| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neointima | D058426 | 3 associated lipids |
| Asbestosis | D001195 | 8 associated lipids |
| Phlebitis | D010689 | 1 associated lipids |
| Picornaviridae Infections | D010850 | 4 associated lipids |
| Eosinophilic Esophagitis | D057765 | 3 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Randolph GJ et al. | Factors and signals that govern the migration of dendritic cells via lymphatics: recent advances. | 2005 | Springer Semin. Immunopathol. | pmid:15338191 |
| Son JK et al. | Ginkgetin, a Biflavone from Ginko biloba leaves, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | 2005 | Biol. Pharm. Bull. | pmid:16327145 |
| Mayatepek E et al. | A patient with neurological symptoms and abnormal leukotriene metabolism: a new defect in leukotriene biosynthesis. | 2005 | Ann. Neurol. | pmid:16315285 |
| Ichiyama T et al. | Cysteinyl leukotrienes induce monocyte chemoattractant protein 1 in human monocytes/macrophages. | 2005 | Clin. Exp. Allergy | pmid:16164450 |
| Hilberg T et al. | Transcription in response to physical stress--clues to the molecular mechanisms of exercise-induced asthma. | 2005 | FASEB J. | pmid:16027142 |
| Payen L et al. | Functional interactions between nucleotide binding domains and leukotriene C4 binding sites of multidrug resistance protein 1 (ABCC1). | 2005 | Mol. Pharmacol. | pmid:15755910 |
| Reims A et al. | Cysteinyl leukotrienes are secretagogues in atrophic coeliac and in normal duodenal mucosa of children. | 2005 | Scand. J. Gastroenterol. | pmid:15764146 |
| Lai YL and Lin TY | Mast cells in citric acid-induced cough of guinea pigs. | 2005 | Toxicol. Appl. Pharmacol. | pmid:15589973 |
| Karwatsky J et al. | The leucotriene C4 binding sites in multidrug resistance protein 1 (ABCC1) include the first membrane multiple spanning domain. | 2005 | Biochemistry | pmid:15628876 |
| Kowalski ML et al. | Inhibition of nasal polyp mast cell and eosinophil activation by desloratadine. | 2005 | Allergy | pmid:15575935 |
| Trandafir CC et al. | Cysteinyl leukotrienes and leukotriene B mediate vasoconstriction to arginine vasopressin in rat basilar artery. | 2005 | Clin. Exp. Pharmacol. Physiol. | pmid:16445567 |
| Ninomiya M et al. | Functional analysis of dog multidrug resistance-associated protein 2 (Mrp2) in comparison with rat Mrp2. | 2005 | Drug Metab. Dispos. | pmid:15507541 |
| Chen ZS et al. | Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). | 2005 | Mol. Pharmacol. | pmid:15537867 |
| Rossi A et al. | Up-regulation of prostaglandin biosynthesis by leukotriene C4 in elicited mice peritoneal macrophages activated with lipopolysaccharide/interferon-{gamma}. | 2005 | J. Leukoc. Biol. | pmid:16046553 |
| Vilariño N et al. | Acute IL-3 priming up-regulates the stimulus-induced Raf-1-Mek-Erk cascade independently of IL-3-induced activation of Erk. | 2005 | J. Immunol. | pmid:16116188 |
| Noguchi T et al. | MRP1 mutated in the L0 region transports SN-38 but not leukotriene C4 or estradiol-17 (beta-D-glucuronate). | 2005 | Biochem. Pharmacol. | pmid:16098482 |
| Conseil G et al. | Role of two adjacent cytoplasmic tyrosine residues in MRP1 (ABCC1) transport activity and sensitivity to sulfonylureas. | 2005 | Biochem. Pharmacol. | pmid:15652236 |
| John AE et al. | Temporal production of CCL28 corresponds to eosinophil accumulation and airway hyperreactivity in allergic airway inflammation. | 2005 | Am. J. Pathol. | pmid:15681819 |
| Cruse G et al. | Activation of human lung mast cells by monomeric immunoglobulin E. | 2005 | Eur. Respir. J. | pmid:15863643 |
| Ito K et al. | Mrp2/Abcc2 transport activity is stimulated by protein kinase Calpha in a baculo virus co-expression system. | 2005 | Life Sci. | pmid:15904671 |
| Rossi MI et al. | Long-term exacerbation by interleukin 13 of IgE-mediated eosinophilia in rats. | 2005 | Int. Immunopharmacol. | pmid:15953562 |
| Oskeritzian CA et al. | Surface CD88 functionally distinguishes the MCTC from the MCT type of human lung mast cell. | 2005 | J. Allergy Clin. Immunol. | pmid:15940129 |
| Nunomura S et al. | Role of the FcepsilonRI beta-chain ITAM as a signal regulator for mast cell activation with monomeric IgE. | 2005 | Int. Immunol. | pmid:15944196 |
