LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Angina Pectoris D000787 27 associated lipids
Anaphylaxis D000707 35 associated lipids
Airway Obstruction D000402 13 associated lipids
Acute-Phase Reaction D000210 12 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Authors Title Published Journal PubMed Link
Westcott JY et al. Arachidonate-induced eicosanoid synthesis in RBL-2H3 cells: stimulation with antigen or A23187 induces prolonged activation of 5-lipoxygenase. 1996 Biochim. Biophys. Acta pmid:8816855
Hsieh KH Evaluation of efficacy of traditional Chinese medicines in the treatment of childhood bronchial asthma: clinical trial, immunological tests and animal study. Taiwan Asthma Study Group. 1996 Pediatr Allergy Immunol pmid:9116877
Ishizuka Y et al. Effect of 1,6-dihydro-2[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidineca rboxyli c acid on ethanol-induced microvascular injury in rats. 1996 Arzneimittelforschung pmid:9125278
Willburger RE et al. Inhibition of eicosanoid release from synovial organ culture by incubation with tepoxalin and its acid metabolite. 1996 Prostaglandins pmid:8936587
Dhillon HS et al. Regional generation of leukotriene C4 after experimental brain injury in anesthetized rats. 1996 J. Neurotrauma pmid:9002063
Loe DW et al. Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport. 1996 J. Biol. Chem. pmid:8621643
Wilborn J et al. Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis. 1996 J. Clin. Invest. pmid:8621765
Meltzer SS et al. Inhibition of exercise-induced bronchospasm by zileuton: a 5-lipoxygenase inhibitor. 1996 Am. J. Respir. Crit. Care Med. pmid:8630575
Hisamatsu K et al. Effect of leukotriene C4 exposure on ciliated cells of the nasal mucosa. 1996 Prostaglandins pmid:8900445
Omar HM et al. Hepatobiliary excretion of cysteinyl leukotrienes in three experimental models of acute hepatic injury. 1996 Inflamm. Res. pmid:8912018
Müller D et al. Bile ductular proliferation and altered leukotriene elimination in thioacetamide-induced fibrosis of rat liver. 1996 J. Hepatol. pmid:8912155
Sedgwick JB et al. Effect of isolation protocol on eosinophil function: Percoll gradients versus immunomagnetic beads. 1996 J. Immunol. Methods pmid:8914593
Burghardt JS et al. Lipid mediators in oxygen-induced airway remodeling and hyperresponsiveness in newborn rats. 1996 Am. J. Respir. Crit. Care Med. pmid:8887572
Pulaski L et al. Identification of the multidrug-resistance protein (MRP) as the glutathione-S-conjugate export pump of erythrocytes. 1996 Eur. J. Biochem. pmid:8917467
Campbell A et al. Overview of allergic mechanisms. Ebastine has more than an antihistamine effect. 1996 Drugs pmid:8983912
Kobayashi S et al. [Inhibitory effect of ONO-1078, a novel leukotriene receptor antagonist, on human peripheral blood eosinophils]. 1996 Arerugi pmid:8990528
Sare M et al. The effects of indomethacin, NDGA, allopurinol and superoxide dismutase on prostaglandin E2 and leukotriene C4 levels after mesenteric ischemia-reperfusion injury. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:9014215
Loe DW et al. ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. 1996 J. Biol. Chem. pmid:8621644
Weber M et al. Deletion of the NH2-terminal residue converts monocyte chemotactic protein 1 from an activator of basophil mediator release to an eosinophil chemoattractant. 1996 J. Exp. Med. pmid:8627182
Brock TG et al. Effects of granulocyte-macrophage colony-stimulating factor on eicosanoid production by mononuclear phagocytes. 1996 J. Immunol. pmid:8786314
Namovic MT et al. Pharmacological modulation of eosinophil influx into the lungs of Brown Norway rats. 1996 Eur. J. Pharmacol. pmid:8960868
Garcia C et al. Effects of synthetic peptido-leukotrienes on bone resorption in vitro. 1996 J. Bone Miner. Res. pmid:8992883
