Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Olynych TJ et al. | Fungal zymosan induces leukotriene production by human mast cells through a dectin-1-dependent mechanism. | 2006 | J. Allergy Clin. Immunol. | pmid:17030235 |
Lee KS et al. | Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice. | 2007 | J. Allergy Clin. Immunol. | pmid:17208595 |
Hamilton RG and Franklin Adkinson N | In vitro assays for the diagnosis of IgE-mediated disorders. | 2004 | J. Allergy Clin. Immunol. | pmid:15316492 |
Macglashan DW and Saini SS | Omalizumab increases the intrinsic sensitivity of human basophils to IgE-mediated stimulation. | 2013 | J. Allergy Clin. Immunol. | pmid:23791510 |
Kowalski ML et al. | Differential effects of aspirin and misoprostol on 15-hydroxyeicosatetraenoic acid generation by leukocytes from aspirin-sensitive asthmatic patients. | 2003 | J. Allergy Clin. Immunol. | pmid:13679808 |
Triggiani M et al. | Lung mast cells are a source of secreted phospholipases A2. | 2009 | J. Allergy Clin. Immunol. | pmid:19541351 |
Di Capite J et al. | Targeting Ca2+ release-activated Ca2+ channel channels and leukotriene receptors provides a novel combination strategy for treating nasal polyposis. | 2009 | J. Allergy Clin. Immunol. | pmid:19895990 |
Miura K et al. | Phosphorylation of cytosolic phospholipase A2 by IL-3 is associated with increased free arachidonic acid generation and leukotriene C4 release in human basophils. | 1998 | J. Allergy Clin. Immunol. | pmid:9768595 |
Meliton AY et al. | Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils. | 2003 | J. Allergy Clin. Immunol. | pmid:12897749 |
Oskeritzian CA et al. | Surface CD88 functionally distinguishes the MCTC from the MCT type of human lung mast cell. | 2005 | J. Allergy Clin. Immunol. | pmid:15940129 |
Shilling AD et al. | Use of canalicular membrane vesicles (CMVs) from rats, dogs, monkeys and humans to assess drug transport across the canalicular membrane. | 2006 May-Jun | J Pharmacol Toxicol Methods | pmid:16176877 |
Ramis I et al. | Application of totally automated on-line sample clean up system for extraction and high-performance liquid chromatography separation of peptide leukotrienes. | 1993 Nov-Dec | J Pharm Biomed Anal | pmid:8123725 |
Syslová K et al. | Immunomagnetic molecular probe with UHPLC-MS/MS: a promising way for reliable bronchial asthma diagnostics based on quantification of cysteinyl leukotrienes. | 2013 Jul-Aug | J Pharm Biomed Anal | pmid:23644905 |
Herron DK et al. | Visualization and comparison of molecular dynamics simulations of leukotriene C4, leukotriene D4, and leukotriene E4. | 1995 | J Mol Graph | pmid:8820302 |
Jakobsson PJ et al. | Characterization of microsomal GST-II by western blot and identification of a novel LTC4 isomer. | 1997 | J Lipid Mediat Cell Signal | pmid:9302651 |
Lam BK et al. | Leukotriene C4 synthase. | 1995 | J Lipid Mediat Cell Signal | pmid:8777577 |
Liebhart J et al. | Production of leukotriene C4 by peripheral blood leukocytes stimulated with anti-fcepsilonRI antibody, PMA, and fMLP does not correlate with irreversible airway obstruction in asthmatics. | 2007 | J Investig Allergol Clin Immunol | pmid:17323856 |
Annila I et al. | Bee venom induces high histamine or high leukotriene C4 release in skin of sensitized beekeepers. | 2000 Jul-Aug | J Investig Allergol Clin Immunol | pmid:11039839 |
Kimura Y et al. | Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. | 1995 | J Ethnopharmacol | pmid:7776662 |
Abad MJ et al. | Anti-inflammatory activity of four Bolivian Baccharis species (Compositae). | 2006 | J Ethnopharmacol | pmid:16202549 |
Quan Z et al. | Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation. | 2010 | J Ethnopharmacol | pmid:20699114 |
Di Sotto A et al. | Pharmacological and phytochemical study on a Sisymbrium officinale Scop. extract. | 2010 | J Ethnopharmacol | pmid:19969059 |
Yang SH and Yu CL | Antiinflammatory effects of Bu-zhong-yi-qi-tang in patients with perennial allergic rhinitis. | 2008 | J Ethnopharmacol | pmid:17980528 |
Hamasaki Y et al. | The Chinese herbal medicine, shinpi-to, inhibits IgE-mediated leukotriene synthesis in rat basophilic leukemia-2H3 cells. | 1997 | J Ethnopharmacol | pmid:9174973 |
Kjellström S et al. | On-line coupling of microdialysis sampling with liquid chromatography for the determination of peptide and non-peptide leukotrienes. | 1998 | J Chromatogr A | pmid:9818423 |
