| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glioma | D005910 | 112 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Takase B et al. | Effects of bepridil on silent myocardial ischemia and eicosanoid metabolism in chronic stable angina pectoris after healing of myocardial infarction. | 1994 | Am. J. Cardiol. | pmid:8198031 |
| Munoz NM et al. | Beta adrenergic modulation of formyl-methionine-leucine-phenylalanine-stimulated secretion of eosinophil peroxidase and leukotriene C4. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8301549 |
| Sathirakul K et al. | Multiple transport systems for organic anions across the bile canalicular membrane. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8301595 |
| Metters KM et al. | Microsomal glutathione S-transferase is the predominant leukotriene C4 binding site in cellular membranes. | 1994 | J. Biol. Chem. | pmid:8175695 |
| Tudhope SR et al. | BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes. | 1994 | Eur. J. Pharmacol. | pmid:7698171 |
| Aktan AO et al. | Does PGE2 act as a mediator for endothelin release? | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7511821 |
| YeÄŸen C et al. | Effect of verapamil and iloprost (ZK 36374) on endothelin release after mesenteric ischemia-reperfusion injury. | 1994 | Eur Surg Res | pmid:7516292 |
| Wettstein M and Häussinger D | [Effect of hypoxia on nitric oxide formation and leukotriene metabolism in the perfused rat liver]. | 1994 | Zentralbl Chir | pmid:7517604 |
| Bürgi B et al. | The degradation product of the C5a anaphylatoxin C5adesarg retains basophil-activating properties. | 1994 | Eur. J. Immunol. | pmid:7517876 |
| Sainte-Laudy J et al. | [Demonstration of sulfite-group-specific IgE in patients with intolerance to preservatives]. | 1994 | Allerg Immunol (Paris) | pmid:7518236 |
| Miadonna A et al. | Modulation of allergen-induced nasal symptoms and mediator release by treatment with N-acetyl-aspartyl-glutamate (ZY15106). | 1994 | Eur. J. Clin. Pharmacol. | pmid:7518775 |
| Casellas F et al. | Abnormal leukotriene C4 released by unaffected jejunal mucosa in patients with inactive Crohn's disease. | 1994 | Gut | pmid:8174991 |
| Böhme M et al. | ATP-dependent export pumps and their inhibition by cyclosporins. | 1994 | Adv. Enzyme Regul. | pmid:7942282 |
| Kurosawa M et al. | Inhibition by a novel peptide leukotriene receptor antagonist ONO-1078 of airway wall thickening and airway hyperresponsiveness to histamine induced by leukotriene C4 or leukotriene D4 in guinea-pigs. | 1994 | Clin. Exp. Allergy | pmid:7842366 |
| Pintos-Morell G et al. | Altered leukotriene generation in leukocytes from cystinotic children. | 1994 | Pediatr. Res. | pmid:7877883 |
| Thioudellet C et al. | Molecular and functional characterization of recombinant human gamma-glutamyltransferase. Coupling of its activity to glutathione levels in V79 cells. | 1994 | Eur. J. Biochem. | pmid:7913033 |
| Jedlitschky G et al. | ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. | 1994 | Cancer Res. | pmid:7915193 |
| Kapuściński A | Leukotriene C4 in the rat brain after resuscitation from clinical death. | 1994 | Folia Neuropathol | pmid:7922113 |
| Ohemeng KA et al. | Novel bishydroxamic acids as 5-lipoxygenase inhibitors. | 1994 | Bioorg. Med. Chem. | pmid:7922131 |
| Busse WW and Sedgwick JB | Eosinophil eicosanoid relations in allergic inflammation of the airways. | 1994 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7771338 |
| Votta BJ and Bertolini DR | Cytokine suppressive anti-inflammatory compounds inhibit bone resorption in vitro. | 1994 Sep-Oct | Bone | pmid:7980964 |
| Georgitis JW et al. | Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. | 1995 | Int. Arch. Allergy Immunol. | pmid:7719157 |
| Szarek JL and Valentovic MA | Release of prostaglandin E2 and leukotriene C4/D4 from airway segments isolated from rats after exposure to ozone for 20 months. | 1995 | Toxicology | pmid:7624868 |
| Porreca E et al. | Modulation of rat vascular smooth muscle cell (VSMC) proliferation by cysteinyl leukotriene D4: a role for mediation of interleukin 1. | 1995 | Atherosclerosis | pmid:7755646 |
| Lam BK et al. | Expression cloning of human LTC4 synthase. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732869 |
