| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Nakamura T et al. | Direct interaction between a quinoline derivative, MS-209, and multidrug resistance protein (MRP) in human gastric cancer cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10049760 |
| Sjölinder M et al. | Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1. | 1999 | J. Lipid Res. | pmid:10064732 |
| Collin N et al. | [Search for a threshold to distinguish between locoregional and systemic reactions using the histamine liberation value and the LTC4 level]. | 1999 | Allerg Immunol (Paris) | pmid:10070593 |
| Sakamoto H et al. | Enhancement of glucuronosyl etoposide transport by glutathione in multidrug resistance-associated protein-overexpressing cells. | 1999 | Cancer Lett. | pmid:10077229 |
| Awasthi S et al. | ATP-Dependent colchicine transport by human erythrocyte glutathione conjugate transporter. | 1999 | Toxicol. Appl. Pharmacol. | pmid:10079207 |
| Lay JC et al. | Cellular and biochemical response of the human lung after intrapulmonary instillation of ferric oxide particles. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10100994 |
| O'Connor BJ et al. | Selective airway responsiveness in asthma. | 1999 | Trends Pharmacol. Sci. | pmid:10101956 |
| Zaitsu M et al. | Effect of dexamethasone on leukotriene synthesis in DMSO-stimulated HL-60 cells. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10102384 |
| Renes J et al. | ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1. | 1999 | Br. J. Pharmacol. | pmid:10188979 |
| Keskil ZA et al. | Changes of arterial arachidonic acid metabolites in hypertensive patients during haemodialysis. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10189068 |
| McWherter CA et al. | Circular permutation of the granulocyte colony-stimulating factor receptor agonist domain of myelopoietin. | 1999 | Biochemistry | pmid:10194378 |
| Carvalho-Tavares J et al. | Assessment of the mechanism of juxtacrine activation and adhesion of leukocytes in liver microcirculation. | 1999 | Am. J. Physiol. | pmid:10198324 |
| Miura K et al. | Extracellular signal-regulated kinases regulate leukotriene C4 generation, but not histamine release or IL-4 production from human basophils. | 1999 | J. Immunol. | pmid:10201947 |
| Constable AL et al. | DMSO induction of the leukotriene LTC4 by Lewis rat Schwann cells. | 1999 | J. Neurol. Sci. | pmid:10202977 |
| Held HD et al. | Characterization of airway and vascular responses in murine lungs. | 1999 | Br. J. Pharmacol. | pmid:10205008 |
| Malaviya R and Uckun FM | Genetic and biochemical evidence for a critical role of Janus kinase (JAK)-3 in mast cell-mediated type I hypersensitivity reactions. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10208864 |
| Masereeuw R et al. | Active lucifer yellow secretion in renal proximal tubule: evidence for organic anion transport system crossover. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10215693 |
| Mayatepek E et al. | A severely affected infant with absence of cysteinyl leukotrienes in cerebrospinal fluid: further evidence that leukotriene C4-synthesis deficiency is a new neurometabolic disorder. | 1999 | Neuropediatrics | pmid:10222453 |
| Takao A et al. | Inhibitory effects of azelastine hydrochloride in alcohol-induced asthma. | 1999 | Ann. Allergy Asthma Immunol. | pmid:10227338 |
| Nilsen A et al. | Short-term exposure of rodents to diesel exhausts: usefulness for studies of genotoxic and immunotoxic effects. | 1999 | Chem. Biol. Interact. | pmid:10227576 |
| Hamasaki Y et al. | Magnolol inhibits leukotriene synthesis in rat basophilic leukemia-2H3 cells. | 1999 | Planta Med. | pmid:10232065 |
| Denizot Y et al. | Are lipid mediators implicated in the production of pro- and anti-inflammatory cytokines during cardiopulmonary bypass graft with extracorporeal circulation? | 1999 | Cytokine | pmid:10328869 |
| Niinuma K et al. | Primary active transport of organic anions on bile canalicular membrane in humans. | 1999 | Am. J. Physiol. | pmid:10330006 |
