LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

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Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Authors Title Published Journal PubMed Link
Vargaftig BB and Singer M Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. 2003 Am. J. Respir. Cell Mol. Biol. pmid:12654629
Zhu X et al. Structural determinants of blockade of eosinophil activation, adhesion and secretion by synthetic analogs of phomactin. 2003 Life Sci. pmid:14519449
Westlake CJ et al. Identification of the structural and functional boundaries of the multidrug resistance protein 1 cytoplasmic loop 3. 2003 Biochemistry pmid:14640677
Shon YH and Nam KS Protective effect of Astragali radix extract on interleukin 1beta-induced in fl ammation in human amnion. 2003 Phytother Res pmid:14595579
Myou S et al. Activation of group IV cytosolic phospholipase A2 in human eosinophils by phosphoinositide 3-kinase through a mitogen-activated protein kinase-independent pathway. 2003 J. Immunol. pmid:14530366
Gentile DA et al. Elevations of local leukotriene C4 levels during viral upper respiratory tract infections. 2003 Ann. Allergy Asthma Immunol. pmid:14533659
Krasnowska M and Medrala W [Effect of IFN-gamma on IGE dependent leukotriene generation by peripheral blood leukocytes in patients with chronic allergic rhinitis in vitro]. 2003 Pneumonol Alergol Pol pmid:14587429
Lee SH and Altenberg GA Transport of leukotriene C4 by a cysteine-less multidrug resistance protein 1 (MRP1). 2003 Biochem. J. pmid:12398766
Llupià J et al. Comparative antiallergic effects of second-generation H1-antihistamines ebastine, cetirizine and loratadine in preclinical models. 2003 Arzneimittelforschung pmid:12642964
Triggiani M et al. Secretory phospholipases A2 activate selective functions in human eosinophils. 2003 J. Immunol. pmid:12626587
Yang R et al. ATP binding to the first nucleotide binding domain of multidrug resistance-associated protein plays a regulatory role at low nucleotide concentration, whereas ATP hydrolysis at the second plays a dominant role in ATP-dependent leukotriene C4 transport. 2003 J. Biol. Chem. pmid:12783859
Muñoz NM et al. Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils. 2003 J. Biol. Chem. pmid:12796497
Dallaire MJ et al. Endothelial cells modulate eosinophil surface markers and mediator release. 2003 Eur. Respir. J. pmid:12797482
Cai Y et al. Bronchial mast cells are the dominating LTC4S-expressing cells in aspirin-tolerant asthma. 2003 Am. J. Respir. Cell Mol. Biol. pmid:12816731
Miller LA et al. Glutathione, S-substituted glutathiones, and leukotriene C4 as substrates for peptidylglycine alpha-amidating monooxygenase. 2003 Arch. Biochem. Biophys. pmid:12646261
Venkatachalam TK et al. Inhibition of mast cell leukotriene release by thiourea derivatives. 2003 Bioorg. Med. Chem. Lett. pmid:12565956
Kwak WJ et al. Papyriflavonol A from Broussonetia papyrifera inhibits the passive cutaneous anaphylaxis reaction and has a secretory phospholipase A2-inhibitory activity. 2003 Biol. Pharm. Bull. pmid:12612436
Plath KE et al. Calcineurin antagonists differentially affect mediator secretion, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases from immunologically activated human basophils. 2003 Clin. Exp. Allergy pmid:12614449
Venkatachalam TK et al. Substituted heterocyclic thiourea compounds as a new class of anti-allergic agents inhibiting IgE/Fc epsilon RI receptor mediated mast cell leukotriene release. 2003 Bioorg. Med. Chem. pmid:12614897
Hattori T et al. Effects of H2O2 on membrane potential of smooth muscle cells in rabbit mesenteric resistance artery. 2003 Eur. J. Pharmacol. pmid:12620501
Söderström M et al. Expression of leukotriene C4 synthase mRNA by the choroid plexus in mouse brain suggests novel neurohormone functions of cysteinyl leukotrienes. 2003 Biochem. Biophys. Res. Commun. pmid:12878209
