LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kobayashi H et al. | Urinary trypsin inhibitor reduces the release of histamine from rat peritoneal mast cells. | 1998 | J. Lab. Clin. Med. | pmid:9579392 |
| Shindo K et al. | Prednisolone inhibits synthesis of 5-H(P)ETE in eosinophils from asthmatic patients during a wheezing attack but not during remission. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9578148 |
| Sporn PH et al. | Keratinocyte growth factor increases LTC4 synthesis and expression of flap in cultured rat alveolar type II cells. | 1997 | Adv. Exp. Med. Biol. | pmid:9561179 |
| Herman CA et al. | Synthesis and action of eicosanoids in warm and cold-acclimated amphibians. | 1997 | Adv. Exp. Med. Biol. | pmid:9561172 |
| Cyrus CB et al. | Leukotrienes C4 and D4 increase the ciliary beat frequency in human upper airway mucosa in vitro. | 1998 | Otolaryngol Head Neck Surg | pmid:9560097 |
| Sabbah A et al. | [Testing basophil activation by flow cytometry in the diagnosis of allergy to hymenopteran venom]. | 1998 | Allerg Immunol (Paris) | pmid:9559061 |
| Scheidegger C et al. | Effects of extracts and of individual components from Petasites on prostaglandin synthesis in cultured skin fibroblasts and on leucotriene synthesis in isolated human peripheral leucocytes. | 1998 | Pharm Acta Helv | pmid:9556438 |
| Gao M et al. | Multidrug resistance protein. Identification of regions required for active transport of leukotriene C4. | 1998 | J. Biol. Chem. | pmid:9553138 |
| Sperber K et al. | Mucin secretion in inflammatory bowel disease: comparison of a macrophage-derived mucin secretagogue (MMS-68) to conventional secretagogues. | 1998 | Inflamm. Bowel Dis. | pmid:9552223 |
| Brady HR et al. | Transcellular pathways and cell adhesion as potential contributors to leukotriene and lipoxin biosynthesis in acute glomerulonephritis. | 1997 | Adv. Exp. Med. Biol. | pmid:9547614 |
| Capra V et al. | Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma. | 1998 | Mol. Pharmacol. | pmid:9547367 |
| Black P et al. | Chemotherapy in experimental brain tumor, part 2: pretreatment with leukotriene C4 prolongs survival. | 1998 | J. Neurooncol. | pmid:9525821 |
| Diven WF et al. | Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla. | 1998 | Ann. Otol. Rhinol. Laryngol. | pmid:9525240 |
| Geuenich S et al. | Induction of leukotriene production by bleomycin and asparaginase in mast cells in vitro and in patients in vivo. | 1998 | Biochem. Pharmacol. | pmid:9514079 |
| Daugschies A and Ruttkowski B | Modulation of migration of Oesophagostomum dentatum larvae by inhibitors and products of eicosanoid metabolism. | 1998 | Int. J. Parasitol. | pmid:9513001 |
| Hundley TR et al. | Characteristics of arachidonic acid generation in human basophils: relationship between the effects of inhibitors of secretory phospholipase A2 activity and leukotriene C4 release. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9495842 |
| Lanas A et al. | Collagen secretion by human gastric and skin fibroblasts: implications for ulcer healing. | 1998 | Eur Surg Res | pmid:9493694 |
| Horak F et al. | Effect of continuous allergen challenge on clinical symptoms and mediator release in dust-mite-allergic patients. | 1998 | Allergy | pmid:9491231 |
| Kitaura K et al. | Effects of organic anions and bile acid conjugates on biliary excretion of LTC4 in the rat. | 1997 | Prostaglandins | pmid:9491205 |
| Fujita M et al. | Cysteinyl leukotrienes induce nasal symptoms of allergic rhinitis via a receptor-mediated mechanism in guinea pigs. | 1997 | Jpn. J. Pharmacol. | pmid:9469641 |