LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

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Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Phlebitis D010689 1 associated lipids
Pseudoxanthoma Elasticum D011561 2 associated lipids
Eosinophilic Esophagitis D057765 3 associated lipids
Common Bile Duct Diseases D003137 3 associated lipids
Cestode Infections D002590 3 associated lipids
Hyperbilirubinemia, Hereditary D006933 3 associated lipids
Neointima D058426 3 associated lipids
Status Asthmaticus D013224 4 associated lipids
Wounds, Nonpenetrating D014949 4 associated lipids
Mesenteric Vascular Occlusion D008641 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Authors Title Published Journal PubMed Link
Hong JT and Glauert HP Comitogenicity of eicosanoids and the peroxisome proliferator ciprofibrate in cultured rat hepatocytes. 1996 J. Cell. Physiol. pmid:8908198
Geirsson A et al. Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells. 1998 J. Cell. Physiol. pmid:9731750
Mayer R et al. Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. 1995 J. Cell Biol. pmid:7559771
Garcia C et al. Effects of synthetic peptido-leukotrienes on bone resorption in vitro. 1996 J. Bone Miner. Res. pmid:8992883
Qian YM et al. Characterization of binding of leukotriene C4 by human multidrug resistance protein 1: evidence of differential interactions with NH2- and COOH-proximal halves of the protein. 2001 J. Biol. Chem. pmid:11507101
Ito K et al. Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. 2001 J. Biol. Chem. pmid:11500505
Iliás A et al. Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). 2002 J. Biol. Chem. pmid:11880368
Metters KM et al. Microsomal glutathione S-transferase is the predominant leukotriene C4 binding site in cellular membranes. 1994 J. Biol. Chem. pmid:8175695
Campbell JD et al. Molecular modeling correctly predicts the functional importance of Phe594 in transmembrane helix 11 of the multidrug resistance protein, MRP1 (ABCC1). 2004 J. Biol. Chem. pmid:14561746
Zhao Q and Chang XB Mutation of the aromatic amino acid interacting with adenine moiety of ATP to a polar residue alters the properties of multidrug resistance protein 1. 2004 J. Biol. Chem. pmid:15355964
Furumoto Y et al. The FcepsilonRIbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production. 2004 J. Biol. Chem. pmid:15355979
Puder M and Soberman RJ Glutathione conjugates recognize the Rossmann fold of glyceraldehyde-3-phosphate dehydrogenase. 1997 J. Biol. Chem. pmid:9099752
Morii E and Oboki K MITF is necessary for generation of prostaglandin D2 in mouse mast cells. 2004 J. Biol. Chem. pmid:15375155
Situ D et al. Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter. 2004 J. Biol. Chem. pmid:15208328
Loe DW et al. Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport. 1996 J. Biol. Chem. pmid:8621643
Gao M et al. Reconstitution of ATP-dependent leukotriene C4 transport by Co-expression of both half-molecules of human multidrug resistance protein in insect cells. 1996 J. Biol. Chem. pmid:8910374
Chang WC et al. Local Ca2+ influx through Ca2+ release-activated Ca2+ (CRAC) channels stimulates production of an intracellular messenger and an intercellular pro-inflammatory signal. 2008 J. Biol. Chem. pmid:18156181
Satake Y et al. Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption. 2004 J. Biol. Chem. pmid:14761945
Haimeur A et al. Charged amino acids in the sixth transmembrane helix of multidrug resistance protein 1 (MRP1/ABCC1) are critical determinants of transport activity. 2002 J. Biol. Chem. pmid:12186871
Zhang DW et al. Determinants of the substrate specificity of multidrug resistance protein 1: role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17. 2002 J. Biol. Chem. pmid:11925441
Loe DW et al. ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. 1996 J. Biol. Chem. pmid:8621644
Maekawa A et al. Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. 2002 J. Biol. Chem. pmid:11932261
Ahamed J and Ali H Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production. 2002 J. Biol. Chem. pmid:11934880
Iram SH and Cole SP Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1). 2012 J. Biol. Chem. pmid:22232552
Mao Q et al. GSH-dependent photolabeling of multidrug resistance protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain. 2002 J. Biol. Chem. pmid:12034727
Saino H et al. The catalytic architecture of leukotriene C4 synthase with two arginine residues. 2011 J. Biol. Chem. pmid:21454538
Iram SH and Cole SP Expression and function of human MRP1 (ABCC1) is dependent on amino acids in cytoplasmic loop 5 and its interface with nucleotide binding domain 2. 2011 J. Biol. Chem. pmid:21177244
Yang Y et al. Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistance-associated protein 1. 2002 J. Biol. Chem. pmid:12235150
Büchler M et al. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. 1996 J. Biol. Chem. pmid:8662992
Yang R et al. ATP binding to the first nucleotide binding domain of multidrug resistance-associated protein plays a regulatory role at low nucleotide concentration, whereas ATP hydrolysis at the second plays a dominant role in ATP-dependent leukotriene C4 transport. 2003 J. Biol. Chem. pmid:12783859
Muñoz NM et al. Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils. 2003 J. Biol. Chem. pmid:12796497
Zhang DW et al. Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state. 2003 J. Biol. Chem. pmid:12954620
Niegowski D et al. Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism. 2014 J. Biol. Chem. pmid:24366866
Yamane Y et al. Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress. 1998 J. Biol. Chem. pmid:9813007
Carter BZ et al. gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene family member, is expressed primarily in spleen. 1998 J. Biol. Chem. pmid:9774450
Kanaoka Y et al. Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. 2013 J. Biol. Chem. pmid:23504326
Bukiya AN et al. Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4. 2014 J. Biol. Chem. pmid:25371198
Murakami M et al. Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells. 1995 J. Biol. Chem. pmid:7559381
Gao M et al. Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1. 2000 J. Biol. Chem. pmid:10777615
Li L et al. Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter. 1998 J. Biol. Chem. pmid:9632674
Bates ME et al. ERK1 and ERK2 activation by chemotactic factors in human eosinophils is interleukin 5-dependent and contributes to leukotriene C(4) biosynthesis. 2000 J. Biol. Chem. pmid:10753897
Alswied A and Parekh AB Ca2+ Influx through Store-operated Calcium Channels Replenishes the Functional Phosphatidylinositol 4,5-Bisphosphate Pool Used by Cysteinyl Leukotriene Type I Receptors. 2015 J. Biol. Chem. pmid:26468289
Cole SP Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter. 2014 J. Biol. Chem. pmid:25281745
Mao Q et al. Functional reconstitution of substrate transport by purified multidrug resistance protein MRP1 (ABCC1) in phospholipid vesicles. 2000 J. Biol. Chem. pmid:10942765
Stride BD et al. Localization of a substrate specificity domain in the multidrug resistance protein. 1999 J. Biol. Chem. pmid:10428874
Conseil G et al. Functional importance of three basic residues clustered at the cytosolic interface of transmembrane helix 15 in the multidrug and organic anion transporter MRP1 (ABCC1). 2006 J. Biol. Chem. pmid:16230346
Bowers RC et al. A novel glutathione containing eicosanoid (FOG7) chemotactic for human granulocytes. 2000 J. Biol. Chem. pmid:10924496
Bakos E et al. Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain. 1998 J. Biol. Chem. pmid:9822694
Christmas P et al. Membrane localization and topology of leukotriene C4 synthase. 2002 J. Biol. Chem. pmid:12023288
Hui Y et al. The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. 2001 J. Biol. Chem. pmid:11591709