Al-Amran FG et al. | Leukotriene biosynthesis inhibition ameliorates acute lung injury following hemorrhagic shock in rats. | 2011 | J Cardiothorac Surg | pmid:21649921 |
Heredi-Szabo K et al. | Characterization of 5(6)-carboxy-2,'7'-dichlorofluorescein transport by MRP2 and utilization of this substrate as a fluorescent surrogate for LTC4. | 2008 | J Biomol Screen | pmid:18349419 |
Mitsunobu F et al. | Different roles of histamine and leukotriene C4 in the airways between patients with atopic and nonatopic asthma. | 1998 | J Asthma | pmid:9669831 |
Xu R et al. | Novel polyhydroxylated steroids from the East China Sea gorgonian Echinogorgia sassapo reticulata with suppressive activity of leukotriene C4 generation and degranulation in bone marrow-derived mast cells. | 2014 | J Asian Nat Prod Res | pmid:24437431 |
Sciuto AM et al. | Post-exposure treatment with isoproterenol attenuates pulmonary edema in phosgene-exposed rabbits. | 1998 Sep-Oct | J Appl Toxicol | pmid:9804432 |
Okamoto M et al. | Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma. | 2000 | Intern. Med. | pmid:10732825 |
Daugschies A and Ruttkowski B | Modulation of migration of Oesophagostomum dentatum larvae by inhibitors and products of eicosanoid metabolism. | 1998 | Int. J. Parasitol. | pmid:9513001 |
Meier HL et al. | Simultaneous initiation of degranulation and inhibition of leukotriene release by soman in human basophils. | 1995 | Int. J. Immunopharmacol. | pmid:7545649 |
Hamasaki Y et al. | (9-[4-acetyl-3-hydroxy-2-n-propylphenoxy) methyl]-3-(1H-tetrazol-5-yl)-4H-pyrido [1,2-a] pyrimidin-4-one), AS-35, inhibits leukotriene synthesis. | 2000 | Int. J. Immunopharmacol. | pmid:10785545 |
Vigorito C et al. | Metabolic and hemodynamic effects of peptide leukotriene C4 and D4 in man. | 1997 | Int. J. Clin. Lab. Res. | pmid:9352380 |
Sharma R et al. | RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance. | 2004 | Int. J. Cancer | pmid:15386349 |
Meszaros P et al. | Long term myriocin treatment increases MRP1 transport activity. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23178537 |
Jung HW et al. | Comparison of the efficacy of KOB03, ketotifen, and montelukast in an experimental mouse model of allergic rhinitis. | 2013 | Int. Immunopharmacol. | pmid:23643816 |
Muraki M et al. | Inhaled montelukast inhibits cysteinyl-leukotriene-induced bronchoconstriction in ovalbumin-sensitized guinea-pigs: the potential as a new asthma medication. | 2009 | Int. Immunopharmacol. | pmid:19706339 |
Fujisaki T et al. | Bestatin selectively suppresses the growth of leukemic stem/progenitor cells with BCR/ABL mRNA transcript in patients with chronic myelogeneous leukemia. | 2003 | Int. Immunopharmacol. | pmid:12781706 |
Yang SH et al. | The stimulatory effects of nasal discharge from patients with perennial allergic rhinitis on normal human neutrophils are normalized after treatment with a new mixed formula of Chinese herbs. | 2002 | Int. Immunopharmacol. | pmid:12469937 |
Rossi MI et al. | Long-term exacerbation by interleukin 13 of IgE-mediated eosinophilia in rats. | 2005 | Int. Immunopharmacol. | pmid:15953562 |
Nunomura S et al. | Role of the FcepsilonRI beta-chain ITAM as a signal regulator for mast cell activation with monomeric IgE. | 2005 | Int. Immunol. | pmid:15944196 |
Georgitis JW et al. | Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. | 1995 | Int. Arch. Allergy Immunol. | pmid:7719157 |
Genovese A et al. | Protein Fv produced during viral hepatitis is an endogenous immunoglobulin superantigen activating human heart mast cells. | 2003 | Int. Arch. Allergy Immunol. | pmid:14707465 |
Genovese A et al. | Role of mast cells, basophils and their mediators in adverse reactions to general anesthetics and radiocontrast media. | 1996 | Int. Arch. Allergy Immunol. | pmid:8645973 |
Davoine F et al. | Interleukin-12 inhibits eosinophil degranulation and migration but does not promote eosinophil apoptosis. | 2006 | Int. Arch. Allergy Immunol. | pmid:16735797 |
Patella V et al. | Oxatomide inhibits the release of proinflammatory mediators from human basophils and mast cells. | 1996 | Int. Arch. Allergy Immunol. | pmid:8753840 |
Hirano T et al. | Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils. | 2004 | Int. Arch. Allergy Immunol. | pmid:15153793 |
