| MeSH term | MeSH ID | Detail |
|---|---|---|
| Rhinitis, Allergic, Seasonal | D006255 | 7 associated lipids |
| Hyperbilirubinemia | D006932 | 11 associated lipids |
| Hyperbilirubinemia, Hereditary | D006933 | 3 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Insect Bites and Stings | D007299 | 4 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Kimura Y et al. | Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. | 1995 | J Ethnopharmacol | pmid:7776662 |
| Szarek JL and Valentovic MA | Release of prostaglandin E2 and leukotriene C4/D4 from airway segments isolated from rats after exposure to ozone for 20 months. | 1995 | Toxicology | pmid:7624868 |
| Meier HL et al. | Simultaneous initiation of degranulation and inhibition of leukotriene release by soman in human basophils. | 1995 | Int. J. Immunopharmacol. | pmid:7545649 |
| Porreca E et al. | Modulation of rat vascular smooth muscle cell (VSMC) proliferation by cysteinyl leukotriene D4: a role for mediation of interleukin 1. | 1995 | Atherosclerosis | pmid:7755646 |
| Lam BK et al. | Expression cloning of human LTC4 synthase. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732869 |
| Cruz JR et al. | Fecal excretion of leukotriene C4 during human disease due to Shigella dysenteriae. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:7714683 |
| Nishikawa M et al. | Effect of leukotriene C4D4 antagonist on colonic damage induced by intracolonic administration of trinitrobenzene sulfonic acid in rats. | 1995 | J. Gastroenterol. | pmid:7719412 |
| Kita H et al. | Eosinophil major basic protein induces degranulation and IL-8 production by human eosinophils. | 1995 | J. Immunol. | pmid:7722326 |
| Iwamoto I et al. | Effect of a selective thromboxane A2 receptor antagonist BAY u3405 on antigen-, leukotriene C4- and leukotriene D4-induced bronchoconstriction in guinea pigs. | 1995 | Int. Arch. Allergy Immunol. | pmid:7647588 |
| Sun J and Herman CA | Cardiovascular effects of N-methyl leukotriene C4, a nonmetabolizable leukotriene C4 analogue, and the antagonism of leukotriene-induced hypotension by Ro 23-3544, in the American bullfrog, Rana catesbeiana. | 1995 | Can. J. Physiol. Pharmacol. | pmid:7648518 |
| Hong JT et al. | Effect of phenobarbital and the peroxisome proliferator ciprofibrate on gamma-Glutamyltranspeptidase activity and leukotriene C4 concentration in cultured rat hepatocytes. | 1995 | J. Biochem. Toxicol. | pmid:8847705 |
| Herman CA et al. | Leukotriene C4-stimulated contractions in bullfrog lung are affected by cold acclimation and calcium antagonists. | 1995 | Prostaglandins | pmid:7480797 |
| Petric R et al. | Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis. | 1995 | Biochim. Biophys. Acta | pmid:7827126 |
| Ju HR et al. | Systemic release of mucosal mast-cell protease in primed brown Norway rats after feeding with beta-lactoglobulin. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7787291 |
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| Yakubu MA et al. | Hematoma-induced enhanced cerebral vasoconstrictions to leukotriene C4 and endothelin-1 in piglets: role of prostanoids. | 1995 | Pediatr. Res. | pmid:7478789 |
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| Ochensberger B et al. | IgE-independent interleukin-4 expression and induction of a late phase of leukotriene C4 formation in human blood basophils. | 1995 | Blood | pmid:7492759 |
| Culo F et al. | Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice. | 1995 | Eur J Gastroenterol Hepatol | pmid:7496865 |
| Sjölinder M et al. | Phorbol ester-induced suppression of leukotriene C4 synthase activity in human granulocytes. | 1995 | FEBS Lett. | pmid:8543026 |
| Brady HR et al. | Lipoxygenase product formation and cell adhesion during neutrophil-glomerular endothelial cell interaction. | 1995 | Am. J. Physiol. | pmid:7840235 |
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| Ganbo T et al. | Inhibition of mucociliary clearance of the eustachian tube by leukotrienes C4 and D4. | 1995 | Ann. Otol. Rhinol. Laryngol. | pmid:7872607 |
| Tsai JJ et al. | Relationship between nasal resistance and airway hyperreactivity following nasal provocation with Dermatophagoides pteronyssinus in allergic rhinitis. | 1995 | Int. Arch. Allergy Immunol. | pmid:7888791 |
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| Sarmiento EU et al. | IL-3, IL-5, and granulocyte-macrophage colony-stimulating factor potentiate basophil mediator release stimulated by eosinophil granule major basic protein. | 1995 | J. Immunol. | pmid:7543541 |
| Engin A et al. | The protective effect of thromboxane synthetase inhibitor UK 38485 against bile duct ligation induced liver injury. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7544015 |
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| Yoshida K et al. | Effect of fibronectin on the production of leukotriene C4 by eosinophils. | 1995 | Int. Arch. Allergy Immunol. | pmid:7549524 |
| Datta YH et al. | Peptido-leukotrienes are potent agonists of von Willebrand factor secretion and P-selectin surface expression in human umbilical vein endothelial cells. | 1995 | Circulation | pmid:7586318 |
| Sengör T et al. | Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. | 1995 | CLAO J | pmid:7586473 |
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| Schauer U et al. | Blood eosinophils, eosinophil-derived proteins, and leukotriene C4 generation in relation to bronchial hyperreactivity in children with atopic dermatitis. | 1995 | Allergy | pmid:7604934 |
| Yamaya M et al. | Epithelial modulation of leukotriene-C4-induced human tracheal smooth muscle contraction. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7881688 |
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