LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Glioma D005910 112 associated lipids
Ulcer D014456 16 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Peritonitis D010538 38 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Leukemia D007938 74 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Myocardial Ischemia D017202 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Authors Title Published Journal PubMed Link
Sabbah A et al. [Allergy to mosquitoes and use of new immunobiological parameters]. 1997 Allerg Immunol (Paris) pmid:9254117
Sainte-Laudy J et al. [Bioclinical interest in the assay of leukotrienes in four cases of sensitization to trophallergens]. 1997 Allerg Immunol (Paris) pmid:9254120
Akagi M et al. Anti-allergic effect of tea-leaf saponin (TLS) from tea leaves (Camellia sinensis var. sinensis). 1997 Biol. Pharm. Bull. pmid:9178940
Stride BD et al. Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. 1997 Mol. Pharmacol. pmid:9281595
Patella V et al. Heterogeneous effects of protamine on human mast cells and basophils. 1997 Br J Anaesth pmid:9215027
Fujita M et al. Cysteinyl leukotrienes induce nasal symptoms of allergic rhinitis via a receptor-mediated mechanism in guinea pigs. 1997 Jpn. J. Pharmacol. pmid:9469641
Schuligoi R et al. Release of calcitonin gene-related peptide in cardiac anaphylaxis. 1997 Naunyn Schmiedebergs Arch. Pharmacol. pmid:9050016
Chavis C et al. Leukotriene E4 plasma levels in adult asthmatic patients with variable disease severity. 1997 Allergy pmid:9201374
Gissurarson SR et al. Effect of lobaric acid on cysteinyl-leukotriene formation and contractile activity of guinea pig taenia coli. 1997 J. Pharmacol. Exp. Ther. pmid:9023290
Vigorito C et al. Metabolic and hemodynamic effects of peptide leukotriene C4 and D4 in man. 1997 Int. J. Clin. Lab. Res. pmid:9352380
Jedlitschky G et al. ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. 1997 Biochem. J. pmid:9355767
Wijnholds J et al. Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. 1997 Nat. Med. pmid:9359705
Mullol J et al. [Eosinophil activation by epithelial cells of the respiratory mucosa. Comparative study of normal mucosa and inflammatory mucosa]. 1997 Med Clin (Barc) pmid:9303983
Gomi A et al. Transient induction of the MRP/GS-X pump and gamma-glutamylcysteine synthetase by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea in human glioma cells. 1997 Cancer Res. pmid:9393752
Medina Avalos MA and Orea Solano M [Macrophages in asthma]. 1997 Sep-Oct Rev Alerg Mex pmid:9432275
Wen FQ et al. Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9758210
Bermejo Benito P et al. In vivo and in vitro antiinflammatory activity of saikosaponins. 1998 Life Sci. pmid:9763210
Templeton AG et al. Effects of S-salbutamol on human isolated bronchus. 1998 Pulm Pharmacol Ther pmid:9802957
Kusuhara H et al. Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line. 1998 J. Pharmacol. Exp. Ther. pmid:9618431
Barnouin K et al. Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione. 1998 Br. J. Cancer pmid:9460989
Zaitsu M et al. Effect of dexamethasone on leukotriene synthesis in DMSO-stimulated HL-60 cells. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:10102384
Brock TG et al. Capacity for repeatable leukotriene generation after transient stimulation of mast cells and macrophages. 1998 Biochem. J. pmid:9445378
Sperber K et al. Mucin secretion in inflammatory bowel disease: comparison of a macrophage-derived mucin secretagogue (MMS-68) to conventional secretagogues. 1998 Inflamm. Bowel Dis. pmid:9552223
Gao M et al. Multidrug resistance protein. Identification of regions required for active transport of leukotriene C4. 1998 J. Biol. Chem. pmid:9553138
Diven WF et al. Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla. 1998 Ann. Otol. Rhinol. Laryngol. pmid:9525240
