LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

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Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Wounds, Nonpenetrating D014949 4 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Common Bile Duct Diseases D003137 3 associated lipids
Cestode Infections D002590 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Authors Title Published Journal PubMed Link
Shon YH et al. Effect of Astragali radix extract on lipopolysaccharide-induced inflammation in human amnion. 2002 Biol. Pharm. Bull. pmid:11824562
Bäck M et al. Modulation of vascular tone and reactivity by nitric oxide in porcine pulmonary arteries and veins. 2002 Acta Physiol. Scand. pmid:11851592
Küsters S et al. Effects of antihistamines on leukotriene and cytokine release from dispersed nasal polyp cells. 2002 Arzneimittelforschung pmid:11878205
Iliás A et al. Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). 2002 J. Biol. Chem. pmid:11880368
Jedlitschky G and Keppler D Transport of leukotriene C4 and structurally related conjugates. 2002 Vitam. Horm. pmid:11898391
Suzuki R and Freed AN Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. 2002 Am. J. Respir. Crit. Care Med. pmid:11779726
Guo A et al. Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). 2002 Drug Metab. Dispos. pmid:11901101
Malaviya R and Uckun FM Role of STAT6 in IgE receptor/FcepsilonRI-mediated late phase allergic responses of mast cells. 2002 J. Immunol. pmid:11751988
Miller DS et al. Xenobiotic efflux pumps in isolated fish brain capillaries. 2002 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:11742838
Norman BH et al. Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1). 2002 Bioorg. Med. Chem. Lett. pmid:11958985
Kolaczkowska E et al. Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes. 2002 Inflammation pmid:11989789
Ravasi S et al. Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma. 2002 Biochem. Pharmacol. pmid:11996896
Bandeira-Melo C et al. IL-16 promotes leukotriene C(4) and IL-4 release from human eosinophils via CD4- and autocrine CCR3-chemokine-mediated signaling. 2002 J. Immunol. pmid:11971026
Zhang DW et al. Determinants of the substrate specificity of multidrug resistance protein 1: role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17. 2002 J. Biol. Chem. pmid:11925441
Maekawa A et al. Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. 2002 J. Biol. Chem. pmid:11932261
Ahamed J and Ali H Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production. 2002 J. Biol. Chem. pmid:11934880
Kingham PJ et al. Adhesion-dependent interactions between eosinophils and cholinergic nerves. 2002 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12003778
Sawatzky DA et al. Eosinophil adhesion to cholinergic nerves via ICAM-1 and VCAM-1 and associated eosinophil degranulation. 2002 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12003784
Thomas LL et al. Immobilized lactoferrin is a stimulus for eosinophil activation. 2002 J. Immunol. pmid:12097406
Mao Q et al. GSH-dependent photolabeling of multidrug resistance protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain. 2002 J. Biol. Chem. pmid:12034727
Conrad S et al. A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance. 2002 Pharmacogenetics pmid:12042670
Fernández SB et al. Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells. 2002 J. Biol. Chem. pmid:12060660
Oliveira SH et al. Increased responsiveness of murine eosinophils to MIP-1beta (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8. 2002 J. Leukoc. Biol. pmid:12050188
Bäck M et al. The contraction of the human pulmonary artery by LTC4 is resistant to cysLT1 antagonists and counteracted by prostacyclin release. 2002 Adv. Exp. Med. Biol. pmid:12664603
Gebhardt T et al. Cultured human intestinal mast cells express functional IL-3 receptors and respond to IL-3 by enhancing growth and IgE receptor-dependent mediator release. 2002 Eur. J. Immunol. pmid:12209644