Henderson WR et al. The importance of leukotrienes in airway inflammation in a mouse model of asthma. 1996 J. Exp. Med. pmid:8879219
Tominaga M et al. ONO-1078 antagonizes diarrhea-causing changes in ion transport and smooth muscle contraction induced by peptidoleukotrienes in rat and human colon in vitro. 1996 J. Pharmacol. Exp. Ther. pmid:8819486
de Paulis A et al. Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine. 1996 J. Allergy Clin. Immunol. pmid:8765829
Büchler M et al. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. 1996 J. Biol. Chem. pmid:8662992
Daffonchio L et al. Protective activity of ketoprofen lysine salt against the pulmonary effects induced by bradykinin in guinea-pigs. 1996 Inflamm. Res. pmid:8737750
Shichinohe K et al. Effect of M-711 on experimental skin reactions induced by chemical mediators in rats. 1996 J. Vet. Med. Sci. pmid:8741601
Zuberbier T et al. Histamine releasability of basophils and skin mast cells in chronic urticaria. 1996 Allergy pmid:8721524
Takase B et al. Change of plasma leukotriene C4 during myocardial ischemia in humans. 1996 Clin Cardiol pmid:8674256
Paul S et al. ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8692921
Przylipiak A et al. Role of leukotriene C4 in follicle-stimulating hormone (FSH) secretion in female rat pituitary. 1996 Gynecol. Endocrinol. pmid:8701793
Hong JT and Glauert HP Comitogenicity of eicosanoids and the peroxisome proliferator ciprofibrate in cultured rat hepatocytes. 1996 J. Cell. Physiol. pmid:8908198
Sainte-Laudy J et al. [Importance of the leukotriene C4 liberation test for the diagnosis of drug allergy (preliminary results)]. 1996 Allerg Immunol (Paris) pmid:8703308
Abe M et al. Evaluation of the effects of steroids on experimental septic lung injury. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8848431
Leier I et al. ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. 1996 Biochem. J. pmid:8670053
Shindo K et al. Priming effect of platelet activating factor on leukotriene C4 from stimulated eosinophils of asthmatic patients. 1996 Thorax pmid:8711647
Itoh K et al. Relationship between airway eosinophilia and airway hyperresponsiveness in a late asthmatic model of guinea pigs. 1996 Int. Arch. Allergy Immunol. pmid:8527956
Tang DG et al. Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8643560
Matsuo M et al. Leukotriene B4 and C4 in cerebrospinal fluid from children with meningitis and febrile seizures. 1996 Pediatr. Neurol. pmid:8703223
Papayianni A et al. Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. 1996 J. Immunol. pmid:8690917
Batirel HF et al. The effect of aqueous garlic extract on the levels of arachidonic acid metabolites (leukotriene C4 and prostaglandin E2) in rat forebrain after ischemia-reperfusion injury. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8804127
Shraga-Levine Z et al. Arachidonic acid and lipoxygenase products stimulate protein kinase C beta mRNA levels in pituitary alpha T3-1 cell line: role in gonadotropin-releasing hormone action. 1996 Biochem. J. pmid:8687415
Ganbo T et al. Leukotriene C4 inhibits ciliary activity in the presence of gamma-glutamyl transpeptidase. 1996 Am. J. Physiol. pmid:8770059
Funayama T et al. Role of Leukotriene-degrading enzymes in pulmonary response to antigen infusion in sensitized guinea pigs in vivo. 1996 Am. J. Respir. Cell Mol. Biol. pmid:8703483
Güllüoğlu BM et al. Endothelin release is augmented with captopril in rat ischemia-reperfusion injury of the liver. 1996 Res Exp Med (Berl) pmid:8903098
Nishisho T et al. Experimental and clinical studies of eicosanoids in cerebrospinal fluid after spinal cord injury. 1996 Neurosurgery pmid:8905750
Breil I et al. Alteration of n-3 fatty acid composition in lung tissue after short-term infusion of fish oil emulsion attenuates inflammatory vascular reaction. 1996 Crit. Care Med. pmid:8917042
