| MeSH term | MeSH ID | Detail |
|---|---|---|
| Rhinitis, Allergic, Seasonal | D006255 | 7 associated lipids |
| Hyperbilirubinemia | D006932 | 11 associated lipids |
| Hyperbilirubinemia, Hereditary | D006933 | 3 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Insect Bites and Stings | D007299 | 4 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Westcott JY et al. | Arachidonate-induced eicosanoid synthesis in RBL-2H3 cells: stimulation with antigen or A23187 induces prolonged activation of 5-lipoxygenase. | 1996 | Biochim. Biophys. Acta | pmid:8816855 |
| Hsieh KH | Evaluation of efficacy of traditional Chinese medicines in the treatment of childhood bronchial asthma: clinical trial, immunological tests and animal study. Taiwan Asthma Study Group. | 1996 | Pediatr Allergy Immunol | pmid:9116877 |
| Ishizuka Y et al. | Effect of 1,6-dihydro-2[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidineca rboxyli c acid on ethanol-induced microvascular injury in rats. | 1996 | Arzneimittelforschung | pmid:9125278 |
| Willburger RE et al. | Inhibition of eicosanoid release from synovial organ culture by incubation with tepoxalin and its acid metabolite. | 1996 | Prostaglandins | pmid:8936587 |
| Loe DW et al. | Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport. | 1996 | J. Biol. Chem. | pmid:8621643 |
| Wilborn J et al. | Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis. | 1996 | J. Clin. Invest. | pmid:8621765 |
| Meltzer SS et al. | Inhibition of exercise-induced bronchospasm by zileuton: a 5-lipoxygenase inhibitor. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8630575 |
| Hisamatsu K et al. | Effect of leukotriene C4 exposure on ciliated cells of the nasal mucosa. | 1996 | Prostaglandins | pmid:8900445 |
| Omar HM et al. | Hepatobiliary excretion of cysteinyl leukotrienes in three experimental models of acute hepatic injury. | 1996 | Inflamm. Res. | pmid:8912018 |
| Müller D et al. | Bile ductular proliferation and altered leukotriene elimination in thioacetamide-induced fibrosis of rat liver. | 1996 | J. Hepatol. | pmid:8912155 |
| Sedgwick JB et al. | Effect of isolation protocol on eosinophil function: Percoll gradients versus immunomagnetic beads. | 1996 | J. Immunol. Methods | pmid:8914593 |
| Burghardt JS et al. | Lipid mediators in oxygen-induced airway remodeling and hyperresponsiveness in newborn rats. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8887572 |
| Pulaski L et al. | Identification of the multidrug-resistance protein (MRP) as the glutathione-S-conjugate export pump of erythrocytes. | 1996 | Eur. J. Biochem. | pmid:8917467 |
| Campbell A et al. | Overview of allergic mechanisms. Ebastine has more than an antihistamine effect. | 1996 | Drugs | pmid:8983912 |
| Kobayashi S et al. | [Inhibitory effect of ONO-1078, a novel leukotriene receptor antagonist, on human peripheral blood eosinophils]. | 1996 | Arerugi | pmid:8990528 |
| Sare M et al. | The effects of indomethacin, NDGA, allopurinol and superoxide dismutase on prostaglandin E2 and leukotriene C4 levels after mesenteric ischemia-reperfusion injury. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9014215 |
| Loe DW et al. | ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. | 1996 | J. Biol. Chem. | pmid:8621644 |
| Weber M et al. | Deletion of the NH2-terminal residue converts monocyte chemotactic protein 1 from an activator of basophil mediator release to an eosinophil chemoattractant. | 1996 | J. Exp. Med. | pmid:8627182 |
| Heimbürger M and Palmblad JE | Effects of leukotriene C4 and D4, histamine and bradykinin on cytosolic calcium concentrations and adhesiveness of endothelial cells and neutrophils. | 1996 | Clin. Exp. Immunol. | pmid:8608646 |
| Brock TG et al. | Effects of granulocyte-macrophage colony-stimulating factor on eicosanoid production by mononuclear phagocytes. | 1996 | J. Immunol. | pmid:8786314 |
| Namovic MT et al. | Pharmacological modulation of eosinophil influx into the lungs of Brown Norway rats. | 1996 | Eur. J. Pharmacol. | pmid:8960868 |
| Garcia C et al. | Effects of synthetic peptido-leukotrienes on bone resorption in vitro. | 1996 | J. Bone Miner. Res. | pmid:8992883 |
| Hackshaw KV et al. | Environmental influences on fatty acid composition of membranes from autoimmune MRL lpr/lpr mice. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804129 |
