| MeSH term | MeSH ID | Detail |
|---|---|---|
| Angina Pectoris | D000787 | 27 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Airway Obstruction | D000402 | 13 associated lipids |
| Acute-Phase Reaction | D000210 | 12 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Okamoto M et al. | Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma. | 2000 | Intern. Med. | pmid:10732825 |
| Mayatepek E | Leukotriene C4 synthesis deficiency: a member of a probably underdiagnosed new group of neurometabolic diseases. | 2000 | Eur. J. Pediatr. | pmid:11079193 |
| Yamashita M et al. | Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells. | 2000 | Br. J. Pharmacol. | pmid:10694244 |
| Sjölinder M et al. | Aberrant expression of active leukotriene C(4) synthase in CD16(+) neutrophils from patients with chronic myeloid leukemia. | 2000 | Blood | pmid:10666225 |
| Sanak M et al. | Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics. | 2000 | Eur. Respir. J. | pmid:10933083 |
| Tsang S et al. | Simplified purification of human basophils. | 2000 | J. Immunol. Methods | pmid:10648851 |
| Ravasi S et al. | A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lung parenchyma. | 2000 | Mol. Pharmacol. | pmid:10825389 |
| Seno K et al. | Pyrrolidine inhibitors of human cytosolic phospholipase A(2). | 2000 | J. Med. Chem. | pmid:10737736 |
| Gao M et al. | Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1. | 2000 | J. Biol. Chem. | pmid:10777615 |
| Goulet JL et al. | Genetic factors determine the contribution of leukotrienes to acute inflammatory responses. | 2000 | J. Immunol. | pmid:10779800 |
| Vidal A et al. | Synthesis of 19-[(2-azido-5-iodo)-benzoyloxy]-LTA4 and enzymatic conversion to the LTC4 analogue. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10762049 |
| Loe DW et al. | Verapamil stimulates glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1). | 2000 | J. Pharmacol. Exp. Ther. | pmid:10773025 |
| Muñoz NM et al. | Augmentation of LTC(4) synthesis in human eosinophils caused by CD3-stimulated Th2-like cells in vitro. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10835322 |
| Hasday JD et al. | Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10764316 |
| Hisamatsu K and Nakajima M | Pranlukast protects leukotriene C4- and D4-induced epithelial cell impairment of the nasal mucosa in vitro. | 2000 | Life Sci. | pmid:11105993 |
| Cederholm T et al. | Impaired leukotriene C4 generation in granulocytes from protein-energy malnourished chronically ill elderly. | 2000 | J. Intern. Med. | pmid:10886494 |
| Venière A et al. | [Importance of blood tests for the diagnosis of drug allergies]. | 2000 | Allerg Immunol (Paris) | pmid:10971854 |
| Zeng H et al. | Transport of amphipathic anions by human multidrug resistance protein 3. | 2000 | Cancer Res. | pmid:10987286 |
| Genovese A et al. | Bacterial immunoglobulin superantigen proteins A and L activate human heart mast cells by interacting with immunoglobulin E. | 2000 | Infect. Immun. | pmid:10992448 |
| Mao Q et al. | Functional reconstitution of substrate transport by purified multidrug resistance protein MRP1 (ABCC1) in phospholipid vesicles. | 2000 | J. Biol. Chem. | pmid:10942765 |
| Bäck M et al. | Prostacyclin modulation of contractions of the human pulmonary artery by cysteinyl-leukotrienes. | 2000 | Eur. J. Pharmacol. | pmid:10936498 |
| Loe DW et al. | Structure-activity studies of verapamil analogs that modulate transport of leukotriene C(4) and reduced glutathione by multidrug resistance protein MRP1. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10973801 |
| Takasaki J et al. | The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10913337 |
| Bossé M et al. | Eosinophil activation status and corticosteroid responsiveness in severe asthma. | 2000 | Int. Arch. Allergy Immunol. | pmid:10899764 |
| Dent G et al. | Involvement of protein tyrosine kinases in activation of human eosinophils by platelet-activating factor. | 2000 | Immunology | pmid:10886400 |
