| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glioma | D005910 | 112 associated lipids |
| Ulcer | D014456 | 16 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Peritonitis | D010538 | 38 associated lipids |
| Drug Hypersensitivity | D004342 | 20 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | D015464 | 17 associated lipids |
| Myocardial Ischemia | D017202 | 11 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Quan Z et al. | Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation. | 2010 | J Ethnopharmacol | pmid:20699114 |
| Alvarenga PH et al. | The function and three-dimensional structure of a thromboxane A2/cysteinyl leukotriene-binding protein from the saliva of a mosquito vector of the malaria parasite. | 2010 | PLoS Biol. | pmid:21152418 |
| Lee SJ et al. | 4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK. | 2010 | Toxicol. Appl. Pharmacol. | pmid:19837106 |
| Chebolu S et al. | Pranlukast prevents cysteinyl leukotriene-induced emesis in the least shrew (Cryptotis parva). | 2010 | Eur. J. Pharmacol. | pmid:19941848 |
| Zhang T et al. | Pharmacology and immunological actions of a herbal medicine ASHMI on allergic asthma. | 2010 | Phytother Res | pmid:19998324 |
| Kawamura F et al. | Effects of menadione, a reactive oxygen generator, on leukotriene secretion from RBL-2H3 cells. | 2010 | Biol. Pharm. Bull. | pmid:20460770 |
| Houssen ME et al. | Natural anti-inflammatory products and leukotriene inhibitors as complementary therapy for bronchial asthma. | 2010 | Clin. Biochem. | pmid:20430018 |
| Kitahata Y et al. | Prolonged culture of mast cells with high-glucose medium enhances the Fc epsilon RI-mediated degranulation response and leukotriene C4 production. | 2010 | Int. Arch. Allergy Immunol. | pmid:20523060 |
| Tancowny BP et al. | Substance P primes lipoteichoic acid- and Pam3CysSerLys4-mediated activation of human mast cells by up-regulating Toll-like receptor 2. | 2010 | Immunology | pmid:20497485 |
| Inoue T et al. | Epigallocatechin-3-gallate inhibits mast cell degranulation, leukotriene C4 secretion, and calcium influx via mitochondrial calcium dysfunction. | 2010 | Free Radic. Biol. Med. | pmid:20510351 |
| Kawakami Y et al. | Functional expression of single-chain antibody to leukotriene C(4). | 2010 | Biochem. Biophys. Res. Commun. | pmid:20079714 |
| Di Sotto A et al. | Pharmacological and phytochemical study on a Sisymbrium officinale Scop. extract. | 2010 | J Ethnopharmacol | pmid:19969059 |
| Black AT et al. | Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. | 2010 | Toxicol. Appl. Pharmacol. | pmid:20840853 |
| Zehnpfennig B et al. | Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. | 2009 | Biochemistry | pmid:19334674 |
| Athayde LA et al. | Blocking central leukotrienes synthesis affects vasopressin release during sepsis. | 2009 | Neuroscience | pmid:19285113 |
| Hashimoto K et al. | Cysteinyl leukotrienes induce monocyte chemoattractant protein-1 in human monocyte/macrophages via mitogen-activated protein kinase and nuclear factor-kappaB pathways. | 2009 | Int. Arch. Allergy Immunol. | pmid:19218821 |
| Martinez-Losa M et al. | Taurine chloramine inhibits functional responses of human eosinophils in vitro. | 2009 | Clin. Exp. Allergy | pmid:19222497 |
| Ramanujam D et al. | Dramatic resolution of respiratory symptoms with imatinib mesylate in patients with chronic myeloid leukemia presenting with lower airway symptoms resembling asthma. | 2009 | Leuk. Lymphoma | pmid:19757309 |
| Muraki M et al. | Inhaled montelukast inhibits cysteinyl-leukotriene-induced bronchoconstriction in ovalbumin-sensitized guinea-pigs: the potential as a new asthma medication. | 2009 | Int. Immunopharmacol. | pmid:19706339 |
| Inoue T et al. | Nitric Oxide positively regulates Ag (I)-induced Ca(2+) influx and mast cell activation: role of a Nitric Oxide Synthase-independent pathway. | 2009 | J. Leukoc. Biol. | pmid:19706839 |