| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pneumococcal Infections | D011008 | 7 associated lipids |
| Eosinophilia | D004802 | 4 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Cough | D003371 | 19 associated lipids |
| Dermatitis, Atopic | D003876 | 19 associated lipids |
| Status Asthmaticus | D013224 | 4 associated lipids |
| Pseudoxanthoma Elasticum | D011561 | 2 associated lipids |
| Rhinitis, Allergic, Perennial | D012221 | 6 associated lipids |
| Acute-Phase Reaction | D000210 | 12 associated lipids |
| Uveitis | D014605 | 14 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Takase B et al. | Effects of bepridil on silent myocardial ischemia and eicosanoid metabolism in chronic stable angina pectoris after healing of myocardial infarction. | 1994 | Am. J. Cardiol. | pmid:8198031 |
| Munoz NM et al. | Beta adrenergic modulation of formyl-methionine-leucine-phenylalanine-stimulated secretion of eosinophil peroxidase and leukotriene C4. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8301549 |
| Sathirakul K et al. | Multiple transport systems for organic anions across the bile canalicular membrane. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8301595 |
| Metters KM et al. | Microsomal glutathione S-transferase is the predominant leukotriene C4 binding site in cellular membranes. | 1994 | J. Biol. Chem. | pmid:8175695 |
| Wardle TD and Turnberg LA | Potential role for interleukin-1 in the pathophysiology of ulcerative colitis. | 1994 | Clin. Sci. | pmid:8033515 |
| Kargman S et al. | Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells. | 1994 | Mol. Pharmacol. | pmid:8190095 |
| Shimizu T et al. | Leukotriene B4 and C4 generation by blood leukocytes after ex vivo stimulation by Ca-ionophore and opsonized zymosan in children with atopic dermatitis. | 1994 | Pediatr Allergy Immunol | pmid:8087194 |
| Mayatepek E et al. | Impaired synthesis of lipoxygenase products in glutathione synthetase deficiency. | 1994 | Pediatr. Res. | pmid:8190517 |
| Willburger RE and Wittenberg RH | Prostaglandin release from lumbar disc and facet joint tissue. | 1994 | Spine | pmid:7825047 |
| Wang D et al. | Concentrations of chemical mediators in nasal secretions of patients with hay fever during natural allergen exposure. | 1994 | Acta Otolaryngol. | pmid:7825440 |
| Goulet JL et al. | Altered inflammatory responses in leukotriene-deficient mice. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7809134 |
| Müller M et al. | Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7809167 |
| Hamasaki Y et al. | Inhibition by dexamethasone of retinoic acid-induced enhancement of leukotriene C4 synthesis in rat basophilic leukemia-1 cells. | 1994 | Am. J. Respir. Cell Mol. Biol. | pmid:8018338 |
| Aktan AO et al. | Does PGE2 act as a mediator for endothelin release? | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7511821 |
| YeÄŸen C et al. | Effect of verapamil and iloprost (ZK 36374) on endothelin release after mesenteric ischemia-reperfusion injury. | 1994 | Eur Surg Res | pmid:7516292 |
| Abela A and Daniel EE | Neural and myogenic effects of leukotrienes C4, D4, and E4 on canine bronchial smooth muscle. | 1994 | Am. J. Physiol. | pmid:8179018 |
| Kurosawa M et al. | Inhibition by a novel peptide leukotriene receptor antagonist ONO-1078 of airway wall thickening and airway hyperresponsiveness to histamine induced by leukotriene C4 or leukotriene D4 in guinea-pigs. | 1994 | Clin. Exp. Allergy | pmid:7842366 |
| Pintos-Morell G et al. | Altered leukotriene generation in leukocytes from cystinotic children. | 1994 | Pediatr. Res. | pmid:7877883 |
| Thioudellet C et al. | Molecular and functional characterization of recombinant human gamma-glutamyltransferase. Coupling of its activity to glutathione levels in V79 cells. | 1994 | Eur. J. Biochem. | pmid:7913033 |
| Shimizu T et al. | Leukotriene B4 and C4 generation by small intestinal mucosa in children with coeliac disease. | 1994 | Digestion | pmid:8063028 |
| Votta BJ and Bertolini DR | Cytokine suppressive anti-inflammatory compounds inhibit bone resorption in vitro. | 1994 Sep-Oct | Bone | pmid:7980964 |
| Murakami M et al. | The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. | 1995 | J. Exp. Med. | pmid:7540649 |
| Porreca E et al. | Modulation of rat vascular smooth muscle cell (VSMC) proliferation by cysteinyl leukotriene D4: a role for mediation of interleukin 1. | 1995 | Atherosclerosis | pmid:7755646 |
