| MeSH term | MeSH ID | Detail |
|---|---|---|
| Rhinitis, Allergic, Seasonal | D006255 | 7 associated lipids |
| Hyperbilirubinemia | D006932 | 11 associated lipids |
| Hyperbilirubinemia, Hereditary | D006933 | 3 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Insect Bites and Stings | D007299 | 4 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang J et al. | [The effects of resuscitation with hypertonic saline solution on the postburn pulmonary injury in scalded dogs]. | 2001 | Zhonghua Shao Shang Za Zhi | pmid:11774813 |
| Suzuki R and Freed AN | Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11779726 |
| Chrubasik S et al. | Harpagophytum extracts. | 2002 | Clin. Pharmacol. Ther. | pmid:11823764 |
| Fukuishi N et al. | Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor. | 2001 | Phytomedicine | pmid:11824521 |
| Bermejo BP et al. | Sesquiterpenes from Jasonia glutinosa: in vitro anti-inflammatory activity. | 2002 | Biol. Pharm. Bull. | pmid:11824534 |
| Shon YH et al. | Effect of Astragali radix extract on lipopolysaccharide-induced inflammation in human amnion. | 2002 | Biol. Pharm. Bull. | pmid:11824562 |
| Sakata K and Bäck M | Receptor preferences of cysteinyl-leukotrienes in the guinea pig lung parenchyma. | 2002 | Eur. J. Pharmacol. | pmid:11834255 |
| Bäck M et al. | Modulation of vascular tone and reactivity by nitric oxide in porcine pulmonary arteries and veins. | 2002 | Acta Physiol. Scand. | pmid:11851592 |
| Küsters S et al. | Effects of antihistamines on leukotriene and cytokine release from dispersed nasal polyp cells. | 2002 | Arzneimittelforschung | pmid:11878205 |
| Iliás A et al. | Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). | 2002 | J. Biol. Chem. | pmid:11880368 |
| Jedlitschky G and Keppler D | Transport of leukotriene C4 and structurally related conjugates. | 2002 | Vitam. Horm. | pmid:11898391 |
| Guo A et al. | Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). | 2002 | Drug Metab. Dispos. | pmid:11901101 |
| Neu IS et al. | Leukotrienes in patients with clinically active multiple sclerosis. | 2002 | Acta Neurol. Scand. | pmid:11903112 |
| Zhang DW et al. | Determinants of the substrate specificity of multidrug resistance protein 1: role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17. | 2002 | J. Biol. Chem. | pmid:11925441 |
| Maekawa A et al. | Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. | 2002 | J. Biol. Chem. | pmid:11932261 |
| Ahamed J and Ali H | Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production. | 2002 | J. Biol. Chem. | pmid:11934880 |
| Norman BH et al. | Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1). | 2002 | Bioorg. Med. Chem. Lett. | pmid:11958985 |
| Bandeira-Melo C et al. | IL-16 promotes leukotriene C(4) and IL-4 release from human eosinophils via CD4- and autocrine CCR3-chemokine-mediated signaling. | 2002 | J. Immunol. | pmid:11971026 |
| Kolaczkowska E et al. | Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes. | 2002 | Inflammation | pmid:11989789 |
| Ravasi S et al. | Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma. | 2002 | Biochem. Pharmacol. | pmid:11996896 |