| MeSH term | MeSH ID | Detail |
|---|---|---|
| Phlebitis | D010689 | 1 associated lipids |
| Pseudoxanthoma Elasticum | D011561 | 2 associated lipids |
| Hyperbilirubinemia, Hereditary | D006933 | 3 associated lipids |
| Cestode Infections | D002590 | 3 associated lipids |
| Neointima | D058426 | 3 associated lipids |
| Eosinophilic Esophagitis | D057765 | 3 associated lipids |
| Common Bile Duct Diseases | D003137 | 3 associated lipids |
| Status Asthmaticus | D013224 | 4 associated lipids |
| Wounds, Nonpenetrating | D014949 | 4 associated lipids |
| Picornaviridae Infections | D010850 | 4 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Qian YM et al. | Characterization of binding of leukotriene C4 by human multidrug resistance protein 1: evidence of differential interactions with NH2- and COOH-proximal halves of the protein. | 2001 | J. Biol. Chem. | pmid:11507101 |
| Bandeira-Melo C et al. | Extranuclear lipid bodies, elicited by CCR3-mediated signaling pathways, are the sites of chemokine-enhanced leukotriene C4 production in eosinophils and basophils. | 2001 | J. Biol. Chem. | pmid:11274187 |
| Zhang DW et al. | Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines. | 2001 | J. Biol. Chem. | pmid:11278596 |
| Ito K et al. | Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport. | 2001 | J. Biol. Chem. | pmid:11278867 |
| Puder M and Soberman RJ | Glutathione conjugates recognize the Rossmann fold of glyceraldehyde-3-phosphate dehydrogenase. | 1997 | J. Biol. Chem. | pmid:9099752 |
| Zhang DW et al. | Identification of a nonconserved amino acid residue in multidrug resistance protein 1 important for determining substrate specificity: evidence for functional interaction between transmembrane helices 14 and 17. | 2001 | J. Biol. Chem. | pmid:11429411 |
| Chang WC and Parekh AB | Close functional coupling between Ca2+ release-activated Ca2+ channels, arachidonic acid release, and leukotriene C4 secretion. | 2004 | J. Biol. Chem. | pmid:15133023 |
| Satake Y et al. | Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption. | 2004 | J. Biol. Chem. | pmid:14761945 |
| Iram SH and Cole SP | Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1). | 2012 | J. Biol. Chem. | pmid:22232552 |
| Sakamoto H et al. | Involvement of phospholipid hydroperoxide glutathione peroxidase in the modulation of prostaglandin D2 synthesis. | 2000 | J. Biol. Chem. | pmid:11010961 |
| Fernández SB et al. | Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells. | 2002 | J. Biol. Chem. | pmid:12060660 |
| Leslie EM et al. | Transport of the beta -O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog. | 2001 | J. Biol. Chem. | pmid:11375986 |
| He P et al. | Oxidative stress suppresses cysteinyl leukotriene generation by mouse bone marrow-derived mast cells. | 2011 | J. Biol. Chem. | pmid:21233206 |
| Koike K et al. | Multiple membrane-associated tryptophan residues contribute to the transport activity and substrate specificity of the human multidrug resistance protein, MRP1. | 2002 | J. Biol. Chem. | pmid:12388549 |
| Yang Y et al. | Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistance-associated protein 1. | 2002 | J. Biol. Chem. | pmid:12235150 |
| Büchler M et al. | cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. | 1996 | J. Biol. Chem. | pmid:8662992 |
| Wijewickrama GT et al. | Systematic evaluation of transcellular activities of secretory phospholipases A2. High activity of group V phospholipases A2 to induce eicosanoid biosynthesis in neighboring inflammatory cells. | 2006 | J. Biol. Chem. | pmid:16476735 |
| Leier I et al. | The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. | 1994 | J. Biol. Chem. | pmid:7961706 |
| Bannenberg G et al. | Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers. | 1999 | J. Biol. Chem. | pmid:9890956 |
| Perrotton T et al. | (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. | 2007 | J. Biol. Chem. | pmid:17646169 |
| Thompson C et al. | Signaling by the cysteinyl-leukotriene receptor 2. Involvement in chemokine gene transcription. | 2008 | J. Biol. Chem. | pmid:18048362 |
| Qian YM et al. | Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1. | 2001 | J. Biol. Chem. | pmid:11102445 |
| Murakami M et al. | Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms. | 2001 | J. Biol. Chem. | pmid:11106649 |
