LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Glomerulonephritis D005921 35 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Hyperbilirubinemia D006932 11 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Nasal Polyps D009298 26 associated lipids
Ear Diseases D004427 7 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Anaphylaxis D000707 35 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

Download all related citations
Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Daffonchio L et al. Protective activity of ketoprofen lysine salt against the pulmonary effects induced by bradykinin in guinea-pigs. 1996 Inflamm. Res. pmid:8737750
Shichinohe K et al. Effect of M-711 on experimental skin reactions induced by chemical mediators in rats. 1996 J. Vet. Med. Sci. pmid:8741601
Zuberbier T et al. Histamine releasability of basophils and skin mast cells in chronic urticaria. 1996 Allergy pmid:8721524
Takase B et al. Change of plasma leukotriene C4 during myocardial ischemia in humans. 1996 Clin Cardiol pmid:8674256
Ruf G et al. Aminoterminal propeptide of type III procollagen: a marker of hepatic fibrosis after bile duct obstruction in the monkey. 1996 Jan-Feb Hepatogastroenterology pmid:8682446
Sabbah A et al. [Allergy to mosquitoes and use of new immunobiological parameters]. 1997 Allerg Immunol (Paris) pmid:9254117
Sainte-Laudy J et al. [Bioclinical interest in the assay of leukotrienes in four cases of sensitization to trophallergens]. 1997 Allerg Immunol (Paris) pmid:9254120
Akagi M et al. Anti-allergic effect of tea-leaf saponin (TLS) from tea leaves (Camellia sinensis var. sinensis). 1997 Biol. Pharm. Bull. pmid:9178940
Stride BD et al. Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. 1997 Mol. Pharmacol. pmid:9281595
Cortijo J et al. Bronchodilator and anti-inflammatory activities of SCA40: studies in human isolated bronchus, human eosinophils, and in the guinea-pig in vivo. 1997 Naunyn Schmiedebergs Arch. Pharmacol. pmid:9453467
Patella V et al. Heterogeneous effects of protamine on human mast cells and basophils. 1997 Br J Anaesth pmid:9215027
Hamasaki Y et al. Post-transcriptional regulation of LTC4 synthase activity by retinoic acid in rat basophilic leukemia cells. 1997 Biochim. Biophys. Acta pmid:9295165
Jakobsson PJ et al. Characterization of microsomal GST-II by western blot and identification of a novel LTC4 isomer. 1997 J Lipid Mediat Cell Signal pmid:9302651
Sabbah A et al. [Anaphylactic or anaphylactoid reactions to paracetamol. Report of 3 cases]. 1997 Allerg Immunol (Paris) pmid:9221011
Leynadier F [Drug allergies: value of the leucotriene C4 release test?]. 1997 Presse Med pmid:9180883
Forssmann U et al. Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. 1997 J. Exp. Med. pmid:9182688
Scoggan KA et al. Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes. 1997 J. Biol. Chem. pmid:9092565
Carter BZ et al. Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice. 1997 J. Biol. Chem. pmid:9139674
Hardcastle JE and Bruch RJ Effect of L-aspartyl-L-phenylalanine methyl ester on leukotriene biosynthesis in macrophage cells. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9384524
Gagari E et al. Differential release of mast cell interleukin-6 via c-kit. 1997 Blood pmid:9108382
Madon J et al. Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein. 1997 FEBS Lett. pmid:9109389
Sala A et al. Pharmacological modulation of human platelet leukotriene C4-synthase. 1997 Biochem. Pharmacol. pmid:9113110
de Paulis A et al. Human synovial mast cells. II. Heterogeneity of the pharmacologic effects of antiinflammatory and immunosuppressive drugs. 1997 Arthritis Rheum. pmid:9082935
Nguyen T and Gupta S Leukotriene C4 secretion from normal murine mast cells by a probenecid-sensitive and multidrug resistance-associated protein-independent mechanism. 1997 J. Immunol. pmid:9144509