| Cruz JR et al. | Fecal excretion of leukotriene C4 during human disease due to Shigella dysenteriae. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:7714683 |
| Nishikawa M et al. | Effect of leukotriene C4D4 antagonist on colonic damage induced by intracolonic administration of trinitrobenzene sulfonic acid in rats. | 1995 | J. Gastroenterol. | pmid:7719412 |
| Kita H et al. | Eosinophil major basic protein induces degranulation and IL-8 production by human eosinophils. | 1995 | J. Immunol. | pmid:7722326 |
| Iwamoto I et al. | Effect of a selective thromboxane A2 receptor antagonist BAY u3405 on antigen-, leukotriene C4- and leukotriene D4-induced bronchoconstriction in guinea pigs. | 1995 | Int. Arch. Allergy Immunol. | pmid:7647588 |
| Sun J and Herman CA | Cardiovascular effects of N-methyl leukotriene C4, a nonmetabolizable leukotriene C4 analogue, and the antagonism of leukotriene-induced hypotension by Ro 23-3544, in the American bullfrog, Rana catesbeiana. | 1995 | Can. J. Physiol. Pharmacol. | pmid:7648518 |
| Laviolette M et al. | Blood eosinophil leukotriene C4 production in asthma of different severities. | 1995 | Eur. Respir. J. | pmid:8575570 |
| Hong JT et al. | Effect of phenobarbital and the peroxisome proliferator ciprofibrate on gamma-Glutamyltranspeptidase activity and leukotriene C4 concentration in cultured rat hepatocytes. | 1995 | J. Biochem. Toxicol. | pmid:8847705 |
| Petric R et al. | Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis. | 1995 | Biochim. Biophys. Acta | pmid:7827126 |
| Ju HR et al. | Systemic release of mucosal mast-cell protease in primed brown Norway rats after feeding with beta-lactoglobulin. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7787291 |
| Tornhamre S et al. | Receptor-mediated regulation of leukotriene C4 synthase activity in human platelets. | 1995 | Eur. J. Biochem. | pmid:8536697 |
| Brandenburg K et al. | Conformation and fluidity of endotoxins as determinants of biological activity. | 1995 | Prog. Clin. Biol. Res. | pmid:8524923 |
| Fiore S and Serhan CN | Lipoxin A4 receptor activation is distinct from that of the formyl peptide receptor in myeloid cells: inhibition of CD11/18 expression by lipoxin A4-lipoxin A4 receptor interaction. | 1995 | Biochemistry | pmid:8527441 |
| Kawana S and Nishiyama S | Pustular psoriasis and aseptic purulent arthritis: possible role of leukotrienes B4 and C4 in a flare of synovitis. | 1995 | Dermatology (Basel) | pmid:7894093 |
| Grønbech JE and Lacy ER | Role of gastric blood flow in impaired defense and repair of aged rat stomachs. | 1995 | Am. J. Physiol. | pmid:7491966 |
| Ochensberger B et al. | IgE-independent interleukin-4 expression and induction of a late phase of leukotriene C4 formation in human blood basophils. | 1995 | Blood | pmid:7492759 |
| Culo F et al. | Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice. | 1995 | Eur J Gastroenterol Hepatol | pmid:7496865 |
| Sjölinder M et al. | Phorbol ester-induced suppression of leukotriene C4 synthase activity in human granulocytes. | 1995 | FEBS Lett. | pmid:8543026 |
| Miyamasu M et al. | Chemotactic agonists induce cytokine generation in eosinophils. | 1995 | J. Immunol. | pmid:7529800 |
| Horikawa T et al. | Melanocyte mitogens induce both melanocyte chemokinesis and chemotaxis. | 1995 | J. Invest. Dermatol. | pmid:7530272 |
| Murakami M et al. | Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells. | 1995 | J. Biol. Chem. | pmid:7559381 |
| Tsai JJ et al. | Relationship between nasal resistance and airway hyperreactivity following nasal provocation with Dermatophagoides pteronyssinus in allergic rhinitis. | 1995 | Int. Arch. Allergy Immunol. | pmid:7888791 |
| Sengör T et al. | Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. | 1995 | CLAO J | pmid:7586473 |
| Sala A and Folco G | LTC4 in normal urine. | 1995 | Eur. J. Clin. Invest. | pmid:7589021 |
| Schauer U et al. | Blood eosinophils, eosinophil-derived proteins, and leukotriene C4 generation in relation to bronchial hyperreactivity in children with atopic dermatitis. | 1995 | Allergy | pmid:7604934 |
| Gorenne I et al. | Effects of beta 2-adrenoceptor agonists on anti-IgE-induced contraction and smooth muscle reactivity in human airways. | 1995 | Br. J. Pharmacol. | pmid:7780648 |