Ichiyama T et al. Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells. 2003 Clin. Exp. Allergy pmid:12801316
Bouchelouche K et al. The cysteinyl-leukotriene D4 induces cytosolic Ca2+ elevation and contraction of the human detrusor muscle. 2003 J. Urol. pmid:12853847
Chrubasik S et al. Harpagophytum extracts. 2002 Clin. Pharmacol. Ther. pmid:11823764
Bermejo BP et al. Sesquiterpenes from Jasonia glutinosa: in vitro anti-inflammatory activity. 2002 Biol. Pharm. Bull. pmid:11824534
Gongadze NV and Kezeli TD Use of zafirlucast, cysteine-containing leukotriene antagonist, in epinephrine-induced heart injury. 2002 Bull. Exp. Biol. Med. pmid:12802449
Shon YH et al. Effect of Astragali radix extract on lipopolysaccharide-induced inflammation in human amnion. 2002 Biol. Pharm. Bull. pmid:11824562
Bäck M et al. Modulation of vascular tone and reactivity by nitric oxide in porcine pulmonary arteries and veins. 2002 Acta Physiol. Scand. pmid:11851592
Küsters S et al. Effects of antihistamines on leukotriene and cytokine release from dispersed nasal polyp cells. 2002 Arzneimittelforschung pmid:11878205
Iliás A et al. Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). 2002 J. Biol. Chem. pmid:11880368
Jedlitschky G and Keppler D Transport of leukotriene C4 and structurally related conjugates. 2002 Vitam. Horm. pmid:11898391
Oliveira SH et al. Stem cell factor induces eosinophil activation and degranulation: mediator release and gene array analysis. 2002 Blood pmid:12453875
Suzuki R and Freed AN Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. 2002 Am. J. Respir. Crit. Care Med. pmid:11779726
Guo A et al. Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). 2002 Drug Metab. Dispos. pmid:11901101
Malaviya R and Uckun FM Role of STAT6 in IgE receptor/FcepsilonRI-mediated late phase allergic responses of mast cells. 2002 J. Immunol. pmid:11751988
Miller DS et al. Xenobiotic efflux pumps in isolated fish brain capillaries. 2002 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:11742838
Ohashi M et al. Effects of phalloidin on the biliary excretion of cholephilic compounds in rats. 2002 Pharmacology pmid:12169763
Arango P and Kountakis SE Presence of cysteinyl leukotrienes in asthmatic patients with chronic sinusitis. 2002 Laryngoscope pmid:12169896
Gibbs BF et al. Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization. 2002 J. Leukoc. Biol. pmid:12149431
Hashizume K and Black KL Increased endothelial vesicular transport correlates with increased blood-tumor barrier permeability induced by bradykinin and leukotriene C4. 2002 J. Neuropathol. Exp. Neurol. pmid:12152787
Haimeur A et al. Charged amino acids in the sixth transmembrane helix of multidrug resistance protein 1 (MRP1/ABCC1) are critical determinants of transport activity. 2002 J. Biol. Chem. pmid:12186871
Norman BH et al. Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1). 2002 Bioorg. Med. Chem. Lett. pmid:11958985
Kolaczkowska E et al. Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes. 2002 Inflammation pmid:11989789
Ravasi S et al. Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma. 2002 Biochem. Pharmacol. pmid:11996896
Bandeira-Melo C et al. IL-16 promotes leukotriene C(4) and IL-4 release from human eosinophils via CD4- and autocrine CCR3-chemokine-mediated signaling. 2002 J. Immunol. pmid:11971026
Zhang DW et al. Determinants of the substrate specificity of multidrug resistance protein 1: role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17. 2002 J. Biol. Chem. pmid:11925441
Maekawa A et al. Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. 2002 J. Biol. Chem. pmid:11932261
Ahamed J and Ali H Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production. 2002 J. Biol. Chem. pmid:11934880
Kingham PJ et al. Adhesion-dependent interactions between eosinophils and cholinergic nerves. 2002 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12003778
Sawatzky DA et al. Eosinophil adhesion to cholinergic nerves via ICAM-1 and VCAM-1 and associated eosinophil degranulation. 2002 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12003784
