| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pneumococcal Infections | D011008 | 7 associated lipids |
| Eosinophilia | D004802 | 4 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Cough | D003371 | 19 associated lipids |
| Dermatitis, Atopic | D003876 | 19 associated lipids |
| Status Asthmaticus | D013224 | 4 associated lipids |
| Pseudoxanthoma Elasticum | D011561 | 2 associated lipids |
| Rhinitis, Allergic, Perennial | D012221 | 6 associated lipids |
| Acute-Phase Reaction | D000210 | 12 associated lipids |
| Uveitis | D014605 | 14 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jafarian A et al. | Effects of RS-albuterol on the development of antigen-mediated airway hyperreactivity in guinea pigs. | 1996 | Clin Rev Allergy Immunol | pmid:8866174 |
| Keppler D et al. | The function of the multidrug resistance proteins (MRP and cMRP) in drug conjugate transport and hepatobiliary excretion. | 1996 | Adv. Enzyme Regul. | pmid:8869738 |
| Tool AT et al. | The effect of salmeterol and nimesulide on chemotaxis and synthesis of PAF and LTC4 by human eosinophils. | 1996 | Eur Respir J Suppl | pmid:8871060 |
| Westcott JY et al. | Arachidonate-induced eicosanoid synthesis in RBL-2H3 cells: stimulation with antigen or A23187 induces prolonged activation of 5-lipoxygenase. | 1996 | Biochim. Biophys. Acta | pmid:8816855 |
| Genovese A et al. | Role of mast cells, basophils and their mediators in adverse reactions to general anesthetics and radiocontrast media. | 1996 | Int. Arch. Allergy Immunol. | pmid:8645973 |
| Patella V et al. | Oxatomide inhibits the release of proinflammatory mediators from human basophils and mast cells. | 1996 | Int. Arch. Allergy Immunol. | pmid:8753840 |
| Willburger RE et al. | Inhibition of eicosanoid release from synovial organ culture by incubation with tepoxalin and its acid metabolite. | 1996 | Prostaglandins | pmid:8936587 |
| Dhillon HS et al. | Regional generation of leukotriene C4 after experimental brain injury in anesthetized rats. | 1996 | J. Neurotrauma | pmid:9002063 |
| Maclouf J et al. | Consequences of transcellular biosynthesis of leukotriene C4 on organ function. | 1996 | Haemostasis | pmid:8979109 |
| Tsikas D et al. | Catalytic hydrogenation of leukotriene B4 enhances sensitivity and specificity of gas chromatography-tandem mass spectrometry techniques and enables simultaneous analysis with cysteinyl leukotrienes in biological fluids. | 1996 | Anal. Biochem. | pmid:8619486 |
| Bäck M et al. | The cysteinyl-leukotriene receptor antagonist BAY u9773 is a competitive antagonist of leukotriene C4 in the guinea-pig ileum. | 1996 | Eur. J. Pharmacol. | pmid:8982726 |
| Akasaka R et al. | Effects of three different Ca(2+)-ATPase inhibitors on Ca2+ response and leukotriene release in RBL-2H3 cells. | 1996 | Inflamm. Res. | pmid:8988402 |
| Gao M et al. | Reconstitution of ATP-dependent leukotriene C4 transport by Co-expression of both half-molecules of human multidrug resistance protein in insect cells. | 1996 | J. Biol. Chem. | pmid:8910374 |
| Hamasaki Y et al. | Inhibition of leukotriene synthesis by azelastine. | 1996 | Ann. Allergy Asthma Immunol. | pmid:8630722 |
| Jutel M et al. | Influence of bee venom immunotherapy on degranulation and leukotriene generation in human blood basophils. | 1996 | Clin. Exp. Allergy | pmid:8911695 |
| Omar HM et al. | Hepatobiliary excretion of cysteinyl leukotrienes in three experimental models of acute hepatic injury. | 1996 | Inflamm. Res. | pmid:8912018 |
| Müller D et al. | Bile ductular proliferation and altered leukotriene elimination in thioacetamide-induced fibrosis of rat liver. | 1996 | J. Hepatol. | pmid:8912155 |
| Sedgwick JB et al. | Effect of isolation protocol on eosinophil function: Percoll gradients versus immunomagnetic beads. | 1996 | J. Immunol. Methods | pmid:8914593 |
| Fukai F et al. | Transcellular biosynthesis of cysteinyl leukotrienes by Kupffer cell-hepatocyte cooperation in rat liver. | 1996 | Cell Biol. Int. | pmid:8858827 |
| de Paulis A et al. | Human synovial mast cells. I. Ultrastructural in situ and in vitro immunologic characterization. | 1996 | Arthritis Rheum. | pmid:8670335 |
| Brock TG et al. | Effects of granulocyte-macrophage colony-stimulating factor on eicosanoid production by mononuclear phagocytes. | 1996 | J. Immunol. | pmid:8786314 |
| Garcia C et al. | Effects of synthetic peptido-leukotrienes on bone resorption in vitro. | 1996 | J. Bone Miner. Res. | pmid:8992883 |