| Hipfner DR et al. | Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein. | 1999 | J. Biol. Chem. | pmid:10336431 |
| Sano A et al. | Inhibition of cPLA2 translocation and leukotriene C4 secretion by fluticasone propionate in exogenously activated human eosinophils. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10351938 |
| Kita H et al. | Does IgE bind to and activate eosinophils from patients with allergy? | 1999 | J. Immunol. | pmid:10352312 |
| Chen ZS et al. | An enhanced active efflux of CPT-11 and SN-38 in cisplatin-resistant human KB carcinoma cells. | 1999 | Cancer Lett. | pmid:10378768 |
| Gibbs BF and Grabbe J | Inhibitors of PI 3-kinase and MEK kinase differentially affect mediator secretion from immunologically activated human basophils. | 1999 | J. Leukoc. Biol. | pmid:10380914 |
| Miadonna A et al. | Nasal response to a single antigen challenge in patients with allergic rhinitis - inflammatory cell recruitment persists up to 48 hours. | 1999 | Clin. Exp. Allergy | pmid:10383595 |
| Vellenga E et al. | Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1. | 1999 | Br. J. Pharmacol. | pmid:10385244 |
| Lynch KR et al. | Characterization of the human cysteinyl leukotriene CysLT1 receptor. | 1999 | Nature | pmid:10391245 |
| Cordoba-Rodriguez R et al. | Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393875 |
| Bischoff SC et al. | IL-4 enhances proliferation and mediator release in mature human mast cells. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393951 |
| Clish CB et al. | Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393980 |
| Irkeç MT et al. | Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers. | 1999 | Ocul. Immunol. Inflamm. | pmid:10410873 |
| Dantzig AH et al. | Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10411602 |
| Rappa G et al. | New insights into the biology and pharmacology of the multidrug resistance protein (MRP) from gene knockout models. | 1999 | Biochem. Pharmacol. | pmid:10413292 |
| Kamisako T et al. | Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2. | 1999 | Hepatology | pmid:10421658 |
| Stride BD et al. | Localization of a substrate specificity domain in the multidrug resistance protein. | 1999 | J. Biol. Chem. | pmid:10428874 |
| Falcón-Pérez JM et al. | Functional domain analysis of the yeast ABC transporter Ycf1p by site-directed mutagenesis. | 1999 | J. Biol. Chem. | pmid:10438540 |
| Campbell EM et al. | Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. | 1999 | J. Immunol. | pmid:10438957 |
| Kawabe T et al. | Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). | 1999 | FEBS Lett. | pmid:10456333 |
| Sarau HM et al. | Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. | 1999 | Mol. Pharmacol. | pmid:10462554 |
| Nakasato H et al. | Prevention of severe premenstrual asthma attacks by leukotriene receptor antagonist. | 1999 | J. Allergy Clin. Immunol. | pmid:10482831 |
| Hagmann W et al. | Purification of the human apical conjugate export pump MRP2 reconstitution and functional characterization as substrate-stimulated ATPase. | 1999 | Eur. J. Biochem. | pmid:10491184 |
| Rao AM et al. | Arachidonic acid and leukotriene C4: role in transient cerebral ischemia of gerbils. | 1999 | Neurochem. Res. | pmid:10492517 |
| Van Aubel RA et al. | Mechanisms and interaction of vinblastine and reduced glutathione transport in membrane vesicles by the rabbit multidrug resistance protein Mrp2 expressed in insect cells. | 1999 | Mol. Pharmacol. | pmid:10496953 |
| Schmidt D et al. | Passive sensitization of human airways increases responsiveness to leukotriene C4. | 1999 | Eur. Respir. J. | pmid:10515407 |
| Muñoz NM et al. | Augmentation of eosinophil degranulation and LTC(4) secretion by integrin-mediated endothelial cell adhesion. | 1999 | Am. J. Physiol. | pmid:10516222 |
| May A et al. | Means of increasing sensitivity of an in vitro diagnostic test for aspirin intolerance. | 1999 | Clin. Exp. Allergy | pmid:10520062 |
| Ko JK and Cho CH | Co-regulation of mucosal nitric oxide and prostaglandin in gastric adaptive cytoprotection. | 1999 | Inflamm. Res. | pmid:10522801 |
