| MeSH term | MeSH ID | Detail |
|---|---|---|
| Phlebitis | D010689 | 1 associated lipids |
| Pseudoxanthoma Elasticum | D011561 | 2 associated lipids |
| Eosinophilic Esophagitis | D057765 | 3 associated lipids |
| Common Bile Duct Diseases | D003137 | 3 associated lipids |
| Cestode Infections | D002590 | 3 associated lipids |
| Hyperbilirubinemia, Hereditary | D006933 | 3 associated lipids |
| Neointima | D058426 | 3 associated lipids |
| Eosinophilia | D004802 | 4 associated lipids |
| Insect Bites and Stings | D007299 | 4 associated lipids |
| Picornaviridae Infections | D010850 | 4 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kamohara M et al. | Functional characterization of cysteinyl leukotriene CysLT(2) receptor on human coronary artery smooth muscle cells. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11587533 |
| Wehner J and Neuber K | Staphylococcus aureus enterotoxins induce histamine and leukotriene release in patients with atopic eczema. | 2001 | Br. J. Dermatol. | pmid:11531797 |
| Sano A et al. | Regulation of eosinophil function by phosphatidylinositol-specific PLC and cytosolic PLA(2). | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11557588 |
| Qian YM et al. | Characterization of binding of leukotriene C4 by human multidrug resistance protein 1: evidence of differential interactions with NH2- and COOH-proximal halves of the protein. | 2001 | J. Biol. Chem. | pmid:11507101 |
| Strenzke N et al. | Mercuric chloride enhances immunoglobulin E-dependent mediator release from human basophils. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11485386 |
| Miura K et al. | Differences in functional consequences and signal transduction induced by IL-3, IL-5, and nerve growth factor in human basophils. | 2001 | J. Immunol. | pmid:11490016 |
| Falcón-Pérez JM et al. | Domain interactions in the yeast ATP binding cassette transporter Ycf1p: intragenic suppressor analysis of mutations in the nucleotide binding domains. | 2001 | J. Bacteriol. | pmid:11466279 |
| Bölke E et al. | Changes of gut barrier function during anesthesia and cardiac surgery. | 2001 | Angiology | pmid:11515987 |
| Abad MJ et al. | Effects of furocoumarins from Cachrys trifida on some macrophage functions. | 2001 | J. Pharm. Pharmacol. | pmid:11518028 |
| Ito K et al. | Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. | 2001 | J. Biol. Chem. | pmid:11500505 |
| Tornhamre S et al. | Inhibitory effects of helenalin and related compounds on 5-lipoxygenase and leukotriene C(4) synthase in human blood cells. | 2001 | Biochem. Pharmacol. | pmid:11543725 |
| Sjöström M et al. | Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor. | 2001 | Eur. J. Biochem. | pmid:11322876 |
| Bandeira-Melo C et al. | Extranuclear lipid bodies, elicited by CCR3-mediated signaling pathways, are the sites of chemokine-enhanced leukotriene C4 production in eosinophils and basophils. | 2001 | J. Biol. Chem. | pmid:11274187 |
| Zhang DW et al. | Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines. | 2001 | J. Biol. Chem. | pmid:11278596 |
| Ito K et al. | Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport. | 2001 | J. Biol. Chem. | pmid:11278867 |
| Leslie EM et al. | Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids. | 2001 | Mol. Pharmacol. | pmid:11306701 |
| Schroeder JT et al. | Human basophils: mediator release and cytokine production. | 2001 | Adv. Immunol. | pmid:11293121 |
| Zhang DW et al. | Identification of a nonconserved amino acid residue in multidrug resistance protein 1 important for determining substrate specificity: evidence for functional interaction between transmembrane helices 14 and 17. | 2001 | J. Biol. Chem. | pmid:11429411 |
| Hevko JM and Murphy RC | Electrospray ionization and tandem mass spectrometry of cysteinyl eicosanoids: leukotriene C4 and FOG7. | 2001 | J. Am. Soc. Mass Spectrom. | pmid:11444597 |
| Cai J et al. | Functional expression of multidrug resistance protein 1 in Pichia pastoris. | 2001 | Biochemistry | pmid:11444977 |
| Zaitsu M et al. | A novel pharmacologic action of glucocorticosteroids on leukotriene C4 catabolism. | 2001 | J. Allergy Clin. Immunol. | pmid:11447392 |
| Ieiri S et al. | The mechanism for the contraction induced by leukotriene C4 in guinea-pig taenia coli. | 2001 | Br. J. Pharmacol. | pmid:11399670 |
