LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Neointima D058426 3 associated lipids
Asbestosis D001195 8 associated lipids
Phlebitis D010689 1 associated lipids
Picornaviridae Infections D010850 4 associated lipids
Eosinophilic Esophagitis D057765 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Authors Title Published Journal PubMed Link
Fujii R et al. Adenosine triphosphate-dependent transport of leukotriene C4 by membrane vesicles prepared from cisplatin-resistant human epidermoid carcinoma tumor cells. 1994 J. Natl. Cancer Inst. pmid:7966417
Leier I et al. The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. 1994 J. Biol. Chem. pmid:7961706
Böhme M et al. ATP-dependent export pumps and their inhibition by cyclosporins. 1994 Adv. Enzyme Regul. pmid:7942282
Black KL et al. Enzymatic barrier protects brain capillaries from leukotriene C4. 1994 J. Neurosurg. pmid:7931622
Volland H et al. Enzyme immunometric assay for leukotriene C4. 1994 J. Immunol. Methods pmid:7930643
Anwar AR et al. Adhesion to fibronectin primes eosinophils via alpha 4 beta 1 (VLA-4). 1994 Immunology pmid:7927493
Matsumoto T et al. Effects of diet on experimentally induced intestinal ulcers in rats: morphology and tissue leukotrienes. 1994 Gut pmid:7926906
Büchler M et al. Functional reconstitution of ATP-dependent transporters from the solubilized hepatocyte canalicular membrane. 1994 Eur. J. Biochem. pmid:7925347
Leff AR Inflammatory mediation of airway hyperresponsiveness by peripheral blood granulocytes. The case for the eosinophil. 1994 Chest pmid:7924496
Ducep JB et al. Synthesis of 5- and 6-fluoro derivatives of 5,8,14-eicosatrienoic and 5,8,11,14-eicosatetraenoic acids. Effects of fluorinated arachidonic acids on leukotriene C4 production by macrophages. 1994 Bioorg. Med. Chem. pmid:7922133
Ohemeng KA et al. Novel bishydroxamic acids as 5-lipoxygenase inhibitors. 1994 Bioorg. Med. Chem. pmid:7922131
Kapuściński A Leukotriene C4 in the rat brain after resuscitation from clinical death. 1994 Folia Neuropathol pmid:7922113
Jedlitschky G et al. ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. 1994 Cancer Res. pmid:7915193
Thioudellet C et al. Molecular and functional characterization of recombinant human gamma-glutamyltransferase. Coupling of its activity to glutathione levels in V79 cells. 1994 Eur. J. Biochem. pmid:7913033
Ohtsuki T et al. Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain. 1995 Am. J. Physiol. pmid:7900879
Kawana S and Nishiyama S Pustular psoriasis and aseptic purulent arthritis: possible role of leukotrienes B4 and C4 in a flare of synovitis. 1995 Dermatology (Basel) pmid:7894093
Scadding GK et al. Effect of short-term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge. 1994 Br J Clin Pharmacol pmid:7893587
Mita H and Shida T Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes. 1995 Arzneimittelforschung pmid:7893266
Tsai JJ et al. Relationship between nasal resistance and airway hyperreactivity following nasal provocation with Dermatophagoides pteronyssinus in allergic rhinitis. 1995 Int. Arch. Allergy Immunol. pmid:7888791
Wang D et al. Correlations between complaints, inflammatory cells and mediator concentrations in nasal secretions after nasal allergen challenge and during natural allergen exposure. 1995 Int. Arch. Allergy Immunol. pmid:7888790
Kawashima T et al. [Inhibitory effect of AS-35. a novel antiallergic drug, on chemical mediator release from human eosinophils]. 1994 Arerugi pmid:7887808
Restrick LJ et al. Reduction in leukotriene B4 generation by bronchoalveolar lavage cells in asthma. 1995 Thorax pmid:7886653
Yamaya M et al. Epithelial modulation of leukotriene-C4-induced human tracheal smooth muscle contraction. 1995 Am. J. Respir. Crit. Care Med. pmid:7881688
Pintos-Morell G et al. Altered leukotriene generation in leukocytes from cystinotic children. 1994 Pediatr. Res. pmid:7877883
