| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glioma | D005910 | 112 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tabas LB and Dantzig AH | A high-throughput assay for measurement of multidrug resistance protein-mediated transport of leukotriene C4 into membrane vesicles. | 2002 | Anal. Biochem. | pmid:12413474 |
| Belinsky MG et al. | Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). | 2002 | Cancer Res. | pmid:12414644 |
| Uemura M et al. | Cysteinyl leukotrienes in the bile of patients with obstructive jaundice. | 2002 | J. Gastroenterol. | pmid:12424566 |
| Evans JF | Cysteinyl leukotriene receptors. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432945 |
| Ren XQ et al. | A positively charged amino acid proximal to the C-terminus of TM17 of MRP1 is indispensable for GSH-dependent binding of substrates and for transport of LTC4. | 2002 | Biochemistry | pmid:12450376 |
| Oliveira SH et al. | Stem cell factor induces eosinophil activation and degranulation: mediator release and gene array analysis. | 2002 | Blood | pmid:12453875 |
| Wiklund CU et al. | Interactions of volatile anesthetics with cholinergic, tachykinin, and leukotriene mechanisms in isolated Guinea pig bronchial smooth muscle. | 2002 | Anesth. Analg. | pmid:12456432 |
| Walch L et al. | Pharmacological evidence for a novel cysteinyl-leukotriene receptor subtype in human pulmonary artery smooth muscle. | 2002 | Br. J. Pharmacol. | pmid:12466244 |
| Yang SH et al. | The stimulatory effects of nasal discharge from patients with perennial allergic rhinitis on normal human neutrophils are normalized after treatment with a new mixed formula of Chinese herbs. | 2002 | Int. Immunopharmacol. | pmid:12469937 |
| Nagase T et al. | A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12505870 |
| Ma L et al. | Identification and characterization of the canine multidrug resistance-associated protein. | 2002 | Mol. Cancer Ther. | pmid:12516967 |
| Chen ZS et al. | Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). | 2003 | Mol. Pharmacol. | pmid:12527806 |
| Tedla N et al. | Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12529506 |
| Liu P et al. | Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12531730 |
| Mastalerz L et al. | Clinical and genetic features underlying the response of patients with bronchial asthma to treatment with a leukotriene receptor antagonist. | 2002 | Eur. J. Clin. Invest. | pmid:12534456 |
| Bellou A et al. | Constitutive nitric oxide synthase inhibition combined with histamine and serotonin receptor blockade improves the initial ovalbumin-induced arterial hypotension but decreases the survival time in brown norway rats anaphylactic shock. | 2003 | Shock | pmid:12558148 |
| Venkatachalam TK et al. | Inhibition of mast cell leukotriene release by thiourea derivatives. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12565956 |
| Serio KJ et al. | Lipopolysaccharide down-regulates the leukotriene C4 synthase gene in the monocyte-like cell line, THP-1. | 2003 | J. Immunol. | pmid:12574384 |
| Wang DY et al. | The upper and lower airway responses to nasal challenge with house-dust mite Blomia tropicalis. | 2003 | Allergy | pmid:12580812 |
| Mizutani N | [Studies on the experimental allergic rhinitis induced by Japanese cedar pollen--role of cysteinyl leukotrienes in nasal allergic symptoms]. | 2003 | Yakugaku Zasshi | pmid:12607939 |
| Kwak WJ et al. | Papyriflavonol A from Broussonetia papyrifera inhibits the passive cutaneous anaphylaxis reaction and has a secretory phospholipase A2-inhibitory activity. | 2003 | Biol. Pharm. Bull. | pmid:12612436 |
| Plath KE et al. | Calcineurin antagonists differentially affect mediator secretion, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases from immunologically activated human basophils. | 2003 | Clin. Exp. Allergy | pmid:12614449 |
| Venkatachalam TK et al. | Substituted heterocyclic thiourea compounds as a new class of anti-allergic agents inhibiting IgE/Fc epsilon RI receptor mediated mast cell leukotriene release. | 2003 | Bioorg. Med. Chem. | pmid:12614897 |