Muñoz NM et al. Eosinophil VLA-4 binding to fibronectin augments bronchial narrowing through 5-lipoxygenase activation. 1996 Am. J. Physiol. pmid:8928818
Paul S et al. Structure and in vitro substrate specificity of the murine multidrug resistance-associated protein. 1996 Biochemistry pmid:8885844
Tenor H et al. Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects. 1996 Br. J. Pharmacol. pmid:8842438
Richter L et al. Increased biliary secretion of cysteinyl-leukotrienes in human bile duct obstruction. 1996 J. Hepatol. pmid:8938552
Sun H et al. Expression and characterization of the multidrug resistance-associated protein in insect cells infected with a recombinant baculovirus. 1996 Oncol. Res. pmid:8938792
Lane SJ and Lee TH Mast cell effector mechanisms. 1996 J. Allergy Clin. Immunol. pmid:8939179
Ruf G et al. Aminoterminal propeptide of type III procollagen: a marker of hepatic fibrosis after bile duct obstruction in the monkey. 1996 Jan-Feb Hepatogastroenterology pmid:8682446
Sabbah A et al. [Allergy to mosquitoes and use of new immunobiological parameters]. 1997 Allerg Immunol (Paris) pmid:9254117
Sainte-Laudy J et al. [Bioclinical interest in the assay of leukotrienes in four cases of sensitization to trophallergens]. 1997 Allerg Immunol (Paris) pmid:9254120
Akagi M et al. Anti-allergic effect of tea-leaf saponin (TLS) from tea leaves (Camellia sinensis var. sinensis). 1997 Biol. Pharm. Bull. pmid:9178940
Stride BD et al. Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. 1997 Mol. Pharmacol. pmid:9281595
Patella V et al. Heterogeneous effects of protamine on human mast cells and basophils. 1997 Br J Anaesth pmid:9215027
Hamasaki Y et al. Post-transcriptional regulation of LTC4 synthase activity by retinoic acid in rat basophilic leukemia cells. 1997 Biochim. Biophys. Acta pmid:9295165
Jakobsson PJ et al. Characterization of microsomal GST-II by western blot and identification of a novel LTC4 isomer. 1997 J Lipid Mediat Cell Signal pmid:9302651
Sabbah A et al. [Anaphylactic or anaphylactoid reactions to paracetamol. Report of 3 cases]. 1997 Allerg Immunol (Paris) pmid:9221011
Leynadier F [Drug allergies: value of the leucotriene C4 release test?]. 1997 Presse Med pmid:9180883
Forssmann U et al. Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. 1997 J. Exp. Med. pmid:9182688
Scoggan KA et al. Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes. 1997 J. Biol. Chem. pmid:9092565
Carter BZ et al. Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice. 1997 J. Biol. Chem. pmid:9139674
KuÅŸtimur S et al. Effect of nordihydroguaretic acid and fluconazole on the LTC4/PGE2 ratio in the kidney of mice damaged by Candida albicans. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9150373
Frieling T et al. Leukotriene-evoked cyclic chloride secretion is mediated by enteric neuronal modulation in guinea-pig colon. 1997 Naunyn Schmiedebergs Arch. Pharmacol. pmid:9151302
Takano T et al. Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. 1997 J. Exp. Med. pmid:9151906
Hardcastle JE and Bruch RJ Effect of L-aspartyl-L-phenylalanine methyl ester on leukotriene biosynthesis in macrophage cells. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9384524
Pedersen KE et al. Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism. 1997 J. Pharmacol. Exp. Ther. pmid:9152370
Abe T et al. [Multidrug resistance protein (MRP)]. 1997 Nippon Rinsho pmid:9155156
Gagari E et al. Differential release of mast cell interleukin-6 via c-kit. 1997 Blood pmid:9108382
Ohtsuka Y et al. Reducing cell membrane n-6 fatty acids attenuate mucosal damage in food-sensitive enteropathy in mice. 1997 Pediatr. Res. pmid:9396566
Madon J et al. Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein. 1997 FEBS Lett. pmid:9109389