Ganbo T et al. Inhibition of mucociliary clearance of the eustachian tube by leukotrienes C4 and D4. 1995 Ann. Otol. Rhinol. Laryngol. pmid:7872607
Enderle GJ et al. Different pathomechanisms of altered biliary leukotriene C4 elimination in isolated perfused rat livers. 1995 Biochem. Pharmacol. pmid:7857316
Petric R and Ford-Hutchinson AW Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis. 1994 Kidney Int. pmid:7853790
Schuil PJ et al. Histamine and leukotriene C4 effects on in vitro ciliary beat frequency of human upper respiratory cilia. 1994 Eur Arch Otorhinolaryngol pmid:7848641
Liu L et al. Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum. 1994 Arzneimittelforschung pmid:7848335
HasanoÄŸlu E et al. The role of prostanoids in the complications of extracorporeal shock wave lithotripsy (ESWL) in children. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7846111
Hubbard NE and Erickson KL Role of 5'-lipoxygenase metabolites in the activation of peritoneal macrophages for tumoricidal function. 1995 Cell. Immunol. pmid:7842477
Kurosawa M et al. Inhibition by a novel peptide leukotriene receptor antagonist ONO-1078 of airway wall thickening and airway hyperresponsiveness to histamine induced by leukotriene C4 or leukotriene D4 in guinea-pigs. 1994 Clin. Exp. Allergy pmid:7842366
Brady HR et al. Lipoxygenase product formation and cell adhesion during neutrophil-glomerular endothelial cell interaction. 1995 Am. J. Physiol. pmid:7840235
Petric R et al. Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis. 1995 Biochim. Biophys. Acta pmid:7827126
Wang D et al. Concentrations of chemical mediators in nasal secretions of patients with hay fever during natural allergen exposure. 1994 Acta Otolaryngol. pmid:7825440
Willburger RE and Wittenberg RH Prostaglandin release from lumbar disc and facet joint tissue. 1994 Spine pmid:7825047
Currie S et al. Phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in MCII mast cells mediated by high-affinity Fc receptor for IgE. 1994 Biochem. J. pmid:7818499
Müller M et al. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:7809167
Goulet JL et al. Altered inflammatory responses in leukotriene-deficient mice. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:7809134
Shimizu T et al. Inhibitory effects of theophylline, terbutaline, and hydrocortisone on leukotriene B4 and C4 generation by human leukocytes in vitro. 1994 Pediatr. Pulmonol. pmid:7800427
Gorenne I et al. Antagonism of leukotriene responses in human airways by BAY x7195. 1995 Eur. J. Pharmacol. pmid:7796856
Ramondt J et al. Sensitivity of ovine myometrial tissue to various eicosanoids in vitro. 1995 Prostaglandins pmid:7792392
Ju HR et al. Systemic release of mucosal mast-cell protease in primed brown Norway rats after feeding with beta-lactoglobulin. 1995 Biosci. Biotechnol. Biochem. pmid:7787291
Gorenne I et al. Effects of beta 2-adrenoceptor agonists on anti-IgE-induced contraction and smooth muscle reactivity in human airways. 1995 Br. J. Pharmacol. pmid:7780648
Kimura Y et al. Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. 1995 J Ethnopharmacol pmid:7776662
Keppler D et al. Transport and metabolism of leukotrienes. 1994 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:7771352
Gardiner PJ et al. Leukotriene receptors and their selective antagonists. 1994 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:7771349
Busse WW and Sedgwick JB Eosinophil eicosanoid relations in allergic inflammation of the airways. 1994 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:7771338
Rodríguez-Ortigosa CM et al. Taurocholate-stimulated leukotriene C4 biosynthesis and leukotriene C4-stimulated choleresis in isolated rat liver. 1995 Gastroenterology pmid:7768385
Porreca E et al. Modulation of rat vascular smooth muscle cell (VSMC) proliferation by cysteinyl leukotriene D4: a role for mediation of interleukin 1. 1995 Atherosclerosis pmid:7755646