| Zhu X et al. | Role of mitogen-activated protein kinase-mediated cytosolic phospholipase A2 activation in arachidonic acid metabolism in human eosinophils. | 2001 | J. Immunol. | pmid:11418683 |
| Gurish MF and Austen KF | The diverse roles of mast cells. | 2001 | J. Exp. Med. | pmid:11435478 |
| Leslie EM et al. | Transport of the beta -O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog. | 2001 | J. Biol. Chem. | pmid:11375986 |
| Muccitelli RM et al. | Cysteinyl leukotriene receptor assays. | 2001 | Curr Protoc Pharmacol | pmid:22293965 |
| Downey P et al. | Renal concentrating defect in mice lacking group IV cytosolic phospholipase A(2). | 2001 | Am. J. Physiol. Renal Physiol. | pmid:11249852 |
| Martin V et al. | Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors. | 2001 | Biochem. Pharmacol. | pmid:11705452 |
| Fukuishi N et al. | Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor. | 2001 | Phytomedicine | pmid:11824521 |
| Oliveira SH et al. | SCF-induced airway hyperreactivity is dependent on leukotriene production. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11350804 |
| Qian YM et al. | Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1. | 2001 | J. Biol. Chem. | pmid:11102445 |
| Murakami M et al. | Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms. | 2001 | J. Biol. Chem. | pmid:11106649 |
| Okayama Y et al. | A comparison of mediators released or generated by IFN-gamma-treated human mast cells following aggregation of Fc gamma RI or Fc epsilon RI. | 2001 | J. Immunol. | pmid:11254731 |
| Duffy SM et al. | Resting and activation-dependent ion channels in human mast cells. | 2001 | J. Immunol. | pmid:11591748 |
| Ohno N et al. | Prognostic significance of multidrug resistance protein in adult T-cell leukemia. | 2001 | Clin. Cancer Res. | pmid:11595704 |
| Miura K et al. | Piceatannol is an effective inhibitor of IgE-mediated secretion from human basophils but is neither selective for this receptor nor acts on syk kinase at concentrations where mediator release inhibition occurs. | 2001 | Clin. Exp. Allergy | pmid:11696049 |
| Bölke E et al. | Inflammatory response during abdominal and thyroid surgery: a prospective clinical trial on mediator release. | 2001 | Shock | pmid:11699069 |
| Fernández MA et al. | New insights into the mechanism of action of the anti-inflammatory triterpene lupeol. | 2001 | J. Pharm. Pharmacol. | pmid:11732756 |
| Thomas LL et al. | Peptide-based analysis of amino acid sequences important to the biological activity of eosinophil granule major basic protein. | 2001 | Immunol. Lett. | pmid:11578692 |
| Annila I et al. | Bee venom induces high histamine or high leukotriene C4 release in skin of sensitized beekeepers. | 2000 Jul-Aug | J Investig Allergol Clin Immunol | pmid:11039839 |
| Okamoto M et al. | Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma. | 2000 | Intern. Med. | pmid:10732825 |
| Nobukata H et al. | Long-term administration of highly purified eicosapentaenoic acid ethyl ester improves the dysfunction of vascular endothelial and smooth muscle cells in male WBN/Kob rats. | 2000 | Metab. Clin. Exp. | pmid:11145121 |
| Mayatepek E | Leukotriene C4 synthesis deficiency: a member of a probably underdiagnosed new group of neurometabolic diseases. | 2000 | Eur. J. Pediatr. | pmid:11079193 |
| Chen A and Zhong N | [Zafirlukast inhibition of leukotriene C4 induced endothelin-1 expression in human airway structural cell]. | 2000 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:11372388 |
| Sanchez Mejia RO et al. | Matrix-associated transforming growth factor-beta1 primes mouse bone marrow-derived mast cells for increased high-affinity Fc receptor for immunoglobulin E-dependent eicosanoid biosynthesis. | 2000 | Am. J. Respir. Cell Mol. Biol. | pmid:10783127 |
| Macfarlane AJ et al. | Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10806153 |
| Sakamoto H et al. | Involvement of phospholipid hydroperoxide glutathione peroxidase in the modulation of prostaglandin D2 synthesis. | 2000 | J. Biol. Chem. | pmid:11010961 |
| Nishio T et al. | Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10973807 |
