| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pulmonary Disease, Chronic Obstructive | D029424 | 16 associated lipids |
| Asthma, Exercise-Induced | D001250 | 10 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Wounds, Nonpenetrating | D014949 | 4 associated lipids |
| Cholestasis, Extrahepatic | D001651 | 7 associated lipids |
| Insect Bites and Stings | D007299 | 4 associated lipids |
| Carotid Artery Injuries | D020212 | 8 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
| Common Bile Duct Diseases | D003137 | 3 associated lipids |
| Cestode Infections | D002590 | 3 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Genovese A et al. | Bacterial immunoglobulin superantigen proteins A and L activate human heart mast cells by interacting with immunoglobulin E. | 2000 | Infect. Immun. | pmid:10992448 |
| Sakamoto H et al. | Involvement of phospholipid hydroperoxide glutathione peroxidase in the modulation of prostaglandin D2 synthesis. | 2000 | J. Biol. Chem. | pmid:11010961 |
| Mitsunobu F et al. | Enhanced peripheral leukocyte leukotriene production and bronchial hyperresponsiveness in asthmatics. | 2000 | Eur. Respir. J. | pmid:11028668 |
| Thorén S and Jakobsson PJ | Coordinate up- and down-regulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells. Inhibition by NS-398 and leukotriene C4. | 2000 | Eur. J. Biochem. | pmid:11029586 |
| Moore BB et al. | GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism. | 2000 | J. Immunol. | pmid:11034414 |
| Annila I et al. | Bee venom induces high histamine or high leukotriene C4 release in skin of sensitized beekeepers. | 2000 Jul-Aug | J Investig Allergol Clin Immunol | pmid:11039839 |
| Ohd JF et al. | Leukotrienes induce cell-survival signaling in intestinal epithelial cells. | 2000 | Gastroenterology | pmid:11040187 |
| Ohbayashi H and Yamaki KI | Both inhalant and intravenous uroguanylin inhibit leukotriene C4-induced airway changes. | 2000 | Peptides | pmid:11068092 |
| Mayatepek E | Leukotriene C4 synthesis deficiency: a member of a probably underdiagnosed new group of neurometabolic diseases. | 2000 | Eur. J. Pediatr. | pmid:11079193 |
| Sapirstein A and Bonventre JV | Specific physiological roles of cytosolic phospholipase A(2) as defined by gene knockouts. | 2000 | Biochim. Biophys. Acta | pmid:11080683 |
| Malaviya R et al. | Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97). | 2000 | J. Pharmacol. Exp. Ther. | pmid:11082424 |
| Capper EA et al. | Modulation of human monocyte activities by tranilast, SB 252218, a compound demonstrating efficacy in restenosis. | 2000 | J. Pharmacol. Exp. Ther. | pmid:11082441 |
| DÃaz AM et al. | In vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L. | 2000 | Biol. Pharm. Bull. | pmid:11085357 |
| Okumura H et al. | Reversal of P-glycoprotein and multidrug-resistance protein-mediated drug resistance in KB cells by 5-O-benzoylated taxinine K. | 2000 | Mol. Pharmacol. | pmid:11093797 |
| Nothacker HP et al. | Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. | 2000 | Mol. Pharmacol. | pmid:11093801 |
| Morlion BJ et al. | Cysteinyl-leukotriene generation as a biomarker for survival in the critically ill. | 2000 | Crit. Care Med. | pmid:11098969 |
| Anderson MR and Blumer JL | Prognostic markers in sepsis: the role of leukotrienes. | 2000 | Crit. Care Med. | pmid:11098993 |
| Qian YM et al. | Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1. | 2001 | J. Biol. Chem. | pmid:11102445 |
| Hisamatsu K and Nakajima M | Pranlukast protects leukotriene C4- and D4-induced epithelial cell impairment of the nasal mucosa in vitro. | 2000 | Life Sci. | pmid:11105993 |
| Murakami M et al. | Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms. | 2001 | J. Biol. Chem. | pmid:11106649 |