| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pseudoxanthoma Elasticum | D011561 | 2 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Respiratory Hypersensitivity | D012130 | 18 associated lipids |
| Rhinitis, Allergic, Perennial | D012221 | 6 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Spinal Cord Injuries | D013119 | 34 associated lipids |
| Status Asthmaticus | D013224 | 4 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Ulcer | D014456 | 16 associated lipids |
| Uveitis | D014605 | 14 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang J et al. | [The effects of resuscitation with hypertonic saline solution on the postburn pulmonary injury in scalded dogs]. | 2001 | Zhonghua Shao Shang Za Zhi | pmid:11774813 |
| Chen A and Zhong N | [Zafirlukast inhibition of leukotriene C4 induced endothelin-1 expression in human airway structural cell]. | 2000 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:11372388 |
| Wang JL et al. | [The mechanism of airway inflammation in eosinophilic bronchitis and cough variant asthma]. | 2011 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:21781515 |
| Zhang Y et al. | [Effects of polydatin on bleomycin-induced pulmonary fibrosis in rats]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22368872 |
| Liu YG and Luo JB | [Effects of among compositions of Herba Ephedrae decoction on genic xpression of 5-lipoxygenase activating protein, IL-4 and leukotriene C4 in asthmatic mice]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17432150 |
| Zhang H et al. | [Study on the effect and mechanism of qinggan xiehuo decoction in treatment of endotoxin-induced uveitis in rabbits]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8762423 |
| Wei EQ et al. | Effect of ONO-1078, a leukotriene antagonist, on capsaicin- and substance P-induced bronchoconstriction and airway microvascular leakage in guinea pigs. | 1996 | Zhongguo Yao Li Xue Bao | pmid:9812736 |
| Wettstein M and Häussinger D | [Effect of hypoxia on nitric oxide formation and leukotriene metabolism in the perfused rat liver]. | 1994 | Zentralbl Chir | pmid:7517604 |
| Müller D et al. | Stimulation of bile flow and inhibition of biliary secretion of taurocholate and leukotriene C4 in thioacetamide-induced liver fibrosis. | 1993 | Z Gastroenterol | pmid:7483705 |
| Wu RY and Wei EQ | [Inhibitory effects of tachykinin receptor antagonists on leukotriene C4-induced cardiovascular responses in guinea pigs]. | 1996 | Yao Xue Xue Bao | pmid:9863223 |
| Wei EQ et al. | [Effect of a leukotriene antagonist, ONO-1078, on electric stimulation of vagus (ESV)-induced bronchoconstriction and microvascular leakage in guinea pigs]. | 1994 | Yao Xue Xue Bao | pmid:7976357 |
| Mizutani N | [Studies on the experimental allergic rhinitis induced by Japanese cedar pollen--role of cysteinyl leukotrienes in nasal allergic symptoms]. | 2003 | Yakugaku Zasshi | pmid:12607939 |
| Ko JK et al. | Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis. | 2004 | World J. Gastroenterol. | pmid:15300893 |
| Ma KF et al. | Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model. | 2008 | World J. Gastroenterol. | pmid:18461660 |
| Jedlitschky G and Keppler D | Transport of leukotriene C4 and structurally related conjugates. | 2002 | Vitam. Horm. | pmid:11898391 |
| Bertin J et al. | Exposure of human astrocytes to leukotriene C4 promotes a CX3CL1/fractalkine-mediated transmigration of HIV-1-infected CD4⺠T cells across an in vitro blood-brain barrier model. | 2014 | Virology | pmid:24725939 |
| Lin TY and London CA | Characterization and modulation of canine mast cell derived eicosanoids. | 2010 | Vet. Immunol. Immunopathol. | pmid:20036014 |
| O'Connor BJ et al. | Selective airway responsiveness in asthma. | 1999 | Trends Pharmacol. Sci. | pmid:10101956 |
| Buyukgebiz O et al. | Allopurinol inhibits endothelin release after mesenteric ischemia-reperfusion injury. | 1995 | Transplant. Proc. | pmid:7482880 |
| González J et al. | Role of leukotrienes B4 and C4 in liver allograft rejection. | 1992 | Transpl. Int. | pmid:14621902 |
| Szarek JL and Valentovic MA | Release of prostaglandin E2 and leukotriene C4/D4 from airway segments isolated from rats after exposure to ozone for 20 months. | 1995 | Toxicology | pmid:7624868 |
| Xiao J et al. | Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury. | 2015 | Toxicol. Sci. | pmid:25432964 |