| Chuman Y et al. | Characterization of the ATP-dependent LTC4 transporter in cisplatin-resistant human KB cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8806607 |
| Henderson WR et al. | The importance of leukotrienes in airway inflammation in a mouse model of asthma. | 1996 | J. Exp. Med. | pmid:8879219 |
| Horsmanheimo L et al. | Histamine and leukotriene C4 release in cutaneous mosquito-bite reactions. | 1996 | J. Allergy Clin. Immunol. | pmid:8757218 |
| Zhang H et al. | [Study on the effect and mechanism of qinggan xiehuo decoction in treatment of endotoxin-induced uveitis in rabbits]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8762423 |
| Tominaga M et al. | ONO-1078 antagonizes diarrhea-causing changes in ion transport and smooth muscle contraction induced by peptidoleukotrienes in rat and human colon in vitro. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8819486 |
| de Paulis A et al. | Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine. | 1996 | J. Allergy Clin. Immunol. | pmid:8765829 |
| Przylipiak A et al. | Role of leukotriene C4 in follicle-stimulating hormone (FSH) secretion in female rat pituitary. | 1996 | Gynecol. Endocrinol. | pmid:8701793 |
| Hong JT and Glauert HP | Comitogenicity of eicosanoids and the peroxisome proliferator ciprofibrate in cultured rat hepatocytes. | 1996 | J. Cell. Physiol. | pmid:8908198 |
| Sainte-Laudy J et al. | [Importance of the leukotriene C4 liberation test for the diagnosis of drug allergy (preliminary results)]. | 1996 | Allerg Immunol (Paris) | pmid:8703308 |
| Abe M et al. | Evaluation of the effects of steroids on experimental septic lung injury. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8848431 |
| Leier I et al. | ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. | 1996 | Biochem. J. | pmid:8670053 |
| Shindo K et al. | Priming effect of platelet activating factor on leukotriene C4 from stimulated eosinophils of asthmatic patients. | 1996 | Thorax | pmid:8711647 |
| Itoh K et al. | Relationship between airway eosinophilia and airway hyperresponsiveness in a late asthmatic model of guinea pigs. | 1996 | Int. Arch. Allergy Immunol. | pmid:8527956 |
| Tang DG et al. | Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8643560 |
| Matsuo M et al. | Leukotriene B4 and C4 in cerebrospinal fluid from children with meningitis and febrile seizures. | 1996 | Pediatr. Neurol. | pmid:8703223 |
| Papayianni A et al. | Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. | 1996 | J. Immunol. | pmid:8690917 |
| Batirel HF et al. | The effect of aqueous garlic extract on the levels of arachidonic acid metabolites (leukotriene C4 and prostaglandin E2) in rat forebrain after ischemia-reperfusion injury. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804127 |
| Shraga-Levine Z et al. | Arachidonic acid and lipoxygenase products stimulate protein kinase C beta mRNA levels in pituitary alpha T3-1 cell line: role in gonadotropin-releasing hormone action. | 1996 | Biochem. J. | pmid:8687415 |
| Ganbo T et al. | Leukotriene C4 inhibits ciliary activity in the presence of gamma-glutamyl transpeptidase. | 1996 | Am. J. Physiol. | pmid:8770059 |
| Güllüoğlu BM et al. | Endothelin release is augmented with captopril in rat ischemia-reperfusion injury of the liver. | 1996 | Res Exp Med (Berl) | pmid:8903098 |
| Nishisho T et al. | Experimental and clinical studies of eicosanoids in cerebrospinal fluid after spinal cord injury. | 1996 | Neurosurgery | pmid:8905750 |
| Breil I et al. | Alteration of n-3 fatty acid composition in lung tissue after short-term infusion of fish oil emulsion attenuates inflammatory vascular reaction. | 1996 | Crit. Care Med. | pmid:8917042 |
| Muñoz NM et al. | Eosinophil VLA-4 binding to fibronectin augments bronchial narrowing through 5-lipoxygenase activation. | 1996 | Am. J. Physiol. | pmid:8928818 |
| Paul S et al. | Structure and in vitro substrate specificity of the murine multidrug resistance-associated protein. | 1996 | Biochemistry | pmid:8885844 |
| Tenor H et al. | Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects. | 1996 | Br. J. Pharmacol. | pmid:8842438 |
| Richter L et al. | Increased biliary secretion of cysteinyl-leukotrienes in human bile duct obstruction. | 1996 | J. Hepatol. | pmid:8938552 |
| Sun H et al. | Expression and characterization of the multidrug resistance-associated protein in insect cells infected with a recombinant baculovirus. | 1996 | Oncol. Res. | pmid:8938792 |