LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Neointima D058426 3 associated lipids
Asbestosis D001195 8 associated lipids
Phlebitis D010689 1 associated lipids
Picornaviridae Infections D010850 4 associated lipids
Eosinophilic Esophagitis D057765 3 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

Download all related citations
Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Herman CA et al. Leukotriene C4-stimulated contractions in bullfrog lung are affected by cold acclimation and calcium antagonists. 1995 Prostaglandins pmid:7480797
Ramondt J et al. Sensitivity of ovine myometrial tissue to various eicosanoids in vitro. 1995 Prostaglandins pmid:7792392
Brandenburg K et al. Conformation and fluidity of endotoxins as determinants of biological activity. 1995 Prog. Clin. Biol. Res. pmid:8524923
Maekawa A et al. Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18931305
Uzonyi B et al. Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16606835
Mandal AK et al. The membrane organization of leukotriene synthesis. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15084748
Kar P et al. Different agonists recruit different stromal interaction molecule proteins to support cytoplasmic Ca2+ oscillations and gene expression. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22509043
Oyoshi MK et al. Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22416124
Paul S et al. ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8692921
Goulet JL et al. Altered inflammatory responses in leukotriene-deficient mice. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:7809134
Müller M et al. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:7809167
Basavarajappa D et al. Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25034252
Tedla N et al. Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12529506
Cordoba-Rodriguez R et al. Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10393875
Tang DG et al. Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8643560
Thomas JW et al. Potent interleukin 3 receptor agonist with selectively enhanced hematopoietic activity relative to recombinant human interleukin 3. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7537376
Bischoff SC et al. IL-4 enhances proliferation and mediator release in mature human mast cells. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10393951
Clish CB et al. Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10393980
Feltenmark S et al. Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18184802
Lam BK et al. Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8052639
Janssen-Timmen U et al. Expression of 5-lipoxygenase in differentiating human skin keratinocytes. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7624354
Leynadier F [Drug allergies: value of the leucotriene C4 release test?]. 1997 Presse Med pmid:9180883
Medrala W et al. [Efficacy and safety of specific immunotherapy of upper airways allergic diseases caused by allergy to mites]. 2006 Pol. Merkur. Lekarski pmid:16875150
Krasnowska M and Medrala W [Effect of IFN-gamma on IGE dependent leukotriene generation by peripheral blood leukocytes in patients with chronic allergic rhinitis in vitro]. 2003 Pneumonol Alergol Pol pmid:14587429
Lecca D et al. The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. 2008 PLoS ONE pmid:18974869
Suram S et al. Cytosolic phospholipase A(2)α and eicosanoids regulate expression of genes in macrophages involved in host defense and inflammation. 2013 PLoS ONE pmid:23950842
Pinho BR et al. Modulation of basophils' degranulation and allergy-related enzymes by monomeric and dimeric naphthoquinones. 2014 PLoS ONE pmid:24587235
Secatto A et al. 5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection. 2012 PLoS ONE pmid:22448213
Alvarenga PH et al. The function and three-dimensional structure of a thromboxane A2/cysteinyl leukotriene-binding protein from the saliva of a mosquito vector of the malaria parasite. 2010 PLoS Biol. pmid:21152418
Díaz Lanza AM et al. Lignan and phenylpropanoid glycosides from Phillyrea latifolia and their in vitro anti-inflammatory activity. 2001 Planta Med. pmid:11345691
Hamasaki Y et al. Magnolol inhibits leukotriene synthesis in rat basophilic leukemia-2H3 cells. 1999 Planta Med. pmid:10232065
Gao YB et al. Low temperature inhibits pollen tube growth by disruption of both tip-localized reactive oxygen species and endocytosis in Pyrus bretschneideri Rehd. 2014 Plant Physiol. Biochem. pmid:24321875
Le Poole IC et al. Organotypic culture of human skin to study melanocyte migration. 1994 Pigment Cell Res. pmid:8072944
Smit NP et al. Stimulation of cultured melanocytes in medium containing a serum substitute: Ultroser-G. 1995 Pigment Cell Res. pmid:7540755
Shon YH and Nam KS Protective effect of Astragali radix extract on interleukin 1beta-induced in fl ammation in human amnion. 2003 Phytother Res pmid:14595579