Lam BK et al. Expression cloning of human LTC4 synthase. 1995 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:7732869
Schauer U et al. Blood eosinophils, leukotriene C4 generation, and bronchial hyperreactivity in formerly preterm infants. 1994 Arch. Dis. Child. pmid:7726609
Kita H et al. Eosinophil major basic protein induces degranulation and IL-8 production by human eosinophils. 1995 J. Immunol. pmid:7722326
Nishikawa M et al. Effect of leukotriene C4D4 antagonist on colonic damage induced by intracolonic administration of trinitrobenzene sulfonic acid in rats. 1995 J. Gastroenterol. pmid:7719412
Georgitis JW et al. Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. 1995 Int. Arch. Allergy Immunol. pmid:7719157
Cruz JR et al. Fecal excretion of leukotriene C4 during human disease due to Shigella dysenteriae. 1995 J. Pediatr. Gastroenterol. Nutr. pmid:7714683
Tudhope SR et al. BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes. 1994 Eur. J. Pharmacol. pmid:7698171
Zuany-Amorim C et al. Characterization and pharmacological modulation of antigen-induced peritonitis in actively sensitized mice. 1993 Br. J. Pharmacol. pmid:7694762
Westcott JY et al. Inactivation of leukotriene C4 in the airways and subsequent urinary leukotriene E4 excretion in normal and asthmatic subjects. 1993 Am. Rev. Respir. Dis. pmid:7694531
Patella V et al. Protein Fv produced during vital hepatitis is a novel activator of human basophils and mast cells. 1993 J. Immunol. pmid:7693815
Westcott JY et al. Inactivation of peptidoleukotrienes in the isolated perfused rat lung. 1993 Arch. Biochem. Biophys. pmid:7692821
Katori M et al. Interaction of substance P and leukotriene C4 in ethanol-induced mucosal injury of rat stomach. 1993 Regul. Pept. pmid:7692504
Tschugguel W et al. High precision measurement of electrical resistance across endothelial cell monolayers. 1995 Pflugers Arch. pmid:7667075
Van Dijk JP et al. Nicotine inhibits cytokine synthesis by mouse colonic mucosa. 1995 Eur. J. Pharmacol. pmid:7664807
Gimpel JA et al. Reduction of reperfusion injury of human myocardium by allopurinol: a clinical study. 1995 Free Radic. Biol. Med. pmid:7649495
Sun J and Herman CA Cardiovascular effects of N-methyl leukotriene C4, a nonmetabolizable leukotriene C4 analogue, and the antagonism of leukotriene-induced hypotension by Ro 23-3544, in the American bullfrog, Rana catesbeiana. 1995 Can. J. Physiol. Pharmacol. pmid:7648518
Iwamoto I et al. Effect of a selective thromboxane A2 receptor antagonist BAY u3405 on antigen-, leukotriene C4- and leukotriene D4-induced bronchoconstriction in guinea pigs. 1995 Int. Arch. Allergy Immunol. pmid:7647588
Juergens UR et al. Inhibition of monocyte leukotriene B4 production after aspirin desensitization. 1995 J. Allergy Clin. Immunol. pmid:7636051
Enomoto F et al. [Evaluation of arachidonic acid metabolites in experimental rat otitis media with effusion]. 1995 Nippon Jibiinkoka Gakkai Kaiho pmid:7629649
Szarek JL and Valentovic MA Release of prostaglandin E2 and leukotriene C4/D4 from airway segments isolated from rats after exposure to ozone for 20 months. 1995 Toxicology pmid:7624868
Janssen-Timmen U et al. Expression of 5-lipoxygenase in differentiating human skin keratinocytes. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7624354
Sun J and Herman CA The American bullfrog (Rana catesbeiana) exhibits differential cardiovascular responses to LTC4 after short- and long-term cold exposure. 1995 Gen. Comp. Endocrinol. pmid:7622015
Romanelli F et al. Arachidonic acid and its metabolites effects on testosterone production by rat Leydig cells. 1995 J. Endocrinol. Invest. pmid:7615904
Austen KF The Paul Kallós Memorial Lecture. From slow-reacting substance of anaphylaxis to leukotriene C4 synthase. 1995 May-Jun Int. Arch. Allergy Immunol. pmid:7613129
