| MeSH term | MeSH ID | Detail |
|---|---|---|
| Brain Diseases, Metabolic, Inborn | D020739 | 10 associated lipids |
| Pulmonary Disease, Chronic Obstructive | D029424 | 16 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Eosinophilic Esophagitis | D057765 | 3 associated lipids |
| Neointima | D058426 | 3 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hirata H et al. | Leukotriene C4 aggravates bleomycin-induced pulmonary fibrosis in mice. | 2013 | Respirology | pmid:23432979 |
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| Kivity S et al. | Eosinophil influx into the airways in patients with exercise-induced asthma. | 2000 | Respir Med | pmid:11192956 |
| Moloney ED et al. | Release of inflammatory mediators from eosinophils following a hyperosmolar stimulus. | 2003 | Respir Med | pmid:12924520 |
| Chaung HC et al. | Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells. | 2009 | Res. Vet. Sci. | pmid:18565553 |
| Bozkurt S et al. | The cytoprotective effect of iloprost against carbon tetrachloride induced necrosis in rat liver. | 1997 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9144840 |
| Bell RR et al. | Cadmium and/or selenium effects on guinea pig lung PGE2, TXB2 and LTC4. | 1997 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9344235 |
| Büyükgebiz O et al. | Captopril increases endothelin serum concentrations and preserves intestinal mucosa after mesenteric ischemia-reperfusion injury. | 1994 | Res Exp Med (Berl) | pmid:7536337 |
| Güllüoğlu BM et al. | Endothelin release is augmented with captopril in rat ischemia-reperfusion injury of the liver. | 1996 | Res Exp Med (Berl) | pmid:8903098 |
| Korzekwa AJ et al. | Leukotrienes modulate secretion of progesterone and prostaglandins during the estrous cycle and early pregnancy in cattle: an in vivo study. | 2010 | Reproduction | pmid:20813877 |
| Korzekwa A et al. | Leukotrienes are auto-/paracrine factors in the bovine corpus luteum: an in vitro study. | 2010 | Reprod. Domest. Anim. | pmid:19645858 |
| Korzekwa AJ et al. | Luteolytic effect of prostaglandin F 2 alpha on bovine corpus luteum depends on cell composition and contact. | 2008 | Reprod. Domest. Anim. | pmid:18282218 |
| Korzekwa A et al. | The influence of tumor necrosis factor alpha (TNF) on the secretory function of bovine corpus luteum: TNF and its receptors expression during the estrous cycle. | 2008 | Reprod Biol | pmid:19092986 |
| Katori M et al. | Interaction of substance P and leukotriene C4 in ethanol-induced mucosal injury of rat stomach. | 1993 | Regul. Pept. | pmid:7692504 |
| Kohrogi H et al. | Release of tachykinins and its metabolism in the airway. | 1993 | Regul. Pept. | pmid:8210488 |
| Templeton AG et al. | Effects of S-salbutamol on human isolated bronchus. | 1998 | Pulm Pharmacol Ther | pmid:9802957 |
| Kurosawa M and Tsukagoshi H | Inhibitory effect of a thromboxane A2 synthetase inhibitor OKY-046 on bronchial hyperresponsiveness to histamine, but not on airway wall thickening, induced by intravenous administration of leukotriene C4 in guinea-pigs. | 1993 | Pulm Pharmacol | pmid:8148578 |
| Planquois JM et al. | Differential inhibition by selective phosphodiesterase inhibitors of antigen, LTC4 and histamine-induced contraction of guinea-pig isolated trachea. | 1996 | Pulm Pharmacol | pmid:9160414 |
| Hung ND et al. | Anti-inflammatory action of arachidonoyl lysophosphatidylcholine or 15-hydroperoxy derivative in zymosan A-induced peritonitis. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19819343 |
| Evans JF | Cysteinyl leukotriene receptors. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432945 |
| Wen FQ et al. | Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758210 |
| Hua Z et al. | Evaluation and interference of serum and skin lesion levels of leukotrienes in patients with eczema. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16757158 |
| Zaitsu M et al. | Effect of dexamethasone on leukotriene synthesis in DMSO-stimulated HL-60 cells. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10102384 |
| KuÅŸtimur S et al. | Effect of nordihydroguaretic acid and fluconazole on the LTC4/PGE2 ratio in the kidney of mice damaged by Candida albicans. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9150373 |