Black P et al. Chemotherapy in experimental brain tumor, part 2: pretreatment with leukotriene C4 prolongs survival. 1998 J. Neurooncol. pmid:9525821
Lanas A et al. Collagen secretion by human gastric and skin fibroblasts: implications for ulcer healing. 1998 Eur Surg Res pmid:9493694
Hundley TR et al. Characteristics of arachidonic acid generation in human basophils: relationship between the effects of inhibitors of secretory phospholipase A2 activity and leukotriene C4 release. 1998 J. Pharmacol. Exp. Ther. pmid:9495842
Shindo K et al. Prednisolone inhibits synthesis of 5-H(P)ETE in eosinophils from asthmatic patients during a wheezing attack but not during remission. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9578148
Kobayashi H et al. Urinary trypsin inhibitor reduces the release of histamine from rat peritoneal mast cells. 1998 J. Lab. Clin. Med. pmid:9579392
Capra V et al. Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma. 1998 Mol. Pharmacol. pmid:9547367
McAlexander MA et al. Inhibition of 5-lipoxygenase diminishes neurally evoked tachykinergic contraction of guinea pig isolated airway. 1998 J. Pharmacol. Exp. Ther. pmid:9580604
Scheidegger C et al. Effects of extracts and of individual components from Petasites on prostaglandin synthesis in cultured skin fibroblasts and on leucotriene synthesis in isolated human peripheral leucocytes. 1998 Pharm Acta Helv pmid:9556438
Sabbah A et al. [Testing basophil activation by flow cytometry in the diagnosis of allergy to hymenopteran venom]. 1998 Allerg Immunol (Paris) pmid:9559061
Cyrus CB et al. Leukotrienes C4 and D4 increase the ciliary beat frequency in human upper airway mucosa in vitro. 1998 Otolaryngol Head Neck Surg pmid:9560097
Nishida M et al. Lack of active lung anaphylaxis in congenitally mast cell-deficient Ws/Ws rats sensitized with the nematode Nippostrongylus brasiliensis. 1998 APMIS pmid:9740510
Dent G et al. Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. 1998 Am. J. Respir. Cell Mol. Biol. pmid:9448055
Pfau JC et al. A comparison of the effects of lipopolysaccharide and ceramide on arachidonic acid metabolism in THP-1 monocytic cells. 1998 Cell. Immunol. pmid:9665757
Mitsunobu F et al. Different roles of histamine and leukotriene C4 in the airways between patients with atopic and nonatopic asthma. 1998 J Asthma pmid:9669831
Lukaszyk A et al. The role of epidermal growth factor in platelet-endothelium interactions. 1998 J. Physiol. Pharmacol. pmid:9670106
Stenke L et al. Novel enzymatic abnormalities in AML and CML in blast crisis: elevated leucocyte leukotriene C4 synthase activity paralleled by deficient leukotriene biosynthesis from endogenous substrate. 1998 Br. J. Haematol. pmid:9674747
Keskil ZA et al. Changes of arterial arachidonic acid metabolites in hypertensive patients during haemodialysis. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:10189068
Haberl C et al. Release of prostaglandin D2 by murine mast cells: importance of metabolite formation for antiproliferative activity. 1998 Mediators Inflamm. pmid:9836493
Peters-Golden M Cell biology of the 5-lipoxygenase pathway. 1998 Am. J. Respir. Crit. Care Med. pmid:9647604
Hamasaki Y et al. Inhibition of leukotriene synthesis by terfenadine in vitro. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9654399
Ito K et al. Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver. 1998 J. Biol. Chem. pmid:9430713
Fadok VA et al. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. 1998 J. Clin. Invest. pmid:9466984
Daugschies A and Ruttkowski B Modulation of migration of Oesophagostomum dentatum larvae by inhibitors and products of eicosanoid metabolism. 1998 Int. J. Parasitol. pmid:9513001
Jonsson EW Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle. 1998 Acta Physiol Scand Suppl pmid:9597121
Geuenich S et al. Induction of leukotriene production by bleomycin and asparaginase in mast cells in vitro and in patients in vivo. 1998 Biochem. Pharmacol. pmid:9514079