Fiorucci S et al. Effect of NSAIDs on pepsinogen secretion and calcium mobilization in isolated chief cells. 1995 Am. J. Physiol. pmid:7611418
Utoh J et al. Is an increase in neutrophil leukotriene-generating capacity a specific phenomenon for cardiopulmonary bypass? 1995 J. Thorac. Cardiovasc. Surg. pmid:7609558
Schauer U et al. Blood eosinophils, eosinophil-derived proteins, and leukotriene C4 generation in relation to bronchial hyperreactivity in children with atopic dermatitis. 1995 Allergy pmid:7604934
Wettstein M et al. Metabolism of cysteinyl leukotrienes in the perfused rat liver: the influence of endotoxin pretreatment and the cellular hydration state. 1995 Hepatology pmid:7601416
Hom JT et al. The amyloidogenic peptide human amylin augments the inflammatory activities of eosinophils. 1995 J. Leukoc. Biol. pmid:7595053
Karmeli F et al. A stable nitroxide radical effectively decreases mucosal damage in experimental colitis. 1995 Gut pmid:7590435
Sala A and Folco G LTC4 in normal urine. 1995 Eur. J. Clin. Invest. pmid:7589021
Sengör T et al. Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. 1995 CLAO J pmid:7586473
Datta YH et al. Peptido-leukotrienes are potent agonists of von Willebrand factor secretion and P-selectin surface expression in human umbilical vein endothelial cells. 1995 Circulation pmid:7586318
Takagi S et al. The pathophysiological roles of heterogeneous eosinophils in allergic rhinitis caused by house dust mites. 1995 Biochem. Mol. Biol. Int. pmid:7581000
Zuberbier T et al. Gangliosides enhance IgE receptor-dependent histamine and LTC4 release from human mast cells. 1995 Biochim. Biophys. Acta pmid:7578275
Shindo K et al. In vivo effect of prednisolone on release of leukotriene C4 in eosinophils obtained from asthmatic patients. 1995 Biochem. Biophys. Res. Commun. pmid:7575557
Prié S et al. Leukotriene C4 receptors on guinea pig tracheocytes. 1995 J. Pharmacol. Exp. Ther. pmid:7562565
Mayer R et al. Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. 1995 J. Cell Biol. pmid:7559771
Murakami M et al. Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells. 1995 J. Biol. Chem. pmid:7559381
Low J et al. Cytoprotective effects of CI-959 in the rat gastric mucosa: modulation of leukocyte adhesion. 1995 Gastroenterology pmid:7557089
Kanwar S et al. Leukotriene C4/D4 induces P-selectin and sialyl Lewis(x)-dependent alterations in leukocyte kinetics in vivo. 1995 Circ. Res. pmid:7554141
Franco L and Velo GP Eicosanoid and gastroprotection by copper derivatives and NDGA. 1995 Inflamm. Res. pmid:7552579
Inoue H et al. Inhibition by actinomycin D of neurogenic mouse ear oedema. 1995 Inflamm. Res. pmid:7552577
Yoshida K et al. Effect of fibronectin on the production of leukotriene C4 by eosinophils. 1995 Int. Arch. Allergy Immunol. pmid:7549524
Takafuji S et al. Effects of physiologic soluble agonists on leukotriene C4 production and degranulation by human eosinophils. 1995 Int. Arch. Allergy Immunol. pmid:7549519
Meier HL et al. Simultaneous initiation of degranulation and inhibition of leukotriene release by soman in human basophils. 1995 Int. J. Immunopharmacol. pmid:7545649
Engin A et al. The protective effect of thromboxane synthetase inhibitor UK 38485 against bile duct ligation induced liver injury. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7544015
Sarmiento EU et al. IL-3, IL-5, and granulocyte-macrophage colony-stimulating factor potentiate basophil mediator release stimulated by eosinophil granule major basic protein. 1995 J. Immunol. pmid:7543541
Nagata M et al. Eosinophil adhesion to vascular cell adhesion molecule-1 activates superoxide anion generation. 1995 J. Immunol. pmid:7543540
Marone G et al. Human heart mast cells in anaphylaxis and cardiovascular disease. 1995 May-Jun Int. Arch. Allergy Immunol. pmid:7542106