| Falcón-Pérez JM et al. | Functional domain analysis of the yeast ABC transporter Ycf1p by site-directed mutagenesis. | 1999 | J. Biol. Chem. | pmid:10438540 |
| Mao Q et al. | Functional reconstitution of substrate transport by purified multidrug resistance protein MRP1 (ABCC1) in phospholipid vesicles. | 2000 | J. Biol. Chem. | pmid:10942765 |
| Stride BD et al. | Localization of a substrate specificity domain in the multidrug resistance protein. | 1999 | J. Biol. Chem. | pmid:10428874 |
| Heise CE et al. | Characterization of the human cysteinyl leukotriene 2 receptor. | 2000 | J. Biol. Chem. | pmid:10851239 |
| Westlake CJ et al. | Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region. | 2004 | J. Biol. Chem. | pmid:15459206 |
| Hong JT et al. | Effect of phenobarbital and the peroxisome proliferator ciprofibrate on gamma-Glutamyltranspeptidase activity and leukotriene C4 concentration in cultured rat hepatocytes. | 1995 | J. Biochem. Toxicol. | pmid:8847705 |
| Ren XQ et al. | A functional role of intracellular loops of human multidrug resistance protein 1. | 2006 | J. Biochem. | pmid:16861249 |
| Falcón-Pérez JM et al. | Domain interactions in the yeast ATP binding cassette transporter Ycf1p: intragenic suppressor analysis of mutations in the nucleotide binding domains. | 2001 | J. Bacteriol. | pmid:11466279 |
| De Castro CM et al. | Modulation by dexamethasone of phospholipase A2 activities in endotoxemic guinea pigs. | 1995 | J. Appl. Physiol. | pmid:8567572 |
| Hevko JM and Murphy RC | Electrospray ionization and tandem mass spectrometry of cysteinyl eicosanoids: leukotriene C4 and FOG7. | 2001 | J. Am. Soc. Mass Spectrom. | pmid:11444597 |
| Devakumar A et al. | Structural analysis of leukotriene C4 isomers using collisional activation and 157 nm photodissociation. | 2008 | J. Am. Soc. Mass Spectrom. | pmid:18024058 |
| De Servi S et al. | Transcardiac release of leukotriene C4 by neutrophils in patients with coronary artery disease. | 1991 | J. Am. Coll. Cardiol. | pmid:2007712 |
| Olynych TJ et al. | Fungal zymosan induces leukotriene production by human mast cells through a dectin-1-dependent mechanism. | 2006 | J. Allergy Clin. Immunol. | pmid:17030235 |
| Yoshisue H et al. | Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts. | 2007 | J. Allergy Clin. Immunol. | pmid:17208594 |
| Lee KS et al. | Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice. | 2007 | J. Allergy Clin. Immunol. | pmid:17208595 |
| Hamilton RG and Franklin Adkinson N | In vitro assays for the diagnosis of IgE-mediated disorders. | 2004 | J. Allergy Clin. Immunol. | pmid:15316492 |
| Austen KF et al. | The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. | 2009 | J. Allergy Clin. Immunol. | pmid:19647860 |
| Macglashan DW and Saini SS | Omalizumab increases the intrinsic sensitivity of human basophils to IgE-mediated stimulation. | 2013 | J. Allergy Clin. Immunol. | pmid:23791510 |
| Kowalski ML et al. | Differential effects of aspirin and misoprostol on 15-hydroxyeicosatetraenoic acid generation by leukocytes from aspirin-sensitive asthmatic patients. | 2003 | J. Allergy Clin. Immunol. | pmid:13679808 |
| Triggiani M et al. | Lung mast cells are a source of secreted phospholipases A2. | 2009 | J. Allergy Clin. Immunol. | pmid:19541351 |
| Di Capite J et al. | Targeting Ca2+ release-activated Ca2+ channel channels and leukotriene receptors provides a novel combination strategy for treating nasal polyposis. | 2009 | J. Allergy Clin. Immunol. | pmid:19895990 |
| Miura K et al. | Phosphorylation of cytosolic phospholipase A2 by IL-3 is associated with increased free arachidonic acid generation and leukotriene C4 release in human basophils. | 1998 | J. Allergy Clin. Immunol. | pmid:9768595 |
| Meliton AY et al. | Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils. | 2003 | J. Allergy Clin. Immunol. | pmid:12897749 |
| Bandeira-Melo C et al. | Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. | 2002 | J. Allergy Clin. Immunol. | pmid:12063527 |
| Zweiman B et al. | Nasal airway changes assessed by acoustic rhinometry and mediator release during immediate and late reactions to allergen challenge. | 1997 | J. Allergy Clin. Immunol. | pmid:9389292 |
| Oskeritzian CA et al. | Surface CD88 functionally distinguishes the MCTC from the MCT type of human lung mast cell. | 2005 | J. Allergy Clin. Immunol. | pmid:15940129 |
| Lane SJ and Lee TH | Mast cell effector mechanisms. | 1996 | J. Allergy Clin. Immunol. | pmid:8939179 |