| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pulmonary Disease, Chronic Obstructive | D029424 | 16 associated lipids |
| Asthma, Exercise-Induced | D001250 | 10 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Wounds, Nonpenetrating | D014949 | 4 associated lipids |
| Cholestasis, Extrahepatic | D001651 | 7 associated lipids |
| Insect Bites and Stings | D007299 | 4 associated lipids |
| Carotid Artery Injuries | D020212 | 8 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
| Common Bile Duct Diseases | D003137 | 3 associated lipids |
| Cestode Infections | D002590 | 3 associated lipids |
| Neointima | D058426 | 3 associated lipids |
| Asbestosis | D001195 | 8 associated lipids |
| Phlebitis | D010689 | 1 associated lipids |
| Picornaviridae Infections | D010850 | 4 associated lipids |
| Eosinophilic Esophagitis | D057765 | 3 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Choi YH et al. | Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms. | 2006 | Arch. Pharm. Res. | pmid:16681034 |
| Davoine F et al. | Interleukin-12 inhibits eosinophil degranulation and migration but does not promote eosinophil apoptosis. | 2006 | Int. Arch. Allergy Immunol. | pmid:16735797 |
| Perng DW et al. | Leukotriene C4 induces TGF-beta1 production in airway epithelium via p38 kinase pathway. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16179583 |
| Kramer MF et al. | Factors contributing to nasal allergic late phase eosinophilia. | 2006 May-Jun | Am J Otolaryngol | pmid:16647984 |
| Shilling AD et al. | Use of canalicular membrane vesicles (CMVs) from rats, dogs, monkeys and humans to assess drug transport across the canalicular membrane. | 2006 May-Jun | J Pharmacol Toxicol Methods | pmid:16176877 |
| Zaitsu M et al. | Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influx. | 2007 | Mol. Immunol. | pmid:17084457 |
| Bakos E and Homolya L | Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1). | 2007 | Pflugers Arch. | pmid:17187268 |
| Nuutinen P et al. | Histamine, but not leukotriene C4, is an essential mediator in cold urticaria wheals. | 2007 | Acta Derm. Venereol. | pmid:17225008 |
| Yoshisue H et al. | Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts. | 2007 | J. Allergy Clin. Immunol. | pmid:17208594 |
| Lee KS et al. | Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice. | 2007 | J. Allergy Clin. Immunol. | pmid:17208595 |
| Yang SL and Lou YJ | Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats. | 2007 | Biochem. Pharmacol. | pmid:17194456 |
| Kopp MV et al. | Omalizumab (Xolair) in children with seasonal allergic rhinitis: leukotriene release as a potential in vitro parameter to monitor therapeutic effects. | 2007 | Pediatr Allergy Immunol | pmid:17680911 |
| Capra V et al. | Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends. | 2007 | Med Res Rev | pmid:16894531 |
| Zhang XC et al. | Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17483291 |
| Chang WC et al. | All-or-none activation of CRAC channels by agonist elicits graded responses in populations of mast cells. | 2007 | J. Immunol. | pmid:17911611 |
| Blanchet MR et al. | Modulation of eosinophil activation in vitro by a nicotinic receptor agonist. | 2007 | J. Leukoc. Biol. | pmid:17289799 |
| Yang SL et al. | Increased leukotriene c4 synthesis accompanied enhanced leukotriene c4 synthase expression and activities of ischemia-reperfusion-injured liver in rats. | 2007 | J. Surg. Res. | pmid:17397868 |
| Yang JJ et al. | Multidrug resistance protein 1 (MRP1) in rabbit conjunctival epithelial cells: its effect on drug efflux and its regulation by adenoviral infection. | 2007 | Pharm. Res. | pmid:17404811 |
| Rao NL et al. | Anti-inflammatory activity of a potent, selective leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17371808 |
| Jame AJ et al. | Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4. | 2007 | Clin. Exp. Allergy | pmid:17517102 |