| Hattori T et al. | Effects of H2O2 on membrane potential of smooth muscle cells in rabbit mesenteric resistance artery. | 2003 | Eur. J. Pharmacol. | pmid:12620501 |
| Triggiani M et al. | Secretory phospholipases A2 activate selective functions in human eosinophils. | 2003 | J. Immunol. | pmid:12626587 |
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| Miller LA et al. | Glutathione, S-substituted glutathiones, and leukotriene C4 as substrates for peptidylglycine alpha-amidating monooxygenase. | 2003 | Arch. Biochem. Biophys. | pmid:12646261 |
| Strait RT et al. | IL-4 exacerbates anaphylaxis. | 2003 | J. Immunol. | pmid:12646651 |
| Vargaftig BB and Singer M | Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12654629 |
| Godinot N et al. | Cloning and functional characterization of the multidrug resistance-associated protein (MRP1/ABCC1) from the cynomolgus monkey. | 2003 | Mol. Cancer Ther. | pmid:12657726 |
| Bäck M et al. | The contraction of the human pulmonary artery by LTC4 is resistant to cysLT1 antagonists and counteracted by prostacyclin release. | 2002 | Adv. Exp. Med. Biol. | pmid:12664603 |
| Konno T et al. | Identification of domains participating in the substrate specificity and subcellular localization of the multidrug resistance proteins MRP1 and MRP2. | 2003 | J. Biol. Chem. | pmid:12682044 |
| Chibana K et al. | Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene C4 and produce eotaxin. | 2003 | J. Immunol. | pmid:12682264 |
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| Reddanna P et al. | Carboxypeptidase A-catalyzed direct conversion of leukotriene C4 to leukotriene F4. | 2003 | Arch. Biochem. Biophys. | pmid:12729612 |
| Leslie EM et al. | Functional and structural consequences of cysteine substitutions in the NH2 proximal region of the human multidrug resistance protein 1 (MRP1/ABCC1). | 2003 | Biochemistry | pmid:12731862 |
| Kalayci O et al. | LTC4 production by eosinophils in asthmatic subjects with alternative forms of ALOX-5 core promoter. | 2003 | Adv. Exp. Med. Biol. | pmid:12751728 |
| Fujisaki T et al. | Bestatin selectively suppresses the growth of leukemic stem/progenitor cells with BCR/ABL mRNA transcript in patients with chronic myelogeneous leukemia. | 2003 | Int. Immunopharmacol. | pmid:12781706 |
| Yang R et al. | ATP binding to the first nucleotide binding domain of multidrug resistance-associated protein plays a regulatory role at low nucleotide concentration, whereas ATP hydrolysis at the second plays a dominant role in ATP-dependent leukotriene C4 transport. | 2003 | J. Biol. Chem. | pmid:12783859 |
| Vargaftig BB and Singer M | Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12794006 |
| Muñoz NM et al. | Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils. | 2003 | J. Biol. Chem. | pmid:12796497 |
| Dallaire MJ et al. | Endothelial cells modulate eosinophil surface markers and mediator release. | 2003 | Eur. Respir. J. | pmid:12797482 |
| Ichiyama T et al. | Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells. | 2003 | Clin. Exp. Allergy | pmid:12801316 |
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| Cai Y et al. | Bronchial mast cells are the dominating LTC4S-expressing cells in aspirin-tolerant asthma. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12816731 |
| Tanaka H et al. | Biliary excretion of phenolphthalein sulfate in rats. | 2003 | Pharmacology | pmid:12837971 |
| Bouchelouche K et al. | The cysteinyl-leukotriene D4 induces cytosolic Ca2+ elevation and contraction of the human detrusor muscle. | 2003 | J. Urol. | pmid:12853847 |
| Mechiche H et al. | Effects of cysteinyl leukotrienes in small human bronchus and antagonist activity of montelukast and its metabolites. | 2003 | Clin. Exp. Allergy | pmid:12859443 |
| Schuhmann MU et al. | Temporal profiles of cerebrospinal fluid leukotrienes, brain edema and inflammatory response following experimental brain injury. | 2003 | Neurol. Res. | pmid:12866196 |