| Lankisch TO et al. | High-affinity cholecystokinin type A receptor/cytosolic phospholipase A2 pathways mediate Ca2+ oscillations via a positive feedback regulation by calmodulin kinase in pancreatic acini. | 1999 | Eur. J. Cell Biol. | pmid:10535305 |
| Mao Q et al. | ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells. | 1999 | Biochim. Biophys. Acta | pmid:10556489 |
| Rao AM et al. | CDP-choline: neuroprotection in transient forebrain ischemia of gerbils. | 1999 | J. Neurosci. Res. | pmid:10561698 |
| Chen ZS et al. | Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. | 1999 | Mol. Pharmacol. | pmid:10570049 |
| Cracowski JL et al. | Functional comparison of the human isolated femoral artery, internal mammary artery, gastroepiploic artery, and saphenous vein. | 1999 | Can. J. Physiol. Pharmacol. | pmid:10588481 |
| Norman BH et al. | Reversal of resistance in multidrug resistance protein (MRP1)-overexpressing cells by LY329146. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10612603 |
| Bandeira-Melo C et al. | Cyclooxygenase-2-derived prostaglandin E2 and lipoxin A4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: relationship with concurrent eosinophilia. | 2000 | J. Immunol. | pmid:10623853 |
| Sundkvist E et al. | Leukotriene C(4) (LTC(4)) does not share a cellular efflux mechanism with cGMP: characterisation of cGMP transport by uptake to inside-out vesicles from human erythrocytes. | 2000 | Biochim. Biophys. Acta | pmid:10631301 |
| Tsang S et al. | Simplified purification of human basophils. | 2000 | J. Immunol. Methods | pmid:10648851 |
| Ding GY et al. | Multidrug resistance-associated protein (MRP) mediated transport of daunomycin and leukotriene C4 (LTC4) in isolated plasma membrane vesicles. | 1999 Jul-Aug | Anticancer Res. | pmid:10652618 |
| Yakubu MA and Leffler CW | Enhanced pial arteriolar sensitivity to bioactive agents following exposure to endothelin-1. | 2000 | Life Sci. | pmid:10665982 |
| Sjölinder M et al. | Aberrant expression of active leukotriene C(4) synthase in CD16(+) neutrophils from patients with chronic myeloid leukemia. | 2000 | Blood | pmid:10666225 |
| Lieberman MW et al. | Gamma-glutamyl leukotrienase cleavage of leukotriene C4. | 1999 | Adv. Exp. Med. Biol. | pmid:10667345 |
| Schweitzer P et al. | Cannabinoid modulation of neuronal activity in adult rat hippocampus. | 1999 | Adv. Exp. Med. Biol. | pmid:10667381 |
| Herman CA and Luczy-Bachman G | Eicosanoids in the brain of warm- and cold-acclimated bullfrogs. | 1999 | Adv. Exp. Med. Biol. | pmid:10667397 |
| Amann R et al. | Eicosanoid release in the endotoxin-primed isolated perfused rat lung and its pharmacological modification. | 1999 | Inflamm. Res. | pmid:10669114 |
| Mayatepek E et al. | Analysis of leukotrienes in cerebrospinal fluid of a reference population and patients with inborn errors of metabolism: further evidence for a pathognomonic profile in LTC(4)-synthesis deficiency. | 2000 | Clin. Chim. Acta | pmid:10686285 |
| Gutmann H et al. | P-glycoprotein- and mrp2-mediated octreotide transport in renal proximal tubule. | 2000 | Br. J. Pharmacol. | pmid:10694230 |
| Yamashita M et al. | Inhibition by troglitazone of the antigen-induced production of leukotrienes in immunoglobulin E-sensitized RBL-2H3 cells. | 2000 | Br. J. Pharmacol. | pmid:10694244 |
| Desplat V et al. | Incorporation and effect of arachidonic acid on the growth of human myeloma cell lines. | 1999 | Mediators Inflamm. | pmid:10704149 |
| Skaltsa H et al. | Inhibition of prostaglandin E2 and leukotriene C4 in mouse peritoneal macrophages and thromboxane B2 production in human platelets by flavonoids from Stachys chrysantha and Stachys candida. | 2000 | Biol. Pharm. Bull. | pmid:10706410 |
| Miura K and MacGlashan DW | Dual phase priming by IL-3 for leukotriene C4 generation in human basophils: difference in characteristics between acute and late priming effects. | 2000 | J. Immunol. | pmid:10706691 |