| Henderson WR et al. | The importance of leukotrienes in airway inflammation in a mouse model of asthma. | 1996 | J. Exp. Med. | pmid:8879219 |
| Crampette L et al. | Inhibition of mediator and cytokine release from dispersed nasal polyp cells by terfenadine. | 1996 | Allergy | pmid:8836342 |
| de Paulis A et al. | Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine. | 1996 | J. Allergy Clin. Immunol. | pmid:8765829 |
| Planquois JM et al. | Differential inhibition by selective phosphodiesterase inhibitors of antigen, LTC4 and histamine-induced contraction of guinea-pig isolated trachea. | 1996 | Pulm Pharmacol | pmid:9160414 |
| Büchler M et al. | cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. | 1996 | J. Biol. Chem. | pmid:8662992 |
| Daffonchio L et al. | Protective activity of ketoprofen lysine salt against the pulmonary effects induced by bradykinin in guinea-pigs. | 1996 | Inflamm. Res. | pmid:8737750 |
| Shichinohe K et al. | Effect of M-711 on experimental skin reactions induced by chemical mediators in rats. | 1996 | J. Vet. Med. Sci. | pmid:8741601 |
| Ionac M et al. | Oxaceprol, an atypical inhibitor of inflammation and joint damage. | 1996 | Pharmacol. Res. | pmid:8971960 |
| Zuberbier T et al. | Histamine releasability of basophils and skin mast cells in chronic urticaria. | 1996 | Allergy | pmid:8721524 |
| Leier I et al. | Identification of the biosynthetic leukotriene C4 export pump in murine mastocytoma cells as a homolog of the multidrug-resistance protein. | 1996 | Eur. J. Biochem. | pmid:8973633 |
| Takase B et al. | Change of plasma leukotriene C4 during myocardial ischemia in humans. | 1996 | Clin Cardiol | pmid:8674256 |
| Paul S et al. | ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8692921 |
| Przylipiak A et al. | Role of leukotriene C4 in follicle-stimulating hormone (FSH) secretion in female rat pituitary. | 1996 | Gynecol. Endocrinol. | pmid:8701793 |
| Sainte-Laudy J et al. | [Importance of the leukotriene C4 liberation test for the diagnosis of drug allergy (preliminary results)]. | 1996 | Allerg Immunol (Paris) | pmid:8703308 |
| Leier I et al. | ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. | 1996 | Biochem. J. | pmid:8670053 |
| Shindo K et al. | Priming effect of platelet activating factor on leukotriene C4 from stimulated eosinophils of asthmatic patients. | 1996 | Thorax | pmid:8711647 |
| Wei EQ et al. | Effect of ONO-1078, a leukotriene antagonist, on capsaicin- and substance P-induced bronchoconstriction and airway microvascular leakage in guinea pigs. | 1996 | Zhongguo Yao Li Xue Bao | pmid:9812736 |
| He L and Zhu J | Distinguishing antemortem from postmortem injuries by LTB4 quantification. | 1996 | Forensic Sci. Int. | pmid:8784990 |
| Batirel HF et al. | The effect of aqueous garlic extract on the levels of arachidonic acid metabolites (leukotriene C4 and prostaglandin E2) in rat forebrain after ischemia-reperfusion injury. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804127 |
| Shraga-Levine Z et al. | Arachidonic acid and lipoxygenase products stimulate protein kinase C beta mRNA levels in pituitary alpha T3-1 cell line: role in gonadotropin-releasing hormone action. | 1996 | Biochem. J. | pmid:8687415 |
| Kang BC et al. | Experimental asthma developed by room air contamination with cockroach allergen. | 1996 | Int. Arch. Allergy Immunol. | pmid:8917126 |
| Wu RY and Wei EQ | [Inhibitory effects of tachykinin receptor antagonists on leukotriene C4-induced cardiovascular responses in guinea pigs]. | 1996 | Yao Xue Xue Bao | pmid:9863223 |
| Ganbo T et al. | Leukotriene C4 inhibits ciliary activity in the presence of gamma-glutamyl transpeptidase. | 1996 | Am. J. Physiol. | pmid:8770059 |
| Funayama T et al. | Role of Leukotriene-degrading enzymes in pulmonary response to antigen infusion in sensitized guinea pigs in vivo. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8703483 |
| Tenor H et al. | Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects. | 1996 | Br. J. Pharmacol. | pmid:8842438 |
| Richter L et al. | Increased biliary secretion of cysteinyl-leukotrienes in human bile duct obstruction. | 1996 | J. Hepatol. | pmid:8938552 |
| Sun H et al. | Expression and characterization of the multidrug resistance-associated protein in insect cells infected with a recombinant baculovirus. | 1996 | Oncol. Res. | pmid:8938792 |
| Lane SJ and Lee TH | Mast cell effector mechanisms. | 1996 | J. Allergy Clin. Immunol. | pmid:8939179 |