| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neointima | D058426 | 3 associated lipids |
| Asbestosis | D001195 | 8 associated lipids |
| Phlebitis | D010689 | 1 associated lipids |
| Picornaviridae Infections | D010850 | 4 associated lipids |
| Eosinophilic Esophagitis | D057765 | 3 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dent G et al. | Involvement of protein tyrosine kinases in activation of human eosinophils by platelet-activating factor. | 2000 | Immunology | pmid:10886400 |
| Cederholm T et al. | Impaired leukotriene C4 generation in granulocytes from protein-energy malnourished chronically ill elderly. | 2000 | J. Intern. Med. | pmid:10886494 |
| Dent G et al. | Up-regulation of human eosinophil leukotriene C4 generation through contact with bronchial epithelial cells. | 2000 | Inflamm. Res. | pmid:10893047 |
| Lopes LR et al. | Reduced inflammatory response in rats fed fat-rich diets: role of leukotrienes. | 2000 | Life Sci. | pmid:10896024 |
| Mayatepek E et al. | Defects in the synthesis of cysteinyl leukotrienes: a new group of inborn errors of metabolism. | 2000 | J. Inherit. Metab. Dis. | pmid:10896305 |
| Bossé M et al. | Eosinophil activation status and corticosteroid responsiveness in severe asthma. | 2000 | Int. Arch. Allergy Immunol. | pmid:10899764 |
| Takasaki J et al. | The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10913337 |
| Taskila K et al. | Histamine and LTC4 in stinging nettle-induced urticaria. | 2000 | Allergy | pmid:10921474 |
| Bowers RC et al. | A novel glutathione containing eicosanoid (FOG7) chemotactic for human granulocytes. | 2000 | J. Biol. Chem. | pmid:10924496 |
| Eglite S et al. | Requirements for C5a receptor-mediated IL-4 and IL-13 production and leukotriene C4 generation in human basophils. | 2000 | J. Immunol. | pmid:10925305 |
| Sainte-Laudy J et al. | Diagnosis of venom allergy by flow cytometry. Correlation with clinical history, skin tests, specific IgE, histamine and leukotriene C4 release. | 2000 | Clin. Exp. Allergy | pmid:10931125 |
| Sanak M et al. | Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics. | 2000 | Eur. Respir. J. | pmid:10933083 |
| Bäck M et al. | Antagonist resistant contractions of the porcine pulmonary artery by cysteinyl-leukotrienes. | 2000 | Eur. J. Pharmacol. | pmid:10936497 |
| Bäck M et al. | Prostacyclin modulation of contractions of the human pulmonary artery by cysteinyl-leukotrienes. | 2000 | Eur. J. Pharmacol. | pmid:10936498 |
| Mao Q et al. | Functional reconstitution of substrate transport by purified multidrug resistance protein MRP1 (ABCC1) in phospholipid vesicles. | 2000 | J. Biol. Chem. | pmid:10942765 |
| Arakida Y et al. | Effect of combined leukotriene D(4) and thromboxane A(2) receptor antagonist on mediator-controlled resistance in guinea pigs. | 2000 | Eur. J. Pharmacol. | pmid:10969159 |
| Venière A et al. | [Importance of blood tests for the diagnosis of drug allergies]. | 2000 | Allerg Immunol (Paris) | pmid:10971854 |
| Loe DW et al. | Structure-activity studies of verapamil analogs that modulate transport of leukotriene C(4) and reduced glutathione by multidrug resistance protein MRP1. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10973801 |
| Nishio T et al. | Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10973807 |
| Zeng H et al. | Transport of amphipathic anions by human multidrug resistance protein 3. | 2000 | Cancer Res. | pmid:10987286 |
| Genovese A et al. | Bacterial immunoglobulin superantigen proteins A and L activate human heart mast cells by interacting with immunoglobulin E. | 2000 | Infect. Immun. | pmid:10992448 |
| Sakamoto H et al. | Involvement of phospholipid hydroperoxide glutathione peroxidase in the modulation of prostaglandin D2 synthesis. | 2000 | J. Biol. Chem. | pmid:11010961 |
| Mitsunobu F et al. | Enhanced peripheral leukocyte leukotriene production and bronchial hyperresponsiveness in asthmatics. | 2000 | Eur. Respir. J. | pmid:11028668 |
| Thorén S and Jakobsson PJ | Coordinate up- and down-regulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells. Inhibition by NS-398 and leukotriene C4. | 2000 | Eur. J. Biochem. | pmid:11029586 |