| Karimi K et al. | Stem cell factor and interleukin-4 increase responsiveness of mast cells to substance P. | 2000 | Exp. Hematol. | pmid:10880748 |
| Yamashita M et al. | Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells. | 2000 | Br. J. Pharmacol. | pmid:10694244 |
| Kivity S et al. | Eosinophil influx into the airways in patients with exercise-induced asthma. | 2000 | Respir Med | pmid:11192956 |
| Hamasaki Y et al. | (9-[4-acetyl-3-hydroxy-2-n-propylphenoxy) methyl]-3-(1H-tetrazol-5-yl)-4H-pyrido [1,2-a] pyrimidin-4-one), AS-35, inhibits leukotriene synthesis. | 2000 | Int. J. Immunopharmacol. | pmid:10785545 |
| Bandeira-Melo C et al. | Cyclooxygenase-2-derived prostaglandin E2 and lipoxin A4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: relationship with concurrent eosinophilia. | 2000 | J. Immunol. | pmid:10623853 |
| Yakubu MA and Leffler CW | Enhanced pial arteriolar sensitivity to bioactive agents following exposure to endothelin-1. | 2000 | Life Sci. | pmid:10665982 |
| Mitsunobu F et al. | Enhanced peripheral leukocyte leukotriene production and bronchial hyperresponsiveness in asthmatics. | 2000 | Eur. Respir. J. | pmid:11028668 |
| Sjölinder M et al. | Aberrant expression of active leukotriene C(4) synthase in CD16(+) neutrophils from patients with chronic myeloid leukemia. | 2000 | Blood | pmid:10666225 |
| Sanak M et al. | Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics. | 2000 | Eur. Respir. J. | pmid:10933083 |
| Tsang S et al. | Simplified purification of human basophils. | 2000 | J. Immunol. Methods | pmid:10648851 |
| Ravasi S et al. | A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lung parenchyma. | 2000 | Mol. Pharmacol. | pmid:10825389 |
| Sapirstein A and Bonventre JV | Specific physiological roles of cytosolic phospholipase A(2) as defined by gene knockouts. | 2000 | Biochim. Biophys. Acta | pmid:11080683 |
| Ohd JF et al. | Leukotrienes induce cell-survival signaling in intestinal epithelial cells. | 2000 | Gastroenterology | pmid:11040187 |
| Arakida Y et al. | Effect of combined leukotriene D(4) and thromboxane A(2) receptor antagonist on mediator-controlled resistance in guinea pigs. | 2000 | Eur. J. Pharmacol. | pmid:10969159 |
| Sullivan GF et al. | Regulation of expression of the multidrug resistance protein MRP1 by p53 in human prostate cancer cells. | 2000 | J. Clin. Invest. | pmid:10792001 |
| Ren XQ et al. | Functional comparison between YCF1 and MRP1 expressed in Sf21 insect cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10753671 |
| Bates ME et al. | ERK1 and ERK2 activation by chemotactic factors in human eosinophils is interleukin 5-dependent and contributes to leukotriene C(4) biosynthesis. | 2000 | J. Biol. Chem. | pmid:10753897 |
| Ohbayashi H and Yamaki KI | Both inhalant and intravenous uroguanylin inhibit leukotriene C4-induced airway changes. | 2000 | Peptides | pmid:11068092 |
| Thorén S and Jakobsson PJ | Coordinate up- and down-regulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells. Inhibition by NS-398 and leukotriene C4. | 2000 | Eur. J. Biochem. | pmid:11029586 |
| Moore BB et al. | GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism. | 2000 | J. Immunol. | pmid:11034414 |
| Robbiani DF et al. | The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. | 2000 | Cell | pmid:11114332 |
| Okumura H et al. | Reversal of P-glycoprotein and multidrug-resistance protein-mediated drug resistance in KB cells by 5-O-benzoylated taxinine K. | 2000 | Mol. Pharmacol. | pmid:11093797 |
| Morlion BJ et al. | Cysteinyl-leukotriene generation as a biomarker for survival in the critically ill. | 2000 | Crit. Care Med. | pmid:11098969 |
| Anderson MR and Blumer JL | Prognostic markers in sepsis: the role of leukotrienes. | 2000 | Crit. Care Med. | pmid:11098993 |
| Malaviya R et al. | Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97). | 2000 | J. Pharmacol. Exp. Ther. | pmid:11082424 |
| Capper EA et al. | Modulation of human monocyte activities by tranilast, SB 252218, a compound demonstrating efficacy in restenosis. | 2000 | J. Pharmacol. Exp. Ther. | pmid:11082441 |
| DÃaz AM et al. | In vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L. | 2000 | Biol. Pharm. Bull. | pmid:11085357 |