Iwamoto I et al. | Effect of a selective thromboxane A2 receptor antagonist BAY u3405 on antigen-, leukotriene C4- and leukotriene D4-induced bronchoconstriction in guinea pigs. | 1995 | Int. Arch. Allergy Immunol. | pmid:7647588 |
Ilarraza R et al. | Montelukast inhibits leukotriene stimulation of human dendritic cells in vitro. | 2012 | Int. Arch. Allergy Immunol. | pmid:22846852 |
Hashimoto K et al. | Cysteinyl leukotrienes induce monocyte chemoattractant protein-1 in human monocyte/macrophages via mitogen-activated protein kinase and nuclear factor-kappaB pathways. | 2009 | Int. Arch. Allergy Immunol. | pmid:19218821 |
Koketsu R et al. | Pretreatment with low levels of FcεRI-crosslinking stimulation enhances basophil mediator release. | 2013 | Int. Arch. Allergy Immunol. | pmid:23711850 |
James A et al. | The influence of aspirin on release of eoxin C4, leukotriene C4 and 15-HETE, in eosinophilic granulocytes isolated from patients with asthma. | 2013 | Int. Arch. Allergy Immunol. | pmid:23921438 |
Itoh K et al. | Relationship between airway eosinophilia and airway hyperresponsiveness in a late asthmatic model of guinea pigs. | 1996 | Int. Arch. Allergy Immunol. | pmid:8527956 |
Kawashima T et al. | Inhibitory effect of pemirolast, a novel antiallergic drug, on leukotriene C4 and granule protein release from human eosinophils. | 1994 | Int. Arch. Allergy Immunol. | pmid:8130655 |
Wang D et al. | Correlations between complaints, inflammatory cells and mediator concentrations in nasal secretions after nasal allergen challenge and during natural allergen exposure. | 1995 | Int. Arch. Allergy Immunol. | pmid:7888790 |
Kitahata Y et al. | Prolonged culture of mast cells with high-glucose medium enhances the Fc epsilon RI-mediated degranulation response and leukotriene C4 production. | 2010 | Int. Arch. Allergy Immunol. | pmid:20523060 |
Patella V et al. | Human heart mast cells: a definitive case of mast cell heterogeneity. | 1995 | Int. Arch. Allergy Immunol. | pmid:7536502 |
Lebel B et al. | Inhibition of mediator release from dispersed nasal polyp cells by cyclosporin A. | 1998 | Int. Arch. Allergy Immunol. | pmid:9693278 |
Austen KF | The Paul Kallós Memorial Lecture. From slow-reacting substance of anaphylaxis to leukotriene C4 synthase. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7613129 |
Tsai JJ et al. | Relationship between nasal resistance and airway hyperreactivity following nasal provocation with Dermatophagoides pteronyssinus in allergic rhinitis. | 1995 | Int. Arch. Allergy Immunol. | pmid:7888791 |
Weber M and Dahinden CA | Basophil and eosinophil activation by CC chemokines. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7542061 |
Kang BC et al. | Experimental asthma developed by room air contamination with cockroach allergen. | 1996 | Int. Arch. Allergy Immunol. | pmid:8917126 |
Takafuji S et al. | Effects of physiologic soluble agonists on leukotriene C4 production and degranulation by human eosinophils. | 1995 | Int. Arch. Allergy Immunol. | pmid:7549519 |
Yoshida K et al. | Effect of fibronectin on the production of leukotriene C4 by eosinophils. | 1995 | Int. Arch. Allergy Immunol. | pmid:7549524 |
Bossé M et al. | Eosinophil activation status and corticosteroid responsiveness in severe asthma. | 2000 | Int. Arch. Allergy Immunol. | pmid:10899764 |
Marone G et al. | Human heart mast cells in anaphylaxis and cardiovascular disease. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7542106 |
Okamoto M et al. | Effects of perilla seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism. | 2000 | Int. Arch. Allergy Immunol. | pmid:10878492 |
Kloprogge E et al. | Cellular communication in leukotriene C4 production between eosinophils and neutrophils. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2509375 |
Schauer U et al. | Enhanced leukotriene C4 production by peripheral eosinophilic granulocytes from children with asthma. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2512259 |
Oh YC et al. | Anti-allergic activity of a platycodon root ethanol extract. | 2010 | Int J Mol Sci | pmid:20717534 |
Borrelli I et al. | Benzene metabolites inhibit the release of proinflammatory mediators and cytokines from human basophils. | 2010 Jul-Sep | Int J Immunopathol Pharmacol | pmid:20943043 |
