Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Marquardt DL et al. | Mast cell desensitization to IgE fails to induce a parallel adenosine receptor desensitization. | 1993 | Agents Actions | pmid:8147265 |
Kurosawa M and Tsukagoshi H | Inhibitory effect of a thromboxane A2 synthetase inhibitor OKY-046 on bronchial hyperresponsiveness to histamine, but not on airway wall thickening, induced by intravenous administration of leukotriene C4 in guinea-pigs. | 1993 | Pulm Pharmacol | pmid:8148578 |
Hamann KJ et al. | Effects of activated eosinophils cultured from human umbilical cord blood on guinea pig trachealis. | 1993 | Am. J. Physiol. | pmid:8214090 |
Sirois MG et al. | Platelet activating factor modulates peptidoleukotriene effects on the permeability of bovine aortic endothelial cell to albumin. | 1993 | Agents Actions | pmid:8273559 |
Wallis RA and Panizzon KL | Protection from hypoxic and N-methyl-D-aspartate injury with azelastine, a leukotriene inhibitor. | 1993 | Eur. J. Pharmacol. | pmid:8405089 |
Katori M et al. | Interaction of substance P and leukotriene C4 in ethanol-induced mucosal injury of rat stomach. | 1993 | Regul. Pept. | pmid:7692504 |
Patella V et al. | Protein Fv produced during vital hepatitis is a novel activator of human basophils and mast cells. | 1993 | J. Immunol. | pmid:7693815 |
Huber W et al. | Leukotriene B4 and C4 production in isolated rat gastric mucosal cells. | 1993 | Am. J. Physiol. | pmid:8279553 |
Sawyer MM et al. | Arachidonic acid immunoregulation in lambs persistently infected with border disease virus. | 1993 | Comp. Immunol. Microbiol. Infect. Dis. | pmid:8281741 |
Renić M et al. | The effect of interleukin 1 alpha on acetaminophen-induced hepatotoxicity. | 1993 | Cytokine | pmid:8218930 |
Laviolette M et al. | Comparison of two modified techniques for purifying blood eosinophils. | 1993 | J. Immunol. Methods | pmid:8228275 |
Kohrogi H et al. | Release of tachykinins and its metabolism in the airway. | 1993 | Regul. Pept. | pmid:8210488 |
Casolaro V et al. | Nimesulide, a sulfonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from human basophils and mast cells. | 1993 | J. Pharmacol. Exp. Ther. | pmid:7505332 |
Weide I et al. | Intravascular cysteinyl-leukotriene formation by clotting whole human blood. Evidence from clamped umbilical vein segments and thrombus specimens. | 1993 | Thromb. Res. | pmid:8122190 |
Mita H et al. | Purification of human blood basophils and leukotriene C4 generation following calcium ionophore stimulation. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7505057 |
Mifune T et al. | Chemical mediator and cellular reaction in the bronchoalveolar lavage fluid of patients with steroid-dependent intractable asthma (SDIA). | 1993 | Acta Med. Okayama | pmid:7505996 |
Marone G et al. | Anti-inflammatory effects of glucocorticoids and cyclosporin A on human basophils. | 1993 | Eur. J. Clin. Pharmacol. | pmid:7508864 |
Kurosawa M et al. | Inhibition of bronchial hyperresponsiveness to histamine induced by intravenous administration of leukotriene C4 by novel thromboxane A2 receptor antagonists ONO-NT-126 and ONO-8809 in guinea-pigs. | 1993 | Clin. Exp. Allergy | pmid:10780891 |
Westcott JY et al. | Inactivation of peptidoleukotrienes in the isolated perfused rat lung. | 1993 | Arch. Biochem. Biophys. | pmid:7692821 |
Westcott JY et al. | Inactivation of leukotriene C4 in the airways and subsequent urinary leukotriene E4 excretion in normal and asthmatic subjects. | 1993 | Am. Rev. Respir. Dis. | pmid:7694531 |