| MeSH term | MeSH ID | Detail |
|---|---|---|
| Periapical Periodontitis | D010485 | 6 associated lipids |
| Bronchial Hyperreactivity | D016535 | 15 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Hyperbilirubinemia, Hereditary | D006933 | 3 associated lipids |
| Rhinitis, Allergic, Seasonal | D006255 | 7 associated lipids |
| Drug Eruptions | D003875 | 30 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Mesenteric Vascular Occlusion | D008641 | 4 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Leukemia-Lymphoma, Adult T-Cell | D015459 | 25 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Enomoto F et al. | [Evaluation of arachidonic acid metabolites in experimental rat otitis media with effusion]. | 1995 | Nippon Jibiinkoka Gakkai Kaiho | pmid:7629649 |
| Murakami M et al. | The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. | 1995 | J. Exp. Med. | pmid:7540649 |
| Gimpel JA et al. | Reduction of reperfusion injury of human myocardium by allopurinol: a clinical study. | 1995 | Free Radic. Biol. Med. | pmid:7649495 |
| Wettstein M et al. | Metabolism of cysteinyl leukotrienes in the perfused rat liver: the influence of endotoxin pretreatment and the cellular hydration state. | 1995 | Hepatology | pmid:7601416 |
| Meier HL et al. | Simultaneous initiation of degranulation and inhibition of leukotriene release by soman in human basophils. | 1995 | Int. J. Immunopharmacol. | pmid:7545649 |
| Shimizu T et al. | Leukotriene B4 and C4 metabolism in small intestine mucosa of children with celiac disease. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:8583294 |
| Sato H et al. | Biological characteristics of chronic eosinophilic leukemia cells with a t(2;5)(p23;q35) translocation. | 1995 | Leuk. Lymphoma | pmid:8590853 |
| Lam BK et al. | Leukotriene C4 synthase. | 1995 | J Lipid Mediat Cell Signal | pmid:8777577 |
| Ono S et al. | [Role of peptide leukotrienes in monocrotaline-induced lung disease]. | 1995 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8821996 |
| RodrÃguez-Ortigosa CM et al. | Taurocholate-stimulated leukotriene C4 biosynthesis and leukotriene C4-stimulated choleresis in isolated rat liver. | 1995 | Gastroenterology | pmid:7768385 |
| Tschugguel W et al. | High precision measurement of electrical resistance across endothelial cell monolayers. | 1995 | Pflugers Arch. | pmid:7667075 |
| Miadonna A et al. | Antiallergic activity of loratadine: inhibition of leukotriene C4 release from human leucocytes. | 1995 | Clin. Exp. Allergy | pmid:7541309 |
| Kristjánsson S et al. | Leukotriene B4 and C4 generation by human leukocytes after ex vivo stimulation with Ca-ionophore and opsonized zymosan in children with atopic asthma. | 1995 | Pediatr Allergy Immunol | pmid:8750311 |
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| Egger D et al. | IL-4 renders mast cells functionally responsive to endothelin-1. | 1995 | J. Immunol. | pmid:7530742 |
| Patella V et al. | The antineoplastic bryostatins affect human basophils and mast cells differently. | 1995 | Blood | pmid:7532037 |
| Weber M et al. | Monocyte chemotactic protein MCP-2 activates human basophil and eosinophil leukocytes similar to MCP-3. | 1995 | J. Immunol. | pmid:7535823 |
| Patella V et al. | Human heart mast cells: a definitive case of mast cell heterogeneity. | 1995 | Int. Arch. Allergy Immunol. | pmid:7536502 |
| Thomas JW et al. | Potent interleukin 3 receptor agonist with selectively enhanced hematopoietic activity relative to recombinant human interleukin 3. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7537376 |
| Smit NP et al. | Stimulation of cultured melanocytes in medium containing a serum substitute: Ultroser-G. | 1995 | Pigment Cell Res. | pmid:7540755 |
| Malaviya R and Abraham SN | Interaction of bacteria with mast cells. | 1995 | Meth. Enzymol. | pmid:7476393 |
| Yakubu MA et al. | Hematoma-induced enhanced cerebral vasoconstrictions to leukotriene C4 and endothelin-1 in piglets: role of prostanoids. | 1995 | Pediatr. Res. | pmid:7478789 |
| Buyukgebiz O et al. | Allopurinol inhibits endothelin release after mesenteric ischemia-reperfusion injury. | 1995 | Transplant. Proc. | pmid:7482880 |
