Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Muccitelli RM et al. | Cysteinyl leukotriene receptor assays. | 2001 | Curr Protoc Pharmacol | pmid:22293965 |
Martin V et al. | Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors. | 2001 | Biochem. Pharmacol. | pmid:11705452 |
Fukuishi N et al. | Antiallergic effect of ardisiaquinone A, a potent 5-lipoxygenase inhibitor. | 2001 | Phytomedicine | pmid:11824521 |
Qian YM et al. | Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1. | 2001 | J. Biol. Chem. | pmid:11102445 |
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Bates ME et al. | ERK1 and ERK2 activation by chemotactic factors in human eosinophils is interleukin 5-dependent and contributes to leukotriene C(4) biosynthesis. | 2000 | J. Biol. Chem. | pmid:10753897 |
Ohbayashi H and Yamaki KI | Both inhalant and intravenous uroguanylin inhibit leukotriene C4-induced airway changes. | 2000 | Peptides | pmid:11068092 |
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Mayatepek E et al. | Defects in the synthesis of cysteinyl leukotrienes: a new group of inborn errors of metabolism. | 2000 | J. Inherit. Metab. Dis. | pmid:10896305 |
Miura K and MacGlashan DW | Dual phase priming by IL-3 for leukotriene C4 generation in human basophils: difference in characteristics between acute and late priming effects. | 2000 | J. Immunol. | pmid:10706691 |
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