Bozkurt S et al. The cytoprotective effect of iloprost against carbon tetrachloride induced necrosis in rat liver. 1997 Res. Commun. Mol. Pathol. Pharmacol. pmid:9144840
Puder M and Soberman RJ Glutathione conjugates recognize the Rossmann fold of glyceraldehyde-3-phosphate dehydrogenase. 1997 J. Biol. Chem. pmid:9099752
Wang D et al. An approach to the understanding of the nasal early-phase reaction induced by nasal allergen challenge. 1997 Allergy pmid:9105520
Fujita M et al. Cysteinyl leukotrienes induce nasal symptoms of allergic rhinitis via a receptor-mediated mechanism in guinea pigs. 1997 Jpn. J. Pharmacol. pmid:9469641
Schuligoi R et al. Release of calcitonin gene-related peptide in cardiac anaphylaxis. 1997 Naunyn Schmiedebergs Arch. Pharmacol. pmid:9050016
Sumizawa T et al. Reversal of multidrug resistance-associated protein-mediated drug resistance by the pyridine analog PAK-104P. 1997 Mol. Pharmacol. pmid:9058594
Brady HR et al. Transcellular pathways and cell adhesion as potential contributors to leukotriene and lipoxin biosynthesis in acute glomerulonephritis. 1997 Adv. Exp. Med. Biol. pmid:9547614
Chavis C et al. Leukotriene E4 plasma levels in adult asthmatic patients with variable disease severity. 1997 Allergy pmid:9201374
Gissurarson SR et al. Effect of lobaric acid on cysteinyl-leukotriene formation and contractile activity of guinea pig taenia coli. 1997 J. Pharmacol. Exp. Ther. pmid:9023290
Herman CA et al. Synthesis and action of eicosanoids in warm and cold-acclimated amphibians. 1997 Adv. Exp. Med. Biol. pmid:9561172
Sporn PH et al. Keratinocyte growth factor increases LTC4 synthesis and expression of flap in cultured rat alveolar type II cells. 1997 Adv. Exp. Med. Biol. pmid:9561179
Monahan J et al. Attenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor. 1997 J. Immunol. pmid:9378992
Vigorito C et al. Metabolic and hemodynamic effects of peptide leukotriene C4 and D4 in man. 1997 Int. J. Clin. Lab. Res. pmid:9352380
Jedlitschky G et al. ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. 1997 Biochem. J. pmid:9355767
Wijnholds J et al. Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. 1997 Nat. Med. pmid:9359705
Damtew B and Spagnuolo PJ Leukotriene C4 from vascular endothelium enhances neutrophil adhesiveness. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9051719
Mullol J et al. [Eosinophil activation by epithelial cells of the respiratory mucosa. Comparative study of normal mucosa and inflammatory mucosa]. 1997 Med Clin (Barc) pmid:9303983
Gomi A et al. Transient induction of the MRP/GS-X pump and gamma-glutamylcysteine synthetase by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea in human glioma cells. 1997 Cancer Res. pmid:9393752
el-Ahmady O et al. Elevated concentrations of interleukins and leukotriene in response to Mycobacterium tuberculosis infection. 1997 Ann. Clin. Biochem. pmid:9133249
Bureau MF et al. 5-Lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs. 1997 Eur. J. Pharmacol. pmid:9137918
Zeltsman D et al. Pathophysiologic plasma levels of leukotriene C4 in relation to the hemodynamic dysfunction and mediator release of graded bacteremia. 1997 Shock pmid:9110414
Kitaura K et al. Effects of organic anions and bile acid conjugates on biliary excretion of LTC4 in the rat. 1997 Prostaglandins pmid:9491205
Bell RR et al. Cadmium and/or selenium effects on guinea pig lung PGE2, TXB2 and LTC4. 1997 Res. Commun. Mol. Pathol. Pharmacol. pmid:9344235
Taichman RS et al. Human osteosarcomas inhibit hematopoietic colony formation: partial reversal by antibody to transforming growth factor-beta 1. 1997 Bone pmid:9315339
Zweiman B et al. Nasal airway changes assessed by acoustic rhinometry and mediator release during immediate and late reactions to allergen challenge. 1997 J. Allergy Clin. Immunol. pmid:9389292
Hamasaki Y et al. The Chinese herbal medicine, shinpi-to, inhibits IgE-mediated leukotriene synthesis in rat basophilic leukemia-2H3 cells. 1997 J Ethnopharmacol pmid:9174973