| Vieira-de-Abreu A et al. | Allergic challenge-elicited lipid bodies compartmentalize in vivo leukotriene C4 synthesis within eosinophils. | 2005 | Am. J. Respir. Cell Mol. Biol. | pmid:15947420 |
| Campbell JD et al. | Molecular modeling correctly predicts the functional importance of Phe594 in transmembrane helix 11 of the multidrug resistance protein, MRP1 (ABCC1). | 2004 | J. Biol. Chem. | pmid:14561746 |
| Zhao Q and Chang XB | Mutation of the aromatic amino acid interacting with adenine moiety of ATP to a polar residue alters the properties of multidrug resistance protein 1. | 2004 | J. Biol. Chem. | pmid:15355964 |
| Furumoto Y et al. | The FcepsilonRIbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production. | 2004 | J. Biol. Chem. | pmid:15355979 |
| Hamilton RG and Franklin Adkinson N | In vitro assays for the diagnosis of IgE-mediated disorders. | 2004 | J. Allergy Clin. Immunol. | pmid:15316492 |
| Ko JK et al. | Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis. | 2004 | World J. Gastroenterol. | pmid:15300893 |
| Morii E and Oboki K | MITF is necessary for generation of prostaglandin D2 in mouse mast cells. | 2004 | J. Biol. Chem. | pmid:15375155 |
| Tarnay JN et al. | The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance-associated protein family. | 2004 | Insect Mol. Biol. | pmid:15373810 |
| Situ D et al. | Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter. | 2004 | J. Biol. Chem. | pmid:15208328 |
| Mayatepek E et al. | Acute metabolic crisis with extreme deficiency of glutathione in combination with decreased levels of leukotriene C4 in a patient with glutathione synthetase deficiency. | 2004 | J. Inherit. Metab. Dis. | pmid:15243994 |
| Rigato I et al. | The human multidrug-resistance-associated protein MRP1 mediates ATP-dependent transport of unconjugated bilirubin. | 2004 | Biochem. J. | pmid:15245331 |
| Piette V et al. | Sinus CT scans and mediator release in nasal secretions after nasal challenge with cypress pollens. | 2004 | Allergy | pmid:15230820 |
| Hirouchi M et al. | Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2. | 2004 | Pharm. Res. | pmid:15180328 |
| Hirano T et al. | Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils. | 2004 | Int. Arch. Allergy Immunol. | pmid:15153793 |
| Ren XQ et al. | Function of the ABC signature sequences in the human multidrug resistance protein 1. | 2004 | Mol. Pharmacol. | pmid:15155846 |
| Dimova-Yaneva D et al. | Eosinophil activation and cysteinyl leukotriene production in infants with respiratory syncytial virus bronchiolitis. | 2004 | Clin. Exp. Allergy | pmid:15080807 |
| Mandal AK et al. | The membrane organization of leukotriene synthesis. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15084748 |
| Findlay VJ et al. | Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug. | 2004 | Mol. Pharmacol. | pmid:15102935 |
| Chang WC and Parekh AB | Close functional coupling between Ca2+ release-activated Ca2+ channels, arachidonic acid release, and leukotriene C4 secretion. | 2004 | J. Biol. Chem. | pmid:15133023 |
| Mayatepek E et al. | Synthesis and metabolism of leukotrienes in gamma-glutamyl transpeptidase deficiency. | 2004 | J. Lipid Res. | pmid:14754911 |
| Takala RS et al. | Pulmonary inflammatory mediators after sevoflurane and thiopentone anaesthesia in pigs. | 2004 | Acta Anaesthesiol Scand | pmid:14674972 |
| Satake Y et al. | Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption. | 2004 | J. Biol. Chem. | pmid:14761945 |
| Ito R et al. | [Effect of pranlukast on histamine release and leukotriene c4 (ltc4) generation from human peripheral basophils]. | 2004 | Arerugi | pmid:14762327 |
| Woolhiser MR et al. | Activation of human mast cells by aggregated IgG through FcgammaRI: additive effects of C3a. | 2004 | Clin. Immunol. | pmid:15003814 |
| Ramires R et al. | Novel inhibitory effect on 5-lipoxygenase activity by the anti-asthma drug montelukast. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15474500 |
| Mitsunobu F et al. | Influence of long-term cigarette smoking on immunoglobulin E-mediated allergy, pulmonary function, and high-resolution computed tomography lung densitometry in elderly patients with asthma. | 2004 | Clin. Exp. Allergy | pmid:14720263 |