Thomas LL et al. Immobilized lactoferrin is a stimulus for eosinophil activation. 2002 J. Immunol. pmid:12097406
Mao Q et al. GSH-dependent photolabeling of multidrug resistance protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain. 2002 J. Biol. Chem. pmid:12034727
Conrad S et al. A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance. 2002 Pharmacogenetics pmid:12042670
Fernández SB et al. Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells. 2002 J. Biol. Chem. pmid:12060660
Oliveira SH et al. Increased responsiveness of murine eosinophils to MIP-1beta (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8. 2002 J. Leukoc. Biol. pmid:12050188
Nobata K et al. Alpha(1L)-, but not alpha(1H)-, adrenoceptor antagonist prevents allergic bronchoconstriction in guinea pigs in vivo. 2002 Eur. J. Pharmacol. pmid:12323390
Koike K et al. Multiple membrane-associated tryptophan residues contribute to the transport activity and substrate specificity of the human multidrug resistance protein, MRP1. 2002 J. Biol. Chem. pmid:12388549
Yang Y et al. Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistance-associated protein 1. 2002 J. Biol. Chem. pmid:12235150
Bandeira-Melo C et al. Intracrine cysteinyl leukotriene receptor-mediated signaling of eosinophil vesicular transport-mediated interleukin-4 secretion. 2002 J. Exp. Med. pmid:12235216
Tabas LB and Dantzig AH A high-throughput assay for measurement of multidrug resistance protein-mediated transport of leukotriene C4 into membrane vesicles. 2002 Anal. Biochem. pmid:12413474
Belinsky MG et al. Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). 2002 Cancer Res. pmid:12414644
Hagmann W et al. Reconstitution of transport-active multidrug resistance protein 2 (MRP2; ABCC2) in proteoliposomes. 2002 Biol. Chem. pmid:12222674
Hashimoto K et al. Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome. 2002 Hepatology pmid:12395335
Bäck M et al. The contraction of the human pulmonary artery by LTC4 is resistant to cysLT1 antagonists and counteracted by prostacyclin release. 2002 Adv. Exp. Med. Biol. pmid:12664603
Gebhardt T et al. Cultured human intestinal mast cells express functional IL-3 receptors and respond to IL-3 by enhancing growth and IgE receptor-dependent mediator release. 2002 Eur. J. Immunol. pmid:12209644
Mastalerz L et al. Clinical and genetic features underlying the response of patients with bronchial asthma to treatment with a leukotriene receptor antagonist. 2002 Eur. J. Clin. Invest. pmid:12534456
Walch L et al. Pharmacological evidence for a novel cysteinyl-leukotriene receptor subtype in human pulmonary artery smooth muscle. 2002 Br. J. Pharmacol. pmid:12466244
Yang SH et al. The stimulatory effects of nasal discharge from patients with perennial allergic rhinitis on normal human neutrophils are normalized after treatment with a new mixed formula of Chinese herbs. 2002 Int. Immunopharmacol. pmid:12469937
Neu IS et al. Leukotrienes in patients with clinically active multiple sclerosis. 2002 Acta Neurol. Scand. pmid:11903112
Ren XQ et al. A positively charged amino acid proximal to the C-terminus of TM17 of MRP1 is indispensable for GSH-dependent binding of substrates and for transport of LTC4. 2002 Biochemistry pmid:12450376
Ma L et al. Identification and characterization of the canine multidrug resistance-associated protein. 2002 Mol. Cancer Ther. pmid:12516967
Wiklund CU et al. Interactions of volatile anesthetics with cholinergic, tachykinin, and leukotriene mechanisms in isolated Guinea pig bronchial smooth muscle. 2002 Anesth. Analg. pmid:12456432
Tsuruoka S et al. Functional analysis of ABCA8, a new drug transporter. 2002 Biochem. Biophys. Res. Commun. pmid:12379217
Sakata K and Bäck M Receptor preferences of cysteinyl-leukotrienes in the guinea pig lung parenchyma. 2002 Eur. J. Pharmacol. pmid:11834255