Zhang T et al. Pharmacology and immunological actions of a herbal medicine ASHMI on allergic asthma. 2010 Phytother Res pmid:19998324
Fukuishi N et al. Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor. 2001 Phytomedicine pmid:11824521
Furukawa M et al. Terpenoids and phenethyl glucosides from Hyssopus cuspidatus (Labiatae). 2011 Phytochemistry pmid:21893325
Cao F et al. Mrp2-related efflux of scutellarin in the intestinal absorption in rats. 2008 Pharmazie pmid:18271309
Ohashi M et al. Effects of phalloidin on the biliary excretion of cholephilic compounds in rats. 2002 Pharmacology pmid:12169763
Tanaka H et al. Biliary excretion of phenolphthalein sulfate in rats. 2003 Pharmacology pmid:12837971
Yang SL et al. Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway. 2007 Pharmacology pmid:17496435
Ionac M et al. Oxaceprol, an atypical inhibitor of inflammation and joint damage. 1996 Pharmacol. Res. pmid:8971960
Conrad S et al. A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance. 2002 Pharmacogenetics pmid:12042670
Megaraj V et al. Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2). 2011 Pharmacogenet. Genomics pmid:21691255
Hirouchi M et al. Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2. 2004 Pharm. Res. pmid:15180328
Yang JJ et al. Multidrug resistance protein 1 (MRP1) in rabbit conjunctival epithelial cells: its effect on drug efflux and its regulation by adenoviral infection. 2007 Pharm. Res. pmid:17404811
Scheidegger C et al. Effects of extracts and of individual components from Petasites on prostaglandin synthesis in cultured skin fibroblasts and on leucotriene synthesis in isolated human peripheral leucocytes. 1998 Pharm Acta Helv pmid:9556438
Bakos E and Homolya L Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1). 2007 Pflugers Arch. pmid:17187268
Tschugguel W et al. High precision measurement of electrical resistance across endothelial cell monolayers. 1995 Pflugers Arch. pmid:7667075
Ohbayashi H and Yamaki KI Both inhalant and intravenous uroguanylin inhibit leukotriene C4-induced airway changes. 2000 Peptides pmid:11068092
Ohtsuka Y et al. Chronic oral antigen exposure induces lymphocyte migration in anaphylactic mouse intestine. 1998 Pediatr. Res. pmid:9803464
Ohtsuka Y et al. Reducing cell membrane n-6 fatty acids attenuate mucosal damage in food-sensitive enteropathy in mice. 1997 Pediatr. Res. pmid:9396566
Mayatepek E et al. Impaired synthesis of lipoxygenase products in glutathione synthetase deficiency. 1994 Pediatr. Res. pmid:8190517
Yakubu MA et al. Hematoma-induced enhanced cerebral vasoconstrictions to leukotriene C4 and endothelin-1 in piglets: role of prostanoids. 1995 Pediatr. Res. pmid:7478789
Pintos-Morell G et al. Altered leukotriene generation in leukocytes from cystinotic children. 1994 Pediatr. Res. pmid:7877883
Shimizu T et al. Inhibitory effects of theophylline, terbutaline, and hydrocortisone on leukotriene B4 and C4 generation by human leukocytes in vitro. 1994 Pediatr. Pulmonol. pmid:7800427
Matsuo M et al. Leukotriene B4 and C4 in cerebrospinal fluid from children with meningitis and febrile seizures. 1996 Pediatr. Neurol. pmid:8703223
Hsieh KH Evaluation of efficacy of traditional Chinese medicines in the treatment of childhood bronchial asthma: clinical trial, immunological tests and animal study. Taiwan Asthma Study Group. 1996 Pediatr Allergy Immunol pmid:9116877
Shimizu T et al. Leukotriene B4 and C4 generation by blood leukocytes after ex vivo stimulation by Ca-ionophore and opsonized zymosan in children with atopic dermatitis. 1994 Pediatr Allergy Immunol pmid:8087194
Kopp MV et al. Omalizumab (Xolair) in children with seasonal allergic rhinitis: leukotriene release as a potential in vitro parameter to monitor therapeutic effects. 2007 Pediatr Allergy Immunol pmid:17680911
Kristjánsson S et al. Leukotriene B4 and C4 generation by human leukocytes after ex vivo stimulation with Ca-ionophore and opsonized zymosan in children with atopic asthma. 1995 Pediatr Allergy Immunol pmid:8750311
Mitsuhashi T et al. Increased production of eicosanoids, TXA2, PGI2 and LTC4 in experimental spinal cord injuries. 1994 Paraplegia pmid:7970857
Shimizu T et al. Effects of pancreatic and snake venom phospholipase A2 on the generation of leukotriene B4 and C4 by human leukocytes in vitro. 1994 Pancreas pmid:8108369
Lee JF et al. Lipoxygenase pathway mediates increases of airway resistance and lung inflation induced by exposure to nanotitanium dioxide in rats. 2014 Oxid Med Cell Longev pmid:24693335
Cyrus CB et al. Leukotrienes C4 and D4 increase the ciliary beat frequency in human upper airway mucosa in vitro. 1998 Otolaryngol Head Neck Surg pmid:9560097
Angi MR et al. [Quantitative evaluation of conjunctival irritation by simultaneous determination of histamine, serotonin and leukotriene C4 in tears]. 1987 Oct-Dec Ophtalmologie pmid:3153930
