| MeSH term | MeSH ID | Detail |
|---|---|---|
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Mesenteric Vascular Occlusion | D008641 | 4 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
| Periapical Periodontitis | D010485 | 6 associated lipids |
| Peritonitis | D010538 | 38 associated lipids |
| Phlebitis | D010689 | 1 associated lipids |
| Picornaviridae Infections | D010850 | 4 associated lipids |
| Pneumococcal Infections | D011008 | 7 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kingham PJ et al. | Adhesion-dependent interactions between eosinophils and cholinergic nerves. | 2002 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12003778 |
| Sawatzky DA et al. | Eosinophil adhesion to cholinergic nerves via ICAM-1 and VCAM-1 and associated eosinophil degranulation. | 2002 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12003784 |
| de las Heras B et al. | Effects of six diterpenes on macrophage eicosanoid biosynthesis. | 2001 | Life Sci. | pmid:12005260 |
| Christmas P et al. | Membrane localization and topology of leukotriene C4 synthase. | 2002 | J. Biol. Chem. | pmid:12023288 |
| Mao Q et al. | GSH-dependent photolabeling of multidrug resistance protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain. | 2002 | J. Biol. Chem. | pmid:12034727 |
| Conrad S et al. | A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance. | 2002 | Pharmacogenetics | pmid:12042670 |
| Oliveira SH et al. | Increased responsiveness of murine eosinophils to MIP-1beta (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8. | 2002 | J. Leukoc. Biol. | pmid:12050188 |
| Fernández SB et al. | Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells. | 2002 | J. Biol. Chem. | pmid:12060660 |
| Bandeira-Melo C et al. | Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. | 2002 | J. Allergy Clin. Immunol. | pmid:12063527 |
| Thomas LL et al. | Immobilized lactoferrin is a stimulus for eosinophil activation. | 2002 | J. Immunol. | pmid:12097406 |
| Gibbs BF et al. | Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization. | 2002 | J. Leukoc. Biol. | pmid:12149431 |
| Hashizume K and Black KL | Increased endothelial vesicular transport correlates with increased blood-tumor barrier permeability induced by bradykinin and leukotriene C4. | 2002 | J. Neuropathol. Exp. Neurol. | pmid:12152787 |
| Ohashi M et al. | Effects of phalloidin on the biliary excretion of cholephilic compounds in rats. | 2002 | Pharmacology | pmid:12169763 |
| Arango P and Kountakis SE | Presence of cysteinyl leukotrienes in asthmatic patients with chronic sinusitis. | 2002 | Laryngoscope | pmid:12169896 |
| Haimeur A et al. | Charged amino acids in the sixth transmembrane helix of multidrug resistance protein 1 (MRP1/ABCC1) are critical determinants of transport activity. | 2002 | J. Biol. Chem. | pmid:12186871 |
| Gebhardt T et al. | Cultured human intestinal mast cells express functional IL-3 receptors and respond to IL-3 by enhancing growth and IgE receptor-dependent mediator release. | 2002 | Eur. J. Immunol. | pmid:12209644 |
| Hagmann W et al. | Reconstitution of transport-active multidrug resistance protein 2 (MRP2; ABCC2) in proteoliposomes. | 2002 | Biol. Chem. | pmid:12222674 |
| Yang Y et al. | Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistance-associated protein 1. | 2002 | J. Biol. Chem. | pmid:12235150 |
| Bandeira-Melo C et al. | Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion. | 2002 | J. Exp. Med. | pmid:12235216 |
| Suzuki Y et al. | Silver activates calcium signals in rat basophilic leukemia-2H3 mast cells by a mechanism that differs from the Fc epsilon RI-activated response. | 2002 | J. Immunol. | pmid:12244196 |