Suzuki Y et al. Silver activates calcium signals in rat basophilic leukemia-2H3 mast cells by a mechanism that differs from the Fc epsilon RI-activated response. 2002 J. Immunol. pmid:12244196
Bandeira-Melo C et al. Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. 2002 J. Allergy Clin. Immunol. pmid:12063527
Uemura M et al. Cysteinyl leukotrienes in the bile of patients with obstructive jaundice. 2002 J. Gastroenterol. pmid:12424566
Christmas P et al. Membrane localization and topology of leukotriene C4 synthase. 2002 J. Biol. Chem. pmid:12023288
Evans JF Cysteinyl leukotriene receptors. 2002 Prostaglandins Other Lipid Mediat. pmid:12432945
ten Hove T et al. Differential susceptibility of multidrug resistance protein-1 deficient mice to DSS and TNBS-induced colitis. 2002 Dig. Dis. Sci. pmid:12353855
Malaviya R and Uckun FM Leflunomide metabolite analogue alpha-cyano-beta-hydroxy-beta-methyl-N-[3-(trifluoromethyl)phenyl]propenamide inhibits IgE/FcepsilonRI receptor-mediated mast cell leukotriene release and allergic asthma in mice. 2001 Sep-Oct Am J Ther pmid:11550070
King BO et al. Tirofiban administration attenuates platelet and platelet-neutrophil conjugation but not neutrophil degranulation during in vitro VAD circulation. 2001 May-Jun ASAIO J. pmid:11374774
Karaman O et al. The comparison of the efficacy of fluticasone propionate with cetirizine in perennial allergic rhinitis. 2001 Mar-Apr Allergol Immunopathol (Madr) pmid:11420028
Abeywardena MY et al. Dietary n-3 and n-6 polyunsaturated oils and airway contractility. 2001 Apr-May Prostaglandins Leukot. Essent. Fatty Acids pmid:11418024
Miura K et al. Localizing a control region in the pathway to leukotriene C(4) secretion following stimulation of human basophils with anti-IgE antibody. 2001 J. Immunol. pmid:11739523
Wang J et al. [The effects of resuscitation with hypertonic saline solution on the postburn pulmonary injury in scalded dogs]. 2001 Zhonghua Shao Shang Za Zhi pmid:11774813
Eppihimer MJ and Schaub RG Soluble P-selectin antagonist mediates rolling velocity and adhesion of leukocytes in acutely inflamed venules. 2001 Microcirculation pmid:11296849
Díaz Lanza AM et al. Lignan and phenylpropanoid glycosides from Phillyrea latifolia and their in vitro anti-inflammatory activity. 2001 Planta Med. pmid:11345691
de las Heras B et al. Effects of six diterpenes on macrophage eicosanoid biosynthesis. 2001 Life Sci. pmid:12005260
Vicente AM et al. Modulation of haem oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages. 2001 Br. J. Pharmacol. pmid:11454666
Aoki M et al. Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. 2001 J. Pharmacol. Exp. Ther. pmid:11504812
Bäck M et al. An alternative pathway for metabolism of leukotriene D(4): effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea. 2001 Br. J. Pharmacol. pmid:11487525
Tohda Y et al. Role of chemical mediators in airway hyperresponsiveness in an asthmatic model. 2001 Respiration pmid:11223734
Setoguchi H et al. Leukotriene C(4) enhances the contraction of porcine tracheal smooth muscle through the activation of Y-27632, a rho kinase inhibitor, sensitive pathway. 2001 Br. J. Pharmacol. pmid:11156567
Amann R et al. Effects of COX-1 and COX-2 inhibitors on eicosanoid biosynthesis and the release of substance P from the guinea-pig isolated perfused lung. 2001 Inflamm. Res. pmid:11235022
Gronert K et al. Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. 2001 Am. J. Pathol. pmid:11141472
Picado C and Valero A COX-1 sparing drugs in aspirin-sensitive asthma. 2001 Clin. Exp. Allergy pmid:11251618
Terlouw SA et al. Role of multidrug resistance protein 2 (MRP2) in glutathione-bimane efflux from Caco-2 and rat renal proximal tubule cells. 2001 Br. J. Pharmacol. pmid:11682439
Schroeder JT et al. Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine. 2001 Clin. Exp. Allergy pmid:11591186
Hui Y et al. The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. 2001 J. Biol. Chem. pmid:11591709