LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Asthma D001249 52 associated lipids
Reperfusion Injury D015427 65 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Colitis D003092 69 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Leukemia D007938 74 associated lipids
Stomach Ulcer D013276 75 associated lipids
Atherosclerosis D050197 85 associated lipids
Brain Ischemia D002545 89 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

Download all related citations
Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Rao AM et al. Arachidonic acid and leukotriene C4: role in transient cerebral ischemia of gerbils. 1999 Neurochem. Res. pmid:10492517
Nakasato H et al. Prevention of severe premenstrual asthma attacks by leukotriene receptor antagonist. 1999 J. Allergy Clin. Immunol. pmid:10482831
O'Connor BJ et al. Selective airway responsiveness in asthma. 1999 Trends Pharmacol. Sci. pmid:10101956
Akpek EA et al. A study of adenosine treatment in experimental acute spinal cord injury. Effect on arachidonic acid metabolites. 1999 Spine pmid:9926381
Niinuma K et al. Primary active transport of organic anions on bile canalicular membrane in humans. 1999 Am. J. Physiol. pmid:10330006
Lärfars G et al. Activation of nitric oxide release and oxidative metabolism by leukotrienes B4, C4, and D4 in human polymorphonuclear leukocytes. 1999 Blood pmid:9949184
Hamasaki Y et al. Magnolol inhibits leukotriene synthesis in rat basophilic leukemia-2H3 cells. 1999 Planta Med. pmid:10232065
Mayatepek E et al. LTB4 and LTC4 are absent in the cerebrospinal fluid of human immunodeficiency virus type 1-seropositive persons with toxoplasmic encephalitis: evidence for inhibition of 5-lipoxygenase by Toxoplasma gondii. 1999 J. Infect. Dis. pmid:9952384
Lay JC et al. Cellular and biochemical response of the human lung after intrapulmonary instillation of ferric oxide particles. 1999 Am. J. Respir. Cell Mol. Biol. pmid:10100994
Lankisch TO et al. High-affinity cholecystokinin type A receptor/cytosolic phospholipase A2 pathways mediate Ca2+ oscillations via a positive feedback regulation by calmodulin kinase in pancreatic acini. 1999 Eur. J. Cell Biol. pmid:10535305
Sarau HM et al. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. 1999 Mol. Pharmacol. pmid:10462554
Cordoba-Rodriguez R et al. Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10393875
Clish CB et al. Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10393980
Sano A et al. Inhibition of cPLA2 translocation and leukotriene C4 secretion by fluticasone propionate in exogenously activated human eosinophils. 1999 Am. J. Respir. Crit. Care Med. pmid:10351938
Kita H et al. Does IgE bind to and activate eosinophils from patients with allergy? 1999 J. Immunol. pmid:10352312
Chen ZS et al. An enhanced active efflux of CPT-11 and SN-38 in cisplatin-resistant human KB carcinoma cells. 1999 Cancer Lett. pmid:10378768
Bannenberg G et al. Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers. 1999 J. Biol. Chem. pmid:9890956
Gibbs BF and Grabbe J Inhibitors of PI 3-kinase and MEK kinase differentially affect mediator secretion from immunologically activated human basophils. 1999 J. Leukoc. Biol. pmid:10380914
Irkeç MT et al. Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers. 1999 Ocul. Immunol. Inflamm. pmid:10410873
Dantzig AH et al. Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities. 1999 J. Pharmacol. Exp. Ther. pmid:10411602
Mayatepek E et al. A severely affected infant with absence of cysteinyl leukotrienes in cerebrospinal fluid: further evidence that leukotriene C4-synthesis deficiency is a new neurometabolic disorder. 1999 Neuropediatrics pmid:10222453
Takao A et al. Inhibitory effects of azelastine hydrochloride in alcohol-induced asthma. 1999 Ann. Allergy Asthma Immunol. pmid:10227338
