| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
| Carcinoma, Small Cell | D018288 | 21 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ducep JB et al. | Synthesis of 5- and 6-fluoro derivatives of 5,8,14-eicosatrienoic and 5,8,11,14-eicosatetraenoic acids. Effects of fluorinated arachidonic acids on leukotriene C4 production by macrophages. | 1994 | Bioorg. Med. Chem. | pmid:7922133 |
| Ibe BO et al. | Plasma and urinary leukotrienes in sickle cell disease: possible role in the inflammatory process. | 1994 | Eur. J. Clin. Invest. | pmid:8187808 |
| Mayatepek E et al. | Impaired synthesis of lipoxygenase products in glutathione synthetase deficiency. | 1994 | Pediatr. Res. | pmid:8190517 |
| Fauler J et al. | Enhanced synthesis of cysteinyl leukotrienes in juvenile rheumatoid arthritis. | 1994 | Arthritis Rheum. | pmid:8129769 |
| Goulet JL et al. | Altered inflammatory responses in leukotriene-deficient mice. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7809134 |
| Müller M et al. | Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7809167 |
| HasanoÄŸlu E et al. | The role of prostanoids in the complications of extracorporeal shock wave lithotripsy (ESWL) in children. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846111 |
| Liu L et al. | Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum. | 1994 | Arzneimittelforschung | pmid:7848335 |
| Fujii R et al. | Adenosine triphosphate-dependent transport of leukotriene C4 by membrane vesicles prepared from cisplatin-resistant human epidermoid carcinoma tumor cells. | 1994 | J. Natl. Cancer Inst. | pmid:7966417 |
| Kawashima T et al. | [Inhibitory effect of AS-35. a novel antiallergic drug, on chemical mediator release from human eosinophils]. | 1994 | Arerugi | pmid:7887808 |
| Raible DG | Erythrocytes increase leukotriene C4 release from human eosinophils: characterization and examination of possible mechanisms. | 1994 | J. Leukoc. Biol. | pmid:8027672 |
| Mitsuhashi T et al. | Increased production of eicosanoids, TXA2, PGI2 and LTC4 in experimental spinal cord injuries. | 1994 | Paraplegia | pmid:7970857 |
| Volland H et al. | Enzyme immunometric assay for leukotriene C4. | 1994 | J. Immunol. Methods | pmid:7930643 |
| Abela A and Daniel EE | Neural and myogenic effects of leukotrienes C4, D4, and E4 on canine bronchial smooth muscle. | 1994 | Am. J. Physiol. | pmid:8179018 |
| Shimizu T et al. | Leukotriene B4 and C4 generation by small intestinal mucosa in children with coeliac disease. | 1994 | Digestion | pmid:8063028 |
| Böhme M et al. | Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver. | 1994 | Gastroenterology | pmid:8020669 |
| Wei EQ et al. | [Effect of a leukotriene antagonist, ONO-1078, on electric stimulation of vagus (ESV)-induced bronchoconstriction and microvascular leakage in guinea pigs]. | 1994 | Yao Xue Xue Bao | pmid:7976357 |
| Nagashima T et al. | The effect of leukotriene C4 on the permeability of brain capillary endothelial cell monolayer. | 1994 | Acta Neurochir Suppl (Wien) | pmid:7976646 |
| Amon U et al. | Control function of protein kinase C isozymes on leukotriene generation from human basophils? | 1994 | Agents Actions | pmid:7976816 |
| Medina L et al. | Leukotriene C4 upregulates collagenase expression and synthesis in human lung fibroblasts. | 1994 | Biochim. Biophys. Acta | pmid:7981229 |