| Hisamatsu K and Nakajima M | Pranlukast protects leukotriene C4- and D4-induced epithelial cell impairment of the nasal mucosa in vitro. | 2000 | Life Sci. | pmid:11105993 |
| Nothacker HP et al. | Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. | 2000 | Mol. Pharmacol. | pmid:11093801 |
| Cederholm T et al. | Impaired leukotriene C4 generation in granulocytes from protein-energy malnourished chronically ill elderly. | 2000 | J. Intern. Med. | pmid:10886494 |
| Venière A et al. | [Importance of blood tests for the diagnosis of drug allergies]. | 2000 | Allerg Immunol (Paris) | pmid:10971854 |
| Zeng H et al. | Transport of amphipathic anions by human multidrug resistance protein 3. | 2000 | Cancer Res. | pmid:10987286 |
| Bäck M et al. | Antagonist resistant contractions of the porcine pulmonary artery by cysteinyl-leukotrienes. | 2000 | Eur. J. Pharmacol. | pmid:10936497 |
| Genovese A et al. | Bacterial immunoglobulin superantigen proteins A and L activate human heart mast cells by interacting with immunoglobulin E. | 2000 | Infect. Immun. | pmid:10992448 |
| Mao Q et al. | Functional reconstitution of substrate transport by purified multidrug resistance protein MRP1 (ABCC1) in phospholipid vesicles. | 2000 | J. Biol. Chem. | pmid:10942765 |
| Tran HS et al. | The cardiovascular hemodynamics and leukotriene kinetics during prostacyclin and anti-prostacyclin antibody infusions in septic shock. | 2000 | Shock | pmid:10847636 |
| Heise CE et al. | Characterization of the human cysteinyl leukotriene 2 receptor. | 2000 | J. Biol. Chem. | pmid:10851239 |
| Bäck M et al. | Prostacyclin modulation of contractions of the human pulmonary artery by cysteinyl-leukotrienes. | 2000 | Eur. J. Pharmacol. | pmid:10936498 |
| Loe DW et al. | Structure-activity studies of verapamil analogs that modulate transport of leukotriene C(4) and reduced glutathione by multidrug resistance protein MRP1. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10973801 |
| Malaviya R and Abraham SN | Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis. | 2000 | J. Leukoc. Biol. | pmid:10857857 |
| Mayatepek E et al. | Defects in the synthesis of cysteinyl leukotrienes: a new group of inborn errors of metabolism. | 2000 | J. Inherit. Metab. Dis. | pmid:10896305 |
| Bossé M et al. | Eosinophil activation status and corticosteroid responsiveness in severe asthma. | 2000 | Int. Arch. Allergy Immunol. | pmid:10899764 |
| Dent G et al. | Up-regulation of human eosinophil leukotriene C4 generation through contact with bronchial epithelial cells. | 2000 | Inflamm. Res. | pmid:10893047 |
| Lopes LR et al. | Reduced inflammatory response in rats fed fat-rich diets: role of leukotrienes. | 2000 | Life Sci. | pmid:10896024 |
| Okamoto M et al. | Effects of perilla seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism. | 2000 | Int. Arch. Allergy Immunol. | pmid:10878492 |
| Mayatepek E et al. | Analysis of leukotrienes in cerebrospinal fluid of a reference population and patients with inborn errors of metabolism: further evidence for a pathognomonic profile in LTC(4)-synthesis deficiency. | 2000 | Clin. Chim. Acta | pmid:10686285 |
| Miura K and MacGlashan DW | Dual phase priming by IL-3 for leukotriene C4 generation in human basophils: difference in characteristics between acute and late priming effects. | 2000 | J. Immunol. | pmid:10706691 |
| Douglas IS et al. | CD4+ T cell and eosinophil adhesion is mediated by specific ICAM-3 ligation and results in eosinophil activation. | 2000 | J. Immunol. | pmid:10706734 |
| Skaltsa H et al. | Inhibition of prostaglandin E2 and leukotriene C4 in mouse peritoneal macrophages and thromboxane B2 production in human platelets by flavonoids from Stachys chrysantha and Stachys candida. | 2000 | Biol. Pharm. Bull. | pmid:10706410 |
| Aiso M et al. | Biliary excretion of bile acids and organic anions in zone 1- and zone 3-injured rats. | 2000 | Liver | pmid:10726959 |
| Gutmann H et al. | P-glycoprotein- and mrp2-mediated octreotide transport in renal proximal tubule. | 2000 | Br. J. Pharmacol. | pmid:10694230 |
| Sundkvist E et al. | Leukotriene C(4) (LTC(4)) does not share a cellular efflux mechanism with cGMP: characterisation of cGMP transport by uptake to inside-out vesicles from human erythrocytes. | 2000 | Biochim. Biophys. Acta | pmid:10631301 |