Denizot Y et al. Are lipid mediators implicated in the production of pro- and anti-inflammatory cytokines during cardiopulmonary bypass graft with extracorporeal circulation? 1999 Cytokine pmid:10328869
Miura K et al. Extracellular signal-regulated kinases regulate leukotriene C4 generation, but not histamine release or IL-4 production from human basophils. 1999 J. Immunol. pmid:10201947
Mao Q et al. ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells. 1999 Biochim. Biophys. Acta pmid:10556489
Held HD et al. Characterization of airway and vascular responses in murine lungs. 1999 Br. J. Pharmacol. pmid:10205008
Rao AM et al. CDP-choline: neuroprotection in transient forebrain ischemia of gerbils. 1999 J. Neurosci. Res. pmid:10561698
Malaviya R and Uckun FM Genetic and biochemical evidence for a critical role of Janus kinase (JAK)-3 in mast cell-mediated type I hypersensitivity reactions. 1999 Biochem. Biophys. Res. Commun. pmid:10208864
Norman BH et al. Reversal of resistance in multidrug resistance protein (MRP1)-overexpressing cells by LY329146. 1999 Bioorg. Med. Chem. Lett. pmid:10612603
Desplat V et al. Incorporation and effect of arachidonic acid on the growth of human myeloma cell lines. 1999 Mediators Inflamm. pmid:10704149
Chen ZS et al. Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. 1999 Mol. Pharmacol. pmid:10570049
Cracowski JL et al. Functional comparison of the human isolated femoral artery, internal mammary artery, gastroepiploic artery, and saphenous vein. 1999 Can. J. Physiol. Pharmacol. pmid:10588481
Nilsen A et al. Short-term exposure of rodents to diesel exhausts: usefulness for studies of genotoxic and immunotoxic effects. 1999 Chem. Biol. Interact. pmid:10227576
Constable AL et al. DMSO induction of the leukotriene LTC4 by Lewis rat Schwann cells. 1999 J. Neurol. Sci. pmid:10202977
Miadonna A et al. Nasal response to a single antigen challenge in patients with allergic rhinitis - inflammatory cell recruitment persists up to 48 hours. 1999 Clin. Exp. Allergy pmid:10383595
Carvalho-Tavares J et al. Assessment of the mechanism of juxtacrine activation and adhesion of leukocytes in liver microcirculation. 1999 Am. J. Physiol. pmid:10198324
Renes J et al. ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1. 1999 Br. J. Pharmacol. pmid:10188979
Schmidt D et al. Passive sensitization of human airways increases responsiveness to leukotriene C4. 1999 Eur. Respir. J. pmid:10515407
Muñoz NM et al. Augmentation of eosinophil degranulation and LTC(4) secretion by integrin-mediated endothelial cell adhesion. 1999 Am. J. Physiol. pmid:10516222
May A et al. Means of increasing sensitivity of an in vitro diagnostic test for aspirin intolerance. 1999 Clin. Exp. Allergy pmid:10520062
Ko JK and Cho CH Co-regulation of mucosal nitric oxide and prostaglandin in gastric adaptive cytoprotection. 1999 Inflamm. Res. pmid:10522801
Van Aubel RA et al. Mechanisms and interaction of vinblastine and reduced glutathione transport in membrane vesicles by the rabbit multidrug resistance protein Mrp2 expressed in insect cells. 1999 Mol. Pharmacol. pmid:10496953
Hagmann W et al. Purification of the human apical conjugate export pump MRP2 reconstitution and functional characterization as substrate-stimulated ATPase. 1999 Eur. J. Biochem. pmid:10491184
Falcón-Pérez JM et al. Functional domain analysis of the yeast ABC transporter Ycf1p by site-directed mutagenesis. 1999 J. Biol. Chem. pmid:10438540
Campbell EM et al. Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. 1999 J. Immunol. pmid:10438957
Kawabe T et al. Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). 1999 FEBS Lett. pmid:10456333
Vellenga E et al. Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1. 1999 Br. J. Pharmacol. pmid:10385244
Stride BD et al. Localization of a substrate specificity domain in the multidrug resistance protein. 1999 J. Biol. Chem. pmid:10428874
Ochensberger B et al. Regulation of cytokine expression and leukotriene formation in human basophils by growth factors, chemokines and chemotactic agonists. 1999 Eur. J. Immunol. pmid:9933081
