et al. Anti-allergic activity of a platycodon root ethanol extract. 2010 Int J Mol Sci pmid:20717534
Okubo M et al. Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors. 2010 Mol Pain pmid:20846451
Korzekwa AJ et al. Leukotrienes modulate secretion of progesterone and prostaglandins during the estrous cycle and early pregnancy in cattle: an in vivo study. 2010 Reproduction pmid:20813877
Austen KF et al. The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. 2009 J. Allergy Clin. Immunol. pmid:19647860
Pecaric-Petkovic T et al. Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33. 2009 Blood pmid:18955562
Togo K et al. Aspirin and salicylates modulate IgE-mediated leukotriene secretion in mast cells through a dihydropyridine receptor-mediated Ca(2+) influx. 2009 Clin. Immunol. pmid:19144570
Ma K et al. Protective effects of asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway. 2009 Eur. J. Pharmacol. pmid:19087874
Celik GE et al. Effect of in vitro aspirin stimulation on basophils in patients with aspirin-exacerbated respiratory disease. 2009 Clin. Exp. Allergy pmid:19486029
Triggiani M et al. Lung mast cells are a source of secreted phospholipases A2. 2009 J. Allergy Clin. Immunol. pmid:19541351
Suzuki Y and Ra C Analysis of the mechanism for the development of allergic skin inflammation and the application for its treatment: aspirin modulation of IgE-dependent mast cell activation: role of aspirin-induced exacerbation of immediate allergy. 2009 J. Pharmacol. Sci. pmid:19609060