Sun H et al. Expression and characterization of the multidrug resistance-associated protein in insect cells infected with a recombinant baculovirus. 1996 Oncol. Res. pmid:8938792
Irkeç MT et al. Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers. 1999 Ocul. Immunol. Inflamm. pmid:10410873
Abe T et al. [Multidrug resistance protein (MRP)]. 1997 Nippon Rinsho pmid:9155156
Enomoto F et al. [Evaluation of arachidonic acid metabolites in experimental rat otitis media with effusion]. 1995 Nippon Jibiinkoka Gakkai Kaiho pmid:7629649
Takase B [Responses of plasma eicosanoids and hemodynamics to myocardial ischemia and the salutary effect of calcium entry blocker]. 1990 Nippon Ika Daigaku Zasshi pmid:2329180
Ono S et al. [Role of peptide leukotrienes in monocrotaline-induced lung disease]. 1995 Nihon Kyobu Shikkan Gakkai Zasshi pmid:8821996
Nishisho T et al. Experimental and clinical studies of eicosanoids in cerebrospinal fluid after spinal cord injury. 1996 Neurosurgery pmid:8905750
Athayde LA et al. Blocking central leukotrienes synthesis affects vasopressin release during sepsis. 2009 Neuroscience pmid:19285113
Mayatepek E et al. A severely affected infant with absence of cysteinyl leukotrienes in cerebrospinal fluid: further evidence that leukotriene C4-synthesis deficiency is a new neurometabolic disorder. 1999 Neuropediatrics pmid:10222453
Schuhmann MU et al. Temporal profiles of cerebrospinal fluid leukotrienes, brain edema and inflammatory response following experimental brain injury. 2003 Neurol. Res. pmid:12866196
Rao AM et al. Arachidonic acid and leukotriene C4: role in transient cerebral ischemia of gerbils. 1999 Neurochem. Res. pmid:10492517
Cortijo J et al. Bronchodilator and anti-inflammatory activities of SCA40: studies in human isolated bronchus, human eosinophils, and in the guinea-pig in vivo. 1997 Naunyn Schmiedebergs Arch. Pharmacol. pmid:9453467
Frieling T et al. Leukotriene-evoked cyclic chloride secretion is mediated by enteric neuronal modulation in guinea-pig colon. 1997 Naunyn Schmiedebergs Arch. Pharmacol. pmid:9151302
Schuligoi R et al. Release of calcitonin gene-related peptide in cardiac anaphylaxis. 1997 Naunyn Schmiedebergs Arch. Pharmacol. pmid:9050016
Ng SW et al. Cysteinyl leukotriene type I receptor desensitization sustains Ca2+-dependent gene expression. 2012 Nature pmid:22230957
Lynch KR et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. 1999 Nature pmid:10391245
Karasuyama H et al. Newly discovered roles for basophils: a neglected minority gains new respect. 2009 Nat. Rev. Immunol. pmid:19039320
Wijnholds J et al. Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. 1997 Nat. Med. pmid:9359705
Dvash E et al. Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage. 2015 Nat Commun pmid:26656251
Stride BD et al. Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. 1997 Mol. Pharmacol. pmid:9281595
Yan D et al. Differential signaling of cysteinyl leukotrienes and a novel cysteinyl leukotriene receptor 2 (CysLT₂) agonist, N-methyl-leukotriene C₄, in calcium reporter and β arrestin assays. 2011 Mol. Pharmacol. pmid:21078884
Leslie EM et al. Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids. 2001 Mol. Pharmacol. pmid:11306701
Ren XQ et al. Function of the ABC signature sequences in the human multidrug resistance protein 1. 2004 Mol. Pharmacol. pmid:15155846
Rothnie A et al. Mechanistic differences between GSH transport by multidrug resistance protein 1 (MRP1/ABCC1) and GSH modulation of MRP1-mediated transport. 2008 Mol. Pharmacol. pmid:18768387
Findlay VJ et al. Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug. 2004 Mol. Pharmacol. pmid:15102935
Sumizawa T et al. Reversal of multidrug resistance-associated protein-mediated drug resistance by the pyridine analog PAK-104P. 1997 Mol. Pharmacol. pmid:9058594
Capra V et al. Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma. 1998 Mol. Pharmacol. pmid:9547367
Kargman S et al. Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells. 1994 Mol. Pharmacol. pmid:8190095
Sarau HM et al. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. 1999 Mol. Pharmacol. pmid:10462554
Okumura H et al. Reversal of P-glycoprotein and multidrug-resistance protein-mediated drug resistance in KB cells by 5-O-benzoylated taxinine K. 2000 Mol. Pharmacol. pmid:11093797
Van Aubel RA et al. Mechanisms and interaction of vinblastine and reduced glutathione transport in membrane vesicles by the rabbit multidrug resistance protein Mrp2 expressed in insect cells. 1999 Mol. Pharmacol. pmid:10496953
Nothacker HP et al. Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. 2000 Mol. Pharmacol. pmid:11093801
Chen ZS et al. Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). 2005 Mol. Pharmacol. pmid:15537867