| Gibbs BF et al. | Ambroxol inhibits IgE-dependent mediator secretion from human skin mast cells. | 2000 | Inflamm. Res. | pmid:10864402 |
| Taskila K et al. | Histamine and LTC4 in stinging nettle-induced urticaria. | 2000 | Allergy | pmid:10921474 |
| Bowers RC et al. | A novel glutathione containing eicosanoid (FOG7) chemotactic for human granulocytes. | 2000 | J. Biol. Chem. | pmid:10924496 |
| Eglite S et al. | Requirements for C5a receptor-mediated IL-4 and IL-13 production and leukotriene C4 generation in human basophils. | 2000 | J. Immunol. | pmid:10925305 |
| Sainte-Laudy J et al. | Diagnosis of venom allergy by flow cytometry. Correlation with clinical history, skin tests, specific IgE, histamine and leukotriene C4 release. | 2000 | Clin. Exp. Allergy | pmid:10931125 |
| Florio G et al. | The immunoglobulin superantigen-binding site of HIV-1 gp120 activates human basophils. | 2000 | AIDS | pmid:10853974 |
| Urasaki T et al. | Induction of the activation-related antigen CD69 on human eosinophils by type IIA phospholipase A2. | 2000 | Inflamm. Res. | pmid:10858018 |
| Schmidt DT et al. | The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C(4)-induced contractions in passively sensitized human airways. | 2000 | Br. J. Pharmacol. | pmid:11139438 |
| Annila I et al. | Bee venom induces high histamine or high leukotriene C4 release in skin of sensitized beekeepers. | 2000 Jul-Aug | J Investig Allergol Clin Immunol | pmid:11039839 |
| Kamohara M et al. | Functional characterization of cysteinyl leukotriene CysLT(2) receptor on human coronary artery smooth muscle cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11587533 |
| Wehner J and Neuber K | Staphylococcus aureus enterotoxins induce histamine and leukotriene release in patients with atopic eczema. | 2001 | Br. J. Dermatol. | pmid:11531797 |
| Sano A et al. | Regulation of eosinophil function by phosphatidylinositol-specific PLC and cytosolic PLA(2). | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11557588 |
| Qian YM et al. | Characterization of binding of leukotriene C4 by human multidrug resistance protein 1: evidence of differential interactions with NH2- and COOH-proximal halves of the protein. | 2001 | J. Biol. Chem. | pmid:11507101 |
| Strenzke N et al. | Mercuric chloride enhances immunoglobulin E-dependent mediator release from human basophils. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11485386 |
| Miura K et al. | Differences in functional consequences and signal transduction induced by IL-3, IL-5, and nerve growth factor in human basophils. | 2001 | J. Immunol. | pmid:11490016 |
| Falcón-Pérez JM et al. | Domain interactions in the yeast ATP binding cassette transporter Ycf1p: intragenic suppressor analysis of mutations in the nucleotide binding domains. | 2001 | J. Bacteriol. | pmid:11466279 |
| Bölke E et al. | Changes of gut barrier function during anesthesia and cardiac surgery. | 2001 | Angiology | pmid:11515987 |
| Abad MJ et al. | Effects of furocoumarins from Cachrys trifida on some macrophage functions. | 2001 | J. Pharm. Pharmacol. | pmid:11518028 |
| Ito K et al. | Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. | 2001 | J. Biol. Chem. | pmid:11500505 |
| Tornhamre S et al. | Inhibitory effects of helenalin and related compounds on 5-lipoxygenase and leukotriene C(4) synthase in human blood cells. | 2001 | Biochem. Pharmacol. | pmid:11543725 |
| Miura K et al. | Localizing a control region in the pathway to leukotriene C(4) secretion following stimulation of human basophils with anti-IgE antibody. | 2001 | J. Immunol. | pmid:11739523 |
| Wang J et al. | [The effects of resuscitation with hypertonic saline solution on the postburn pulmonary injury in scalded dogs]. | 2001 | Zhonghua Shao Shang Za Zhi | pmid:11774813 |
| Eppihimer MJ and Schaub RG | Soluble P-selectin antagonist mediates rolling velocity and adhesion of leukocytes in acutely inflamed venules. | 2001 | Microcirculation | pmid:11296849 |