| Lam BK et al. | Expression cloning of human LTC4 synthase. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732869 |
| Cruz JR et al. | Fecal excretion of leukotriene C4 during human disease due to Shigella dysenteriae. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:7714683 |
| Nishikawa M et al. | Effect of leukotriene C4D4 antagonist on colonic damage induced by intracolonic administration of trinitrobenzene sulfonic acid in rats. | 1995 | J. Gastroenterol. | pmid:7719412 |
| Shimizu T et al. | Leukotriene B4 and C4 metabolism in small intestine mucosa of children with celiac disease. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:8583294 |
| RodrÃguez-Ortigosa CM et al. | Taurocholate-stimulated leukotriene C4 biosynthesis and leukotriene C4-stimulated choleresis in isolated rat liver. | 1995 | Gastroenterology | pmid:7768385 |
| Tschugguel W et al. | High precision measurement of electrical resistance across endothelial cell monolayers. | 1995 | Pflugers Arch. | pmid:7667075 |
| Miadonna A et al. | Antiallergic activity of loratadine: inhibition of leukotriene C4 release from human leucocytes. | 1995 | Clin. Exp. Allergy | pmid:7541309 |
| Tornhamre S et al. | Receptor-mediated regulation of leukotriene C4 synthase activity in human platelets. | 1995 | Eur. J. Biochem. | pmid:8536697 |
| Grønbech JE and Lacy ER | Role of gastric blood flow in impaired defense and repair of aged rat stomachs. | 1995 | Am. J. Physiol. | pmid:7491966 |
| Ochensberger B et al. | IgE-independent interleukin-4 expression and induction of a late phase of leukotriene C4 formation in human blood basophils. | 1995 | Blood | pmid:7492759 |
| Culo F et al. | Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice. | 1995 | Eur J Gastroenterol Hepatol | pmid:7496865 |
| Murakami M et al. | Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells. | 1995 | J. Biol. Chem. | pmid:7559381 |
| Sampson AP et al. | Persistent increase in plasma and urinary leukotrienes after acute asthma. | 1995 | Arch. Dis. Child. | pmid:7492159 |
| Restrick LJ et al. | Reduction in leukotriene B4 generation by bronchoalveolar lavage cells in asthma. | 1995 | Thorax | pmid:7886653 |
| De Castro CM et al. | Modulation by dexamethasone of phospholipase A2 activities in endotoxemic guinea pigs. | 1995 | J. Appl. Physiol. | pmid:8567572 |
| Engin A et al. | The protective effect of thromboxane synthetase inhibitor UK 38485 against bile duct ligation induced liver injury. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7544015 |
| Takafuji S et al. | Effects of physiologic soluble agonists on leukotriene C4 production and degranulation by human eosinophils. | 1995 | Int. Arch. Allergy Immunol. | pmid:7549519 |
| Yoshida K et al. | Effect of fibronectin on the production of leukotriene C4 by eosinophils. | 1995 | Int. Arch. Allergy Immunol. | pmid:7549524 |
| Datta YH et al. | Peptido-leukotrienes are potent agonists of von Willebrand factor secretion and P-selectin surface expression in human umbilical vein endothelial cells. | 1995 | Circulation | pmid:7586318 |
| Sengör T et al. | Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. | 1995 | CLAO J | pmid:7586473 |
| Sala A and Folco G | LTC4 in normal urine. | 1995 | Eur. J. Clin. Invest. | pmid:7589021 |
| Schauer U et al. | Blood eosinophils, eosinophil-derived proteins, and leukotriene C4 generation in relation to bronchial hyperreactivity in children with atopic dermatitis. | 1995 | Allergy | pmid:7604934 |
| Herron DK et al. | Visualization and comparison of molecular dynamics simulations of leukotriene C4, leukotriene D4, and leukotriene E4. | 1995 | J Mol Graph | pmid:8820302 |
| Gorenne I et al. | Effects of beta 2-adrenoceptor agonists on anti-IgE-induced contraction and smooth muscle reactivity in human airways. | 1995 | Br. J. Pharmacol. | pmid:7780648 |
| Karmeli F et al. | A stable nitroxide radical effectively decreases mucosal damage in experimental colitis. | 1995 | Gut | pmid:7590435 |
| Utoh J et al. | Is an increase in neutrophil leukotriene-generating capacity a specific phenomenon for cardiopulmonary bypass? | 1995 | J. Thorac. Cardiovasc. Surg. | pmid:7609558 |
| Janssen-Timmen U et al. | Expression of 5-lipoxygenase in differentiating human skin keratinocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7624354 |