LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Neointima D058426 3 associated lipids
Eosinophilic Esophagitis D057765 3 associated lipids
Atherosclerosis D050197 85 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Carcinoma, Small Cell D018288 21 associated lipids
Myocardial Ischemia D017202 11 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Reperfusion Injury D015427 65 associated lipids
Wounds, Nonpenetrating D014949 4 associated lipids
Uveitis D014605 14 associated lipids
Ulcer D014456 16 associated lipids
Stomach Ulcer D013276 75 associated lipids
Status Asthmaticus D013224 4 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

Download all related citations
Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Taichman RS et al. Human osteosarcomas inhibit hematopoietic colony formation: partial reversal by antibody to transforming growth factor-beta 1. 1997 Bone pmid:9315339
Mullol J et al. [Eosinophil activation by epithelial cells of the respiratory mucosa. Comparative study of normal mucosa and inflammatory mucosa]. 1997 Med Clin (Barc) pmid:9303983
Jakobsson PJ et al. Characterization of microsomal GST-II by western blot and identification of a novel LTC4 isomer. 1997 J Lipid Mediat Cell Signal pmid:9302651
Hamasaki Y et al. Post-transcriptional regulation of LTC4 synthase activity by retinoic acid in rat basophilic leukemia cells. 1997 Biochim. Biophys. Acta pmid:9295165
Stride BD et al. Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. 1997 Mol. Pharmacol. pmid:9281595
Cunningham FM et al. Pharmacology of the 5-lipoxygenase inhibitors BAY Y 1015 and BAY X 1005 in the horse. 1997 J. Vet. Pharmacol. Ther. pmid:9280370
Sainte-Laudy J et al. [Bioclinical interest in the assay of leukotrienes in four cases of sensitization to trophallergens]. 1997 Allerg Immunol (Paris) pmid:9254120
Sabbah A et al. [Allergy to mosquitoes and use of new immunobiological parameters]. 1997 Allerg Immunol (Paris) pmid:9254117
Ibe BO et al. Leukotriene synthesis by isolated perinatal ovine intrapulmonary vessels correlates with age-related changes in 5-lipoxygenase protein. 1997 Biochem. Mol. Med. pmid:9232199
Bacha EA et al. Gastric antigen challenge releases gastrin and eicosanoids and protects against ethanol. 1997 J. Surg. Res. pmid:9228931
Sabbah A et al. [Anaphylactic or anaphylactoid reactions to paracetamol. Report of 3 cases]. 1997 Allerg Immunol (Paris) pmid:9221011
Patella V et al. Heterogeneous effects of protamine on human mast cells and basophils. 1997 Br J Anaesth pmid:9215027
Chavis C et al. Leukotriene E4 plasma levels in adult asthmatic patients with variable disease severity. 1997 Allergy pmid:9201374
Forssmann U et al. Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. 1997 J. Exp. Med. pmid:9182688
Leynadier F [Drug allergies: value of the leucotriene C4 release test?]. 1997 Presse Med pmid:9180883
Genovese A et al. Loratadine and desethoxylcarbonyl-loratadine inhibit the immunological release of mediators from human Fc epsilon RI+ cells. 1997 Clin. Exp. Allergy pmid:9179431
Akagi M et al. Anti-allergic effect of tea-leaf saponin (TLS) from tea leaves (Camellia sinensis var. sinensis). 1997 Biol. Pharm. Bull. pmid:9178940
Hamasaki Y et al. The Chinese herbal medicine, shinpi-to, inhibits IgE-mediated leukotriene synthesis in rat basophilic leukemia-2H3 cells. 1997 J Ethnopharmacol pmid:9174973
Planquois JM et al. Differential inhibition by selective phosphodiesterase inhibitors of antigen, LTC4 and histamine-induced contraction of guinea-pig isolated trachea. 1996 Pulm Pharmacol pmid:9160414
Abe T et al. [Multidrug resistance protein (MRP)]. 1997 Nippon Rinsho pmid:9155156