| Rachmilewitz D et al. | Sulfhydryl blocker-induced rat colonic inflammation is ameliorated by inhibition of nitric oxide synthase. | 1995 | Gastroenterology | pmid:7541005 |
| Kurokawa H et al. | Gamma-glutamylcysteine synthetase gene overexpression results in increased activity of the ATP-dependent glutathione S-conjugate export pump and cisplatin resistance. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7488097 |
| Low J et al. | Cytoprotective effects of CI-959 in the rat gastric mucosa: modulation of leukocyte adhesion. | 1995 | Gastroenterology | pmid:7557089 |
| Sun J and Herman CA | The American bullfrog (Rana catesbeiana) exhibits differential cardiovascular responses to LTC4 after short- and long-term cold exposure. | 1995 | Gen. Comp. Endocrinol. | pmid:7622015 |
| Shindo K et al. | In vivo effect of prednisolone on release of leukotriene C4 in eosinophils obtained from asthmatic patients. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575557 |
| Zuberbier T et al. | Gangliosides enhance IgE receptor-dependent histamine and LTC4 release from human mast cells. | 1995 | Biochim. Biophys. Acta | pmid:7578275 |
| Restrick LJ et al. | Reduction in leukotriene B4 generation by bronchoalveolar lavage cells in asthma. | 1995 | Thorax | pmid:7886653 |
| Takagi S et al. | The pathophysiological roles of heterogeneous eosinophils in allergic rhinitis caused by house dust mites. | 1995 | Biochem. Mol. Biol. Int. | pmid:7581000 |
| Inoue H et al. | Inhibition by actinomycin D of neurogenic mouse ear oedema. | 1995 | Inflamm. Res. | pmid:7552577 |
| Franco L and Velo GP | Eicosanoid and gastroprotection by copper derivatives and NDGA. | 1995 | Inflamm. Res. | pmid:7552579 |
| Kanwar S et al. | Leukotriene C4/D4 induces P-selectin and sialyl Lewis(x)-dependent alterations in leukocyte kinetics in vivo. | 1995 | Circ. Res. | pmid:7554141 |
| Mayer R et al. | Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. | 1995 | J. Cell Biol. | pmid:7559771 |
| Prié S et al. | Leukotriene C4 receptors on guinea pig tracheocytes. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7562565 |
| Hom JT et al. | The amyloidogenic peptide human amylin augments the inflammatory activities of eosinophils. | 1995 | J. Leukoc. Biol. | pmid:7595053 |
| Enderle GJ et al. | Different pathomechanisms of altered biliary leukotriene C4 elimination in isolated perfused rat livers. | 1995 | Biochem. Pharmacol. | pmid:7857316 |
| Mita H and Shida T | Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes. | 1995 | Arzneimittelforschung | pmid:7893266 |
| Fiorucci S et al. | Effect of NSAIDs on pepsinogen secretion and calcium mobilization in isolated chief cells. | 1995 | Am. J. Physiol. | pmid:7611418 |
| Nagata M et al. | Eosinophil adhesion to vascular cell adhesion molecule-1 activates superoxide anion generation. | 1995 | J. Immunol. | pmid:7543540 |
| De Castro CM et al. | Modulation by dexamethasone of phospholipase A2 activities in endotoxemic guinea pigs. | 1995 | J. Appl. Physiol. | pmid:8567572 |
| Ohtsuki T et al. | Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain. | 1995 | Am. J. Physiol. | pmid:7900879 |
| Hubbard NE and Erickson KL | Role of 5'-lipoxygenase metabolites in the activation of peritoneal macrophages for tumoricidal function. | 1995 | Cell. Immunol. | pmid:7842477 |
| Yamaya M et al. | Epithelial modulation of leukotriene-C4-induced human tracheal smooth muscle contraction. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7881688 |
| Herron DK et al. | Visualization and comparison of molecular dynamics simulations of leukotriene C4, leukotriene D4, and leukotriene E4. | 1995 | J Mol Graph | pmid:8820302 |
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| Juergens UR et al. | Inhibition of monocyte leukotriene B4 production after aspirin desensitization. | 1995 | J. Allergy Clin. Immunol. | pmid:7636051 |
| Ganbo T et al. | The effects of leukotrienes C4 and D4 on ciliary activity of human paranasal sinus mucosa in vitro. | 1995 | Rhinology | pmid:8919211 |
| Utoh J et al. | Is an increase in neutrophil leukotriene-generating capacity a specific phenomenon for cardiopulmonary bypass? | 1995 | J. Thorac. Cardiovasc. Surg. | pmid:7609558 |