Ma L et al. Identification and characterization of the canine multidrug resistance-associated protein. 2002 Mol. Cancer Ther. pmid:12516967
Wiklund CU et al. Interactions of volatile anesthetics with cholinergic, tachykinin, and leukotriene mechanisms in isolated Guinea pig bronchial smooth muscle. 2002 Anesth. Analg. pmid:12456432
Tsuruoka S et al. Functional analysis of ABCA8, a new drug transporter. 2002 Biochem. Biophys. Res. Commun. pmid:12379217
Suzuki Y et al. Silver activates calcium signals in rat basophilic leukemia-2H3 mast cells by a mechanism that differs from the Fc epsilon RI-activated response. 2002 J. Immunol. pmid:12244196
Christmas P et al. Membrane localization and topology of leukotriene C4 synthase. 2002 J. Biol. Chem. pmid:12023288
Malaviya R and Uckun FM Leflunomide metabolite analogue alpha-cyano-beta-hydroxy-beta-methyl-N-[3-(trifluoromethyl)phenyl]propenamide inhibits IgE/FcepsilonRI receptor-mediated mast cell leukotriene release and allergic asthma in mice. 2001 Sep-Oct Am J Ther pmid:11550070
King BO et al. Tirofiban administration attenuates platelet and platelet-neutrophil conjugation but not neutrophil degranulation during in vitro VAD circulation. 2001 May-Jun ASAIO J. pmid:11374774
Karaman O et al. The comparison of the efficacy of fluticasone propionate with cetirizine in perennial allergic rhinitis. 2001 Mar-Apr Allergol Immunopathol (Madr) pmid:11420028
Abeywardena MY et al. Dietary n-3 and n-6 polyunsaturated oils and airway contractility. 2001 Apr-May Prostaglandins Leukot. Essent. Fatty Acids pmid:11418024
Kamohara M et al. Functional characterization of cysteinyl leukotriene CysLT(2) receptor on human coronary artery smooth muscle cells. 2001 Biochem. Biophys. Res. Commun. pmid:11587533
Wehner J and Neuber K Staphylococcus aureus enterotoxins induce histamine and leukotriene release in patients with atopic eczema. 2001 Br. J. Dermatol. pmid:11531797
Sano A et al. Regulation of eosinophil function by phosphatidylinositol-specific PLC and cytosolic PLA(2). 2001 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:11557588
Qian YM et al. Characterization of binding of leukotriene C4 by human multidrug resistance protein 1: evidence of differential interactions with NH2- and COOH-proximal halves of the protein. 2001 J. Biol. Chem. pmid:11507101
Strenzke N et al. Mercuric chloride enhances immunoglobulin E-dependent mediator release from human basophils. 2001 Toxicol. Appl. Pharmacol. pmid:11485386
Leslie EM et al. Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids. 2001 Mol. Pharmacol. pmid:11306701
Schroeder JT et al. Human basophils: mediator release and cytokine production. 2001 Adv. Immunol. pmid:11293121
Zhang DW et al. Identification of a nonconserved amino acid residue in multidrug resistance protein 1 important for determining substrate specificity: evidence for functional interaction between transmembrane helices 14 and 17. 2001 J. Biol. Chem. pmid:11429411
Hevko JM and Murphy RC Electrospray ionization and tandem mass spectrometry of cysteinyl eicosanoids: leukotriene C4 and FOG7. 2001 J. Am. Soc. Mass Spectrom. pmid:11444597
Cai J et al. Functional expression of multidrug resistance protein 1 in Pichia pastoris. 2001 Biochemistry pmid:11444977
Zaitsu M et al. A novel pharmacologic action of glucocorticosteroids on leukotriene C4 catabolism. 2001 J. Allergy Clin. Immunol. pmid:11447392
Leslie EM et al. Transport of the beta -O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog. 2001 J. Biol. Chem. pmid:11375986
Qian YM et al. Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1. 2001 J. Biol. Chem. pmid:11102445
Murakami M et al. Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms. 2001 J. Biol. Chem. pmid:11106649
Fernández MA et al. New insights into the mechanism of action of the anti-inflammatory triterpene lupeol. 2001 J. Pharm. Pharmacol. pmid:11732756
Thomas LL et al. Peptide-based analysis of amino acid sequences important to the biological activity of eosinophil granule major basic protein. 2001 Immunol. Lett. pmid:11578692