| Strenzke N et al. | Mercuric chloride enhances immunoglobulin E-dependent mediator release from human basophils. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11485386 |
| Liu W et al. | Coupling of UDP-glucuronosyltransferases and multidrug resistance-associated proteins is responsible for the intestinal disposition and poor bioavailability of emodin. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22982073 |
| Bridges CC et al. | MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21134393 |
| Lee SJ et al. | 4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK. | 2010 | Toxicol. Appl. Pharmacol. | pmid:19837106 |
| Awasthi S et al. | ATP-Dependent colchicine transport by human erythrocyte glutathione conjugate transporter. | 1999 | Toxicol. Appl. Pharmacol. | pmid:10079207 |
| Aleo MD et al. | An underlying role for hepatobiliary dysfunction in cyclosporine A nephrotoxicity. | 2008 | Toxicol. Appl. Pharmacol. | pmid:18407308 |
| Lai YL and Lin TY | Mast cells in citric acid-induced cough of guinea pigs. | 2005 | Toxicol. Appl. Pharmacol. | pmid:15589973 |
| Black AT et al. | Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. | 2010 | Toxicol. Appl. Pharmacol. | pmid:20840853 |
| Lin CH and Lai YL | Mast cell mediators in citric acid-induced airway constriction of guinea pigs. | 2005 | Toxicol. Appl. Pharmacol. | pmid:16039945 |
| Weide I et al. | Intravascular cysteinyl-leukotriene formation by clotting whole human blood. Evidence from clamped umbilical vein segments and thrombus specimens. | 1993 | Thromb. Res. | pmid:8122190 |
| Shindo K et al. | Priming effect of platelet activating factor on leukotriene C4 from stimulated eosinophils of asthmatic patients. | 1996 | Thorax | pmid:8711647 |
| Lee TH and Christie PE | Leukotrienes and aspirin induced asthma. | 1993 | Thorax | pmid:8303620 |
| Dahlén B et al. | Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects. | 1993 | Thorax | pmid:8303624 |
| Restrick LJ et al. | Reduction in leukotriene B4 generation by bronchoalveolar lavage cells in asthma. | 1995 | Thorax | pmid:7886653 |
| Randolph GJ et al. | Factors and signals that govern the migration of dendritic cells via lymphatics: recent advances. | 2005 | Springer Semin. Immunopathol. | pmid:15338191 |
| Akpek EA et al. | A study of adenosine treatment in experimental acute spinal cord injury. Effect on arachidonic acid metabolites. | 1999 | Spine | pmid:9926381 |
| Willburger RE and Wittenberg RH | Prostaglandin release from lumbar disc and facet joint tissue. | 1994 | Spine | pmid:7825047 |
| Chen X et al. | [Preventive effects of montelukast on hypoxic pulmonary hypertension in rats]. | 2003 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:12910720 |
| Eun JC et al. | The 5-lipoxygenase pathway is required for acute lung injury following hemorrhagic shock. | 2012 | Shock | pmid:22392149 |
| Bellou A et al. | Constitutive nitric oxide synthase inhibition combined with histamine and serotonin receptor blockade improves the initial ovalbumin-induced arterial hypotension but decreases the survival time in brown norway rats anaphylactic shock. | 2003 | Shock | pmid:12558148 |
| Zeltsman D et al. | Pathophysiologic plasma levels of leukotriene C4 in relation to the hemodynamic dysfunction and mediator release of graded bacteremia. | 1997 | Shock | pmid:9110414 |
| Tran HS et al. | The cardiovascular hemodynamics and leukotriene kinetics during prostacyclin and anti-prostacyclin antibody infusions in septic shock. | 2000 | Shock | pmid:10847636 |
| Bölke E et al. | Inflammatory response during abdominal and thyroid surgery: a prospective clinical trial on mediator release. | 2001 | Shock | pmid:11699069 |
| Suzuki H and Sugiyama Y | Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2. | 1998 | Semin. Liver Dis. | pmid:9875554 |
| Ahmed LA et al. | Role of the KATP channel in the protective effect of nicorandil on cyclophosphamide-induced lung and testicular toxicity in rats. | 2015 | Sci Rep | pmid:26403947 |
| Reims A et al. | Cysteinyl leukotrienes are secretagogues in atrophic coeliac and in normal duodenal mucosa of children. | 2005 | Scand. J. Gastroenterol. | pmid:15764146 |
| Ganbo T et al. | The effects of leukotrienes C4 and D4 on ciliary activity of human paranasal sinus mucosa in vitro. | 1995 | Rhinology | pmid:8919211 |
| Medina Avalos MA and Orea Solano M | [Macrophages in asthma]. | 1997 Sep-Oct | Rev Alerg Mex | pmid:9432275 |