LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Fauler J et al. | Enhanced synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis. | 1994 | Arthritis Rheum. | pmid:8129769 |
| Kawashima T et al. | Inhibitory effect of pemirolast, a novel antiallergic drug, on leukotriene C4 and granule protein release from human eosinophils. | 1994 | Int. Arch. Allergy Immunol. | pmid:8130655 |
| Marquardt DL et al. | Mast cell desensitization to IgE fails to induce a parallel adenosine receptor desensitization. | 1993 | Agents Actions | pmid:8147265 |
| Kurosawa M and Tsukagoshi H | Inhibitory effect of a thromboxane A2 synthetase inhibitor OKY-046 on bronchial hyperresponsiveness to histamine, but not on airway wall thickening, induced by intravenous administration of leukotriene C4 in guinea-pigs. | 1993 | Pulm Pharmacol | pmid:8148578 |
| Casellas F et al. | Abnormal leukotriene C4 released by unaffected jejunal mucosa in patients with inactive Crohn's disease. | 1994 | Gut | pmid:8174991 |
| Metters KM et al. | Microsomal glutathione S-transferase is the predominant leukotriene C4 binding site in cellular membranes. | 1994 | J. Biol. Chem. | pmid:8175695 |
| Abela A and Daniel EE | Neural and myogenic effects of leukotrienes C4, D4, and E4 on canine bronchial smooth muscle. | 1994 | Am. J. Physiol. | pmid:8179018 |
| Ibe BO et al. | Plasma and urinary leukotrienes in sickle cell disease: possible role in the inflammatory process. | 1994 | Eur. J. Clin. Invest. | pmid:8187808 |
| Kargman S et al. | Protein kinase C-dependent regulation of sulfidopeptide leukotriene biosynthesis and leukotriene C4 synthase in neutrophilic HL-60 cells. | 1994 | Mol. Pharmacol. | pmid:8190095 |
| Mayatepek E et al. | Impaired synthesis of lipoxygenase products in glutathione synthetase deficiency. | 1994 | Pediatr. Res. | pmid:8190517 |
| Takase B et al. | Effects of bepridil on silent myocardial ischemia and eicosanoid metabolism in chronic stable angina pectoris after healing of myocardial infarction. | 1994 | Am. J. Cardiol. | pmid:8198031 |
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| Kohrogi H et al. | Release of tachykinins and its metabolism in the airway. | 1993 | Regul. Pept. | pmid:8210488 |
| Hamann KJ et al. | Effects of activated eosinophils cultured from human umbilical cord blood on guinea pig trachealis. | 1993 | Am. J. Physiol. | pmid:8214090 |
| Renić M et al. | The effect of interleukin 1 alpha on acetaminophen-induced hepatotoxicity. | 1993 | Cytokine | pmid:8218930 |
| Huwiler A and Pfeilschifter J | A role for protein kinase C-alpha in zymosan-stimulated eicosanoid synthesis in mouse peritoneal macrophages. | 1993 | Eur. J. Biochem. | pmid:8223588 |
| Böhme M et al. | Differential inhibition by cyclosporins of primary-active ATP-dependent transporters in the hepatocyte canalicular membrane. | 1993 | FEBS Lett. | pmid:8224162 |
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| Ebersole JL et al. | Inflammatory mediators and immunoglobulins in GCF from healthy, gingivitis and periodontitis sites. | 1993 | J. Periodont. Res. | pmid:8263728 |
| Sirois MG et al. | Platelet activating factor modulates peptidoleukotriene effects on the permeability of bovine aortic endothelial cell to albumin. | 1993 | Agents Actions | pmid:8273559 |
| Rainsford KD | Leukotrienes in the pathogenesis of NSAID-induced gastric and intestinal mucosal damage. | 1993 | Agents Actions | pmid:8273575 |
| Butenko IG et al. | Anti-inflammatory properties and inhibition of leukotriene C4 biosynthesis in vitro by flavonoid baicalein from Scutellaria baicalensis georgy roots. | 1993 | Agents Actions | pmid:8273583 |
| Huber W et al. | Leukotriene B4 and C4 production in isolated rat gastric mucosal cells. | 1993 | Am. J. Physiol. | pmid:8279553 |
| Sawyer MM et al. | Arachidonic acid immunoregulation in lambs persistently infected with border disease virus. | 1993 | Comp. Immunol. Microbiol. Infect. Dis. | pmid:8281741 |
| Devalia JL et al. | Human bronchial epithelial cell dysfunction following in vitro exposure to nitrogen dioxide. | 1993 | Eur. Respir. J. | pmid:8287947 |
| Sala A et al. | Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit. | 1993 | Br. J. Pharmacol. | pmid:8298810 |
| Munoz NM et al. | Beta adrenergic modulation of formyl-methionine-leucine-phenylalanine-stimulated secretion of eosinophil peroxidase and leukotriene C4. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8301549 |
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| Sjölinder M et al. | Phorbol ester-induced suppression of leukotriene C4 synthase activity in human granulocytes. | 1995 | FEBS Lett. | pmid:8543026 |
| De Castro CM et al. | Modulation by dexamethasone of phospholipase A2 activities in endotoxemic guinea pigs. | 1995 | J. Appl. Physiol. | pmid:8567572 |
| Klapan I et al. | Arachidonic acid metabolites and sinonasal polyposis. I. Possible prognostic value. | 1995 Nov-Dec | Am J Otolaryngol | pmid:8572256 |
| Laviolette M et al. | Blood eosinophil leukotriene C4 production in asthma of different severities. | 1995 | Eur. Respir. J. | pmid:8575570 |
| Schäfer S and Walland A | Staurosporine inhibits the effects of leukotrienes C4 and D4 in isolated guinea pig heart and trachea. | 1995 | Methods Find Exp Clin Pharmacol | pmid:8577209 |
| Wang H et al. | Regulation of anti-SRBC antibody production by opioids and their mechanisms. | 1995 | Chin. Med. Sci. J. | pmid:8580479 |
| Shimizu T et al. | Leukotriene B4 and C4 metabolism in small intestine mucosa of children with celiac disease. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:8583294 |
| Sato H et al. | Biological characteristics of chronic eosinophilic leukemia cells with a t(2;5)(p23;q35) translocation. | 1995 | Leuk. Lymphoma | pmid:8590853 |
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| Tsikas D et al. | Catalytic hydrogenation of leukotriene B4 enhances sensitivity and specificity of gas chromatography-tandem mass spectrometry techniques and enables simultaneous analysis with cysteinyl leukotrienes in biological fluids. | 1996 | Anal. Biochem. | pmid:8619486 |
| Loe DW et al. | Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport. | 1996 | J. Biol. Chem. | pmid:8621643 |