Tsuruta R et al. Soluble vascular cell adhesion molecule (VCAM)-Fc fusion protein induces leukotriene C4 secretion in platelet-activating factor-stimulated eosinophils. 1999 J. Leukoc. Biol. pmid:9886248
Brock TG et al. Decreased leukotriene C4 synthesis accompanies adherence-dependent nuclear import of 5-lipoxygenase in human blood eosinophils. 1999 J. Immunol. pmid:9973428
Lieberman MW et al. Gamma-glutamyl leukotrienase cleavage of leukotriene C4. 1999 Adv. Exp. Med. Biol. pmid:10667345
Schweitzer P et al. Cannabinoid modulation of neuronal activity in adult rat hippocampus. 1999 Adv. Exp. Med. Biol. pmid:10667381
Herman CA and Luczy-Bachman G Eicosanoids in the brain of warm- and cold-acclimated bullfrogs. 1999 Adv. Exp. Med. Biol. pmid:10667397
Amann R et al. Eicosanoid release in the endotoxin-primed isolated perfused rat lung and its pharmacological modification. 1999 Inflamm. Res. pmid:10669114
Ding GY et al. Multidrug resistance-associated protein (MRP) mediated transport of daunomycin and leukotriene C4 (LTC4) in isolated plasma membrane vesicles. 1999 Jul-Aug Anticancer Res. pmid:10652618
Nobukata H et al. Long-term administration of highly purified eicosapentaenoic acid ethyl ester improves the dysfunction of vascular endothelial and smooth muscle cells in male WBN/Kob rats. 2000 Metab. Clin. Exp. pmid:11145121
Nishio T et al. Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate. 2000 Biochem. Biophys. Res. Commun. pmid:10973807
Karimi K et al. Stem cell factor and interleukin-4 increase responsiveness of mast cells to substance P. 2000 Exp. Hematol. pmid:10880748
Sapirstein A and Bonventre JV Specific physiological roles of cytosolic phospholipase A(2) as defined by gene knockouts. 2000 Biochim. Biophys. Acta pmid:11080683
Gao M et al. Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1. 2000 J. Biol. Chem. pmid:10777615
Goulet JL et al. Genetic factors determine the contribution of leukotrienes to acute inflammatory responses. 2000 J. Immunol. pmid:10779800
Ohd JF et al. Leukotrienes induce cell-survival signaling in intestinal epithelial cells. 2000 Gastroenterology pmid:11040187
Vidal A et al. Synthesis of 19-[(2-azido-5-iodo)-benzoyloxy]-LTA4 and enzymatic conversion to the LTC4 analogue. 2000 Bioorg. Med. Chem. Lett. pmid:10762049
Arakida Y et al. Effect of combined leukotriene D(4) and thromboxane A(2) receptor antagonist on mediator-controlled resistance in guinea pigs. 2000 Eur. J. Pharmacol. pmid:10969159
Loe DW et al. Verapamil stimulates glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1). 2000 J. Pharmacol. Exp. Ther. pmid:10773025
Muñoz NM et al. Augmentation of LTC(4) synthesis in human eosinophils caused by CD3-stimulated Th2-like cells in vitro. 2000 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:10835322
Sullivan GF et al. Regulation of expression of the multidrug resistance protein MRP1 by p53 in human prostate cancer cells. 2000 J. Clin. Invest. pmid:10792001
Ren XQ et al. Functional comparison between YCF1 and MRP1 expressed in Sf21 insect cells. 2000 Biochem. Biophys. Res. Commun. pmid:10753671
Bates ME et al. ERK1 and ERK2 activation by chemotactic factors in human eosinophils is interleukin 5-dependent and contributes to leukotriene C(4) biosynthesis. 2000 J. Biol. Chem. pmid:10753897
Ohbayashi H and Yamaki KI Both inhalant and intravenous uroguanylin inhibit leukotriene C4-induced airway changes. 2000 Peptides pmid:11068092
Thorén S and Jakobsson PJ Coordinate up- and down-regulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells. Inhibition by NS-398 and leukotriene C4. 2000 Eur. J. Biochem. pmid:11029586
Moore BB et al. GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism. 2000 J. Immunol. pmid:11034414
Robbiani DF et al. The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. 2000 Cell pmid:11114332