| Trompier D et al. | Verapamil and its derivative trigger apoptosis through glutathione extrusion by multidrug resistance protein MRP1. | 2004 | Cancer Res. | pmid:15256468 |
| Hui Y et al. | Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic blood pressure. | 2004 | Circulation | pmid:15545522 |
| DÃaz AM et al. | Phenylpropanoid glycosides from Scrophularia scorodonia: in vitro anti-inflammatory activity. | 2004 | Life Sci. | pmid:15010262 |
| Koike K et al. | Mapping of the MRPm5 epitope to the cytosolic region between transmembrane helices 13 and 14 in the drug and organic anion transporter, MRP1 (ABCC1). | 2004 | Biochem. Biophys. Res. Commun. | pmid:14975760 |
| Westlake CJ et al. | Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region. | 2004 | J. Biol. Chem. | pmid:15459206 |
| Sharma R et al. | RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance. | 2004 | Int. J. Cancer | pmid:15386349 |
| Karimi K et al. | Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells. | 2004 | Eur. J. Pharmacol. | pmid:15063154 |
| Lam BK | Leukotriene C(4) synthase. | 2003 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12895593 |
| Bandeira-Melo C and Weller PF | Eosinophils and cysteinyl leukotrienes. | 2003 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12895596 |
| Vargaftig BB and Singer M | Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12654629 |
| Zhu X et al. | Structural determinants of blockade of eosinophil activation, adhesion and secretion by synthetic analogs of phomactin. | 2003 | Life Sci. | pmid:14519449 |
| Westlake CJ et al. | Identification of the structural and functional boundaries of the multidrug resistance protein 1 cytoplasmic loop 3. | 2003 | Biochemistry | pmid:14640677 |
| Shon YH and Nam KS | Protective effect of Astragali radix extract on interleukin 1beta-induced in fl ammation in human amnion. | 2003 | Phytother Res | pmid:14595579 |
| Myou S et al. | Activation of group IV cytosolic phospholipase A2 in human eosinophils by phosphoinositide 3-kinase through a mitogen-activated protein kinase-independent pathway. | 2003 | J. Immunol. | pmid:14530366 |
| Gentile DA et al. | Elevations of local leukotriene C4 levels during viral upper respiratory tract infections. | 2003 | Ann. Allergy Asthma Immunol. | pmid:14533659 |
| Krasnowska M and Medrala W | [Effect of IFN-gamma on IGE dependent leukotriene generation by peripheral blood leukocytes in patients with chronic allergic rhinitis in vitro]. | 2003 | Pneumonol Alergol Pol | pmid:14587429 |
| Chen YH et al. | IFN-alpha inhibits IL-3 priming of human basophil cytokine secretion but not leukotriene C4 and histamine release. | 2003 | J. Allergy Clin. Immunol. | pmid:14610485 |
| Deng YM et al. | Coincidental increase of leukotriene B4 between cerebral cortex and lung tissue of sensitized rats. | 2003 | Acta Pharmacol. Sin. | pmid:14531949 |
| Shimizu T et al. | Effects of n-3 polyunsaturated fatty acids on indomethacin-induced changes in eicosanoid production and blood flow in the gastric mucosa of rats. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878448 |
| Keitel V et al. | A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2). | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12388192 |
| Schuhmann MU et al. | Temporal profiles of cerebrospinal fluid leukotrienes, brain edema and inflammatory response following experimental brain injury. | 2003 | Neurol. Res. | pmid:12866196 |
| Lee SH and Altenberg GA | Transport of leukotriene C4 by a cysteine-less multidrug resistance protein 1 (MRP1). | 2003 | Biochem. J. | pmid:12398766 |
| Llupià J et al. | Comparative antiallergic effects of second-generation H1-antihistamines ebastine, cetirizine and loratadine in preclinical models. | 2003 | Arzneimittelforschung | pmid:12642964 |
| Skarzynski DJ et al. | Roles of tumor necrosis factor-alpha of the estrous cycle in cattle: an in vivo study. | 2003 | Biol. Reprod. | pmid:12904309 |
| Triggiani M et al. | Secretory phospholipases A2 activate selective functions in human eosinophils. | 2003 | J. Immunol. | pmid:12626587 |