Sala A et al. Pharmacological modulation of human platelet leukotriene C4-synthase. 1997 Biochem. Pharmacol. pmid:9113110
Genovese A et al. Loratadine and desethoxylcarbonyl-loratadine inhibit the immunological release of mediators from human Fc epsilon RI+ cells. 1997 Clin. Exp. Allergy pmid:9179431
Fujita M et al. Cysteinyl leukotrienes induce nasal symptoms of allergic rhinitis via a receptor-mediated mechanism in guinea pigs. 1997 Jpn. J. Pharmacol. pmid:9469641
Schuligoi R et al. Release of calcitonin gene-related peptide in cardiac anaphylaxis. 1997 Naunyn Schmiedebergs Arch. Pharmacol. pmid:9050016
Sumizawa T et al. Reversal of multidrug resistance-associated protein-mediated drug resistance by the pyridine analog PAK-104P. 1997 Mol. Pharmacol. pmid:9058594
Ibe BO et al. Leukotriene synthesis by isolated perinatal ovine intrapulmonary vessels correlates with age-related changes in 5-lipoxygenase protein. 1997 Biochem. Mol. Med. pmid:9232199
Brady HR et al. Transcellular pathways and cell adhesion as potential contributors to leukotriene and lipoxin biosynthesis in acute glomerulonephritis. 1997 Adv. Exp. Med. Biol. pmid:9547614
Chavis C et al. Leukotriene E4 plasma levels in adult asthmatic patients with variable disease severity. 1997 Allergy pmid:9201374
Gissurarson SR et al. Effect of lobaric acid on cysteinyl-leukotriene formation and contractile activity of guinea pig taenia coli. 1997 J. Pharmacol. Exp. Ther. pmid:9023290
Wijnholds J et al. Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. 1997 Nat. Med. pmid:9359705
Mullol J et al. [Eosinophil activation by epithelial cells of the respiratory mucosa. Comparative study of normal mucosa and inflammatory mucosa]. 1997 Med Clin (Barc) pmid:9303983
Gomi A et al. Transient induction of the MRP/GS-X pump and gamma-glutamylcysteine synthetase by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea in human glioma cells. 1997 Cancer Res. pmid:9393752
Cunningham FM et al. Pharmacology of the 5-lipoxygenase inhibitors BAY Y 1015 and BAY X 1005 in the horse. 1997 J. Vet. Pharmacol. Ther. pmid:9280370
el-Ahmady O et al. Elevated concentrations of interleukins and leukotriene in response to Mycobacterium tuberculosis infection. 1997 Ann. Clin. Biochem. pmid:9133249
Bureau MF et al. 5-Lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs. 1997 Eur. J. Pharmacol. pmid:9137918
Zeltsman D et al. Pathophysiologic plasma levels of leukotriene C4 in relation to the hemodynamic dysfunction and mediator release of graded bacteremia. 1997 Shock pmid:9110414
Kitaura K et al. Effects of organic anions and bile acid conjugates on biliary excretion of LTC4 in the rat. 1997 Prostaglandins pmid:9491205
Hsueh W et al. Injurious and protective mechanisms in the gut. Interaction of PAF, phospholipase A2, eicosanoids, and nitric oxide synthase. 1997 Adv. Exp. Med. Biol. pmid:9321977
Chow JY et al. The potentiating actions of cigarette smoking on ethanol-induced gastric mucosal damage in rats. 1997 Gastroenterology pmid:9322514
Keppler D et al. The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes. 1997 Adv. Enzyme Regul. pmid:9381978
Bailey JM et al. Activation of mitogen-induced T-lymphocyte proliferation by leukotriene C-4. 1997 Biochem. Soc. Trans. pmid:9388724
Zweiman B et al. Nasal airway changes assessed by acoustic rhinometry and mediator release during immediate and late reactions to allergen challenge. 1997 J. Allergy Clin. Immunol. pmid:9389292
Bacha EA et al. Gastric antigen challenge releases gastrin and eicosanoids and protects against ethanol. 1997 J. Surg. Res. pmid:9228931
Hamasaki Y et al. The Chinese herbal medicine, shinpi-to, inhibits IgE-mediated leukotriene synthesis in rat basophilic leukemia-2H3 cells. 1997 J Ethnopharmacol pmid:9174973