| DÃaz Lanza AM et al. | Lignan and phenylpropanoid glycosides from Phillyrea latifolia and their in vitro anti-inflammatory activity. | 2001 | Planta Med. | pmid:11345691 |
| Sjöström M et al. | Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor. | 2001 | Eur. J. Biochem. | pmid:11322876 |
| Bandeira-Melo C et al. | Extranuclear lipid bodies, elicited by CCR3-mediated signaling pathways, are the sites of chemokine-enhanced leukotriene C4 production in eosinophils and basophils. | 2001 | J. Biol. Chem. | pmid:11274187 |
| Zhang DW et al. | Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines. | 2001 | J. Biol. Chem. | pmid:11278596 |
| Ito K et al. | Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport. | 2001 | J. Biol. Chem. | pmid:11278867 |
| Leslie EM et al. | Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids. | 2001 | Mol. Pharmacol. | pmid:11306701 |
| Schroeder JT et al. | Human basophils: mediator release and cytokine production. | 2001 | Adv. Immunol. | pmid:11293121 |
| Zhang DW et al. | Identification of a nonconserved amino acid residue in multidrug resistance protein 1 important for determining substrate specificity: evidence for functional interaction between transmembrane helices 14 and 17. | 2001 | J. Biol. Chem. | pmid:11429411 |
| Hevko JM and Murphy RC | Electrospray ionization and tandem mass spectrometry of cysteinyl eicosanoids: leukotriene C4 and FOG7. | 2001 | J. Am. Soc. Mass Spectrom. | pmid:11444597 |
| Cai J et al. | Functional expression of multidrug resistance protein 1 in Pichia pastoris. | 2001 | Biochemistry | pmid:11444977 |
| Zaitsu M et al. | A novel pharmacologic action of glucocorticosteroids on leukotriene C4 catabolism. | 2001 | J. Allergy Clin. Immunol. | pmid:11447392 |
| Ieiri S et al. | The mechanism for the contraction induced by leukotriene C4 in guinea-pig taenia coli. | 2001 | Br. J. Pharmacol. | pmid:11399670 |
| Zhu X et al. | Role of mitogen-activated protein kinase-mediated cytosolic phospholipase A2 activation in arachidonic acid metabolism in human eosinophils. | 2001 | J. Immunol. | pmid:11418683 |
| Gurish MF and Austen KF | The diverse roles of mast cells. | 2001 | J. Exp. Med. | pmid:11435478 |
| de las Heras B et al. | Effects of six diterpenes on macrophage eicosanoid biosynthesis. | 2001 | Life Sci. | pmid:12005260 |
| Leslie EM et al. | Transport of the beta -O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog. | 2001 | J. Biol. Chem. | pmid:11375986 |
| Muccitelli RM et al. | Cysteinyl leukotriene receptor assays. | 2001 | Curr Protoc Pharmacol | pmid:22293965 |
| Downey P et al. | Renal concentrating defect in mice lacking group IV cytosolic phospholipase A(2). | 2001 | Am. J. Physiol. Renal Physiol. | pmid:11249852 |
| Vicente AM et al. | Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages. | 2001 | Br. J. Pharmacol. | pmid:11454666 |
| Martin V et al. | Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors. | 2001 | Biochem. Pharmacol. | pmid:11705452 |
| Aoki M et al. | Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11504812 |
| Bäck M et al. | An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea. | 2001 | Br. J. Pharmacol. | pmid:11487525 |
| Fukuishi N et al. | Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor. | 2001 | Phytomedicine | pmid:11824521 |
| Oliveira SH et al. | SCF-induced airway hyperreactivity is dependent on leukotriene production. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11350804 |
| Qian YM et al. | Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1. | 2001 | J. Biol. Chem. | pmid:11102445 |
| Murakami M et al. | Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms. | 2001 | J. Biol. Chem. | pmid:11106649 |
| Okayama Y et al. | A comparison of mediators released or generated by IFN-gamma-treated human mast cells following aggregation of Fc gamma RI or Fc epsilon RI. | 2001 | J. Immunol. | pmid:11254731 |
| Tohda Y et al. | Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. | 2001 | Respiration | pmid:11223734 |