| Douglas IS et al. | CD4+ T cell and eosinophil adhesion is mediated by specific ICAM-3 ligation and results in eosinophil activation. | 2000 | J. Immunol. | pmid:10706734 |
| Aiso M et al. | Biliary excretion of bile acids and organic anions in zone 1- and zone 3-injured rats. | 2000 | Liver | pmid:10726959 |
| Okamoto M et al. | Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma. | 2000 | Intern. Med. | pmid:10732825 |
| Seno K et al. | Pyrrolidine inhibitors of human cytosolic phospholipase A(2). | 2000 | J. Med. Chem. | pmid:10737736 |
| Ren XQ et al. | Functional comparison between YCF1 and MRP1 expressed in Sf21 insect cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10753671 |
| Bates ME et al. | ERK1 and ERK2 activation by chemotactic factors in human eosinophils is interleukin 5-dependent and contributes to leukotriene C(4) biosynthesis. | 2000 | J. Biol. Chem. | pmid:10753897 |
| Vidal A et al. | Synthesis of 19-[(2-azido-5-iodo)-benzoyloxy]-LTA4 and enzymatic conversion to the LTC4 analogue. | 2000 | Bioorg. Med. Chem. Lett. | pmid:10762049 |
| Hasday JD et al. | Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10764316 |
| Loe DW et al. | Verapamil stimulates glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1). | 2000 | J. Pharmacol. Exp. Ther. | pmid:10773025 |
| Gao M et al. | Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1. | 2000 | J. Biol. Chem. | pmid:10777615 |
| Goulet JL et al. | Genetic factors determine the contribution of leukotrienes to acute inflammatory responses. | 2000 | J. Immunol. | pmid:10779800 |
| Kurosawa M et al. | Inhibition of bronchial hyperresponsiveness to histamine induced by intravenous administration of leukotriene C4 by novel thromboxane A2 receptor antagonists ONO-NT-126 and ONO-8809 in guinea-pigs. | 1993 | Clin. Exp. Allergy | pmid:10780891 |
| Sanchez Mejia RO et al. | Matrix-associated transforming growth factor-beta1 primes mouse bone marrow-derived mast cells for increased high-affinity Fc receptor for immunoglobulin E-dependent eicosanoid biosynthesis. | 2000 | Am. J. Respir. Cell Mol. Biol. | pmid:10783127 |
| Hamasaki Y et al. | (9-[4-acetyl-3-hydroxy-2-n-propylphenoxy) methyl]-3-(1H-tetrazol-5-yl)-4H-pyrido [1,2-a] pyrimidin-4-one), AS-35, inhibits leukotriene synthesis. | 2000 | Int. J. Immunopharmacol. | pmid:10785545 |
| Sullivan GF et al. | Regulation of expression of the multidrug resistance protein MRP1 by p53 in human prostate cancer cells. | 2000 | J. Clin. Invest. | pmid:10792001 |
| Macfarlane AJ et al. | Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10806153 |
| Ravasi S et al. | A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lung parenchyma. | 2000 | Mol. Pharmacol. | pmid:10825389 |
| Muñoz NM et al. | Augmentation of LTC(4) synthesis in human eosinophils caused by CD3-stimulated Th2-like cells in vitro. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10835322 |
| Tran HS et al. | The cardiovascular hemodynamics and leukotriene kinetics during prostacyclin and anti-prostacyclin antibody infusions in septic shock. | 2000 | Shock | pmid:10847636 |
| Heise CE et al. | Characterization of the human cysteinyl leukotriene 2 receptor. | 2000 | J. Biol. Chem. | pmid:10851239 |
| Florio G et al. | The immunoglobulin superantigen-binding site of HIV-1 gp120 activates human basophils. | 2000 | AIDS | pmid:10853974 |
| Malaviya R and Abraham SN | Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis. | 2000 | J. Leukoc. Biol. | pmid:10857857 |
| Urasaki T et al. | Induction of the activation-related antigen CD69 on human eosinophils by type IIA phospholipase A2. | 2000 | Inflamm. Res. | pmid:10858018 |
| Gibbs BF et al. | Ambroxol inhibits IgE-dependent mediator secretion from human skin mast cells. | 2000 | Inflamm. Res. | pmid:10864402 |
| Okamoto M et al. | Effects of perilla seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism. | 2000 | Int. Arch. Allergy Immunol. | pmid:10878492 |
| Karimi K et al. | Stem cell factor and interleukin-4 increase responsiveness of mast cells to substance P. | 2000 | Exp. Hematol. | pmid:10880748 |