Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Damtew B and Spagnuolo PJ | Leukotriene C4 from vascular endothelium enhances neutrophil adhesiveness. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9051719 |
Schuligoi R et al. | Release of calcitonin gene-related peptide in cardiac anaphylaxis. | 1997 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9050016 |
Gissurarson SR et al. | Effect of lobaric acid on cysteinyl-leukotriene formation and contractile activity of guinea pig taenia coli. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9023290 |
Sare M et al. | The effects of indomethacin, NDGA, allopurinol and superoxide dismutase on prostaglandin E2 and leukotriene C4 levels after mesenteric ischemia-reperfusion injury. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9014215 |
Dhillon HS et al. | Regional generation of leukotriene C4 after experimental brain injury in anesthetized rats. | 1996 | J. Neurotrauma | pmid:9002063 |
Garcia C et al. | Effects of synthetic peptido-leukotrienes on bone resorption in vitro. | 1996 | J. Bone Miner. Res. | pmid:8992883 |
Kobayashi S et al. | [Inhibitory effect of ONO-1078, a novel leukotriene receptor antagonist, on human peripheral blood eosinophils]. | 1996 | Arerugi | pmid:8990528 |
Akasaka R et al. | Effects of three different Ca(2+)-ATPase inhibitors on Ca2+ response and leukotriene release in RBL-2H3 cells. | 1996 | Inflamm. Res. | pmid:8988402 |
Campbell A et al. | Overview of allergic mechanisms. Ebastine has more than an antihistamine effect. | 1996 | Drugs | pmid:8983912 |
Bäck M et al. | The cysteinyl-leukotriene receptor antagonist BAY u9773 is a competitive antagonist of leukotriene C4 in the guinea-pig ileum. | 1996 | Eur. J. Pharmacol. | pmid:8982726 |
Maclouf J et al. | Consequences of transcellular biosynthesis of leukotriene C4 on organ function. | 1996 | Haemostasis | pmid:8979109 |
Leier I et al. | Identification of the biosynthetic leukotriene C4 export pump in murine mastocytoma cells as a homolog of the multidrug-resistance protein. | 1996 | Eur. J. Biochem. | pmid:8973633 |
Ionac M et al. | Oxaceprol, an atypical inhibitor of inflammation and joint damage. | 1996 | Pharmacol. Res. | pmid:8971960 |
Namovic MT et al. | Pharmacological modulation of eosinophil influx into the lungs of Brown Norway rats. | 1996 | Eur. J. Pharmacol. | pmid:8960868 |
Lane SJ and Lee TH | Mast cell effector mechanisms. | 1996 | J. Allergy Clin. Immunol. | pmid:8939179 |
Sun H et al. | Expression and characterization of the multidrug resistance-associated protein in insect cells infected with a recombinant baculovirus. | 1996 | Oncol. Res. | pmid:8938792 |
Richter L et al. | Increased biliary secretion of cysteinyl-leukotrienes in human bile duct obstruction. | 1996 | J. Hepatol. | pmid:8938552 |
Willburger RE et al. | Inhibition of eicosanoid release from synovial organ culture by incubation with tepoxalin and its acid metabolite. | 1996 | Prostaglandins | pmid:8936587 |
Muñoz NM et al. | Eosinophil VLA-4 binding to fibronectin augments bronchial narrowing through 5-lipoxygenase activation. | 1996 | Am. J. Physiol. | pmid:8928818 |
Ganbo T et al. | The effects of leukotrienes C4 and D4 on ciliary activity of human paranasal sinus mucosa in vitro. | 1995 | Rhinology | pmid:8919211 |