| Setoguchi H et al. | Leukotriene C(4) enhances the contraction of porcine tracheal smooth muscle through the activation of Y-27632, a rho kinase inhibitor, sensitive pathway. | 2001 | Br. J. Pharmacol. | pmid:11156567 |
| Amann R et al. | Effects of COX-1 and COX-2 inhibitors on eicosanoid biosynthesis and the release of substance P from the guinea-pig isolated perfused lung. | 2001 | Inflamm. Res. | pmid:11235022 |
| Gronert K et al. | Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. | 2001 | Am. J. Pathol. | pmid:11141472 |
| Picado C and Valero A | COX-1 sparing drugs in aspirin-sensitive asthma. | 2001 | Clin. Exp. Allergy | pmid:11251618 |
| Terlouw SA et al. | Role of multidrug resistance protein 2 (MRP2) in glutathione-bimane efflux from Caco-2 and rat renal proximal tubule cells. | 2001 | Br. J. Pharmacol. | pmid:11682439 |
| Schroeder JT et al. | Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. | 2001 | Clin. Exp. Allergy | pmid:11591186 |
| Hui Y et al. | The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. | 2001 | J. Biol. Chem. | pmid:11591709 |
| Duffy SM et al. | Resting and activation-dependent ion channels in human mast cells. | 2001 | J. Immunol. | pmid:11591748 |
| Ohno N et al. | Prognostic significance of multidrug resistance protein in adult T-cell leukemia. | 2001 | Clin. Cancer Res. | pmid:11595704 |
| Miura K et al. | Piceatannol is an effective inhibitor of IgE-mediated secretion from human basophils but is neither selective for this receptor nor acts on syk kinase at concentrations where mediator release inhibition occurs. | 2001 | Clin. Exp. Allergy | pmid:11696049 |
| Bölke E et al. | Inflammatory response during abdominal and thyroid surgery: a prospective clinical trial on mediator release. | 2001 | Shock | pmid:11699069 |
| Fernández MA et al. | New insights into the mechanism of action of the anti-inflammatory triterpene lupeol. | 2001 | J. Pharm. Pharmacol. | pmid:11732756 |
| Thomas LL et al. | Peptide-based analysis of amino acid sequences important to the biological activity of eosinophil granule major basic protein. | 2001 | Immunol. Lett. | pmid:11578692 |
| Abeywardena MY et al. | Dietary n-3 and n-6 polyunsaturated oils and airway contractility. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418024 |
| Karaman O et al. | The comparison of the efficacy of fluticasone propionate with cetirizine in perennial allergic rhinitis. | 2001 Mar-Apr | Allergol Immunopathol (Madr) | pmid:11420028 |
| King BO et al. | Tirofiban administration attenuates platelet and platelet-neutrophil conjugation but not neutrophil degranulation during in vitro VAD circulation. | 2001 May-Jun | ASAIO J. | pmid:11374774 |
| Malaviya R and Uckun FM | Leflunomide metabolite analogue alpha-cyano-beta-hydroxy-beta-methyl-N-[3-(trifluoromethyl)phenyl]propenamide inhibits IgE/FcepsilonRI receptor-mediated mast cell leukotriene release and allergic asthma in mice. | 2001 Sep-Oct | Am J Ther | pmid:11550070 |
| Jedlitschky G and Keppler D | Transport of leukotriene C4 and structurally related conjugates. | 2002 | Vitam. Horm. | pmid:11898391 |
| Guo A et al. | Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). | 2002 | Drug Metab. Dispos. | pmid:11901101 |
| Malaviya R and Uckun FM | Role of STAT6 in IgE receptor/FcepsilonRI-mediated late phase allergic responses of mast cells. | 2002 | J. Immunol. | pmid:11751988 |
| Zhang DW et al. | Determinants of the substrate specificity of multidrug resistance protein 1: role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17. | 2002 | J. Biol. Chem. | pmid:11925441 |
| Maekawa A et al. | Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. | 2002 | J. Biol. Chem. | pmid:11932261 |
| Ahamed J and Ali H | Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production. | 2002 | J. Biol. Chem. | pmid:11934880 |
| Kingham PJ et al. | Adhesion-dependent interactions between eosinophils and cholinergic nerves. | 2002 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12003778 |