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Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. |
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Ann. Allergy Asthma Immunol. |
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Pneumonol Alergol Pol |
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2003 |
Acta Pharmacol. Sin. |
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Eur. Respir. J. |
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Glutathione, S-substituted glutathiones, and leukotriene C4 as substrates for peptidylglycine alpha-amidating monooxygenase. |
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Arch. Biochem. Biophys. |
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IL-4 exacerbates anaphylaxis. |
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Bestatin selectively suppresses the growth of leukemic stem/progenitor cells with BCR/ABL mRNA transcript in patients with chronic myelogeneous leukemia. |
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Int. Immunopharmacol. |
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Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. |
2003 |
Br. J. Pharmacol. |
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Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state. |
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Differential effects of aspirin and misoprostol on 15-hydroxyeicosatetraenoic acid generation by leukocytes from aspirin-sensitive asthmatic patients. |
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J. Allergy Clin. Immunol. |
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Cloning and functional characterization of the multidrug resistance-associated protein (MRP1/ABCC1) from the cynomolgus monkey. |
2003 |
Mol. Cancer Ther. |
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N-glycosylation controls functional activity of Oatp1, an organic anion transporter. |
2003 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
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Expression of leukotriene C4 synthase mRNA by the choroid plexus in mouse brain suggests novel neurohormone functions of cysteinyl leukotrienes. |
2003 |
Biochem. Biophys. Res. Commun. |
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Dexamethasone accelerates catabolism of leukotriene C4 in bronchial epithelial cells. |
2003 |
Eur. Respir. J. |
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Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils. |
2003 |
J. Allergy Clin. Immunol. |
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[Preventive effects of montelukast on hypoxic pulmonary hypertension in rats]. |
2003 |
Sichuan Da Xue Xue Bao Yi Xue Ban |
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Regulation and kinetics of platelet-activating factor and leukotriene C4 synthesis by activated human basophils. |
2003 |
Clin. Exp. Allergy |
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[Studies on the experimental allergic rhinitis induced by Japanese cedar pollen--role of cysteinyl leukotrienes in nasal allergic symptoms]. |
2003 |
Yakugaku Zasshi |
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The cysteinyl-leukotriene D4 induces cytosolic Ca2+ elevation and contraction of the human detrusor muscle. |
2003 |
J. Urol. |
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A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. |
2003 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
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Chrubasik S et al. |
Harpagophytum extracts. |
2002 |
Clin. Pharmacol. Ther. |
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Sesquiterpenes from Jasonia glutinosa: in vitro anti-inflammatory activity. |
2002 |
Biol. Pharm. Bull. |
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Gongadze NV and Kezeli TD |
Use of zafirlucast, cysteine-containing leukotriene antagonist, in epinephrine-induced heart injury. |
2002 |
Bull. Exp. Biol. Med. |
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Effect of Astragali radix extract on lipopolysaccharide-induced inflammation in human amnion. |
2002 |
Biol. Pharm. Bull. |
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Modulation of vascular tone and reactivity by nitric oxide in porcine pulmonary arteries and veins. |
2002 |
Acta Physiol. Scand. |
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Effects of antihistamines on leukotriene and cytokine release from dispersed nasal polyp cells. |
2002 |
Arzneimittelforschung |
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Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). |
2002 |
J. Biol. Chem. |
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Transport of leukotriene C4 and structurally related conjugates. |
2002 |
Vitam. Horm. |
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Stem cell factor induces eosinophil activation and degranulation: mediator release and gene array analysis. |
2002 |
Blood |
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Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. |
2002 |
Am. J. Respir. Crit. Care Med. |
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Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). |
2002 |
Drug Metab. Dispos. |
pmid:11901101
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Malaviya R and Uckun FM |
Role of STAT6 in IgE receptor/FcepsilonRI-mediated late phase allergic responses of mast cells. |
2002 |
J. Immunol. |
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Xenobiotic efflux pumps in isolated fish brain capillaries. |
2002 |
Am. J. Physiol. Regul. Integr. Comp. Physiol. |
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Effects of phalloidin on the biliary excretion of cholephilic compounds in rats. |
2002 |
Pharmacology |
pmid:12169763
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Arango P and Kountakis SE |
Presence of cysteinyl leukotrienes in asthmatic patients with chronic sinusitis. |
2002 |
Laryngoscope |
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Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization. |
2002 |
J. Leukoc. Biol. |
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Increased endothelial vesicular transport correlates with increased blood-tumor barrier permeability induced by bradykinin and leukotriene C4. |
2002 |
J. Neuropathol. Exp. Neurol. |
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2002 |
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Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1). |
2002 |
Bioorg. Med. Chem. Lett. |
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Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes. |
2002 |
Inflammation |
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Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma. |
2002 |
Biochem. Pharmacol. |
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IL-16 promotes leukotriene C(4) and IL-4 release from human eosinophils via CD4- and autocrine CCR3-chemokine-mediated signaling. |
2002 |
J. Immunol. |
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Determinants of the substrate specificity of multidrug resistance protein 1: role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17. |
2002 |
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Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. |
2002 |
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Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production. |
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2002 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
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Am. J. Physiol. Lung Cell Mol. Physiol. |
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J. Immunol. |
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GSH-dependent photolabeling of multidrug resistance protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain. |
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J. Biol. Chem. |
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A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance. |
2002 |
Pharmacogenetics |
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Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells. |
2002 |
J. Biol. Chem. |
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Increased responsiveness of murine eosinophils to MIP-1beta (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8. |
2002 |
J. Leukoc. Biol. |