| Yang R et al. | ATP binding to the first nucleotide binding domain of multidrug resistance-associated protein plays a regulatory role at low nucleotide concentration, whereas ATP hydrolysis at the second plays a dominant role in ATP-dependent leukotriene C4 transport. | 2003 | J. Biol. Chem. | pmid:12783859 |
| Muñoz NM et al. | Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils. | 2003 | J. Biol. Chem. | pmid:12796497 |
| Dallaire MJ et al. | Endothelial cells modulate eosinophil surface markers and mediator release. | 2003 | Eur. Respir. J. | pmid:12797482 |
| Cai Y et al. | Bronchial mast cells are the dominating LTC4S-expressing cells in aspirin-tolerant asthma. | 2003 | Am. J. Respir. Cell Mol. Biol. | pmid:12816731 |
| Miller LA et al. | Glutathione, S-substituted glutathiones, and leukotriene C4 as substrates for peptidylglycine alpha-amidating monooxygenase. | 2003 | Arch. Biochem. Biophys. | pmid:12646261 |
| Strait RT et al. | IL-4 exacerbates anaphylaxis. | 2003 | J. Immunol. | pmid:12646651 |
| Fujisaki T et al. | Bestatin selectively suppresses the growth of leukemic stem/progenitor cells with BCR/ABL mRNA transcript in patients with chronic myelogeneous leukemia. | 2003 | Int. Immunopharmacol. | pmid:12781706 |
| Arumugam TV et al. | Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. | 2003 | Br. J. Pharmacol. | pmid:12967936 |
| Zhang DW et al. | Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state. | 2003 | J. Biol. Chem. | pmid:12954620 |
| Chen ZS et al. | Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). | 2003 | Mol. Pharmacol. | pmid:12527806 |
| Lee TK et al. | N-glycosylation controls functional activity of Oatp1, an organic anion transporter. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12702494 |
| Tedla N et al. | Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12529506 |
| Liu P et al. | Cysteinyl leukotriene-dependent [Ca2+]i responses to angiotensin II in cardiomyocytes. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12531730 |
| Venkatachalam TK et al. | Inhibition of mast cell leukotriene release by thiourea derivatives. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12565956 |
| Kwak WJ et al. | Papyriflavonol A from Broussonetia papyrifera inhibits the passive cutaneous anaphylaxis reaction and has a secretory phospholipase A2-inhibitory activity. | 2003 | Biol. Pharm. Bull. | pmid:12612436 |
| Plath KE et al. | Calcineurin antagonists differentially affect mediator secretion, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases from immunologically activated human basophils. | 2003 | Clin. Exp. Allergy | pmid:12614449 |
| Venkatachalam TK et al. | Substituted heterocyclic thiourea compounds as a new class of anti-allergic agents inhibiting IgE/Fc epsilon RI receptor mediated mast cell leukotriene release. | 2003 | Bioorg. Med. Chem. | pmid:12614897 |
| Hattori T et al. | Effects of H2O2 on membrane potential of smooth muscle cells in rabbit mesenteric resistance artery. | 2003 | Eur. J. Pharmacol. | pmid:12620501 |
| Söderström M et al. | Expression of leukotriene C4 synthase mRNA by the choroid plexus in mouse brain suggests novel neurohormone functions of cysteinyl leukotrienes. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12878209 |
| Zaitsu M et al. | Dexamethasone accelerates catabolism of leukotriene C4 in bronchial epithelial cells. | 2003 | Eur. Respir. J. | pmid:12882448 |
| Meliton AY et al. | Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils. | 2003 | J. Allergy Clin. Immunol. | pmid:12897749 |
| Ichiyama T et al. | Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells. | 2003 | Clin. Exp. Allergy | pmid:12801316 |
| Mizutani N | [Studies on the experimental allergic rhinitis induced by Japanese cedar pollen--role of cysteinyl leukotrienes in nasal allergic symptoms]. | 2003 | Yakugaku Zasshi | pmid:12607939 |
| Bouchelouche K et al. | The cysteinyl-leukotriene D4 induces cytosolic Ca2+ elevation and contraction of the human detrusor muscle. | 2003 | J. Urol. | pmid:12853847 |
| Mechiche H et al. | Effects of cysteinyl leukotrienes in small human bronchus and antagonist activity of montelukast and its metabolites. | 2003 | Clin. Exp. Allergy | pmid:12859443 |
| Nagase T et al. | A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12505870 |