Cotti E and Torabinejad M | Detection of leukotriene C4 in human periradicular lesions. | 1994 | Int Endod J | pmid:8034369 |
Tarnay JN et al. | The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance-associated protein family. | 2004 | Insect Mol. Biol. | pmid:15373810 |
Hung ND et al. | Oral administration of 2-docosahexaenoyl lysophosphatidylcholine displayed anti-inflammatory effects on zymosan A-induced peritonitis. | 2011 | Inflammation | pmid:20490641 |
Kolaczkowska E et al. | Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes. | 2002 | Inflammation | pmid:11989789 |
Han YS et al. | Macelignan inhibits histamine release and inflammatory mediator production in activated rat basophilic leukemia mast cells. | 2012 | Inflammation | pmid:22729280 |
Schuligoi R et al. | Effects of the cyclooxygenase-2 inhibitor NS-398 on thromboxane and leukotriene synthesis in rat peritoneal cells. | 1998 | Inflamm. Res. | pmid:9657255 |
Akasaka R et al. | Effects of three different Ca(2+)-ATPase inhibitors on Ca2+ response and leukotriene release in RBL-2H3 cells. | 1996 | Inflamm. Res. | pmid:8988402 |
Omar HM et al. | Hepatobiliary excretion of cysteinyl leukotrienes in three experimental models of acute hepatic injury. | 1996 | Inflamm. Res. | pmid:8912018 |
Ebihara S et al. | A simple preparation method for mouse eosinophils and their responses to anti-allergic drugs. | 2007 | Inflamm. Res. | pmid:17406808 |
Horizoe T et al. | ER-34122, a novel dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity in an arachidonic acid-induced ear inflammation model. | 1998 | Inflamm. Res. | pmid:9831321 |
Ohashi H et al. | Sulochrin inhibits eosinophil activation and chemotaxis. | 1998 | Inflamm. Res. | pmid:9831326 |
Theron AJ et al. | Leukotrienes C4 and D4 sensitize human neutrophils for hyperreactivity to chemoattractants. | 2009 | Inflamm. Res. | pmid:19184354 |
Daffonchio L et al. | Protective activity of ketoprofen lysine salt against the pulmonary effects induced by bradykinin in guinea-pigs. | 1996 | Inflamm. Res. | pmid:8737750 |
Inoue H et al. | Inhibition by actinomycin D of neurogenic mouse ear oedema. | 1995 | Inflamm. Res. | pmid:7552577 |
Franco L and Velo GP | Eicosanoid and gastroprotection by copper derivatives and NDGA. | 1995 | Inflamm. Res. | pmid:7552579 |
Ko JK and Cho CH | Co-regulation of mucosal nitric oxide and prostaglandin in gastric adaptive cytoprotection. | 1999 | Inflamm. Res. | pmid:10522801 |
Gibbs BF et al. | Ambroxol inhibits IgE-dependent mediator secretion from human skin mast cells. | 2000 | Inflamm. Res. | pmid:10864402 |
Urasaki T et al. | Cytosolic phospholipase A2, increased and activated in the eosinophils of patients with hypereosinophilic syndrome in vivo, is involved in the augmented release of leukotriene C4. | 1999 | Inflamm. Res. | pmid:9987681 |
Urasaki T et al. | Induction of the activation-related antigen CD69 on human eosinophils by type IIA phospholipase A2. | 2000 | Inflamm. Res. | pmid:10858018 |
Dent G et al. | Up-regulation of human eosinophil leukotriene C4 generation through contact with bronchial epithelial cells. | 2000 | Inflamm. Res. | pmid:10893047 |
Amann R et al. | Effects of COX-1 and COX-2 inhibitors on eicosanoid biosynthesis and the release of substance P from the guinea-pig isolated perfused lung. | 2001 | Inflamm. Res. | pmid:11235022 |
Amann R et al. | Eicosanoid release in the endotoxin-primed isolated perfused rat lung and its pharmacological modification. | 1999 | Inflamm. Res. | pmid:10669114 |
Sperber K et al. | Mucin secretion in inflammatory bowel disease: comparison of a macrophage-derived mucin secretagogue (MMS-68) to conventional secretagogues. | 1998 | Inflamm. Bowel Dis. | pmid:9552223 |
Genovese A et al. | Bacterial immunoglobulin superantigen proteins A and L activate human heart mast cells by interacting with immunoglobulin E. | 2000 | Infect. Immun. | pmid:10992448 |
Pelclová D et al. | Leukotrienes B4, C4, D4 and E4 in the exhaled breath condensate (EBC), blood and urine in patients with pneumoconiosis. | 2012 | Ind Health | pmid:22785421 |
Mochizuki Y et al. | Suppressive activity of epinastine hydrochloride on eosinophil activation in vitro. | 2008 Jan-Feb | In Vivo | pmid:18396776 |
Chae HS and Chin YW | Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells. | 2012 | Immunopharmacol Immunotoxicol | pmid:21854102 |