Okumura H et al. Reversal of P-glycoprotein and multidrug-resistance protein-mediated drug resistance in KB cells by 5-O-benzoylated taxinine K. 2000 Mol. Pharmacol. pmid:11093797
Morlion BJ et al. Cysteinyl-leukotriene generation as a biomarker for survival in the critically ill. 2000 Crit. Care Med. pmid:11098969
Anderson MR and Blumer JL Prognostic markers in sepsis: the role of leukotrienes. 2000 Crit. Care Med. pmid:11098993
Hasday JD et al. Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics. 2000 Am. J. Respir. Crit. Care Med. pmid:10764316
Nothacker HP et al. Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. 2000 Mol. Pharmacol. pmid:11093801
Bäck M et al. Antagonist resistant contractions of the porcine pulmonary artery by cysteinyl-leukotrienes. 2000 Eur. J. Pharmacol. pmid:10936497
Heise CE et al. Characterization of the human cysteinyl leukotriene 2 receptor. 2000 J. Biol. Chem. pmid:10851239
Malaviya R and Abraham SN Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis. 2000 J. Leukoc. Biol. pmid:10857857
Mayatepek E et al. Defects in the synthesis of cysteinyl leukotrienes: a new group of inborn errors of metabolism. 2000 J. Inherit. Metab. Dis. pmid:10896305
Takasaki J et al. The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor. 2000 Biochem. Biophys. Res. Commun. pmid:10913337
Taskila K et al. Histamine and LTC4 in stinging nettle-induced urticaria. 2000 Allergy pmid:10921474
Bowers RC et al. A novel glutathione containing eicosanoid (FOG7) chemotactic for human granulocytes. 2000 J. Biol. Chem. pmid:10924496
Eglite S et al. Requirements for C5a receptor-mediated IL-4 and IL-13 production and leukotriene C4 generation in human basophils. 2000 J. Immunol. pmid:10925305
Sainte-Laudy J et al. Diagnosis of venom allergy by flow cytometry. Correlation with clinical history, skin tests, specific IgE, histamine and leukotriene C4 release. 2000 Clin. Exp. Allergy pmid:10931125
Florio G et al. The immunoglobulin superantigen-binding site of HIV-1 gp120 activates human basophils. 2000 AIDS pmid:10853974
Urasaki T et al. Induction of the activation-related antigen CD69 on human eosinophils by type IIA phospholipase A2. 2000 Inflamm. Res. pmid:10858018
Dent G et al. Up-regulation of human eosinophil leukotriene C4 generation through contact with bronchial epithelial cells. 2000 Inflamm. Res. pmid:10893047
Schmidt DT et al. The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C(4)-induced contractions in passively sensitized human airways. 2000 Br. J. Pharmacol. pmid:11139438
Lopes LR et al. Reduced inflammatory response in rats fed fat-rich diets: role of leukotrienes. 2000 Life Sci. pmid:10896024
Okamoto M et al. Effects of perilla seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism. 2000 Int. Arch. Allergy Immunol. pmid:10878492
Miura K and MacGlashan DW Dual phase priming by IL-3 for leukotriene C4 generation in human basophils: difference in characteristics between acute and late priming effects. 2000 J. Immunol. pmid:10706691
Douglas IS et al. CD4+ T cell and eosinophil adhesion is mediated by specific ICAM-3 ligation and results in eosinophil activation. 2000 J. Immunol. pmid:10706734
Skaltsa H et al. Inhibition of prostaglandin E2 and leukotriene C4 in mouse peritoneal macrophages and thromboxane B2 production in human platelets by flavonoids from Stachys chrysantha and Stachys candida. 2000 Biol. Pharm. Bull. pmid:10706410
Aiso M et al. Biliary excretion of bile acids and organic anions in zone 1- and zone 3-injured rats. 2000 Liver pmid:10726959
Gutmann H et al. P-glycoprotein- and mrp2-mediated octreotide transport in renal proximal tubule. 2000 Br. J. Pharmacol. pmid:10694230
Sundkvist E et al. Leukotriene C(4) (LTC(4)) does not share a cellular efflux mechanism with cGMP: characterisation of cGMP transport by uptake to inside-out vesicles from human erythrocytes. 2000 Biochim. Biophys. Acta pmid:10631301