| MeSH term | MeSH ID | Detail |
|---|---|---|
| Periapical Periodontitis | D010485 | 6 associated lipids |
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Hyperbilirubinemia, Hereditary | D006933 | 3 associated lipids |
| Rhinitis, Allergic, Seasonal | D006255 | 7 associated lipids |
| Drug Eruptions | D003875 | 30 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Mesenteric Vascular Occlusion | D008641 | 4 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wen FQ et al. | Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758210 |
| Bermejo Benito P et al. | In vivo and in vitro antiinflammatory activity of saikosaponins. | 1998 | Life Sci. | pmid:9763210 |
| Templeton AG et al. | Effects of S-salbutamol on human isolated bronchus. | 1998 | Pulm Pharmacol Ther | pmid:9802957 |
| Kusuhara H et al. | Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9618431 |
| Barnouin K et al. | Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione. | 1998 | Br. J. Cancer | pmid:9460989 |
| Zaitsu M et al. | Effect of dexamethasone on leukotriene synthesis in DMSO-stimulated HL-60 cells. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10102384 |
| Brock TG et al. | Capacity for repeatable leukotriene generation after transient stimulation of mast cells and macrophages. | 1998 | Biochem. J. | pmid:9445378 |
| Sperber K et al. | Mucin secretion in inflammatory bowel disease: comparison of a macrophage-derived mucin secretagogue (MMS-68) to conventional secretagogues. | 1998 | Inflamm. Bowel Dis. | pmid:9552223 |
| Gao M et al. | Multidrug resistance protein. Identification of regions required for active transport of leukotriene C4. | 1998 | J. Biol. Chem. | pmid:9553138 |
| Diven WF et al. | Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla. | 1998 | Ann. Otol. Rhinol. Laryngol. | pmid:9525240 |
| Black P et al. | Chemotherapy in experimental brain tumor, part 2: pretreatment with leukotriene C4 prolongs survival. | 1998 | J. Neurooncol. | pmid:9525821 |
| Lanas A et al. | Collagen secretion by human gastric and skin fibroblasts: implications for ulcer healing. | 1998 | Eur Surg Res | pmid:9493694 |
| Hundley TR et al. | Characteristics of arachidonic acid generation in human basophils: relationship between the effects of inhibitors of secretory phospholipase A2 activity and leukotriene C4 release. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9495842 |
| Shindo K et al. | Prednisolone inhibits synthesis of 5-H(P)ETE in eosinophils from asthmatic patients during a wheezing attack but not during remission. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9578148 |
| Kobayashi H et al. | Urinary trypsin inhibitor reduces the release of histamine from rat peritoneal mast cells. | 1998 | J. Lab. Clin. Med. | pmid:9579392 |
| Capra V et al. | Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma. | 1998 | Mol. Pharmacol. | pmid:9547367 |
| McAlexander MA et al. | Inhibition of 5-lipoxygenase diminishes neurally evoked tachykinergic contraction of guinea pig isolated airway. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9580604 |
| Scheidegger C et al. | Effects of extracts and of individual components from Petasites on prostaglandin synthesis in cultured skin fibroblasts and on leucotriene synthesis in isolated human peripheral leucocytes. | 1998 | Pharm Acta Helv | pmid:9556438 |
| Sabbah A et al. | [Testing basophil activation by flow cytometry in the diagnosis of allergy to hymenopteran venom]. | 1998 | Allerg Immunol (Paris) | pmid:9559061 |
| Cyrus CB et al. | Leukotrienes C4 and D4 increase the ciliary beat frequency in human upper airway mucosa in vitro. | 1998 | Otolaryngol Head Neck Surg | pmid:9560097 |
| Suzuki H and Sugiyama Y | Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2. | 1998 | Semin. Liver Dis. | pmid:9875554 |
| Dent G et al. | Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9448055 |
| Pfau JC et al. | A comparison of the effects of lipopolysaccharide and ceramide on arachidonic acid metabolism in THP-1 monocytic cells. | 1998 | Cell. Immunol. | pmid:9665757 |
| Mitsunobu F et al. | Different roles of histamine and leukotriene C4 in the airways between patients with atopic and nonatopic asthma. | 1998 | J Asthma | pmid:9669831 |
| Lukaszyk A et al. | The role of epidermal growth factor in platelet-endothelium interactions. | 1998 | J. Physiol. Pharmacol. | pmid:9670106 |
