LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Neointima D058426 3 associated lipids
Eosinophilic Esophagitis D057765 3 associated lipids
Atherosclerosis D050197 85 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Carcinoma, Small Cell D018288 21 associated lipids
Myocardial Ischemia D017202 11 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Reperfusion Injury D015427 65 associated lipids
Wounds, Nonpenetrating D014949 4 associated lipids
Uveitis D014605 14 associated lipids
Ulcer D014456 16 associated lipids
Stomach Ulcer D013276 75 associated lipids
Status Asthmaticus D013224 4 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Marquardt DL et al. Mast cell desensitization to IgE fails to induce a parallel adenosine receptor desensitization. 1993 Agents Actions pmid:8147265
Kurosawa M and Tsukagoshi H Inhibitory effect of a thromboxane A2 synthetase inhibitor OKY-046 on bronchial hyperresponsiveness to histamine, but not on airway wall thickening, induced by intravenous administration of leukotriene C4 in guinea-pigs. 1993 Pulm Pharmacol pmid:8148578
Hamann KJ et al. Effects of activated eosinophils cultured from human umbilical cord blood on guinea pig trachealis. 1993 Am. J. Physiol. pmid:8214090
Sirois MG et al. Platelet activating factor modulates peptidoleukotriene effects on the permeability of bovine aortic endothelial cell to albumin. 1993 Agents Actions pmid:8273559
Wallis RA and Panizzon KL Protection from hypoxic and N-methyl-D-aspartate injury with azelastine, a leukotriene inhibitor. 1993 Eur. J. Pharmacol. pmid:8405089
Katori M et al. Interaction of substance P and leukotriene C4 in ethanol-induced mucosal injury of rat stomach. 1993 Regul. Pept. pmid:7692504
Patella V et al. Protein Fv produced during vital hepatitis is a novel activator of human basophils and mast cells. 1993 J. Immunol. pmid:7693815
Huber W et al. Leukotriene B4 and C4 production in isolated rat gastric mucosal cells. 1993 Am. J. Physiol. pmid:8279553
Sawyer MM et al. Arachidonic acid immunoregulation in lambs persistently infected with border disease virus. 1993 Comp. Immunol. Microbiol. Infect. Dis. pmid:8281741
Renić M et al. The effect of interleukin 1 alpha on acetaminophen-induced hepatotoxicity. 1993 Cytokine pmid:8218930
Laviolette M et al. Comparison of two modified techniques for purifying blood eosinophils. 1993 J. Immunol. Methods pmid:8228275
Kohrogi H et al. Release of tachykinins and its metabolism in the airway. 1993 Regul. Pept. pmid:8210488
Casolaro V et al. Nimesulide, a sulfonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from human basophils and mast cells. 1993 J. Pharmacol. Exp. Ther. pmid:7505332
Weide I et al. Intravascular cysteinyl-leukotriene formation by clotting whole human blood. Evidence from clamped umbilical vein segments and thrombus specimens. 1993 Thromb. Res. pmid:8122190
Mita H et al. Purification of human blood basophils and leukotriene C4 generation following calcium ionophore stimulation. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:7505057
Mifune T et al. Chemical mediator and cellular reaction in the bronchoalveolar lavage fluid of patients with steroid-dependent intractable asthma (SDIA). 1993 Acta Med. Okayama pmid:7505996
Marone G et al. Anti-inflammatory effects of glucocorticoids and cyclosporin A on human basophils. 1993 Eur. J. Clin. Pharmacol. pmid:7508864
Kurosawa M et al. Inhibition of bronchial hyperresponsiveness to histamine induced by intravenous administration of leukotriene C4 by novel thromboxane A2 receptor antagonists ONO-NT-126 and ONO-8809 in guinea-pigs. 1993 Clin. Exp. Allergy pmid:10780891
Westcott JY et al. Inactivation of peptidoleukotrienes in the isolated perfused rat lung. 1993 Arch. Biochem. Biophys. pmid:7692821
Westcott JY et al. Inactivation of leukotriene C4 in the airways and subsequent urinary leukotriene E4 excretion in normal and asthmatic subjects. 1993 Am. Rev. Respir. Dis. pmid:7694531