LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Phlebitis D010689 1 associated lipids
Pseudoxanthoma Elasticum D011561 2 associated lipids
Eosinophilic Esophagitis D057765 3 associated lipids
Common Bile Duct Diseases D003137 3 associated lipids
Cestode Infections D002590 3 associated lipids
Hyperbilirubinemia, Hereditary D006933 3 associated lipids
Neointima D058426 3 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Picornaviridae Infections D010850 4 associated lipids
Mesenteric Vascular Occlusion D008641 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Authors Title Published Journal PubMed Link
Herman CA et al. Leukotriene C4-stimulated contractions in bullfrog lung are affected by cold acclimation and calcium antagonists. 1995 Prostaglandins pmid:7480797
Ramondt J et al. Sensitivity of ovine myometrial tissue to various eicosanoids in vitro. 1995 Prostaglandins pmid:7792392
Brandenburg K et al. Conformation and fluidity of endotoxins as determinants of biological activity. 1995 Prog. Clin. Biol. Res. pmid:8524923
Maekawa A et al. Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18931305
Uzonyi B et al. Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16606835
Mandal AK et al. The membrane organization of leukotriene synthesis. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15084748
Kar P et al. Different agonists recruit different stromal interaction molecule proteins to support cytoplasmic Ca2+ oscillations and gene expression. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22509043
Oyoshi MK et al. Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22416124
Paul S et al. ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8692921
Goulet JL et al. Altered inflammatory responses in leukotriene-deficient mice. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:7809134
Müller M et al. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:7809167
Basavarajappa D et al. Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25034252
Tedla N et al. Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12529506
Cordoba-Rodriguez R et al. Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10393875
Tang DG et al. Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8643560
Thomas JW et al. Potent interleukin 3 receptor agonist with selectively enhanced hematopoietic activity relative to recombinant human interleukin 3. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7537376
Bischoff SC et al. IL-4 enhances proliferation and mediator release in mature human mast cells. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10393951
Clish CB et al. Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10393980
Feltenmark S et al. Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18184802
Lam BK et al. Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8052639
Janssen-Timmen U et al. Expression of 5-lipoxygenase in differentiating human skin keratinocytes. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7624354
Leynadier F [Drug allergies: value of the leucotriene C4 release test?]. 1997 Presse Med pmid:9180883
Medrala W et al. [Efficacy and safety of specific immunotherapy of upper airways allergic diseases caused by allergy to mites]. 2006 Pol. Merkur. Lekarski pmid:16875150
Krasnowska M and Medrala W [Effect of IFN-gamma on IGE dependent leukotriene generation by peripheral blood leukocytes in patients with chronic allergic rhinitis in vitro]. 2003 Pneumonol Alergol Pol pmid:14587429
Lecca D et al. The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. 2008 PLoS ONE pmid:18974869
Suram S et al. Cytosolic phospholipase A(2)α and eicosanoids regulate expression of genes in macrophages involved in host defense and inflammation. 2013 PLoS ONE pmid:23950842
Pinho BR et al. Modulation of basophils' degranulation and allergy-related enzymes by monomeric and dimeric naphthoquinones. 2014 PLoS ONE pmid:24587235
Secatto A et al. 5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection. 2012 PLoS ONE pmid:22448213
Alvarenga PH et al. The function and three-dimensional structure of a thromboxane A2/cysteinyl leukotriene-binding protein from the saliva of a mosquito vector of the malaria parasite. 2010 PLoS Biol. pmid:21152418
Díaz Lanza AM et al. Lignan and phenylpropanoid glycosides from Phillyrea latifolia and their in vitro anti-inflammatory activity. 2001 Planta Med. pmid:11345691
Hamasaki Y et al. Magnolol inhibits leukotriene synthesis in rat basophilic leukemia-2H3 cells. 1999 Planta Med. pmid:10232065
Gao YB et al. Low temperature inhibits pollen tube growth by disruption of both tip-localized reactive oxygen species and endocytosis in Pyrus bretschneideri Rehd. 2014 Plant Physiol. Biochem. pmid:24321875
Le Poole IC et al. Organotypic culture of human skin to study melanocyte migration. 1994 Pigment Cell Res. pmid:8072944
Smit NP et al. Stimulation of cultured melanocytes in medium containing a serum substitute: Ultroser-G. 1995 Pigment Cell Res. pmid:7540755
Shon YH and Nam KS Protective effect of Astragali radix extract on interleukin 1beta-induced in fl ammation in human amnion. 2003 Phytother Res pmid:14595579
Zhang T et al. Pharmacology and immunological actions of a herbal medicine ASHMI on allergic asthma. 2010 Phytother Res pmid:19998324
Fukuishi N et al. Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor. 2001 Phytomedicine pmid:11824521
Furukawa M et al. Terpenoids and phenethyl glucosides from Hyssopus cuspidatus (Labiatae). 2011 Phytochemistry pmid:21893325
Cao F et al. Mrp2-related efflux of scutellarin in the intestinal absorption in rats. 2008 Pharmazie pmid:18271309
Ohashi M et al. Effects of phalloidin on the biliary excretion of cholephilic compounds in rats. 2002 Pharmacology pmid:12169763
Tanaka H et al. Biliary excretion of phenolphthalein sulfate in rats. 2003 Pharmacology pmid:12837971
Yang SL et al. Sodium nitroprusside regulates mRNA expressions of LTC4 synthesis enzymes in hepatic ischemia/reperfusion injury rats via NF-kappaB signaling pathway. 2007 Pharmacology pmid:17496435
Ionac M et al. Oxaceprol, an atypical inhibitor of inflammation and joint damage. 1996 Pharmacol. Res. pmid:8971960
Conrad S et al. A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance. 2002 Pharmacogenetics pmid:12042670
Megaraj V et al. Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2). 2011 Pharmacogenet. Genomics pmid:21691255
Hirouchi M et al. Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2. 2004 Pharm. Res. pmid:15180328
Yang JJ et al. Multidrug resistance protein 1 (MRP1) in rabbit conjunctival epithelial cells: its effect on drug efflux and its regulation by adenoviral infection. 2007 Pharm. Res. pmid:17404811
Scheidegger C et al. Effects of extracts and of individual components from Petasites on prostaglandin synthesis in cultured skin fibroblasts and on leucotriene synthesis in isolated human peripheral leucocytes. 1998 Pharm Acta Helv pmid:9556438
Bakos E and Homolya L Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1). 2007 Pflugers Arch. pmid:17187268
Tschugguel W et al. High precision measurement of electrical resistance across endothelial cell monolayers. 1995 Pflugers Arch. pmid:7667075