| Stenke L et al. | Novel enzymatic abnormalities in AML and CML in blast crisis: elevated leucocyte leukotriene C4 synthase activity paralleled by deficient leukotriene biosynthesis from endogenous substrate. | 1998 | Br. J. Haematol. | pmid:9674747 |
| Keskil ZA et al. | Changes of arterial arachidonic acid metabolites in hypertensive patients during haemodialysis. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10189068 |
| Haberl C et al. | Release of prostaglandin D2 by murine mast cells: importance of metabolite formation for antiproliferative activity. | 1998 | Mediators Inflamm. | pmid:9836493 |
| Peters-Golden M | Cell biology of the 5-lipoxygenase pathway. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9647604 |
| Ito K et al. | Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver. | 1998 | J. Biol. Chem. | pmid:9430713 |
| Fadok VA et al. | Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. | 1998 | J. Clin. Invest. | pmid:9466984 |
| Daugschies A and Ruttkowski B | Modulation of migration of Oesophagostomum dentatum larvae by inhibitors and products of eicosanoid metabolism. | 1998 | Int. J. Parasitol. | pmid:9513001 |
| Jonsson EW | Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle. | 1998 | Acta Physiol Scand Suppl | pmid:9597121 |
| Geuenich S et al. | Induction of leukotriene production by bleomycin and asparaginase in mast cells in vitro and in patients in vivo. | 1998 | Biochem. Pharmacol. | pmid:9514079 |
| Bartosz G et al. | Human mast cells secreting leukotriene C4 express the MRP1 gene-encoded conjugate export pump. | 1998 Aug-Sep | Biol. Chem. | pmid:9792445 |
| Sciuto AM et al. | Post-exposure treatment with isoproterenol attenuates pulmonary edema in phosgene-exposed rabbits. | 1998 Sep-Oct | J Appl Toxicol | pmid:9804432 |
| Mayatepek E et al. | LTB4 and LTC4 are absent in the cerebrospinal fluid of human immunodeficiency virus type 1-seropositive persons with toxoplasmic encephalitis: evidence for inhibition of 5-lipoxygenase by Toxoplasma gondii. | 1999 | J. Infect. Dis. | pmid:9952384 |
| Lay JC et al. | Cellular and biochemical response of the human lung after intrapulmonary instillation of ferric oxide particles. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10100994 |
| Lynch KR et al. | Characterization of the human cysteinyl leukotriene CysLT1 receptor. | 1999 | Nature | pmid:10391245 |
| Hipfner DR et al. | Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein. | 1999 | J. Biol. Chem. | pmid:10336431 |
| Chen ZS et al. | Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. | 1999 | Mol. Pharmacol. | pmid:10570049 |
| Cracowski JL et al. | Functional comparison of the human isolated femoral artery, internal mammary artery, gastroepiploic artery, and saphenous vein. | 1999 | Can. J. Physiol. Pharmacol. | pmid:10588481 |
| Nakamura T et al. | Direct interaction between a quinoline derivative, MS-209, and multidrug resistance protein (MRP) in human gastric cancer cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10049760 |
| Sjölinder M et al. | Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1. | 1999 | J. Lipid Res. | pmid:10064732 |
| Constable AL et al. | DMSO induction of the leukotriene LTC4 by Lewis rat Schwann cells. | 1999 | J. Neurol. Sci. | pmid:10202977 |
| Ochensberger B et al. | Regulation of cytokine expression and leukotriene formation in human basophils by growth factors, chemokines and chemotactic agonists. | 1999 | Eur. J. Immunol. | pmid:9933081 |
| Tsuruta R et al. | Soluble vascular cell adhesion molecule (VCAM)-Fc fusion protein induces leukotriene C4 secretion in platelet-activating factor-stimulated eosinophils. | 1999 | J. Leukoc. Biol. | pmid:9886248 |
| Brock TG et al. | Decreased leukotriene C4 synthesis accompanies adherence-dependent nuclear import of 5-lipoxygenase in human blood eosinophils. | 1999 | J. Immunol. | pmid:9973428 |
| Urasaki T et al. | Cytosolic phospholipase A2, increased and activated in the eosinophils of patients with hypereosinophilic syndrome in vivo, is involved in the augmented release of leukotriene C4. | 1999 | Inflamm. Res. | pmid:9987681 |
| Moneret-Vautrin DA et al. | Human basophil activation measured by CD63 expression and LTC4 release in IgE-mediated food allergy. | 1999 | Ann. Allergy Asthma Immunol. | pmid:9988204 |