| Hardcastle JE and Bruch RJ | Effect of L-aspartyl-L-phenylalanine methyl ester on leukotriene biosynthesis in macrophage cells. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9384524 |
| Abeywardena MY et al. | Dietary n-3 and n-6 polyunsaturated oils and airway contractility. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418024 |
| Sare M et al. | The effects of indomethacin, NDGA, allopurinol and superoxide dismutase on prostaglandin E2 and leukotriene C4 levels after mesenteric ischemia-reperfusion injury. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9014215 |
| Shindo K et al. | Prednisolone inhibits synthesis of 5-H(P)ETE in eosinophils from asthmatic patients during a wheezing attack but not during remission. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9578148 |
| Hackshaw KV et al. | Environmental influences on fatty acid composition of membranes from autoimmune MRL lpr/lpr mice. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804129 |
| Shimizu T et al. | Effects of n-3 polyunsaturated fatty acids on indomethacin-induced changes in eicosanoid production and blood flow in the gastric mucosa of rats. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878448 |
| Damtew B and Spagnuolo PJ | Leukotriene C4 from vascular endothelium enhances neutrophil adhesiveness. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9051719 |
| HasanoÄŸlu E et al. | The role of prostanoids in the complications of extracorporeal shock wave lithotripsy (ESWL) in children. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846111 |
| Abe M et al. | Evaluation of the effects of steroids on experimental septic lung injury. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8848431 |
| Zaitsu M et al. | Interleukin-18 primes human basophilic KU812 cells for higher leukotriene synthesis. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16280246 |
| Anadol AZ et al. | Role of endogenous endothelin peptides in intestinal ischemia-reperfusion injury in rats. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9849655 |
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| Bandeira-Melo C and Weller PF | Eosinophils and cysteinyl leukotrienes. | 2003 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12895596 |
| Aktan AO et al. | Does PGE2 act as a mediator for endothelin release? | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7511821 |
| Mita H et al. | Purification of human blood basophils and leukotriene C4 generation following calcium ionophore stimulation. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7505057 |
| Batirel HF et al. | The effect of aqueous garlic extract on the levels of arachidonic acid metabolites (leukotriene C4 and prostaglandin E2) in rat forebrain after ischemia-reperfusion injury. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804127 |
| Keskil ZA et al. | Changes of arterial arachidonic acid metabolites in hypertensive patients during haemodialysis. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10189068 |
| Engin A et al. | The protective effect of thromboxane synthetase inhibitor UK 38485 against bile duct ligation induced liver injury. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7544015 |
| Raghavenra H et al. | Eugenol--the active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16216483 |
| Hamasaki Y et al. | Inhibition of leukotriene synthesis by terfenadine in vitro. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654399 |
| Willburger RE et al. | Inhibition of eicosanoid release from synovial organ culture by incubation with tepoxalin and its acid metabolite. | 1996 | Prostaglandins | pmid:8936587 |
| Herman CA et al. | Leukotriene C4-stimulated contractions in bullfrog lung are affected by cold acclimation and calcium antagonists. | 1995 | Prostaglandins | pmid:7480797 |
| Baker SR et al. | The pharmacology of N-methyl LTC4; a metabolically stable LTC4-mimetic. | 1990 | Prostaglandins | pmid:2255765 |
| Ramondt J et al. | Sensitivity of ovine myometrial tissue to various eicosanoids in vitro. | 1995 | Prostaglandins | pmid:7792392 |
| Kitaura K et al. | Effects of organic anions and bile acid conjugates on biliary excretion of LTC4 in the rat. | 1997 | Prostaglandins | pmid:9491205 |