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Alpha(1L)-, but not alpha(1H)-, adrenoceptor antagonist prevents allergic bronchoconstriction in guinea pigs in vivo. |
2002 |
Eur. J. Pharmacol. |
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Multiple membrane-associated tryptophan residues contribute to the transport activity and substrate specificity of the human multidrug resistance protein, MRP1. |
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Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistance-associated protein 1. |
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J. Exp. Med. |
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A high-throughput assay for measurement of multidrug resistance protein-mediated transport of leukotriene C4 into membrane vesicles. |
2002 |
Anal. Biochem. |
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Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). |
2002 |
Cancer Res. |
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Reconstitution of transport-active multidrug resistance protein 2 (MRP2; ABCC2) in proteoliposomes. |
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Biol. Chem. |
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Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome. |
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Hepatology |
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The contraction of the human pulmonary artery by LTC4 is resistant to cysLT1 antagonists and counteracted by prostacyclin release. |
2002 |
Adv. Exp. Med. Biol. |
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Cultured human intestinal mast cells express functional IL-3 receptors and respond to IL-3 by enhancing growth and IgE receptor-dependent mediator release. |
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Eur. J. Immunol. |
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Clinical and genetic features underlying the response of patients with bronchial asthma to treatment with a leukotriene receptor antagonist. |
2002 |
Eur. J. Clin. Invest. |
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Pharmacological evidence for a novel cysteinyl-leukotriene receptor subtype in human pulmonary artery smooth muscle. |
2002 |
Br. J. Pharmacol. |
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The stimulatory effects of nasal discharge from patients with perennial allergic rhinitis on normal human neutrophils are normalized after treatment with a new mixed formula of Chinese herbs. |
2002 |
Int. Immunopharmacol. |
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Leukotrienes in patients with clinically active multiple sclerosis. |
2002 |
Acta Neurol. Scand. |
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A positively charged amino acid proximal to the C-terminus of TM17 of MRP1 is indispensable for GSH-dependent binding of substrates and for transport of LTC4. |
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Biochemistry |
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Identification and characterization of the canine multidrug resistance-associated protein. |
2002 |
Mol. Cancer Ther. |
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Interactions of volatile anesthetics with cholinergic, tachykinin, and leukotriene mechanisms in isolated Guinea pig bronchial smooth muscle. |
2002 |
Anesth. Analg. |
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Functional analysis of ABCA8, a new drug transporter. |
2002 |
Biochem. Biophys. Res. Commun. |
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Eur. J. Pharmacol. |
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Silver activates calcium signals in rat basophilic leukemia-2H3 mast cells by a mechanism that differs from the Fc epsilon RI-activated response. |
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Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. |
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J. Allergy Clin. Immunol. |
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Cysteinyl leukotrienes in the bile of patients with obstructive jaundice. |
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J. Gastroenterol. |
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Membrane localization and topology of leukotriene C4 synthase. |
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Prostaglandins Other Lipid Mediat. |
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Differential susceptibility of multidrug resistance protein-1 deficient mice to DSS and TNBS-induced colitis. |
2002 |
Dig. Dis. Sci. |
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Leflunomide metabolite analogue alpha-cyano-beta-hydroxy-beta-methyl-N-[3-(trifluoromethyl)phenyl]propenamide inhibits IgE/FcepsilonRI receptor-mediated mast cell leukotriene release and allergic asthma in mice. |
2001 Sep-Oct |
Am J Ther |
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Tirofiban administration attenuates platelet and platelet-neutrophil conjugation but not neutrophil degranulation during in vitro VAD circulation. |
2001 May-Jun |
ASAIO J. |
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The comparison of the efficacy of fluticasone propionate with cetirizine in perennial allergic rhinitis. |
2001 Mar-Apr |
Allergol Immunopathol (Madr) |
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Dietary n-3 and n-6 polyunsaturated oils and airway contractility. |
2001 Apr-May |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:11418024
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Eppihimer MJ and Schaub RG |
Soluble P-selectin antagonist mediates rolling velocity and adhesion of leukocytes in acutely inflamed venules. |
2001 |
Microcirculation |
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Lignan and phenylpropanoid glycosides from Phillyrea latifolia and their in vitro anti-inflammatory activity. |
2001 |
Planta Med. |
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Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor. |
2001 |
Eur. J. Biochem. |
pmid:11322876
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Bandeira-Melo C et al. |
Extranuclear lipid bodies, elicited by CCR3-mediated signaling pathways, are the sites of chemokine-enhanced leukotriene C4 production in eosinophils and basophils. |
2001 |
J. Biol. Chem. |
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Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines. |
2001 |
J. Biol. Chem. |
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Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages. |
2001 |
Br. J. Pharmacol. |
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Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. |
2001 |
J. Pharmacol. Exp. Ther. |
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Bäck M et al. |
An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea. |
2001 |
Br. J. Pharmacol. |
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Oliveira SH et al. |
SCF-induced airway hyperreactivity is dependent on leukotriene production. |
2001 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:11350804
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Okayama Y et al. |
A comparison of mediators released or generated by IFN-gamma-treated human mast cells following aggregation of Fc gamma RI or Fc epsilon RI. |
2001 |
J. Immunol. |
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Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. |
2001 |
Clin. Exp. Allergy |
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The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. |
2001 |
J. Biol. Chem. |
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Resting and activation-dependent ion channels in human mast cells. |
2001 |
J. Immunol. |
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Prognostic significance of multidrug resistance protein in adult T-cell leukemia. |
2001 |
Clin. Cancer Res. |
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Miura K et al. |
Piceatannol is an effective inhibitor of IgE-mediated secretion from human basophils but is neither selective for this receptor nor acts on syk kinase at concentrations where mediator release inhibition occurs. |
2001 |
Clin. Exp. Allergy |
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Inflammatory response during abdominal and thyroid surgery: a prospective clinical trial on mediator release. |
2001 |
Shock |
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