LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

Download all related citations
Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
pmid:
Nakamura T et al. Direct interaction between a quinoline derivative, MS-209, and multidrug resistance protein (MRP) in human gastric cancer cells. 1999 Biochem. Biophys. Res. Commun. pmid:10049760
Sjölinder M et al. Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1. 1999 J. Lipid Res. pmid:10064732
Collin N et al. [Search for a threshold to distinguish between locoregional and systemic reactions using the histamine liberation value and the LTC4 level]. 1999 Allerg Immunol (Paris) pmid:10070593
Sakamoto H et al. Enhancement of glucuronosyl etoposide transport by glutathione in multidrug resistance-associated protein-overexpressing cells. 1999 Cancer Lett. pmid:10077229
Awasthi S et al. ATP-Dependent colchicine transport by human erythrocyte glutathione conjugate transporter. 1999 Toxicol. Appl. Pharmacol. pmid:10079207
Lay JC et al. Cellular and biochemical response of the human lung after intrapulmonary instillation of ferric oxide particles. 1999 Am. J. Respir. Cell Mol. Biol. pmid:10100994
O'Connor BJ et al. Selective airway responsiveness in asthma. 1999 Trends Pharmacol. Sci. pmid:10101956
Zaitsu M et al. Effect of dexamethasone on leukotriene synthesis in DMSO-stimulated HL-60 cells. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:10102384
Renes J et al. ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1. 1999 Br. J. Pharmacol. pmid:10188979
Keskil ZA et al. Changes of arterial arachidonic acid metabolites in hypertensive patients during haemodialysis. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:10189068
McWherter CA et al. Circular permutation of the granulocyte colony-stimulating factor receptor agonist domain of myelopoietin. 1999 Biochemistry pmid:10194378
Carvalho-Tavares J et al. Assessment of the mechanism of juxtacrine activation and adhesion of leukocytes in liver microcirculation. 1999 Am. J. Physiol. pmid:10198324
Miura K et al. Extracellular signal-regulated kinases regulate leukotriene C4 generation, but not histamine release or IL-4 production from human basophils. 1999 J. Immunol. pmid:10201947
Constable AL et al. DMSO induction of the leukotriene LTC4 by Lewis rat Schwann cells. 1999 J. Neurol. Sci. pmid:10202977
Held HD et al. Characterization of airway and vascular responses in murine lungs. 1999 Br. J. Pharmacol. pmid:10205008
Malaviya R and Uckun FM Genetic and biochemical evidence for a critical role of Janus kinase (JAK)-3 in mast cell-mediated type I hypersensitivity reactions. 1999 Biochem. Biophys. Res. Commun. pmid:10208864
Masereeuw R et al. Active lucifer yellow secretion in renal proximal tubule: evidence for organic anion transport system crossover. 1999 J. Pharmacol. Exp. Ther. pmid:10215693
Mayatepek E et al. A severely affected infant with absence of cysteinyl leukotrienes in cerebrospinal fluid: further evidence that leukotriene C4-synthesis deficiency is a new neurometabolic disorder. 1999 Neuropediatrics pmid:10222453
Takao A et al. Inhibitory effects of azelastine hydrochloride in alcohol-induced asthma. 1999 Ann. Allergy Asthma Immunol. pmid:10227338
Nilsen A et al. Short-term exposure of rodents to diesel exhausts: usefulness for studies of genotoxic and immunotoxic effects. 1999 Chem. Biol. Interact. pmid:10227576
Hamasaki Y et al. Magnolol inhibits leukotriene synthesis in rat basophilic leukemia-2H3 cells. 1999 Planta Med. pmid:10232065
Denizot Y et al. Are lipid mediators implicated in the production of pro- and anti-inflammatory cytokines during cardiopulmonary bypass graft with extracorporeal circulation? 1999 Cytokine pmid:10328869
Niinuma K et al. Primary active transport of organic anions on bile canalicular membrane in humans. 1999 Am. J. Physiol. pmid:10330006
Hipfner DR et al. Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein. 1999 J. Biol. Chem. pmid:10336431
Sano A et al. Inhibition of cPLA2 translocation and leukotriene C4 secretion by fluticasone propionate in exogenously activated human eosinophils. 1999 Am. J. Respir. Crit. Care Med. pmid:10351938
Kita H et al. Does IgE bind to and activate eosinophils from patients with allergy? 1999 J. Immunol. pmid:10352312
Chen ZS et al. An enhanced active efflux of CPT-11 and SN-38 in cisplatin-resistant human KB carcinoma cells. 1999 Cancer Lett. pmid:10378768
Gibbs BF and Grabbe J Inhibitors of PI 3-kinase and MEK kinase differentially affect mediator secretion from immunologically activated human basophils. 1999 J. Leukoc. Biol. pmid:10380914
Miadonna A et al. Nasal response to a single antigen challenge in patients with allergic rhinitis - inflammatory cell recruitment persists up to 48 hours. 1999 Clin. Exp. Allergy pmid:10383595
Vellenga E et al. Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1. 1999 Br. J. Pharmacol. pmid:10385244
Lynch KR et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. 1999 Nature pmid:10391245
Cordoba-Rodriguez R et al. Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10393875
Bischoff SC et al. IL-4 enhances proliferation and mediator release in mature human mast cells. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10393951
Clish CB et al. Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10393980
Irkeç MT et al. Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers. 1999 Ocul. Immunol. Inflamm. pmid:10410873
Dantzig AH et al. Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities. 1999 J. Pharmacol. Exp. Ther. pmid:10411602
Rappa G et al. New insights into the biology and pharmacology of the multidrug resistance protein (MRP) from gene knockout models. 1999 Biochem. Pharmacol. pmid:10413292
Kamisako T et al. Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2. 1999 Hepatology pmid:10421658
Stride BD et al. Localization of a substrate specificity domain in the multidrug resistance protein. 1999 J. Biol. Chem. pmid:10428874
Falcón-Pérez JM et al. Functional domain analysis of the yeast ABC transporter Ycf1p by site-directed mutagenesis. 1999 J. Biol. Chem. pmid:10438540
Campbell EM et al. Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. 1999 J. Immunol. pmid:10438957
Kawabe T et al. Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). 1999 FEBS Lett. pmid:10456333
Sarau HM et al. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. 1999 Mol. Pharmacol. pmid:10462554
Nakasato H et al. Prevention of severe premenstrual asthma attacks by leukotriene receptor antagonist. 1999 J. Allergy Clin. Immunol. pmid:10482831
Hagmann W et al. Purification of the human apical conjugate export pump MRP2 reconstitution and functional characterization as substrate-stimulated ATPase. 1999 Eur. J. Biochem. pmid:10491184
Rao AM et al. Arachidonic acid and leukotriene C4: role in transient cerebral ischemia of gerbils. 1999 Neurochem. Res. pmid:10492517
Van Aubel RA et al. Mechanisms and interaction of vinblastine and reduced glutathione transport in membrane vesicles by the rabbit multidrug resistance protein Mrp2 expressed in insect cells. 1999 Mol. Pharmacol. pmid:10496953
Schmidt D et al. Passive sensitization of human airways increases responsiveness to leukotriene C4. 1999 Eur. Respir. J. pmid:10515407
Muñoz NM et al. Augmentation of eosinophil degranulation and LTC(4) secretion by integrin-mediated endothelial cell adhesion. 1999 Am. J. Physiol. pmid:10516222