| Moore BB et al. | GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism. | 2000 | J. Immunol. | pmid:11034414 |
| Annila I et al. | Bee venom induces high histamine or high leukotriene C4 release in skin of sensitized beekeepers. | 2000 Jul-Aug | J Investig Allergol Clin Immunol | pmid:11039839 |
| Ohd JF et al. | Leukotrienes induce cell-survival signaling in intestinal epithelial cells. | 2000 | Gastroenterology | pmid:11040187 |
| Ohbayashi H and Yamaki KI | Both inhalant and intravenous uroguanylin inhibit leukotriene C4-induced airway changes. | 2000 | Peptides | pmid:11068092 |
| Mayatepek E | Leukotriene C4 synthesis deficiency: a member of a probably underdiagnosed new group of neurometabolic diseases. | 2000 | Eur. J. Pediatr. | pmid:11079193 |
| Sapirstein A and Bonventre JV | Specific physiological roles of cytosolic phospholipase A(2) as defined by gene knockouts. | 2000 | Biochim. Biophys. Acta | pmid:11080683 |
| Malaviya R et al. | Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97). | 2000 | J. Pharmacol. Exp. Ther. | pmid:11082424 |
| Capper EA et al. | Modulation of human monocyte activities by tranilast, SB 252218, a compound demonstrating efficacy in restenosis. | 2000 | J. Pharmacol. Exp. Ther. | pmid:11082441 |
| DÃaz AM et al. | In vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L. | 2000 | Biol. Pharm. Bull. | pmid:11085357 |
| Okumura H et al. | Reversal of P-glycoprotein and multidrug-resistance protein-mediated drug resistance in KB cells by 5-O-benzoylated taxinine K. | 2000 | Mol. Pharmacol. | pmid:11093797 |
| Nothacker HP et al. | Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. | 2000 | Mol. Pharmacol. | pmid:11093801 |
| Morlion BJ et al. | Cysteinyl-leukotriene generation as a biomarker for survival in the critically ill. | 2000 | Crit. Care Med. | pmid:11098969 |
| Anderson MR and Blumer JL | Prognostic markers in sepsis: the role of leukotrienes. | 2000 | Crit. Care Med. | pmid:11098993 |
| Qian YM et al. | Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1. | 2001 | J. Biol. Chem. | pmid:11102445 |
| Hisamatsu K and Nakajima M | Pranlukast protects leukotriene C4- and D4-induced epithelial cell impairment of the nasal mucosa in vitro. | 2000 | Life Sci. | pmid:11105993 |
| Murakami M et al. | Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms. | 2001 | J. Biol. Chem. | pmid:11106649 |
| Robbiani DF et al. | The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. | 2000 | Cell | pmid:11114332 |
| Schmidt DT et al. | The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C(4)-induced contractions in passively sensitized human airways. | 2000 | Br. J. Pharmacol. | pmid:11139438 |
| Gronert K et al. | Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. | 2001 | Am. J. Pathol. | pmid:11141472 |
| Nobukata H et al. | Long-term administration of highly purified eicosapentaenoic acid ethyl ester improves the dysfunction of vascular endothelial and smooth muscle cells in male WBN/Kob rats. | 2000 | Metab. Clin. Exp. | pmid:11145121 |
| Setoguchi H et al. | Leukotriene C(4) enhances the contraction of porcine tracheal smooth muscle through the activation of Y-27632, a rho kinase inhibitor, sensitive pathway. | 2001 | Br. J. Pharmacol. | pmid:11156567 |
| Kivity S et al. | Eosinophil influx into the airways in patients with exercise-induced asthma. | 2000 | Respir Med | pmid:11192956 |
| Tohda Y et al. | Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. | 2001 | Respiration | pmid:11223734 |
| Amann R et al. | Effects of COX-1 and COX-2 inhibitors on eicosanoid biosynthesis and the release of substance P from the guinea-pig isolated perfused lung. | 2001 | Inflamm. Res. | pmid:11235022 |
| Downey P et al. | Renal concentrating defect in mice lacking group IV cytosolic phospholipase A(2). | 2001 | Am. J. Physiol. Renal Physiol. | pmid:11249852 |
| Picado C and Valero A | COX-1 sparing drugs in aspirin-sensitive asthma. | 2001 | Clin. Exp. Allergy | pmid:11251618 |